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PubMed1980

[Research in nursing: an interdisciplinary field].

This paper describes the growing importance of research in the nursing field and reviews its development since Florence Nightingale's day in the last century, and its revitalization with the help of the international organizations. Research, an empirical process by nature, is the application of the scientific method, in which reliable solutions to concrete problems are found by objective procedures. One of its characteristics is the framing of concepts, that is, the development of a logical, scientific chain of reasoning by which relationships between facts are established or inferred. Nursing embraces many activities that are traditionally referred to as the nursing process which, stated simply, is no more than an application of the scientific method. That it is applied with greater rigor in the sciences themselves does not detract from the scientific dimensions of nursing practice. It is perhaps going too far to regard all professional nurses as researchers. They may, however, be expected to have the intellectual curiosity to pursue lines of inquiry in their extensive field. They should continue to do so as participants in a joint effort with other disciplines to solve problems relating to health.

England↗
PubMed2004

[Applied ecology: retrospect and prospect].

Applied ecology is evolved into a principal part of modern ecology that rapidly develops. The major stimulus for the development of applied ecology roots in seeking the solutions for the problems of human populations, resources and environments. Through four decades, the science of applied ecology has been becoming a huge group of disciplines. The future for the applied ecology should concern more with human-influenced and managed ecosystems, and acknowledge humans as the components of ecosystems. Nowadays and in future, the top-priorities in applied ecology should include following fields: sustainable ecosystems and biosphere, ecosystem services and ecological design, ecological assessment of genetically modified organisms, ecology of biological invasions, epidemical ecology, ecological forecasting, ecological process and its control. The authors believe that the comprehensive and active research hotspots coupled some new traits would occur around these fields in foreseeable future.

Conservation of Natural Resources↗
PubMed1993

[An alternative methodology for the teaching of anatomy in nursing studies at the University of Carabobo].

An alternative methodology for the teaching of Human Anatomy which contributes to improve academic yield by Nursing students at the Faculty of Health Sciences of the University of Carabobo is presented. A total of 50 first-year Nursing students who participated in the experiment were divided into 2 groups, control and experimental. This research project was of the almost-experimental type and the work methodology was experimental-evaluation. Three instruments were used to obtain data: an investigation of the Lickert school type consisting of 40 proposals related to the students attitude concerning the study of this discipline and in view of a teaching methodology (EAEAM), accompanied by the school of Interests of Thurstone and by the Psychometric Test of Raven, to determine relationships in accordance with the research objectives. In function of the empirical results of the experiment and of revision of the literature pertaining to this theme, a methodological proposal is presented for the teaching of Human Anatomy; its theoretical-practical nature demands: previous study, observation, discussion and, fundamentally, subdivision, as an alternative to improve academic yield by Nursing students.

Anatomy↗
PubMed1996

Public health research and lay knowledge.

Social science research into the social patterning of health and illness is extensive. One important aspect of this has been work on lay knowledge about health and illness. In this paper we develop three main arguments. First, we suggest that recent developments in social science understanding of the nature and significance of lay knowledge should be more widely recognized within the social sciences themselves. Second, we argue that if public health research, whatever the disciplinary perspective, is to provide an understanding of contemporary health problems that is simultaneously more robust and more holistic, it must incorporate and develop the theoretical and conceptual insights offered by this recent work on lay knowledge and with lay people. Finally, we argue that in order to accomplish this it will be necessary to construct research questions in such a way that the conventional distinctions between science and non-science, and the methodological wrangles associated with this distinction, become marginal to the research process. This will inevitably involve conflicts between members of different professional groups. These conflicts provide the opportunity for open debate on the science and politics of public health research and represent a challenge for the many disciplines involved in this field.

Forecasting↗
PubMedDate not supplied

Use of nuclear physics methods in life sciences in the USSR.

