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PubMed1992

Cancer induction in mice by feeding the raw false morel mushroom Gyromitra esculenta.

One of the false morel mushrooms, Gyromitra esculenta, was administered p.o. to Swiss mice that were 6 weeks old at the beginning of the experiment. The mushrooms were fed to the mice for 3 days and were followed by a semisynthetic diet for 4 days each week for life. The treatment induced tumors in the lungs, nasal cavity, blood vessels, forestomach, glandular stomach, cecum, and liver in the following incidences: 80, 10, 50, 16, 4, 28, and 6% in females, and 70, 12, 32, 18, 20, 22, and 12% in males. In the untreated controls, the corresponding tumor incidences were 28, 0, 14, 0, 0, 8, and 0% in females and 38, 0, 6, 0, 0, 8, and 2% in males. The light microscopic examination revealed the typical appearance of adenomas and adenocarcinomas of lungs, adenomas and adenocarcinomas of nasal cavities, hemangiomas and hemangiosarcomas of blood vessels, squamous cell papillomas and carcinomas of the forestomach, adenomas and adenocarcinomas of the glandular stomach, polypoid adenomas and adenocarcinomas of the cecum, and hepatomas. The work demonstrates the carcinogenic action of the raw G. esculenta mushroom.

Animals↗

PubMedDate not supplied

[The amount of nitrites in edible mushrooms harvested from Bistriţa Valley].

In our study has been determined the amount of nitrites in edible mushrooms which grown in different zones from Bistriţa Valley, near to the "Fibrex-nylon" Complex Savinesti. The nitrites has been extracted with water, in the aqueous extract we determined spectrophotometrically nitrites with Griesz Reagent. The results were expressed in mg nitrites/g dried product (105 degrees C). We analysed 41 samples of edible mushrooms (22 samples harvested on october 2001, 19 harvested on september 2002). The nitrites concentrations in mushrooms are between 2.06 and 49.88 (samples harvested on october 2001), between 1.98 and 31.84 (samples harvested on september 2002). The highest values for samples harvested on october 2001 was determined in Laccaria lacata, Collybia butiracea, Hygrophorus chrysodon, Russula nigricans, for the samples harvested on september 2002 the highest values was determined in Boletus granulatus, Macrolepiota procera.

Agaricales↗

PubMed2005

Occupational asthma caused by white mushroom.

The commercial growing of white mushroom (Agaricus bisporus) is a frequent activity in certain Spain regions as La Rioja. We report two cases of white mushroom workers suffering from asthma caused by hypersensitivity to basidiocarp and spores of white mushroom.

Adult↗

PubMed2006

[Abnormal meiosis in bisporic mutants of white button mushroom Agaricus bisporus (Lange) Imbach].

A formerly developed method of obtaining spread preparations of mushroom basidial nuclei was applied to study of meiotic prophase I in bisporic white button mushroom (Agaricus bisporus) strains. Meiotic recombination and assemblage of axial structures (axial elements and synaptonemal complexes) of chromosomes in meiotic prophase I are interrelated. It is known that the frequency of meiotic recombination is reduced in the bisporic A. bisporus variety. We showed that formation of axial structures of meiotic chromosomes in bisporic strains of this mushroom was disrupted. The phenotypes of disruptions in spread prophase nuclei are diverse. In leptotene and early zygotene, many nuclei contain abnormal, often short, and, as a rule, few chromosomal axial elements. The abnormalities in the formation of synaptonemal complexes at the zygotene-diplotene stage are of the same kind and even more pronounced. We discovered an important feature of meiosis in A. bisporus associated with fruit-body morphogenesis. Meiosis starting in basidia (meiocytes) of young closed fruit bodies is accompanied by disruption of chromatin condensation in prophase I and, probably, is arrested. After indusium breakage, the course of meiosis normalizes. Preparations with clearly observable chromosomal axial structures can be obtained only at this stage of fruit-body development.

