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Results for “LABYRINTH DISEASES”

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At least 559 records · Page 31Linked to original sources
PubMed2005

In vivo zebrafish assays for toxicity testing.

Toxicity, due to complications of in vivo adsorption, distribution, metabolism and excretion (ADME), is a major cause of failure during drug development; many drugs shown to be safe in cell culture prove toxic in animal studies. Effective in vivo toxicity screening early in the development process can reduce the number of compounds that progress to laborious and costly late-stage animal testing. The transparent zebrafish provides accessibility to internal organs, tissues and even cells, and has emerged as an invaluable model organism for toxicity testing and drug discovery. Straightforward in vivo zebrafish assays can serve as an intermediate step between cell-based and mammalian testing, thus streamlining the drug development time-line.

Animals↗
PubMed1978

[Compensatory processes during unilateral loss of vestibular function].

Changes in the compensation of the sequences of the unilateral loss of the labyrinthine function were studied in rabbits. Destruction of the labyrinth was accompanied by ocular nystagmus, increase of frequency of respiration and heart contractions, and EEG-activation. Investigations carried out showed these reactions to be extinguished at different time. At the late periods of labyrinthectomy a considerable asymmetry of nystagmus reaction to the angular accelerations equal in intensity, but opposite in direction was revealed. Stimulation of an intact otolith labyrinth was accompanied by the appearance of positional nystagmus. The results obtained indicated imperfection of the compensatory mechanisms during complete unilateral loss of the vestibular function.

Animals↗
PubMedDate not supplied

[Bilateral deafness due to the local use of framycetin (author's transl)].

A case is reported of total bilateral cochleo-vestibular destruction following instillation of Framycetin into the middle ear, under pressure, through a transtympanic drain. Toxicity of Framycetin after local use is exceptional and only one case, reported by Ransome, was found in the published literature. The interest of this observation is that, by using puncture of the foot of the stapes, it was possible to find Framycetin in the perilymphatic liquid three weeks after the injection of the product.

Administration, Topical↗
PubMed1979

The rationale and technique of head exercises in the treatment of vertigo.

The central compensation mechanisms for vertigo resulting from vestibular lesions are described together with the scientific basis for head exercises in vestibular rehabilitation. The indications and contra-indications for head exercises are discussed and the Cawthorne-Cooksey regime of exercises illustrated.

Exercise Therapy↗