Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “MYOSITIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 559 records · Page 31Linked to original sources
PubMed2006

[Acute myositis associated with influenza].

Benign acute myositis associated with influenza is reported from all over the world. The characteristics of this disorder is calf pain and difficulty walking during a viral illness (3-8 days) and creatine kinase levels are mildly or moderately elevated. Recovery occurred within 1 week. Midchildhood (mean age: 6-8 years) is most commonly affected and boys are more commonly than girls and its ratio is 2.4 : 1 by Shimizu in Japan (1993). Elderly patients are also reported. Viral studies show that influenza B is more commonly than influenza A and the ratio is 6 : 1 by Hu in Taiwan (2004), 2.4 : 1 by Shimizu in Japan (1993). Muscle histology revealed isolated segmental muscle degeneration and necrosis without frank myositis. A direct role of influenza virus in its genesis is not clear. An age-related response and occurrence primarily on boys may reflect a genetic predisposition.

Acute Disease↗
PubMed1991

Clinically unsuspected inclusion body myositis.

We describe a patient with inclusion body myositis presenting as chronic, therapy resistant polymyositis. Our report highlights the slow evolution of inclusion body myositis in some patients, and emphasizes the diagnostic importance of examining one or more muscle biopsy specimens by both frozen section and electron microscopy.

Biopsy↗
PubMed1991

[The clinical diagnosis of protozoal myositis syndrome (Neospora caninum) of puppies].

Nine puppies suffered from progressive paresis with muscle wasting, hyporeflexia and extensor rigidity. CK-activity in serum was elevated and electrodiagnostic findings were indicative of lower motor neuron disease. Although lesions were also found in the CNS, additional neurological signs were rare, but CSF examination revealed the presence of inflammatory lesions. On pathologic examination, all animals had a disseminated necrotizing myositis. In addition, a disseminated encephalomyelitis was found as well as, in 2 cases, a neuritis. In the lesions of 6 animals protozoal organisms were found which were immunocytochemically identified as Neospora caninum. Our results show that the protozoal myositis-encephalitis syndrome in puppies can be diagnosed in the clinic with high probability. A clinical differentiation between toxoplasmosis and Neospora caninum infection is presently difficult.

Animals↗
PubMed1990

Myositis ossificans in tetanus. A rare complication.

Myositis ossificans developing as a complication of tetanus is very rare. There are only nine cases reported so far. We report here a case of a young female who developed myositis ossificans in both the elbow joints as a complication of severe tetanus.

Adult↗
PubMed1991

Orbital myositis following an upper respiratory tract infection: contribution of high resolution CT and MRI.

A case of isolated unilateral extraocular muscle myositis following an acute upper respiratory tract infection is reported. Painful eye movements, restricted eye motility and exophthalmus but a normal visual acuity are the most important clinical findings. High resolution contrast enhanced CT and MRI are the imaging modalities of choice to differentiate from other orbital pathologies. The solitary enlarged muscle was clearly seen on both the contrast enhanced CT and the MR examination. Preseptal cellulitis was better seen on MRI, whereas high resolution CT was superior in the demonstration of periscleritis. Graves' ophthalmopathy and orbital cellulitis first have to be excluded. Corticosteroids are the therapy of choice in orbital myositis. A control, contrast enhanced CT after 4 weeks showed an almost normal muscle.

Adrenal Cortex Hormones↗
PubMed1991

Giant cell myocarditis and myositis associated with thymoma and leprosy.

Myocarditis is an inflammatory form of heart disease which is usually preceded by a viral infection. Giant cell myocarditis is an uncommon and nonspecific form of this disease. Sporadic reports have linked giant cell myocarditis with thymoma and concomitant myositis. The authors report a patient with leprosy who, six months after initiation of treatment, developed sudden onset of congestive heart failure and cardiac arrhythmias unresponsive to aggressive medical therapy. In addition to confirming leprosy, autopsy showed a mixed cell type thymoma, severe giant cell myocarditis and extensive myositis.

Aged↗
PubMed1990

[A case of isolated focal myositis successfully treated by arterial injection of prednisolone--its findings by CT scan and MRI].

A 25-year-old woman with a 2 years history of painful enlargement of the left calf visited our clinic because of ache in the left calf which became severe enough to interfere her walk. She had no history of trauma to the calf, and family history was negative for muscle disease. Physical examination showed an enlarged left calf muscle with pain which was evoked by stretching of the Achilles tendon. There was no muscle weakness or neurological abnormality. Laboratory tests were all within normal limits, including erythrocyte sedimentation rate and serum enzymes such as creatine kinase and aldolase. The CT scan revealed an isolated round-shaped low density area in the left calf muscle, which showed up as a markedly high signal intensity on T2 weighted images of MRI. The lesion was confirmed to be the lateral head of the gastrocnemius muscle. The specimen obtained from the affected muscle demonstrated degenerative and inflammatory changes together with excess fibrosis. There was no sarcoid lesion or malignancy. From the above results, the present case was thought to have isolated focal myositis. Prednisolone 80 mg (40 mg, twice, at 4-day intervals) was given to the left femoral artery without any trouble. Thereafter the patient became free from pain and difficulty in walking, and the lesion demonstrated by CT scan disappeared in 15 days. However, the high signal intensity on T2 weighted images faintly remained until the 54th day after the treatment. In summary, MRI is more sensitive than CT scan for detection of isolated focal myositis, which might be successfully treated by arterial injection of prednisolone within a short period than any other conventional methods.