Analytical nuclear physics methods, as well as radioanalytical, X-ray, and radiometric techniques are widely used in the Soviet Union in life sciences studies. Main approaches to the study of natural materials by activation analysis, including bulk analyses, localized analyses, speciation, and in vivo experiments are described. Examples of applications in agriculture to increase protein content of wheat, to improve crop yield, and to enhance resistivity of cotton plants to diseases are given. Activation analysis is used in medicine for prognosis and study of processes of pathogenesis. Detailed information on trace elements is valuable in environmental studies, and general regularities in biogeochemistry may be clarified with activation analysis.

Activation Analysis↗
PubMed2000

Solution to Darwin's dilemma: discovery of the missing Precambrian record of life.

In 1859, in On the Origin of Species, Darwin broached what he regarded to be the most vexing problem facing his theory of evolution-the lack of a rich fossil record predating the rise of shelly invertebrates that marks the beginning of the Cambrian Period of geologic time ( approximately 550 million years ago), an "inexplicable" absence that could be "truly urged as a valid argument" against his all embracing synthesis. For more than 100 years, the "missing Precambrian history of life" stood out as one of the greatest unsolved mysteries in natural science. But in recent decades, understanding of life's history has changed markedly as the documented fossil record has been extended seven-fold to some 3,500 million years ago, an age more than three-quarters that of the planet itself. This long-sought solution to Darwin's dilemma was set in motion by a small vanguard of workers who blazed the trail in the 1950s and 1960s, just as their course was charted by a few pioneering pathfinders of the previous century, a history of bold pronouncements, dashed dreams, search, and final discovery.

Animals↗
PubMedDate not supplied

Complementary roles for toxicologic pathology and mathematics in toxicogenomics, with special reference to data interpretation and oscillatory dynamics.

Toxicogenomics is an emerging multidisciplinary science that will profoundly impact the practice of toxicology. New generations of biologists, using evolving toxicogenomics tools, will generate massive data sets in need of interpretation. Mathematical tools are necessary to cluster and otherwise find meaningful structure in such data. The linking of this structure to gene functions and disease processes, and finally the generation of useful data interpretation remains a significant challenge. The training and background of pathologists make them ideally suited to contribute to the field of toxicogenomics, from experimental design to data interpretation. Toxicologic pathology, a discipline based on pattern recognition, requires familiarity with the dynamics of disease processes and interactions between organs, tissues, and cell populations. Optimal involvement of toxicologic pathologists in toxicogenomics requires that they communicate effectively with the many other scientists critical for the effective application of this complex discipline to societal problems. As noted by Petricoin III et al (Nature Genetics 32, 474-479, 2002), cooperation among regulators, sponsors and experts will be essential for realizing the potential of microarrays for public health. Following a brief introduction to the role of mathematics in toxicogenomics, "data interpretation" from the perspective of a pathologist is briefly discussed. Based on oscillatory behavior in the liver, the importance of an understanding of mathematics is addressed, and an approach to learning mathematics "later in life" is provided. An understanding of pathology by mathematicians involved in toxicogenomics is equally critical, as both mathematics and pathology are essential for transforming toxicogenomics data sets into useful knowledge.

Animals↗
PubMed2000

Available pathways database (APD): an essential resource for combinatorial biology.

A relational database, the Available Pathways Database (APD), has been constructed of microbial natural products, their producing strains, and their biosynthetic pathways. The database allows the ready selection of donor strains for combinatorial biology experiments. It provides the same type of resource for combinatorial biology as the Available Chemicals Directory (ACD) does for combinatorial chemical library generation. Its cataloging ability can also provide insight into novel aspects of biosynthetic routes. In particular, no 10-unit Type I polyketides were found in the compilation of this edition of the APD (Version I).

Bacteria↗
PubMed2003

Chemical versus biological explanations: interdisciplinarity and reductionism in the 19th century life sciences.

