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At least 559 records · Page 31Linked to original sources
PubMed1984

Instability of the ankle due to a separate centre of ossification in the lateral malleolus.

A case of recurrent instability of the ankle is reported. It was associated with a separate centre of ossification in the lateral malleolus. While such extra ossification centres for both malleoli are recognized, they have not hitherto been incriminated as a cause of instability. The successful treatment of this case is described and the incidence and significance of separate ossification centres for the malleoli are discussed.

Adolescent↗
PubMed1984

Ossification of the paravertebral ligaments: a frequent complication of hypoparathyroidism.

Various forms of paravertebral ligamentous ossification (PVLO) were detected radiologically in 9 (53%) of 17 consecutive patients with hypoparathyroidism. A significant correlation was found between the period during which the patient was untreated and the incidence of ossification. Serum levels of calcium, phosphate, and their ionic product appeared not to influence the incidence. All the patients with PVLO exhibited evidence of ectopic calcification. The fact that ectopic ossification, which is histologically distinct from ectopic calcification, is frequently associated with hypoparathyroidism suggests that similar pathogenetic mechanisms are responsible for the development of these two conditions. The high incidence of PVLO in hypoparathyroid patients in this study may explain some of the neurologic findings in hypoparathyroidism that have been hard to explain simply on the basis of altered neuromuscular excitability.

Adult↗
PubMed1989

Heterotopic ossification: a case report and immunohistochemical observations.

This report describes the case of a 69-year-old man with adenocarcinoma of the transverse colon who developed heterotopic ossification in a metastatic axillary lymph node. The areas of pathologic bone formation were characterized by the appearance of osteoblast-like cells at the surfaces of the mineral deposits. Immunostaining for alkaline phosphatase revealed a significant concentration of this enzyme in these cells and, to a lesser degree, on the apical membrane of the glandular cells of the adenocarcinoma adjacent to the ossification centers. Proliferating mesenchymal cells in close proximity to the areas of osteogenesis also showed significant immunolabeling. We conclude that metastatic colonic carcinoma can promote heterotopic ossification, and that alkaline phosphatase is intimately associated with bone formation under these pathologic conditions.

Adenocarcinoma↗
PubMed1991

Ossification of the cervical ligamentum flavum.

A case of a 61-year-old man with ossification of the cervical ligamentum flavum is reported. The ossification was located on the left side of C3-4. The symptoms improved with laminectomy and resection. Ossification of the ligamentum flavum usually occurs in the lower thoracic spine, and is rare in the cervical region. Including the present one, only eight cases have been reported to our knowledge. The clinical features and pathogenesis are discussed.

Cervical Vertebrae↗
PubMed1985

Endochondral ossification of the condyle in rats on a strontium or low-calcium diet.

The mechanism of abnormal endochondral ossification induced by administration of strontium salts was studied in the mandibular condyles of rats by radiographic, histologic, and histochemical methods. It was shown by radiographic and histologic findings that ossification of the mandibular ramus was clearly inhibited in rats fed a low-calcium diet and rats fed a strontium diet. The change in appearance of the mandibular condyles of the rats fed strontium was more severe than that in those fed low amounts of calcium. From the histochemical findings, it was suggested that the metabolic dysfunction of chondroitin sulfate, periodic acid-Schiff positive materials, and collagen in the hypertrophic zone of the condylar cartilage (or in the part corresponding to trabecular bone of the mandibular ramus) was one factor inhibiting normal endochondral ossification.

Animals↗
PubMedDate not supplied

Characterization of cultured cells derived from ossification of the posterior longitudinal ligament of the spine.

Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common cause of spinal canal stenosis and myelopathy in Orientals. OPLL is characterized by heterotopic new bone formation in ligamentous tissue. To investigate the pathogenesis of OPLL, human posterior longitudinal ligament cells were cultured and their in vitro morphological and biochemical characteristics were studied. Cell cultures from control subjects with normal spinal ligaments did not show any osteoblastic properties. In contrast, cell lines (OG1-OG5) obtained from an OPLL patient showed several different phenotypic characteristics for osteoblasts. OG1 cells showed typical osteoblast-like phenotypic characteristics (i.e., in vitro calcification, high alkaline phosphatase [ALP] activity, and elevation of cAMP levels by parathyroid hormone [PTH]). All cell lines (OG1-OG5) responded to PTH and PGE2 by markedly increasing cAMP levels, ALP activities varied among the cell lines. The OG1 and OG2 cells exhibited a high level of ALP activity. Compared with cell lines from the non-ossification group, the activities were higher in the OG3 and OG4 cells, but not significantly in the OG5 cells. Only in the OG3 cells, CT caused an increase in cAMP level and ALP activity, and its stimulatory effects demonstrated that CT had a direct, in vitro action on ligament cells of OPLL patients to stimulate osteoblastic differentiation. It is clear that some cells from ligaments with OPLL had several phenotypes characteristic of osteoblasts, but cells from ligaments without ossification did not show any osteoblastic properties. This observation is considered to be an important clue to understanding the pathophysiology of OPLL.