Agaricus↗

PubMed2006

[Influence of storing conditions of on quality and safety quality and safety of mushroom tins].

The invention relates to the influence of period of time and storage conditions on microbiological, physical-and-chemical, sensory indices of mushrooms in brine salted (enzyme mushrooms). The invention establishes the fact that mushroom tin storage in a refrigerator at temperature between 0 degrees C and + 4 degrees C provides high quality and microbiological stability of the product during 2 years, storage in a warehouse with temperature between +10 degrees C and +18 degrees C - for 1 year.

Agaricales↗

PubMed1995

Characterization of K+ currents and the cAMP-dependent modulation in cultured Drosophila mushroom body neurons identified by lacZ expression.

Electrophysiological analysis of cultured neurons provides a potential approach toward understanding the physiological defects that may contribute to abnormal behavior exhibited by mutants of the fruit fly Drosophila. However, its application has been restricted by an inability to identify a particular functional or anatomical subpopulation of neurons from the CNS. To study neurons composing the CNS mushroom body proposed as a center for insect olfactory learning, we utilized a Drosophila enhancer detector line that expresses a lacZ reporter gene in these neurons and identified them in acutely dissociated larval CNS cultures by vital fluorescent staining. The patch-clamp analysis suggests that whole-cell voltage-activated K+ currents can be classified into two types in identified mushroom body neurons. Type 1 current comprises a TEA-sensitive slowly inactivating current and noninactivating component while type 2 current contains a 4-AP-sensitive transient A-current and a noninactivating component. Application of cAMP analogs induced distinct modulation of type 1 and type 2 currents. Our results demonstrate that the expression of the lacZ gene and the subsequent staining do not significantly alter the different types of K+ currents. This initial characterization provides a basis for further analysis of mutations that impair learning and memory resulting from an abnormal cAMP cascade preferentially expressed in the mushroom body.

Animals↗

PubMed1995

Dietary oyster mushroom (Pleurotus ostreatus) accelerates plasma cholesterol turnover in hypercholesterolaemic rat.

The effect of adding 5% powdered oyster mushroom (Pleurotus ostreatus) during 12 weeks on kinetic parameters of cholesterol metabolism was studied in male rats (Wistar, initial body weight 85 g) fed a semisynthetic diet containing 0.3% of cholesterol. The plasma cholesterol decay curve (examined for the final 29 days of the experiment after a single dose of cholesterol-4-14C) was evaluated by mathematical analysis using a two-pool model of plasma cholesterol metabolism. The oyster mushroom in the diet reduced the half-times of both exponentials resulting in lower calculated values (by 28%) of total entry of cholesterol into the body cholesterol pool (absorption+endogenous synthesis) and lower sizes of both pools (with slower and faster cholesterol exchange). The rate of cholesterol exchange between the pools was enhanced and the rate of total clearance of cholesterol from the system (metabolic turnover rate of cholesterol i.e. the rate of degradation and excretion of cholesterol from the organism) was enhanced by 50%. The oyster mushroom diet effectively prevented the progress of hypercholesterolaemia (decrease by 38%) and cholesterol accumulation in liver (decrease by 25%) that were induced by the cholesterol diet.

Animals↗

PubMed1997

[Regulation of cholesterol metabolism with dietary addition of oyster mushrooms (Pleurotus ostreatus) in rats with hypercholesterolemia].