This paper analyzes four controversies in the 19th century life sciences: the nature of fermentation, the nature of infectious diseases, the generation of life from inanimate matter, and vitalism. All these controversies appear to concern chemical versus biological explanations, suggesting that reduction of biology to chemistry was the common underlying issue. My analysis rejects such interpretations, including the labels for explanation, and instead points out sophisticated forms of interdisciplinarity between chemistry, medicine, and biology in the first three debates. I argue that the philosophically favored perspective on reductionism, historically induced by a few physicians in the fourth debate, leads us astray from understanding interdisciplinary research.

Biological Science Disciplines↗
PubMedDate not supplied

[The genome and its metaphors. Detectives, heroes or prophets?].

The new genetics, or the impetus given to this discipline by the Genome Project, aims to a change of paradigm of the Health Sciences. This change is postulated from a phenotypic approach to a genotypic one, thereby excluding the influence of the environment, which could seriously undermine the grounds for the development and exercise of Public Health. Since the beginning of the genome project, information on genetic discoveries has frequently been reported in the mass media. Metaphors are often used by geneticists and journalists to convey the complex concepts of genetic research for which there are no equivalents in the lay language. The media do not merely shape the social agenda but also provide the space in which health culture is constructed. We present the results of a preliminary study exploring the metaphors used in the three most widely-read national daily newspapers in Spain, namely ABC, El Pais and El Mundo, when reporting news of the new genetics. The possible consequences of the natural history of these metaphors, or the process through which figurative terms acquire a literal meaning, are discussed. A preliminary taxonomy for the metaphors identified was developed. Fifty-one out of 342 identified headings (14.8%) contained metaphors. Strategic metaphors such as program, control, code, map, and puzzle, were the most commonly used, followed by teleological ones such as mystery or God language and finally war-like metaphors such as attack, defeat, and capture. The three groups of metaphors are characterized by an attempt to giving intentionality to genes. Strategic metaphors predominated over teleological and war-like ones and thus a technocratic perspective could form the basis of the future construction of health culture.

Genome, Human↗
PubMed2003

Rational design and engineering of delivery systems for therapeutics: biomedical exercises in colloid and surface science.

Engineering delivery systems of therapeutic agents has grown into an independent field, transcending the scope of traditional disciplines and capturing the interest of both academic and industrial research. At the same time, the acceleration in the discovery of new therapeutic moieties (chemical, biological, genetic and radiological) has led to an increasing demand for delivery systems capable of protecting, transporting, and selectively depositing those therapeutic agents to desired sites. The vast majority of delivery systems physically reside in the colloidal domain, while their surface properties and interfacial interactions with the biological milieu critically determine the pharmacological profiles of the delivered therapeutic agents. Interestingly though, the colloidal and surface properties of delivery systems are commonly overlooked in view of the predominant attention placed on the therapeutic effectiveness achieved. Moreover, the development and evaluation of novel delivery systems towards clinical use is often progressed by serendipity rather than a systematic design process, often leading to failure. The present article will attempt to illustrate the colloid and interfacial perspective of a delivery event, as well as exemplify the vast opportunities offered by treating, analysing and manipulating delivery systems as colloidal systems. Exploring and defining the colloid and surface nature of the interactions taking place between the biological moieties in the body and an administered delivery vehicle will allow for the rational engineering of effective delivery systems. A design scheme is also proposed on the way in which the engineering of advanced delivery systems should be practiced towards their transformation from laboratory inventions to clinically viable therapeutics. Lastly, three case studies are presented, demonstrating how rational manipulation of the colloidal and surface properties of delivery systems can lead to newly engineered systems relevant to chemotherapy, gene therapy and radiotherapy.

Biomedical Engineering↗
PubMed2000

Dual control of melanogenesis and melanoma growth: overview molecular to clinical level and the reverse.

