Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Lymphangitis”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 559 records · Page 31Linked to original sources
PubMed2003

An antigen detection assay for diagnosing filariasis.

In this study we examined the diagnostic potential of monoclonal antibodies (MAb) reactive to antigens of adult Brugia malayi, their microfilariae and antigen of Dirofilaria immitis. The MAb of clone 17E10, which were of IgM isotype, reacted to the inner cuticles and internal content of both male and female worms and also to the sheath and internal content of microfilariae in utero. However, these MAb did not react to the sheath of blood circulating microfilariae. The MAb 17E10 produced a smear pattern between 37 to > 200 kDa in the Western blot analysis against a SDS-PAGE separated extract of B. malayi. The epitopes were non-protein in nature as indicated by their resistance to proteinase-K treatment. The MAb 17E10 were applied in a sandwich ELISA to detect filarial antigen in the buffy coat and plasma of patients. We tested patients with different clinical manifestations of brugian filariasis, i.e. microfilaremia (M), lymphangitis (L) and elephantiasis (E), as well as non-symptomatic inhabitants of a filariasis endemic area (NE), and compared them to samples from non-symptomatic inhabitants of disease non-endemic areas (NNE). It was found that 22 of 31 (70.9%) of M, 7 of 13 (53.8%) of L, 2 of 14 (14.2%) of E, 10 of 100 (10.0%) of NE and none (0%) of the NNE were positive for antigenaemia. The assay was also positive in 14 of 15 (93.3%) blood samples from B. malayi microfilaremic cats and in 7 of 7 (100%) blood samples of Dirofilaria immitis microfilaremic dogs. The so-developed test has a high potential for routine diagnosis of active filariasis, for epidemiological studies in both humans and reservoir animals and for monitoring treatment efficacy.

Animals↗
PubMed2001

Recurrence of sporotrichosis in cats with zoonotic involvement.

The aim of this work is to describe the prevalence of the disease in the same cattery after three years, and to report a case of human sporotrichosis following a cat scratch. In May 1997, four felines presenting a cachexy state and ulcerous lesions on the head, nose and limbs were examined in a veterinary clinic in the town of Rio Grande (RS-Brazil). Exudate and crusts were collected for microbiological diagnosis. The cat's owner returned to the clinic reporting that another eleven felines presented similar lesions. She had ulcerous lesions on her hand and ascending lymphangitis. She was conducted to medical examination where exudate and crusts from the lesions were collected and after the culture Sporothrix schenckii was isolated. After three years the same person sought veterinary assistance for seven more cats with similar lesions to the five previously described. Microbiological tests resulted again in isolation of S. schenckii. Treatment with potassium iodine was effective for the cure of human sporotrichosis, whereas for the felines it showed toxic effect. Only one showed regression of the disease while all the others presented progression of the lesions or even death. The authors call attention to the possible persistence of S. schenckii in cat populations.

Journal Article↗
PubMed2000

[Sucrose saturated solution bioactivity over Sporothrix schenckii].

The purpose of this work was to determine the in vitrobioactivity of a sucrose saturated solution with eugenol (Dickinson, from Dr. Preston Lab. Argentine) and polyethylenglycol 400 ( Merck, from Merck Chemistry Argentine) over Sporothrix schenkii. This dimorphic fungi causes sporothricosis, a sub-acute or chronic infection that affects mainly skin, showing an ulcerous initial lesion with nodular lymphangitis. A strain suspension in Sabouraud dextrose 2% broth (Merck, from Merck Chemistry Argentine) equivalent to Mc Farland N degrees 5 was used, to which the sucrose saturated solution with eugenol and polyethylenglycol 400 was added. Strain viability was measured by seeding aliquots of the original suspension every 15 seconds after initial contact on Sabouraud dextrose agar plates (Britania, from Britania Lab. S.R.L. Argentine). These plates were incubated at 28 degrees C and periodically inspected during 30 days. The strain was viable until 2 min of contact with the solution, after that time no growth was detected. Fungal death may be due to cellular dehydration as a consequence of the low water activity of the referred saturated solution.

English Abstract↗
PubMed2005

Peripheral health workers' knowledge and practices related to filarial lymphedema care: a study in an endemic district of Orissa, India.

