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At least 559 records · Page 31Linked to original sources
PubMed1983

Immunofluorescent localization of myosin at the anterior pole of the coccidian, Toxoplasma gondii.

Indirect immunofluorescence using anti-myosin rabbit sera showed myosin localized in a characteristic pattern at the anterior pole of Toxoplasma gondii. This polar fluorescent staining was abolished by pre-absorption of the anti-sera with myosin extracted from avian muscle. Both intracellular and extracellular T. gondii showed similar patterns when formaldehyde-fixed, but neither showed polar fluorescence when acetone was used as the sole fixative. Immunofluorescent staining of live T. gondii revealed no polar fluorescence, suggesting that myosin is not present on the outer parasite membrane. Anti-myosin serum did not prevent host cell invasion and plaque formation in the presence of human complement. Inhibition of contractile proteins with cytochalasin D inhibited T. gondii motility and infectivity in a plaque formation assay. The pattern of polar fluorescence described here resembles the IgM-associated polar staining frequently detected in human sera, but we believe it is a different phenomenon because human sera that showed such staining retained their activity after pre-absorption with avian myosin. The unusual localization of myosin at the anterior pole of T. gondii tachyzoites may play a role in the function of anterior organelles, which are thought to facilitate the invasion of host cells.

Animals↗
PubMed1995

Patellar tendinitis--a case report of elongation and ossification of the inferior pole of the patella.

Patellar tendinitis is a condition that occurs in patients who are involved in repetitive use of the extension mechanism. The most common symptoms are pain at the inferior pole of the patella, and radiographic changes may also occur. This case report demonstrates an extreme example of elongation of the inferior pole of the patellar tendon. The ossification caused the patient pain, which was resolved with surgical removal of the bone.

Adult↗
PubMed2006

Self-guided brisk walking training with or without poles: a randomized-controlled trial in middle-aged women.

Walking with poles (Nordic walking, NW) has become popular. We compared training responses of brisk walking (W) or NW on cardiorespiratory and neuromuscular fitness. We randomized 121 non-obese sedentary women (aged 50-60) to an NW or W group (NWG, WG), to train 40 min four times weekly for 13 weeks. Intensity was based on subjective perception of exertion. Cardiorespiratory performance was assessed in four levels corresponding to 50%, 65%, 80% and 100% of peak VO(2). Fifty-four NWG and 53 WG subjects completed the study. The mean intensity was about 50% of heart rate (HR) reserve. The baseline peak VO(2) was 25.8 (SD 3.9) mL/min/kg. Both groups improved peak VO(2) similarly (NWG 2.5 mL/min/kg, 95% confidence interval (CI) 1.9-3.3; WG 2.6, CI 1.9-3.3). In the submaximal stages while walking with or without poles, HR and lactate decreased after training in both groups, but the changes were not statistically significantly different between the groups. Of the neuromuscular tests after training, the only significant difference between the groups was in the leg strength in the one-leg squat, favoring WG. In conclusion, both training modes improved similarly health-enhancing physical fitness, and they were feasible and safe.

Cross-Sectional Studies↗
PubMed2000

Line spectral frequencies are poles and zeros of the glottal driving-point impedance of a discrete matched-impedance vocal tract model.

This correspondence demonstrates that the line spectral frequencies (LSFs) are the pole and zero frequencies of the glottal driving-point impedance of a discrete matched-impedance vocal-tract model. Several well-known characteristics of the LSFs, including the interlacing of pole and zero frequencies, are shown to follow naturally from this proof.

Humans↗
PubMed2006

Pole and global shape of 25143 Itokawa.

The locations of the pole and rotation axis of asteroid 25143 Itokawa were derived from Asteroid Multiband Imaging Camera data on the Hayabusa spacecraft. The retrograde pole orientation had a right ascension of 90.53 degrees and a declination of -66.30 degrees (52000 equinox) or equivalently 128.5 degrees and -89.66 degrees in ecliptic coordinates with a 3.9 degrees margin of error. The surface area is 0.393 square kilometers, the volume is 0.018378 cubic kilometers with a 5% margin of error, and the three axis lengths are 535 meters by 294 meters by 209 meters. The global Itokawa revealed a boomerang-shaped appearance composed of two distinct parts with partly faceted regions and a constricted ring structure.

Journal Article↗
PubMed1999

Topography of the lunar poles from radar interferometry: a survey of cold trap locations.