BACKGROUND: It is generally accepted that lowering of serum cholesterol levels reduces the risk of atherosclerosis. Identification and characterization of natural substances with hypocholesterolemic activity useful in dietetic prevention or treatment of hypercholesterolemia is still relevant in countries with persistent progression of hypercholesterolemia. Addition of oyster mushroom (Pleurotus ostreatus), an industrially produced wood-rotting fungus, to the diet effectively reduced cholesterol accumulation in serum and liver of rats fed a cholesterol diet. The aim of a series of experiments was to explain the biochemical mechanism of this effect. METHODS AND RESULTS: Male Wistar rats fed a cholesterol (0.3%) diet shortly after weaning for a period of 8-10 weeks were used in the experiments. The addition of 5% of dried oyster mushroom to the diet had following effects: reduction of cholesterol level both in serum (5.12 +/- 0.55 vs. 3.44 +/- 0.16 mmol/l, p < 0.02) and liver (241 +/- 12 vs. 113 +/- 11 mmol/kg, p < 0.001); redistribution of cholesterol in favour of high-density lipoproteins; reduced production of very-low-density lipoproteins (135 +/- 7 vs. 96.5 +/- 5 mumol/h/kg, p < 0.001); reduced cholesterol absorption (61.2 +/- 2 vs. 53 +/- 2%, p < 0.02) and reduced HMG-CoA activity in liver (137 +/- 16 vs. 86 +/- 9 pmol/min/mg proteins, p < 0.02). Simultaneously, an increase in 7 alfa-hydroxylase activity in liver (17 +/- 1 vs. 22 +/- 1 pmol/min/mg proteins. p < 0.02) and bile acid excretion (7 +/- 0.9 vs. 11 +/- 0.5 mg/day/rat, p < 0.02) was observed. (Values shown are means +/- SEM.) CONCLUSIONS: Biochemical mechanism of hypocholesterolemic effect of oyster mushroom on cholesterol-fed rats includes reduced production of cholesterol-rich very-low-density and low-density lipoproteins which principally determine cholesterol levels in serum. This effect is related to decreased absorption and biosynthesis of cholesterol together with increase in cholesterol catabolism and excretion of degradation products-bile acids.

Animals↗

PubMed1998

A novel octopamine receptor with preferential expression in Drosophila mushroom bodies.

Octopamine is a neuromodulator that mediates diverse physiological processes in invertebrates. In some insects, such as honeybees and fruit flies, octopamine has been shown to be a major stimulator of adenylyl cyclase and to function in associative learning. To identify an octopamine receptor mediating this function in Drosophila, putative biogenic amine receptors were cloned by a novel procedure using PCR and single-strand conformation polymorphism. One new receptor, octopamine receptor in mushroom bodies (OAMB), was identified as an octopamine receptor because human and Drosophila cell lines expressing OAMB showed increased cAMP and intracellular Ca2+ levels after octopamine application. Immunohistochemical analysis using an antibody made to the receptor revealed highly enriched expression in the mushroom body neuropil and the ellipsoid body of central complex, brain areas known to be crucial for olfactory learning and motor control, respectively. The preferential expression of OAMB in mushroom bodies and its capacity to produce cAMP accumulation suggest an important role in synaptic modulation underlying behavioral plasticity.

Adrenergic Agents↗

PubMed1997

Dose-dependent hypocholesterolaemic effect of oyster mushroom (Pleurotus ostreatus) in rats.

A highly significant negative correlation (r=-0.981, p < 0.001) between the amount of oyster mushroom (Pleurotus ostreatus) in the diet and cholesterol levels in the serum has been found in male Wistar rats fed shortly after weaning by a a diet with 0.3% cholesterol. The addition of 1.0, 2.5 and 5.0% of oyster mushroom to the diet reduced the levels of serum cholesterol by 11, 31 and 46%, respectively. The diet containing 5% of oyster mushroom suppressed cholesterol accumulation in the liver and increased the fraction of cholesterol carried by high-density lipoproteins.

Animals↗

PubMed1998

Airborne occupational allergic contact dermatitis from champignon mushroom.

BACKGROUND: Allergic contact dermatitis from mushrooms has only seldom been reported. OBJECTIVES: We report on a mushroom picker who developed skin symptoms from occupational exposure to the mushroom champignon. METHODS: Conventional patch testing and prick testings were performed. RESULTS: Erythema and vesicular edemic dermatitis appeared around the eyes, on the cheeks, around the nose, and around the lips of a 31-year-old woman who had been involved in the commercial production of champignons for 5 years. Prick testing to champignon was negative, but patch testing with raw champignon provoked a 2+ allergic reaction and was negative in the controls. CONCLUSION: Our patient had been occupationally sensitized from exposure to champignon. The allergen is not known but may be a low-molecularweight chemical or a protein present in the champignon.