Utilizing increased melanin pigmentation and accentuated melanogenesis seen in malignant melanoma, we newly developed melanoma-selective boron neutron capture therapy (BNCT) after designing and synthesizing the 10B-DOPA analogue, 10B-p-boronophenylalanine (10B-BPA). After multi-disciplined and extensive basic and pre-clinical investigations, we successfully treated 18 cases of human melanoma. Recently, we found that accentuated synthesis of melanin monomers, richest within coated vesicles (CV) in melanoma cells, plays a critical role in attracting 10B-BPA through chemical complex formation of monomers and 10B-BPA. CV are indeed BPA-localizing organelles. This led us to the new clinical endeavor that BPA may possess the potential ability to suppress melanin polymer formation through 'melanin monomer trapping' out of the melanogenic pathway which is highly regulated by the function of CV in pigment cells. It was soon found that melanin polymer formation can be suppressed by BPA at the chemical and cellular levels, then at the clinical level. Our discovery, that single molecule 10B-BPA possesses the dual nature of eradication of melanoma with BNCT and suppression of melanin hyperpigmentation, resulted from pursuing bilateral feedback at each stage from pure science to clinical application and vice versa. A further example of bilateral feedback is the development of gene-transfer applied BNCT (gBNCT). This also has its roots in clinical hurdles faced in treating amelanotic melanomas by 10B-BPA BNCT. The transfer of tyrosinase and melanin monomer synthesis-related genes into target cancer cells has produced more effective BNCT and may lead to gBNCT for non-melanoma cancers.

Animals↗
PubMed1987

Laboratory experiments in the study of the chemistry of the outer planets.

The investigation of chemical evolution of bodies in our solar system has, in the past, included observations, theoretical modeling, and laboratory simulations. Of these programs, the last one has been the most criticized due to the inherent difficulties in accurately recreating alien environments in the laboratory. Processes such as wall reactions and changes in chemistry due to difficulties in achieving realistic conditions of temperature, pressure, composition, and energy flux may yield results which are not truly representative of the systems being modeled. However, many laboratory studies have been done which have yielded data useful in planetary science. Gross simulations of atmospheric chemistry have placed constraints on the nature of complex molecules expected in planetary atmospheres. More precise studies of specific chemical processes have provided information about the sources and properties of product gases and aerosols. Determinations of basic properties such as spectral features and reaction rate constants yield data useful in the interpretation of observations and in computational modeling. Alone, and in conjunction with modeling, laboratory experiments will continue to be used to further our understanding of the outer solar system, and some experiments that need to be done are listed.

Aerosols↗
PubMedDate not supplied

[Biomedicine or anthropological medicine].

The huge developments in the biological research and in the technics used in other spheres of science (physics, mathematics, chemistry, cybernetics, etc.) have a great influence on the constitution of the actual medical paradigm, as well as other non strictly scientific factors. These external factors are economic, political and cultural ones -such as the pharmaceutical industry and the public health systems, the privatisation of health services, the large amount of professionals, the advances in the medical instruments, etc. The theoritician of the Heidelberg School, called this prevalent model "biomedical" or "natural-scientific", underlying this way the tendance to the biological reductionism in relation to the concept of "illness" thus excluding the subjectivity, the history and the sociability of the patient when dealing with the pain, the inability and the death. Since the middle of XXth Century a serious criticism of this medical paradigm has been raised. This criticism revolved around the so called anthropological or integral model. This article makes a revision of this problem from a historical and epistemological outlook, revisiting some specific features in the psychiatric field.

Anthropology, Physical↗
PubMed1999

[Clinical research methods in the nursing discipline framework].

Within the nursing discipline, the research helps or should help to develop and assess the theories related to the relevant phenomena. A professional discipline such as ours determines the relevant phenomena through its sphere of activity and the priorities of the society in general. With time, the disciplines develop a preference in the way of thinking about their discipline. At that point, there is no singular approach to the development of knowledge inside the nursing discipline, and no consensus either on the way of carrying out nursing research, whether it is applied or not. From time immemorial, the logical and systematic chain of reasoning coupled with the minute observation, the reflection and the intuition have built up the processes essential to the understanding of the human natural phenomena. Thus, the nursing research was mainly influenced by the two prevailing approaches (quantitative and qualitative) both focused on the experience, but using different strategies to get in touch with reality. Recently, the triangulation of the research elements seems more frequent, whether it is the combination of theories, of methods or of researchers of different disciplines with different perspectives. Each approach has its own methods and criteria to collect and analyse the data, then to interpret and check the results. The reproduction and the confirmation of this knowledge through additional and critical research are essential if we want this knowledge to be recognized by this discipline.