Detailed topographic maps of the lunar poles have been obtained by Earth-based radar interferometry with the 3.5-centimeter wavelength Goldstone Solar System Radar. The interferometer provided maps 300 kilometers by 1000 kilometers of both polar regions at 150-meter spatial resolution and 50-meter height resolution. Using ray tracing, these digital elevation models were used to locate regions that are in permanent shadow from solar illumination and may harbor ice deposits. Estimates of the total extent of shadowed areas poleward of 87.5 degrees latitude are 1030 and 2550 square kilometers for the north and south poles, respectively.

Ice↗
PubMed2006

Localization of the naturally occurring plasmid ColE1 at the cell pole.

The naturally occurring plasmid ColE1 was found to localize as a cluster in one or both of the cell poles of Escherichia coli. In addition to the polar localization of ColE1 in most cells, movement of the plasmid to the midcell position was observed in time-lapse studies. ColE1 could be displaced from its polar location by the p15A replicon, pBAD33, but not by plasmid RK2. The displacement of ColE1 by pBAD33 resulted in an almost random positioning of ColE1 foci in the cell and also in a loss of segregational stability, as evidenced by the large number of cells carrying pBAD33 with no visible ColE1 focus and as confirmed by ColE1 stability studies. The addition of the active partitioning systems of the F plasmid (sopABC) or RK2 (O(B1) incC korB) resulted in movement of the ColE1 replicon from the cell pole to within the nucleoid region. This repositioning did not result in destabilization but did result in an increase in the number of plasmid foci, most likely due to partial declustering. These results are consistent with the importance of par regions to the localization of plasmids to specific regions of the cell and demonstrate both localization and dynamic movement for a naturally occurring plasmid that does not encode a replication initiation protein or a partitioning system that is required for plasmid stability.

Bacterial Proteins↗
PubMed1985

Discontinuity of charge on cell wall poles of Bacillus subtilis.

When cell wall poles of Bacillus subtilis were treated with dilute cationized ferritin, label was found only at discrete patches. Since cationized ferritin binds to negatively charged groups, the pole regions that retain label most likely represent localized surface sites of high electronegativity, indicating that the cell wall of B. subtilis is, at least, partially differentiated.

Bacillus subtilis↗
PubMed1999

Poles apart: biodiversity and biogeography of sea ice bacteria.

This review introduces the subjects of bacterial biodiversity and biogeography. Studies of biogeography are important for understanding biodiversity, the occurrence of threatened species, and the ecological role of free-living and symbiotic prokaryotes. A set of postulates is proposed for biogeography as a guide to determining whether prokaryotes are "cosmopolitan" (found in more than one geographic location on Earth) or candidate endemic species. The term "geovar" is coined to define a geographical variety of prokaryote that is restricted to one area on Earth or one host species. This review discusses sea ice bacteriology as a test case for examining bacterial diversity and biogeography. Approximately 7% of Earth's surface is covered by sea ice, which is colonized principally by psychrophilic microorganisms. This extensive community of microorganisms, referred to as the sea ice microbial community (SIMCO), contains algae (mostly diatoms), protozoa, and bacteria. Recent investigations indicate that the sea ice bacteria fall into four major phylogenetic groups: the proteobacteria, the Cytophaga-Flavobacterium-Bacteroides (CFB) group, and the high and low mol percent gram-positive bacteria. Archaea associated with sea ice communities have also been reported. Several novel bacterial genera and species have been discovered, including Polaromonas, Polaribacter, Psychroflexus, Gelidibacter, and Octadecabacter; many others await study. Some of the gram-negative sea ice bacteria have among the lowest maximum temperatures for growth known, < 10 degrees C for some strains. The polar sea ice environment is an ideal habitat for studying microbial biogeography because of the dispersal issues involved. Dispersal between poles is problematic because of the long distances and the difficulty of transporting psychrophilic bacteria across the equator. Studies to date indicate that members of some genera occur at both poles; however, cosmopolitan species have not yet been discovered. Additional research on polar sea ice bacteria is needed to resolve this issue and extend our understanding of its microbial diversity.

Antarctic Regions↗
PubMed1979

Renal duplication with a diminutive lower pole: the Nubbin sign.

Eight patients with a duplex kidney demonstrated severe attenuation of parenchyma in the lower pole. The radiographic appearance of a diminutive lower collecting system indicated the proper diagnosis when there was sufficient parenchyma for visualization. Parenchymal attenuation may represent either hypoplasia or inflammatory atrophy. Whichever the cause, it is important that the diminutive lower pole not be mistaken for a renal mass, extrinsic tumor, renal infarction, or a postoperative change.