The Global Program to Eliminate Lymphatic Filariasis (GPELF), which includes alleviation of disability and suffering of patients, is run primarily in India by the primary health care system. The present study assessed the knowledge and practices related to lymphedema care among peripheral health workers of the primary health care system in a filarial-endemic district of Orissa, India. A total of 41 health workers sampled across the district were subjected to in-depth interviews. The results showed that many lymphedema patients visit the peripheral health institutions mostly for the treatment of acute episodes of lymphangitis. Many health workers do not know the concept of foot care and its importance in lymphedema management. However, a few health workers advised the patients to follow some components of foot care. The knowledge levels and practices of peripheral health workers are not at desirable levels. The medical and paramedical staff of the peripheral health institutions should be oriented about the management of lymphedema and peripheral health workers should promote the foot care practices. For the GPELF as a whole to prove successful, the patients who already have lymphedema need to be cared for and have their morbidity relieved as much as possible.

Elephantiasis, Filarial↗
PubMed2005

[A pilot study of TS-1+CDDP therapy for highly advanced stage IV gastric cancer].

We performed a pilot study of combination chemotherapy with TS-1 and cisplatin for highly advanced gastric cancer. From June 2002, 12 patients with multiple liver metastases, carcinomatous lymphangitis or peritoneal dissemination, were enrolled in the study. TS-1 was administered at a daily dose on day 1-21 and an intermediate-dose of cisplatin (60 mg/m2) was administered on day 8. The combination was repeated in a 5-week cycle. The median administered cycles were three (one to eight). An objective response was obtained in 9 cases (75.0%) of primary sites and 6 cases of metastatic sites. No severe hematological toxicity occurred, and grade 3 stomatitis (in one case) and vomiting (in two cases) occurred as non-hematological toxicities. The improvement of clinical symptoms such as appetite loss and abdominal discomfort was obtained in 9 of 10 cases. The median survival time is 244 days. The TS-1/CDDP regimen had almost no survival benefits, but may induce relief of symptoms due to cancer and better quality of life.

Administration, Oral↗
PubMed2004

Pure pulmonary arterial tumour embolism--a rare cause of pulmonary infarction.

Pulmonary vascular involvement in the natural course of spread of malignant tumours can produce respiratory distress and often manifests as lymphangitis carcinomatosis or carcinomatous arteriopathy. Pulmonary infarction due to arterial tumour embolism is infrequent. This is a report of a treated case of cervical cancer in middle-aged woman who presented after three years with infarction of the lungs following arterial tumour emboli.

Carcinoma, Squamous Cell↗
PubMed2005

Primary congenital lymphedema involving all limbs and genitalia.

Primary congenital lymphedema is the rarest form of primary lymphedema. Lymphedema of the extremities presents at birth and rarely involves the genitalia. There has never been a reported case in Thailand. The authors herby report a case of a 6-year-old boy who presented with progressive swelling of the lower legs since birth. The edema progressed into his scrotum and his arms. There was no history of lymphangitis or cellulites. Physical examination revealed a generalized non-pitting edema of all extremities, more on the right leg than the left leg. Swelling of the scrotum and penis was also detected. A diagnosis of primary congenital lymphedema was confirmed with lymphoscintigraphy.

Child↗
PubMed2006

Mycobacterium marinum arthritis mimicking rheumatoid arthritis.

Mycobacterium marinum is an atypical mycobacterium found in salt and fresh water. M. marinum infection occurs following skin trauma in fresh or salt water and usually presents as a localized granuloma or sporotrichotic lymphangitis. It rarely affects the musculoskeletal system. We describe a patient who presented with subcutaneous nodules and an inflammatory arthritis that was thought to be rheumatoid arthritis, and was treated as such with corticosteroids, methotrexate, and anti-tumor necrosis factor-alpha therapy, with worsening of his arthritis.

Aged↗
PubMed2005

[Erysipelas].

Erysipelas is an acute dermo-hypodermal infection (non necrotizing) of bacterial origin, mainly group A beta-haemolytic streptococcus. The lower limbs are affected in more than 80% of the cases and the identified risk factors are disruption of cutaneous barrier, lymphoedema and obesity. Diagnosis is clinical and based upon the association of an acute inflammatory plaque with fever, lymphangitis, adenopathy and leukocytosis. Bacteriology is usually not helpful because of low sensitivity or delayed positivity. In the atypical forms erysipelas must be distinguished from necrotizing fasciitis and acute vein thrombosis. Penicillin remains the gold standard treatment, although new drugs, given their pharmacodynamic profile, may be used. Recurrence is the main complication, being crucial the correct treatment of the risk factors.