Adult↗
PubMed1990

Imaging rounds #103. Myositis ossificans in association with congenital radioulnar synostosis and congenital anterior radial head dislocation.

Although the initial trauma was minimal in this unusual case of bilateral congenital radioulnar synostosis and anterior radial head dislocation associated with myositis ossificans, a progressive decrease in elbow ROM ensued. Manipulation under general anesthesia was performed to improve flexion and extension of the involved elbow. This manipulation most likely initiated or enhanced the process of myositis ossificans in the elbow. Final treatment consisted of reassurance and active ROM exercises, with resolution of symptoms.

Adult↗
PubMed1990

Orbital myositis--a case report.

Orbital myositis is an idiopathic inflammatory condition involving the extraocular muscles. A case of presumed orbital myositis is presented, displaying typical features on orbital computed tomography, and a dramatic response to corticosteroid therapy. Atypical features of acute-on-chronic course, and concomitant sinus disease are discussed. A differential diagnosis of enlarged extraocular muscles is also discussed, and the benefits of corticosteroid trial before formal biopsy in the appropriate clinical setting is emphasised.

Adult↗
PubMed1990

Equine postanaesthetic myositis: a possible role for free radical generation and membrane lipoperoxidation.

A method for the evaluation of total plasma antihydroxyl and antiperferryl activity is described. This method was applied to horse plasma obtained during halothane anaesthesia. In horses suffering from postanaesthetic myositis, a significant decrease in the antiperferryl activity was observed during anaesthesia particularly when the muscular compression produced by the weight of the horse was released. In the affected muscles, strong oxidants could therefore be generated during the reperfusion of the ischaemic muscles and might initiate membrane lipid peroxidation. This phenomenon could possibly explain the muscular damage observed in equine postanaesthetic myositis.

Anesthesia, General↗
PubMed1990

Autoantibodies to aminoacyl-transfer RNA synthetases for isoleucine and glycine. Two additional synthetases are antigenic in myositis.

Autoantibodies to three of the aminoacyl-transfer RNA (tRNA) synthetases have been reported (for histidine, threonine, and alanine). Most patients with these autoantibodies have polymyositis, and the majority also have interstitial lung disease. This study examined the question of whether autoantibodies to other aminoacyl-tRNA synthetases occur in the sera of myositis patients. We tested sera from patients with myositis with unidentified anticytoplasmic antibodies that immunoprecipitate tRNA for the ability to inhibit the aminoacyl-tRNA synthetases for the remaining 17 amino acids. Three sera showed strong inhibitory activity for a synthetase. OJ and NJ sera (and IgG) significantly inhibited isoleucyl-tRNA synthetase activity, each with 94% inhibition at the screening dilution, whereas other test sera and controls all inhibited less than 50%. OJ and NJ sera immunoprecipitated identical patterns of tRNA, and identical, complex patterns of high m.w. polypeptides that were consistent with the multienzyme synthetase complex of which isoleucyl-tRNA synthetase is a part. EJ serum (and IgG) significantly inhibited glycyl-tRNA synthetase, and immunoprecipitated a unique pattern of transfer RNA, and a strong predominant protein band of 77 kDa. These data strongly suggest that OJ and NJ have autoantibodies to isoleucyl-tRNA synthetase, and that EJ has antibodies to glycyl-tRNA synthetase. The findings of signs of muscle involvement in all three patients, and severe interstitial lung disease in OJ, strengthens the association of antisynthetases with these conditions.

Amino Acyl-tRNA Synthetases↗
PubMed1990

[Proliferative myositis].

We report on a 42-year-old woman showing a rapidly growing tumor on her left flank; it was removed by surgery. Histological examination revealed the typical picture of proliferative myositis. Since the clinical symptoms of this disease are nonspecific, the diagnosis always depends on histological evidence. Despite its rapid growth and its cellular pleomorphism, proliferative myositis is a reactive process and has to be differentiated histologically from sarcoma of the soft tissue.

Adipose Tissue↗
PubMed1989

Epitope mapping of the cloned human autoantigen, histidyl-tRNA synthetase. Analysis of the myositis-associated anti-Jo-1 autoimmune response.

Autoantibodies that bind aminoacyl-tRNA synthetases are strongly associated with the human inflammatory myopathies polymyositis and dermatomyositis, but their molecular origins and relationship to pathogenesis are not known. To address these issues, we wished to identify the autoantigenic epitopes which react with these autoantibodies and to this end, we previously isolated a full length cDNA clone encoding the target Ag recognized most frequently by myositis sera, histidyl-tRNA synthetase (HRS). In the present study, we have analyzed the HRS autoepitopes by two amino acid insertion linker mutagenesis of HRS proteins expressed in Cos 1 cells. A series of mutant HRS cDNA were constructed and the expressed proteins were tested for enzyme activity and for immune reactivity with a panel of sera with anti-Jo-1 antibodies. Immunoblotting and immunoprecipitation analyses revealed that anti-Jo-1 antibodies recognize multiple conformation-dependent and independent epitopes on HRS and that the autoepitopes vary among different myositis patients.