Adult↗
PubMed2000

Effects of angiotensin II on regional afferent and efferent arteriole dimensions and the glomerular pole.

The diversity of renal arteriole diameters in different cortical regions has important consequences for control of glomerular capillary pressure. We examined whether intrarenal angiotensin II (ANG II; 0.1, 1, or 5 ng. kg(-1). min(-1)) in anesthetized rabbits acts preferentially on pre- or postglomerular vessels using vascular casting. ANG II produced dose-related reductions in afferent and efferent diameters in the outer, mid, and inner cortex, without effecting arterial pressure. Afferent diameter decreased more than efferent in the outer and mid cortex (P < 0.05) but by a similar extent in juxtamedullary nephrons (P = 0.58). Calculated efferent resistance increased more than afferent, especially in the outer cortex (127 vs. 24 units; 5 ng. kg(-1). min(-1) ANG II). ANG II produced significant dose-related increases in the distance between the arterioles at the entrance to the glomerular pole in all regions. Thus afferent diameter decreased more in response to ANG II, but efferent resistance rose more due to smaller resting luminal dimensions. The results also indicate that glomerular pole dimensions change in response to ANG II.

Angiotensin II↗
PubMed1995

Mnemonic firing of neurons in the monkey temporal pole during a visual recognition memory task.

1. We examined single-neuronal activity in the temporal pole of monkeys, including the anterior ventromedial temporal (VMT) cortex (the temporopolar cortex, area 36, area 35, and the entorhinal cortex) and the anterior inferotemporal (IT) cortex, during a visual recognition memory task. In the task, a trial began when the monkey pressed a lever. After a waiting period, a visual sample stimulus (S) was presented one to four times on a monitor with an interstimulus delay. Thereafter, a new stimulus (R) was presented. The monkeys were trained to remember S during the delay period and to release the lever in response to R. Colored photographs of natural objects were used as visual stimuli. 2. About 70% of the recorded neurons (225 of 311) responded to at least one of the Ss tested. Thirty percent of these neurons (68 of 225) continued to fire during the subsequent delay periods. In 75% of these neurons (51 of 68), the firing during the delay period strongly correlated with the response to S. 3. The discharge rate during the delay period did not correlate with the monkey's eye movements, pressing or releasing of the lever, or the reaction time. 4. If the monkey erroneously released the lever in response to S or during the delay period, the firing disappeared after the erroneous lever release. If the monkey failed to release the lever in response to R, the firing persisted even after R was withdrawn. The discharge rate in incorrect trials was comparable with that in correct trials. The neurons were considered to fire for as long as the memory of S was necessary. 5. Firing persisted even when an achromatic version or half (even a portion) of S was presented, indicating that the color, a particular portion, or the entire shape of S was not always necessary to elicit firing. 6. An S that elicited firing during the delay period invariably elicited a visual response. Neurons that fired during the delay period showed a higher stimulus selectivity than other visually responsive neurons in the anterior VMT cortex. Thus neurons that fire during the delay period represent a subgroup of visually responsive neurons that are selectively tuned to a certain stimulus. 7. More neurons fired during the delay period in the anterior VMT cortex than in the anterior IT cortex. 8. We conclude that firing during the delay period by neurons in the temporal pole reflects the short-term storage of visual information regarding a particular S.

Animals↗
PubMed1999

Ureterocele arising from a lower-pole moiety.

We report on an uncommon case of a ureterocele arising from the lower-pole ureter in a duplex system. To our knowledge, this represents the 3rd such case reported in the English literature. Ultrasonography and retrograde pyelogram established the diagnosis. The patient underwent left upper-pole nephroureterectomy with excision of the ureterocele and cross-trigonal ureteral reimplantation.

Child, Preschool↗
PubMed2003

Outcome and safety of extracorporeal shock wave lithotripsy as first-line therapy of lower pole nephrolithiasis.