Anti-Bacterial Agents↗
PubMed2001

Imaging of musculoskeletal soft tissue infection.

The role of different imaging techniques in the assessment of musculoskeletal soft tissue infection will be reviewed in this article. As classification according to the causative agent is impossible with imaging, soft tissue infections will be classified in view of their location. Consecutively, musculoskeletal soft tissue infections of the joints, tendons and bursae, muscles, the skin and its related structures as well as infectious lymphadenitis and lymphangitis will be discussed.

Diagnostic Imaging↗
PubMed2006

[Subacute necrotizing lymphadenitis showing lymphatic blockade-mediated acute respiratory failure].

A 24-year-old woman was referred to our hospital with fever and cervical lymphadenopathy. On admission, her serum concentration of soluble IL-2 receptor had increased to 1,740 IU/ml, LDH was 2,889 IU/l, and ferritin was 2,389 ng/ml. Dyspnea became evident (PaO2 60 Torr) with a further increase of serum ferritin to 96,552 mg/ml on day 11. Chest CT findings showed the thickening of the interlobular septa, bilateral pleural effusion, and swelling of mediastinal lymph nodes, symptoms which were very similar to those associated with lymphangitis carcinomatosis. She received steroid pulse therapy (methylprednisolone, 1,000 mg/day for three days). This resulted in a rapid improvement of her dyspnea and disappearance of the lymphatic blockade-mediated pulmonary findings in two days. A cervical lymph node biopsy was performed on day 12, and revealed that she had subacute lymphadenitis (Kikuchi disease). This case suggests that acute respiratory failure should be considered in cases of Kikuchi disease when associated with a lymphatic blockade.

Acute Disease↗
PubMed1991

Morbidity of Brown Recluse spider bites. Clinical picture, treatment and prognosis.

A retrospective review was made of 35 cases of Brown Recluse spider bites treated during a period of 21 years. The most common location of the bite was on the lower limbs, particularly the thigh. The main systemic manifestations were fever, malaise and maculopapular rash, but there were no cases of hemolysis, coagulopathy, or of renal or neurologic involvement. Signs indicating a poor prognosis appeared to be lymphangitis, generalized maculopapular rash and location of the bite on the thigh or abdomen. Most cases were treated effectively by rest, elevation of the affected part of the body, local cleansing, and prophylactic antibiotics. On the basis of this experience it was concluded that only when lesions show a necrotic area measuring 2 to 3 cm should patients be treated with systemic corticosteroids. In most such cases, administration of corticosteroids for 14-21 days proved sufficient to avoid the need for surgery. Only 5 cases required surgical intervention.

Adolescent↗
PubMedDate not supplied

Filariasis in a child from southern Turkey: a case report.

Filariasis is a parasitic condition in which the lymphatic system is invaded by filarial nematodes. The initial signs are those of lymphangitis and lymphadenitis. The manifestations include edema in the extremities and elephantiasis due to lymphatic obstruction. Filariasis is endemic to most parts of the world, but occurs only sporadically in Turkey. This report describes a case of filariasis in a child who presented with fever and extensive lower-extremity edema.

Albendazole↗
PubMed1991

Metastatic prostatic adenocarcinoma-diagnosed by bronchoalveolar lavage and tumour marker determination.

We report a patient who presented with a diffuse interstitial lung disease in whom clinical and radiologic investigation led to the suspicion of lymphangitis carcinomatosa. Bronchoalveolar lavage (BAL) was performed and revealed the presence of prostatic specific antigen (PSA) positive cells. A prostatic needle aspiration confirmed the diagnosis of adenocarcinoma. This case demonstrates the value of tumour marker determination in BAL.

Adenocarcinoma↗
PubMed1991

Vascular abnormalities in experimental and human lymphatic filariasis.