Acid Phosphatase↗
PubMed2005

Trochanteric heterotopic ossification after total hip arthroplasty performed using a direct lateral approach.

A unique pattern and location of symptomatic heterotopic ossification (HO) was observed in patients having total hip arthroplasty (THA) performed using a direct lateral approach, situated outside the hip capsule, distal, lateral, and anterior to the greater trochanter, designated as trochanteric heterotopic ossification (THO). Radiographs of 1420 consecutive primary total hip arthroplasties were reviewed. Three hundred and seventy hips (26%) developed HO around the hip and greater trochanter. One hundred of these hips (27%) demonstrated THO, without classic HO. Of the 270 cases containing a Brooker component, 110 hips exhibited additional HO (THO). Thus, THO occurred in 210 (14.8%) of 1420 THAs. Two patients required surgical excision of the HO after maturity, gaining full relief without recurrence. Trochanteric heterotopic ossification should be considered as a possible cause of early postoperative pain after THA performed using a direct lateral approach.

Arthroplasty, Replacement, Hip↗
PubMed2005

Early changes in prostaglandins precede bone formation in a rabbit model of heterotopic ossification.

We have tested the hypothesis that the formation of heterotopic ossification (HO) in a rabbit model is correlated with a local increase in specific prostaglandins that may modulate mechanisms of ossification. Rabbits were sacrificed at 1 to 21 days following the daily forcible flexion of immobilized knees. The extraction and analysis of prostaglandins (PG) E2, F2alpha, D2, 6-keto-F1alpha, and thromboxane B2 in vastus intermedius muscles of manipulated legs revealed increases compared to control hindlimbs for all five prostaglandins, albeit of differing magnitude. The earliest increase was observed for PGF2alpha after 24 h (to 2.6-fold of control) with peak levels observed at day ten (185-fold of control). PGE2 was increased above control from 2 to 21 days following manipulation, with a peak level of 33-fold of control after 10 days. In a separate arm of the study, the role of PGE2 was investigated through the use of pharmacological antagonist of the PGE2 receptors and one of its second messengers, cAMP. Rabbits were preadministered the PGE2/PGD receptor antagonist AH 6809 or the cAMP antagonist Rp-cAMP prior to undergoing the regimen of limb immobilization and passive exercise. Both AH 6809 and Rp-cAMP were found to prevent the later development of radiographically documented heterotopic ossification in 15 out of 16 animals, thus identifying prostaglandins as being required for the development of ectopic bone. In this latter group, all but one pharmacologically treated animal showed an absence of HO at 3, 4, 5, or 6 weeks. These findings suggest an obligate cascade of prostaglandins for HO that offers the potential for novel prophylactic therapies, including those that target receptors for specific prostaglandins.

Animals↗
PubMed2004

Gene expression in human osteoblastic cells from normal and heterotopic ossification.

Heterotopic ossification (HO), a possible complication of head injury, develops in sites where it is not normally present like at the vicinity of joints. It may cause pain, decrease motion and in severe cases complete joint ankylosis requiring surgical intervention. To our knowledge, no study has been made to analyze HO at the molecular level on human biopsies, whereas its etiology remains to be determined. We defined a procedure of cell fractionation from bone resections and developed quantitative RT-PCR to compare genetic expression patterns between human normal osteoblasts and heterotopic ossification forming cells. This quantitative study demonstrated a specific and strong overexpression of osteocalcin mRNA in HO-isolated cells associated with a significant upregulation of type 1 collagen and osteonectin mRNA while histological analysis showed only small cellular variations. Our results give a first molecular characterization of heterotopic ossification and we conclude that such overexpressions in HO-isolated cells could be associated with the high activity of this pathological bone.

Adult↗
PubMed2006

[Bilateral ossification of the auricular cartilage].

Auricular petrification is an infrequent finding in which the ears become completely or partially rigid. The most frequent cause is the calcification of the auricular cartilage and, infrequently, auricular ossification. Ossification may be due to hypothermia, physical factors, inflammatory processes and different endocrinopathies. Severe hypothermia is the most frequent cause. We present a case of bilateral ossification of the auricular cartilage secondary to hypothermia.

Aged, 80 and over↗
PubMed2000

Ectopic metaplastic ossification after sternotomy.

Ectopic ossification is a rare complication after a major operation. We report a case of cutaneous infection and metaplastic ossification in an 80-year-old man who underwent coronary artery bypass grafting 4 years earlier. Computed tomographic scan demonstrated a partial pseudarthrosis of the corpus sterni. The infected part of the sternal scar was excised and sternal wires were removed. Eight months later, the wound has healed without complications and the cutaneous ossification is unaltered.

Aged↗
PubMed2001

Rare clinical diagnosis of dendriform pulmonary ossification.