INTRODUCTION: The aim of this study is to assess the efficiency of extracorporeal shock wave lithotripsy (ESWL) as initial therapy for isolated lower pole kidney stones smaller than 20 mm. PATIENTS AND METHODS: During a 24-month period 116 patients with previously untreated single stones under 20 mm in diameter were treated with a Dornier lithotripter S. They were analyzed with regard to stone site and size, number of ESWL sessions, auxiliary measures, retreatment rates, complications and the time taken for stone clearance. RESULTS: 76 patients (65.5%) became stone free, 50 of them (43.1%) within 3 months after ESWL. Depending on stone size the stone-free rates were 67.1% for patients with a stone diameter of <10 mm (59 of 88 patients), and 60.7% for stone diameters between 10 and 20 mm (17 of 28 patients). Complications during and after treatment were rare, i.e. the necessity of ureteral stent insertion due to colic (n = 10), endoscopic stone removal (n = 2), acute pyelonephritis (n = 1), stonestreet (n = 1) and 1 case of hematoma not requiring intervention. The recurrence rate during follow-up (13.2-36.9, mean 25.0 months) was low: 16 patients (13.8%) had recurrent or persistent stones, and 74 patients (63.8%) had no evidence of urolithiasis. CONCLUSIONS: ESWL is a safe and efficient first-line therapy for treatment of isolated small lower pole kidney stones with acceptable stone-free rates, low morbidity, few complications and a low stone recurrence rate.

Adult↗
PubMed1983

Intraocular SF6 gas applications: treatment of retinal detachments caused by holes at the posterior pole.

Retinal detachments caused by holes in the posterior pole are rare among rhegmatogenous detachments, but the central position of the holes causes considerable difficulties on surgery. The use of intraocular gas bubbles affords new possibilities for the treatment of these cases. Among 1,800 consecutively treated retinal detachments, we found only 21 which were due exclusively to one or more holes at the posterior pole; of these, only 7 exhibited a hole directly in the macula. The operative treatment of these 21 detachments consisted of an intraocular gas tamponade effected through injection of SF6 combined with cryo- and laser coagulation of the periphery of the holes. Reattachment of the macula and improved visual acuity were achieved in 19 cases. The postoperative follow-up ranges from 4 to 60 months, with a mean of 29 months.

Adolescent↗
PubMed1984

Atrophies 'like flows' of the retinal pigment epithelium: a neuroepithelium-draining method of the posterior pole.

17 cases of eyes affected jointly by diseases of the posterior pole (central serous chorioretinopathy, serous detachment of pigmented epithelium, melanoma, osteoma, hemangioma) and flow-like atrophy of the pigmented epithelium, originating from the lesion and always directed downwards, are presented. It is likely that serous detachment of the neuroepithelium constituting the original wound (central serous chorioretinopathy) or the secondary one (serous detachment of the pigmented epithelium) of the posterior pole prolongs itself downwards, leaving a localized atrophy as a mark on the pigmented epithelium. The eventual draining role of serous detachment of the neuroepithelium by this 'flow' is disputed.

Adult↗
PubMed1985

Evaluation of argon laser photocoagulation of the posterior pole in oedematous diabetic retinopathy.

The authors present the results obtained in the treatment of oedematous diabetic retinopathy of 70 patients, i.e. 129 eyes. Follow-up was from 6 months to 6 years. Argon laser photocoagulation of the posterior pole is simple and without risk at the early stages of oedematous retinopathy, and has also proved to be effective in the later stages. Out of 115 eyes exhibiting oedemas of the posterior pole, 84% were stabilized or improved. The same encouraging results were obtained in the case of macular oedemas. Ideally, regular follow-up and treatment as required should prevent cystoid degeneration of the macula.

Diabetes Mellitus, Type 1↗
PubMed2006

Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18.

The venous pole of the mammalian heart is a structurally and electrically complex region, yet the lineage and molecular mechanisms underlying its formation have remained largely unexplored. In contrast to classical studies that attribute the origin of the myocardial sinus horns to the embryonic venous pole, we find that the sinus horns form only after heart looping by differentiation of mesenchymal cells of the septum transversum region into myocardium. The myocardial sinus horns and their mesenchymal precursor cells never express Nkx2-5, a transcription factor critical for heart development. In addition, lineage studies show that the sinus horns do not derive from cells previously positive for Nkx2-5. In contrast, the sinus horns express the T-box transcription factor gene Tbx18. Mice deficient for Tbx18 fail to form sinus horns from the pericardial mesenchyme and have defective caval veins, whereas the pulmonary vein and atrial structures are unaffected. Our studies define a novel heart precursor population that contributes exclusively to the myocardium surrounding the sinus horns or systemic venous tributaries of the developing heart, which are a source of congenital malformation and cardiac arrhythmias.

Animals↗