Superficial mycoses in Melbourne.
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Serum lysozyme of 138 patients with various systemic mycosis was determine by means of a new technique. It is reported that the levels of the enzyme are very low, particularly in the most serious diseases. The significance of this finding is discussed.
Mycotic involvement of viscera and nervous system develops in patients with immunodeficiency, during antibiotic treatment, and application of invasive methods of diagnosis and treatment, promoting penetration of the agent into the blood, which often results in development of mycotic foci in the visceral parenchyma and nervous system. The involvement is diagnosed from resistance to common therapy and is verified by laboratory investigations: microscopic examination of biological substrates, inoculation in nutrient media, serological tests, and histological analysis of biopsy specimens. Etiotropic therapy is carried out by antimycotic drugs with due regard for the agent sensitivity, drug pharmacokinetics, and drug tolerance. Antimycotic therapy should be carried out by a physician with at least the minimal knowledge of mycology.
Authors describe ten new cases of Entomophthoromycosis in Cameroon. In four cases of subcutaneous phycomycosis, Basidiobolus meristoporus was isolated in one case. In six cases of rhino-entomophthoromycosis, we have obtained by culture two Basidiobolus meristoporus and one Entomophthora coronata. In Cameroon, rhino-entomophthoromycosis may be caused by the two species Basidiobolus meristoporus and Entomophthora coronata.
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A review of the literature on asteroid bodies (Splendore-Hoeppli phenomenon) as well as an immunoelectronmicroscopic study on asteroid bodies with Candida albicans and electronmicroscopic observations on asteroid bodies with Aspergillus are presented. The following definitions are proposed: Asteroid bodies with Candida albicans: precipitate consisting of fungal antigen and antibodies of host origin in light microscopically visible dimension deposited on the cell wall surface of Candida cells in parasitic condition. Asteroid bodies with Aspergillus: precipitate consisting of fungal antigen, antibodies of host origin and necrotic cellular detritus originated from cells of host defense, in light microscopically visible dimension, deposited on the cell wall surface of abortive Aspergillus cells, reduced in longitudinal growth, in parasitic condition.
Over 4 years 1.241 fish were examined mycologically. In 182 (14.7%) of them positive results were obtained. Most of the isolates belonged to the following genera: Cladosporium, Saprolegnia, Candida and Penicillium. Fungal infections were correlated with findings of Saprolegnia, Branchiomyces, Pythium, Ichtyophonus and sometimes Cladosporium. Most fungal isolates were etiologically irrelevant for diseases or death.
The incidence of invasive fungal infection (IFI) has increased considerably over the past 20 years, and transplant recipients are at especially high risk for fungal infections owing to their overall immunosuppressed condition. Organ transplantation procedures were incorporated as a therapeutic option for many patients who lacked the normal functions of organs such as the heart, liver, kidney, lung, pancreas and small bowel. The prevalence of IFI in solid organ transplant (SOTR) patients ranges from 5 to 50% in kidney and liver transplants, respectively. In bone marrow transplant (BMT) patients, IFI are major causes of morbidity and mortality due to the protracted neutropenic period and graft-versus-host disease. Candida spp. and Aspergillus spp. account for >80% of fungal episodes in both SOTR and BMT. The development of new immunosuppressive agents, new prophylaxis strategies (as pre-emptive therapy) and the improvement in surgical techniques led to increase survival of transplant recipients. In this session, a clear and concise update of the recent advances in the laboratory diagnosis of candidiasis and aspergillosis in this kind of patients was presented. However, we still need to establish more rapid, sensitive and specific methods for IFI diagnosis. Representatives of the 'Subcomision de Infecciones en el Paciente Neutropenico y Transplantado (SIPNYT)' de la Sociedad Argentina de Infectologia (SADI), presented the results of an unusual multicenter study both retrospective and descriptive studies of IFI in SOTR and BMT patients in Argentina. In addition, a study of IFI in 1,861 SOTR patients from four centers and the analysis of IFI in 2,066 BMT patients from all 12 BMT centers from Argentina was presented. From these studies it can be concluded that 'all transplant recipients are not the same' and that they should be stratified according to their different risk degrees in order to determine the best prophylaxis and treatment strategies.
The incidence of new pathogenic agents in the fungi group has been on the rise over the past few years. This can be explained by the similar increase in elderly patients, precarious situations or immunodeficient states, together with the high degree of instrumentation in hospitals and the indiscriminate use of antibiotics and antimycotics both to cure and prevent. This study includes emerging fungi, isolated in the aforementioned individuals, which belong to the filamentous and dimorphic fungi groups, and yeasts. In view of their number, only the main ones are mentioned, together with the clinical manifestations they produce and the grounds for their diagnosis and treatment.