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A carcinofetal antigen located on the membrane of cells from rat intestinal carcinoma in culture.

Heteroantisera were produced in rabbits by immunization with cultivated cells from rat intestinal carcinomas. The sera were made specific by in vivo absorption in syngeneic rats. On immunofluorescence, these sera recognized a membrane-associated antigen common to five different intestinal carcinomas and to fetal intestine. The antigen was not detected in noncancerous adult intestine, nonintestinal fetal tissues, or three nonintestinal tumor cell lines.

Animals↗

[Role of X-ray CT in the evaluation of extension of ovarian cancer].

To evaluate the utility of X-ray computed tomography (CT) in the management of malignant ovarian tumor, preoperative CT of 89 patients with ovarian cancer were analyzed on the basis of their surgically confirmed findings. Relationships between CT findings and clinical factors such as actual tumor spread, stage, and accomplished surgery were studied. The results obtained were as follows. 1. The rates of correct diagnosis in tumor spread were 79.8% for tumor growth on the external surface of the ovary, 77.6% for involvement of both ovaries, 79.8% for ascites, 78.2% for metastasis to the uterus, 68.2% for peritoneal metastasis, 77.0% for metastasis to the intestine, and 79.3% for the metastasis to the omentum. 2. Comparing the stage suggested by CT (CT stage) and the stage revealed by surgery (surgical stage), the stages coincided in 57 patients (64.0%). CT stages were overestimated in 9 cases and underestimated in 23 cases. 3. As for the practicability of surgery, either complete or standard operation was performed in 31 of 33 cases (93.9%) of CT stage I, 21 of 28 (75.0%) of CT stage II, and 11 of 28 (39.3%) of CT stage III. The possibility of accomplishing surgery was very low when CT indicated stage III disease.

Female↗

[Cutaneous symptoms of carcinoid tumours of the small bowel (author's transl)].

Cutaneous symptoms of carcinoid tumours are classified in 4 groups: --Acute type: flusch and vasomotor signs (the caracters of which are described). --Chronic type: telangiectasia, hyperpigmentation, sclerodermia-like, cutaneous maetastasis. --Rare type with non-diagnostic sign. --Types in association with other dermatological conditions either unrelated disease or with a likely related disease such as phacomatosis. Dermatological diagnosis is generally easy as cutaneous symptoms is concomitant with metastatic tumours and increased levels of serotonin and 5-H.I.A. The carcinoid syndrom may take place in the concept of the tumours of the A.P.U.D. system on clinical, embryological, histological and biochemical basis.

Apudoma↗

[An animal model for tumors of the large intestine].

Dimethylhydrazine (DMH) and its derivatives induced in many animal species tumors of the large intestine with a great specificity and reproductibility. Oour personal observations using rats BD IX injected weekly with DMH are summarized in this presentation. The induced tumors appear as invaded tumors already at the microscopic stade. Their growth is best described by a Gompertz function. The number of induced tumors increases with time as a non linear function. This model is very useful for the study of the biology of human tumors with a low development.

Animals↗

Promotion of azoxymethane-induced intestinal cancer by high-fat diet in rats.

Promotional properties of a high-fat diet in intestinal cancer were studied by feeding a 30% beef fat diet to 8 groups of rats (25 rats/group) for time periods varying from 1 to 21 weeks after 8 weekly s.c. injections of azoxymethane (AOM) (8 mg/ kg). Two other groups were fed the high-fat diet, one for 8 weeks prior to and the other during AOM injections. A 5% fat diet was fed to rats when not on the 30% fat diet and to a control group of 25 animals. High fat diet increased intestinal tumor frequency up to 2-fold when given for at least 4 weeks after but not during or prior to AOM injections; this increase occurred even after a prolonged interval (10 weeks) between the last AOM injection and the high-fat diet. In general, tumor frequency increased according to the length of time animals were fed the high-fat diet after AOM. Therefore, the high-fat diet in this model exhibited most of the properties of promoters developed from murine skin cancer, thus adding support to the concept that excess dietary fat acts at the promotional phase of carcinogenesis.

Animals↗