Adult↗

PubMed1998

Mushroom bodies of the cockroach: activity and identities of neurons recorded in freely moving animals.

This article describes novel attributes of the mushroom bodies of cockroaches revealed by recording from neurons in freely moving insects. The results suggest several hitherto unrecognized functions of the mushroom bodies: extrinsic neurons that discriminate between imposed and self-generated sensory stimulation, extrinsic neurons that monitor motor actions, and a third class of extrinsic neurons that predict episodes of locomotion and modulate their activity depending on the turning direction. Electrophysiological units have been correlated with neurons that were partially stained by uptake of copper ions and silver intensification. Neurons so revealed correspond to Golgi-impregnated or Lucifer yellow-filled neurons and demonstrate that their processes generally ascend to other areas of the protocerebrum. The present results support the idea of multiple roles for the mushroom bodies. These include sensory discrimination, the integration of sensory perception with motor actions, and, as described in the companion article, a role in place memory.

Animals↗

PubMed2003

The mushroom bodies of Drosophila melanogaster: an immunocytological and golgi study of Kenyon cell organization in the calyces and lobes.

Golgi impregnations reveal a variety of dendritic morphologies amongst Kenyon cells in the mushroom bodies of Drosophila melanogaster. Different morphological types of Kenyon cells contribute axon-like processes to five divisions of the medial and vertical lobes. Four of these divisions have characteristic affinities to antibodies raised against aspartate, glutamate, and taurine. A newly described posterior subdivision of the medial lobe, here named the betac lobe with its vertical branch alphac, comprises glutamatergic Kenyon cells that are probably homologous to glutamatergic Kenyon cells in the cockroach and honey bee, and are the last neurons to differentiate. The first neurons to differentiate, which supply the gamma lobe, are equipped with clawed dendritic specializations and are the structural homologues of clawed class II Kenyon cells supplying the gamma lobes in cockroaches and honey bees. Three intermediate divisions lie between the betac lobe and gamma lobe. These are, from the back towards the front, the beta lobe, the beta' lobe, and a narrow division between beta' and gamma called the beta" lobe. The fused calyx of the Drosophila mushroom body is comparable to the double calyces of Hymenoptera, here exemplified by a basal taxon, Diprion pini. Further similarities between the hymenopteran calyces and those of Drosophila are suggested by the segregation of different types of Kenyon cell dendrites within the calyx neuropil. The organization of afferents from the antennal lobes also defines regions in the Drosophila calyx that may be homologous to the lip and basal ring regions of the honey bee calyces. As in honey bees, GABAergic processes densely invade Drosophila's calyces, which also contain a sparse but uniform distribution of octopaminergic elements. Microsc. Res. Tech. 62:151-169, 2003.

Animal Structures↗

PubMed1986

Mushroom poisoning due to Cortinarius speciosissimus: electron microscope study in rats.

The effects of a poisonous mushroom, Cortinarius speciosissimus, on rat kidney were studied by transmission electron microscopy. Suspension of dried mushroom (500 mg/kg body weight) was administered as a single dose directly into the esophagus. The kidneys were fixed by perfusion, and both cortex and medulla were sampled. C. speciosissimus toxin acted primarily on the epithelial cells of the proximal tubules. No changes were seen in the glomeruli. First ultrastructural changes were observed at 2 days in the renal cortex. The most prominent damage occurred at 5 days, when most of the proximal tubular cells appeared necrotic. Dark bodies (diameter 0.15-0.5 micron) spaced by 25-45 nm were frequently found in the damaged tubular cell nuclei. Regeneration of the tubular cells was seen at 10 days. After 2 months, increased amount of collagen fibres were seen between tubules. The nuclear changes in the damaged tubular cells and the slowly manifesting toxicity suggest that C. speciosissimus toxin acts on nuclei or nucleoli and/or metabolic pathways associated with them.