Dendriform pulmonary ossification, defined as "widespread heterotopic bone formation within the lungs," is a rare entity, which is usually diagnosed upon postmortem examination. The case of a 43-year-old man with dendriform pulmonary ossification is presented. In this patient's case, thoracoscopic biopsy was an excellent diagnostic modality for identifying dendriform pulmonary ossification. Although this entity has been reported rarely, with improved technology and survival we might expect its prevalence to increase.

Adult↗
PubMed2002

Heterotopic ossification in the orbit.

BACKGROUND: While calcification of orbital hemangiomas has been reported previously, no reports exist of heterotopic ossifications occurring within the orbit. CASE DESCRIPTION: A 30-year-old male presented with spontaneous onset of painless progressive proptosis of the left eye, with diplopia. The preoperative radiologic findings are presented. The lesion was excised completely. The pathologic features and probable causes are discussed. CONCLUSIONS: Heterotopic ossification of the orbit should be considered in the differential diagnosis of an orbital lesion showing radiologic features of calcification or ossification.

Adult↗
PubMed1980

Dendriform pulmonary ossification.

Four cases of dendriform pulmonary ossification are reported from postmortem roentgenography of isolated lungs. All showed pathoanatomical evidence of chronic fibrosing, mostly interstitial, rarely intraalveolar pneumonia, besides the typical manifestations of dendriform pulmonary ossification. Microscopy revealed fluid transition from proliferating, interstitially increased connective tissue to fully developed osseous structures. These dendriform structures can be seen in some analogy to the structural pattern of interstitial, bronchovascular as well as septal connective tissue; however, actual topographical correlation between bone structures and blood or lymph vessels could not be safely determined. Our observations suggest that dendriform pulmonary ossification may be interpreted as a rare complication, or special manifestation, of chronic fibrosing interstitial inflammation of the lung.

Aged↗
PubMed1983

Heterotopic ossification of the intestinal mesentery. Report of a case following intraabdominal surgery.

In a 55-year-old male a nodular mass of heterotopic ossification developed in the intestinal mesentery two weeks after coloproctectomy for severe ulcerative colitis. The lesion was located close to the ileostoma where it encroached upon the intestinal wall and led to luminal obstruction. Histological examination of the tumour mass showed actively proliferating mesenchymal cells forming irregular areas of primitive osteoid and bone. The process appeared consistent with an early stage of heterotopic ossification where the short history explains the absence of the "zone phenomenon" usually characterizing such lesions. By reviewing the literature the reported case appears unique as other cases of intraabdominal heterotopic ossification have not been encountered.

Colitis, Ulcerative↗
PubMed1994

Failure of arthroscopic decompression by subacromial heterotopic ossification causing recurrent impingement.

Heterotopic ossification is a well-recognized complication of musculoskeletal trauma and elective orthopaedic surgery. A series of 10 cases of arthroscopic subacromial decompressions developed postoperative heterotopic bone. In eight, the ectopic bone caused recurrent shoulder impingement. These are the first reported cases in which heterotopic ossification compromised the results of an arthroscopic procedure. It is recommended that the patient at risk (e.g., with active spondolytic arthropathy or a profile of hypertrophic pulmonary osteoarthropathy--obesity, diabetes with a history of chronic pulmonary disease) be considered for heterotopic ossification prophylaxis.

Adult↗
PubMed2005

[Ossification of the common posterior longitudinal ligament of the spine and spinal cord compression in a patient from Senegal].

INTRODUCTION: Ossification of the posterior longitudinal ligament of the spine is a rare cause medullar compression. OBSERVATION: A 50-year-old man from Senegal was referred with recent-onset mechanical lumbar pain with proximal motor deficiency of the lower limbs and somatosensory disorders. Magnetic resonance imaging revealed layered medullar compression, due to anterior cervical and mixed anterior and posterior thoracic ossification. Corticosteroid treatment led to regression of the pain and neurological disorders within a few days. DISCUSSION: This case report of ossification of the posterior longitudinal ligament of the spine appears to be an idiopathic form corresponding to the "Japanese disease" initially thought to be limited to that population.

Anti-Inflammatory Agents↗
PubMed1988

Indomethacin for the prevention of heterotopic ossification following total hip arthroplasty. Effectiveness, contraindications, and adverse effects.

Seventy-four patients undergoing total hip arthroplasty considered to be at high risk for heterotopic ossification were given 75 mg of indomethacin daily for 6 weeks after operation and studied clinically and radiographically for a minimum of 6 months. Twenty-seven patients (37%) could not complete the drug course. Of the 47 (63%) patients completing treatment, only 2 (4%) had grade IIA (mild) and no patients had more severe heterotopic ossification. No major complications were attributed to the use of indomethacin. These findings support the evidence that indomethacin can effectively prevent higher grades of heterotopic ossification following total hip arthroplasty. However, approximately one-third of the patients were unable to complete the course of drug therapy, limiting the overall usefulness of indomethacin. Surgeons prescribing indomethacin must also be aware of its contraindications and adverse effects.

Hip Joint↗