Whereas clinical descriptions of grotesque lymphedema and standard light microscopy in human filariasis have elucidated the natural progression of this disease, the link between the nematode and vascular abnormalities including elephantiasis remains poorly understood. Accordingly, we examined the nature and distribution of lymphatic and blood vascular derangements in a variety of tissues and organs from 37 ferrets acutely and chronically infected with Brugia malayi and in 15 patients with Wuchereria bancrofti or Brugia malayi infestation (resected skin, subcutaneous tissue, and lymph nodes) using light and transmission electron microscopy, immunohistochemistry, and in vivo microscopy. In ferrets, eosinophilic abscesses and epithelioid and giant cell granulomas with fragmented worms in various stages of disintegration were found in multiple organs. Blood microvasculopathy consisted of endothelial hyperplasia, focal thickening and stenosis, vessel obliteration with marked perivascular infiltration of lymphocytes, plasma cells, eosinophils, and numerous large macrophages laden with a coarse golden-brown pigment. Endothelial ballooning and swelling, pavementing, denuding, scarring, and sludge formation were seen along with high endothelium in atypical locations. Dilated lymphatics were most prominent near adult worms and showed plump endothelium, thickened walls and valves, thrombus formation, and often perilymphangitis and adjacent tissue fibrosis. In vivo microscopy showed wriggling live adult worms in dilated incompetent sludge-filled groin lymphatics even when microfilaremia and peripheral edema were absent. In human tissues, in addition to "pachyderm" skin changes (keratosis, papillomatosis, acanthosis and collagen deposition), there was blood vessel and lymphatic vasculopathy similar to ferrets (angiocentric inflammation, congestion, vasculitis, thrombosis, thickened vessel walls, dilated lymphatics, lymphangitis, reactive lymph nodal hyperplasia and nodal fibrosis). These changes reflect generalized endothelial damage due to worm products, physical injury to valves and vessel walls from lymphatic-dwelling live worms, and host immune reactivity. Whereas adult worms target the lymphatic apparatus, their offspring and the host immune response primarily affects the blood microvasculature.

Animals↗
PubMed1976

[Pulmonary metastasis from Vater's ampullomas].

The authors report two cases of carcinoma of the ampulla of Vater with numerous pulmonary metastases. This carcinoma is a malignant tumour with a very poor short-term prognosis. This tumour develops at the expense of the ampulla of Vater and may give rise to numerous pulmonary metastases and carcinomato,s lymphangitis. Authors are not unanimous concerning the course and prognosis of these tumours. In fact, one may note two tendencies, one optimistic, which seems to us erroneous, the other pessimistic, which we share.

Adenocarcinoma↗
PubMed1977

The swollen leg.

Systemic causes of leg edema include idiopathic cyclic edema, heart failure, cirrhosis, nephrosis and other hypoproteinemic states. Lymphedema may be primary, or secondary to neoplasm, lymphangitis, retroperitoneal fibrosis and, rarely (in the U.S.), filariasis. Thrombophlebitis and chronic venous insufficiency are not uncommon causes. Finally, infection, ischemia, lipedema, vascular anomalies, tumors and trauma can be responsible for the swollen leg.

Arteriovenous Fistula↗
PubMed1991

[An anthrax epidemic in Switzerland. Clinical, diagnostic and epidemiological aspects of a mostly forgotten disease].

On average in Switzerland there is only one case of human anthrax every two years, and this is almost exclusively caused through contact with sick animals in agriculture. However, within less than 3 years, 25 workers in one textile factory have contracted this anthropo-zoonosis. 24 cases had cutaneous and one inhalation anthrax. The infection was imported in goat's hair from Pakistan. This almost unique industrial epidemic was due to various circumstances. In particular, the rarity of the illness contributed to a general lack of experience and therefore hindered recognition of the clinical symptoms. In addition, repeated attempts failed to identify the pathogenic agent conclusively. In most cases, the diagnosis was only confirmed retrospectively using the Russian allergen "Anthraxin"--an intracutaneous test unknown up to that time in human medicine in the West--and later also by EIA. All the patients recovered. The clinical picture, diagnosis and epidemiology of cutaneous anthrax are described in detail. The typical features are, in the beginning, a pruritic insect-bite-like pimple, then a painless ulcer surrounded by serous-hemorrhagic, often rapidly confluent vesicles and non-pitting edema. On the ground of the ulcer a black necrosis develops which is never colliquative but is transformed into the typical pitch-black firmly adherent eschar. Lymphadenitis and lymphangitis are concomitant manifestations. The bacteriological findings and occupational history are decisive for the diagnosis. Anthrax spores can survive many decades. The vegetative organisms are highly susceptible to almost all antibiotics. The latter prevent the invasion of the anthrax bacilli and the toxinemia if administered in time, but they do not influence the development of the local lesions. For the detection of anthrax bacillus, sterile swabs should be soaked in the fluid of the vesicles. It must be done before beginning of any antibiotic treatment. For the examination of animal products, preparatory procedures are necessary to destroy contaminants that may be antagonistic to or overgrow Bacillus anthracis.

Adult↗