Clinical Nursing Research↗
PubMed1996

[History of gynecologic treatment of infertility].

Within less than 20 years this branch of the infertility treatment by new reproductive medical technologies has left behind the original concept of bypassing blocked tubes. It has started to bypass nature. As the extracorporal way, however of shortest duration within the human prenatal development, exposes the human being to external influences, the discussion about the pros and cons of the new technologies is already abundant and still rising. The field named infertility-treatment was once in the middle and in the heart of the gynecologic discipline. It gave rise to the most intellectual branch of gynecology, the gynecologic endocrinology. Undoubtedly, there are tendencies at present to make "Reproductive Medicine" an independent discipline splitting from gynecology and obstetrics, with only the core remaining gynecology, but with the addition of essential constituents coming from genetics, human biology, andrology, medical ethics, even from sociology and law. Gynecology would tremendously suffer from this loss. The field "Reproductive Medicine" has gained the most attentive audience far beyond the scope of our gynecologic profession. One thinks it should have calm and peace to grow further in the same way other fields of medicine flourish, guided by science, concience and compassion. The juxta-medical expansion of the field could as well not have been foreseen one-hundred years ago.

Europe↗
PubMedDate not supplied

[From disease to health: the individual, society, environment and culture].

With the onset of science-based medicine in the mid-19th century, environmental factors were almost totally discarded as health determinants. This was a complete rupture with the medical thinking which had prevailed since the time of Hippocrates. Yet, for the vast majority of mankind, harmony with environmental reality remains the most important determinant of good or ill health. This scission explains to a great extent the differences between traditional and Western medicine, which are based on entirely different concepts and on distinct paradigms. Environment as a health determinant--in its broadest definition to include both physical and social environments--is again being considered of importance as a result of better understanding of causality factors, and because of the influence of disciplines such as ecology and epidemiology. Here we show that human societies can develop different methods of adjusting to their environments, some of which would increase the risks of disease and others which can be considered as resistance factors of a social nature. Societies and individuals alike are not equal in relation to health risks.

Cultural Characteristics↗
PubMed1986

[The administration of knowledge. The biological and the social in the training of health personnel in Latin America].

The article starts with the concept of the management of knowledge, a component of the mission of PAHO as formulated in 1982. The purpose of the article is to consider what ideas have been formulated on the biological and social elements in medicine and how, and to what extent, they have been put into practice. The first part of the document discusses the theory of medicine and the social sciences, and the biological and social nature of the health-disease process. The second part traces the historical development of the biological and social approaches in relation to the degree to which these elements have been isolated and integrated in instruction. The first stage, the decade of the fifties, was characterized by the influence of the Flexner Report: instruction was organized in a cycle of the basic and clinical sciences; there was almost complete separation between medicine and society, and seminars in the Hemisphere proposed the inclusion of an integrated approach. The second stage, the decade of the sixties, was one of the great advances in theory and practice. Hemispheric meetings among health authorities, professional associations and groups of social scientists, physicians, and educators explicitly expounded the need for integration of the social and biological elements into medical education. The biological basis of study plans was reinforced as well. The third stage, the decade of the seventies, was one of consolidation of social medicine in the profession and the intensification of studies in that discipline. The idea then emerged of interdependence between medical education, medical practice, and the organization of health services in a social context. The authors examine the years of the eighties as an unfinished stage of culmination of the integration of the social and biological elements in medicine with inclusion of the idea of the physician's commitment to society.

Biology↗