Animals↗

PubMed1983

Mushroom poisoning caused by species of the genus Cortinarius Fries.

Symptomatology, clinical characteristics and pathogenesis of mushroom poisoning caused by Cortinarius species are surveyed. The isolation of a bipyridine--orellanine--from Cortinarius orellanus is held to be responsible for the nephrotoxicity of this species as well as the closely related C. speciosissimus. The present knowledge on the toxicity of structurally related and well-known bipyridines such as paraquat and diquat is brought up and found comparable to orellanine toxicity. Pharmacokinetic experiments on the nephrotoxic bipyridines suggest that haemoperfusion is a rational therapy of intoxicated persons, even several days after mushroom ingestion.

2,2'-Dipyridyl↗

PubMed1993

Studies on some edible wild mushrooms from Nigeria: 1. Nutritional, teratogenic and toxic considerations.

The biological value of 5 mushrooms Chlorophyllum molybditis, Psathyrella atroumbonata, Termitomyces robustus, Termitomyces striatus and Volvariella esculenta from our collection of wild edible mushrooms were determined using weanling rats. C. molybditis supported rapid growth with PER (2.63) higher than the casein control (2.50). P. atroumbonata was average in biological performance (PER 1.50) while T. robustus and V. esculenta did not support growth at all. Rats on T. striatus dried at 60 degrees C for 48 h lost weight rapidly and showed pathological signs of toxicity by the second day. All rats on this diet died by the fourth day of the experiment. When the diet of T. striatus dried at 90 degrees C for about 8 h was fed, the rats gained weight marginally but all survived. Prolonged storage of T. striatus at 60 degrees C for 5-8 weeks also seemed to detoxify the poisonous component such that PER and NPR values were 0.8 and 2.0 respectively. 2 pairs each of adult rats fed C. molybditis and Tricholoma lobayensis diets for 10 days were mated. Rats of C. molybditis diet gave 5 and 6 litters each and only one of these litters seemed to have retarded growth. Rats on T. lobayensis diet did not produce any litters for 14 weeks but the female produced off-spring when mated with control male rats.

Animals↗

PubMed1995

[Boron content of Hungarian edible wild mushrooms].

The boron contents of 68 edible common macrofungi of Hungary were analysed. The average boron content of the examples was 11.74 mg/kg dry mass, this is higher than the average value of green plants of Hungary (7.4 mg/kg dry mass). Although the highest boron contents were found in the examples from woods near Budapest, the differences between the various sites are not significant. It seems that the site has not an important effect on the boron content of mushrooms. Some taxonomical groups are examples of higher, others are examples of lower boron content. The highest concentration of boron (54.3 mg/kg dry mass) was found in the species Marasmius wynnei which indicates a bioconcentration of four to five fold to the average boron level. Significant bioaccumulation of analysed edible species was not established, but the poisoning mushroom Mycena pura has a very great (401-607 mg/kg dry mass) boron concentration. This accumulation is observed to the first time.

Basidiomycota↗

PubMed1984

Influence of zinc, D-penicillamine and oxygen on poisoning with Amanita phalloides. Zinc accelerates liver regeneration and prevents the depletion of brain noradrenaline caused by the mushroom.

Pretreatment with zinc aspartate increased the survival rate of mice poisoned with a lyophilisate from the mushroom Amanita phalloides (APL). In the livers of the zinc-treated animals, confluent necrosis was cleared earlier. Zinc also prevented the reduction of brain noradrenaline caused by the mushroom as well as the rise of brain dopamine and brain weight. D-Penicillamine also protected against the lethal effects of APL. The survival afforded by zinc pretreatment was marginally ameliorated by additional oxygenation.

Amanita↗