Amino Acyl-tRNA Synthetases↗
PubMed1989

[Myositis with inclusion bodies: a little-known variety of idiopathic inflammatory myopathy].

The authors report two male patients with inclusion body myositis (IBM) and review the features of this condition in the literature. This is an uncommon type of idiopathic myositis which involves males more often than females; it usually develops in elderly patients; its course is very slow; it is usually associated with distal weakness; neurophysiological studies show a mixed "myogenic" and "neurogenic" pattern; and it is usually unresponsive to corticosteroids. The diagnosis is basically made on the basis of the histological features, mainly consisting of vacuoles surrounded by a basophilic haze in histochemical stains of frozen tissue and, particularly, by the presence of characteristic microfilaments in ultrastructural studies.

Humans↗
PubMedDate not supplied

Retroperitoneal infectious myositis.

A case of retroperitoneal infectious myositis is described. The symptoms of infectious myositis may be confused with those of other more frequent soft tissue pathologies (haematoma and sarcomata). This infection is more frequent in countries with a tropical climate. The most frequent aetiological agent is Staphylococcus aureus. This paper reports on the diagnostic and therapeutic problems of this disease as recently observed at the Division of Surgical Oncology of the National Cancer Institute in Genoa.

Adult↗
PubMed1989

Induction of equine postanesthetic myositis after halothane-induced hypotension.

Wick catheters were used to measure intracompartmental pressures of the extensor carpi radialis muscles and long heads of the triceps brachii muscles of 7 horses maintained under halothane anesthesia during controlled ventilation. Horses were positioned in left lateral recumbency on a water bed for 4 hours. Using a crossover design, 6 of the 7 horses were subjected to normotensive and hypotensive anesthesia on separate occasions. Hypotension was achieved by increasing the inspired halothane concentration. Hematologic and biochemical measurements were determined at designated intervals before, during, and for 7 days after each anesthetic episode. Under hypotensive conditions, 2 horses developed severe generalized myositis and were euthanatized. Three of the 5 other horses developed swelling of the downside masseter muscle, 4 demonstrated mild extensor deficits of the downside forelimb, and 1 had a severe extensor deficit of the uppermost hind limb. As a group, the hypotensive horses had markedly increased activities of serum enzymes (creatine kinase, aspartate transaminase, and blood lactate) and abnormalities in calcium-phosphorus homeostasis. Lameness or enzyme alterations were not observed in normotensive horses. Although the intracompartmental pressure values were markedly increased in the muscle bellies of the compressed limbs of all horses, there was a statistically significant difference in intracompartmental pressures between the downside or compressed muscle compartments of the extensor carpi radialis of hypotensive and normotensive horses. High concentrations of halothane may predispose anesthetized horses to postanesthetic myositis, even when protective padding is used. Intracompartmental muscle pressure, as measured by the wick catheter, may not be a reliable predictor of equine postanesthetic lameness.

Anesthesia, Inhalation↗
PubMed1987

Coxsackievirus B 1 induced murine polymyositis: acute infection with active virus is required for myositis.

Although the etiology of human polymyositis (PM) remains obscure, group B coxsackieviruses (CVB) have been implicated in disease pathogenesis and a particular strain of type 1 CVB (CVB 1) has been shown to cause in mice an inflammatory myositis which is similar to human PM. After infection of neonatal Swiss mice with active CVB 1, virus replicated to high titers in muscle and produced acute myonecrosis. Viral titers peaked in muscle at Day 7 and virus was undetectable after Day 14. Myocytes regenerated, but a chronic inflammatory myositis, involving principally proximal muscle groups of the hind limbs, was observed by Day 14 and persisted through at least Day 70. Injection of inactivated virus resulted in no clinical or histological disease. Anti-CVB 1 antibody was demonstrated in mice injected with inactivated or active virus pools. This report establishes the need for active virus in the pathogenesis of CVB 1 induced murine PM.

Acute Disease↗
PubMed1987

[Permanent constriction of the jaws due to progressive ossifying myositis].

A case is reported of progressive ossifying myositis (fibrodysplasia ossificans progressiva, Münchmeyer's disease) with onset at 16 years of age by a lesion of internal pterygoid with limitation of opening of mouth. Surgery to relieve ankylosis was followed by recurrence. Diagnosis was established only after the appearance of lesions in other regions (sternocleidomastoid, latissimus dorsi, lumbar muscles...). Clinical and paraclinical signs of this exceptionally rare disease are reviewed and diagnostic difficulties at onset of the disease discussed. Treatment of acute myositis episodes with diphosphonates delays passage to the ossification stage, allowing local surgery to be performed with less risk of relapse.

Adolescent↗