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At least 559 records · Page 31Linked to original sources
PubMed1998

Photoallergic contact dermatitis due to combined UVB (4-methylbenzylidene camphor/octyl methoxycinnamate) and UVA (benzophenone-3/butyl methoxydibenzoylmethane) absorber sensitization.

In a 71-year-old male Caucasian patient with persistent eczema on light-exposed skin, photocontact allergy was demonstrated to the UV filter substances 4-methylbenzylidene camphor (UVB), octyl methoxycinnamate (UVB), benzophenone-3 (UVA) and butyl methoxydibenzoylmethane (UVA) present in sunscreen products used by the patient over several years. A significantly reduced UVB sensitivity of 25 mJ/cm2 in this patient (normal minimal erythema dose in our laboratory = 70-130 mJ/cm2) was considered an early indication of a persistent light reaction. Topical anti-inflammatory treatment over 2 weeks together with consequent application of a sunscreen containing Mexoryl SX/titanium dioxide led to complete remission. Taking into account the widespread use of the above UV filter substances not only in sun protection products, but also in cosmetics such as antiaging lotions and day care products, the possible risk of allergy to these chemicals has to be taken seriously. The substitution of known photocontact sensitizers in UV filters by photostable compounds and detailed product information are the basis of preventive strategies.

Aged↗
PubMed1999

A case of acral Darier's disease.

A sporadic case of acral Darier's disease in a 20-year-old woman is reported. The disease was diagnosed on the basis of clinical, histological and ultrastructural data. Only few cases of exclusively acral clinical manifestations of Darier's disease have been described in the literature.

Adult↗
PubMed2000

Pigmentation and pits at uncommon sites in a case with reticulate acropigmentation of Kitamura.

Reticulate acropigmentation of Kitamura is now reported from all over the world. Additional features are being readily recognized. Our cases had pigmentation and pits on the dorsa of the distal phalanges of the fingers and toes - the classical features - as well as widely distributed pits on the palms, palmar aspect and sides of the fingers. The involvement in our cases was more pronounced than in the previously reported ones.

Adult↗
PubMed2003

Treatment failures and relapses in onychomycosis: a stubborn clinical problem.

The therapeutic outcome of onychomycoses is uncertain. Comparative short-term efficacy studies on antifungals abound and report contradictory findings. Few unbiased follow-up studies have scrutinized the long-term outcome. Basically, none of the current antifungals can guarantee cure in all instances. In addition, relapses are not rare. The causes of therapeutic failure in onychomycoses are multiple. The most important are the lack of diagnostic accuracy, inadequate antifungal choice or delivery modality, and presence of dormant conidia, sequestrated mycelium pockets or resistant fungal species. The concept of fungicidal drug derived from selected in vitro studies appears irrelevant in clinical practice.

Administration, Oral↗
PubMed1997

Epidemiology and ecology of onychomycosis.

The epidemiology and ecology of onychomycosis are complex and little understood. Most is known about tinea unguium, dermatophytic nail infection, and its causative agents. This is often categorised according to the precise locus on the nail of the infection. The principal infectious propagules are thought to be the arthroconidia or chlamydospores which form within the solid substratum of invaded nail tissue. The process of infecting new hosts appears to be facilitated by abrasion, moistening and scratching. The role of the non-dermatophyte yeast Candida as an agent of onychomycosis per se may have been overestimated. The range of interactions between dermatophytes and non-dermatophytes in nails is complex and poorly understood. There may be at least six distinct ecological categories of non-dermatophyte isolations from nails. It would be of clinical interest to know which species found in mixed infections were never able to advance beyond 'secondary colonisation', as they would not require specific treatment.

Adult↗
PubMed1997

Oral terbinafine (Lamisil) in the treatment of fungal infections of the skin and nails.

The efficacy and safety of antifungal drugs depend upon their mode of action, the minimal inhibitory concentration (MIC) and its relationship to the minimal fungicidal concentration (MFC), the spectrum of activity and drug kinetics at the involved site. Terbinafine acts at the fungal cell wall. Its MIC against dermatophytes is the lowest of all currently available systemic antifungal agents. It is the only one with an MIC:MFC ratio of 1:1 so that terbinafine should be effective over very short treatment durations in dermatophyte infections of the scalp, palms and soles, and nail, providing that drug penetration is adequate, as it appears to be. Therapeutic levels persist for a considerable period after the cessation of treatment, also favouring short-duration therapy. Terbinafine is effective against all varieties of dermatophyte. Terbinafine given over 4 weeks or less is effective against Trichophyton of the scalp in children and adults. Its efficacy in zoophilic ectrothrix infection is anecdotal, but it is likely on theoretical grounds. Terbinafine is also effective against pityriasis versicolor and vaginal candidosis, but only topically. As of March 1996, around 3,000,000 patients have been treated worldwide with terbinafine, mostly for 12 weeks for toe-nail onychomycosis. Gastro-intestinal disturbance and minor skin rashes are seen in 5 and 2% of patients, respectively.

Administration, Oral↗
PubMed1996

Leukocytoclastic vasculitis in subacute cutaneous lupus erythematosus: clinicopathologic study of three cases and review of the literature.

BACKGROUND: Leukocytoclastic vasculitis associated with subacute cutaneous lupus erythematosus (SCLE) was observed by Sontheimer et al. in their first clinical series of patients with SCLE, although recent reports have suggested that its frequency was rare. OBJECTIVE: To evaluate the prevalence of cutaneous leukocytoclastic vasculitis (CLV) in patients with SCLE and to describe the clinicopathologic manifestations, response to treatment and prognosis of this subgroup of patients. METHODS: We reviewed all cases of SCLE seen at the Hospital de la Princesa from 1980 to 1995. RESULTS: Three (9%) of our 27 patients with SCLE exhibited CLV and SCLE. Purpura, maculoerythematous lesions, urticaria, nodules and necrotic lesions on the leg, trunk and palmoplantar regions were present in our patients with CLV and SCLE. Histologically, SCLE-associated CLV was a small-sized vessel leukocytoclastic vasculitis with intravascular thrombosis in the deep dermis and coexistence of lesions of CLV and SCLE. CONCLUSION: In our patients, CLV was self-limited and not associated with a worsened prognosis, with only cutaneous involvement in their further relapses of SCLE.

Adult↗
PubMed1996

Diphencyprone in the management of refractory palmoplantar and periungual warts: an open study.

BACKGROUND: Induction of delayed-type hypersensitivity has recently been introduced for resistant viral warts. The method is not painful and less destructive than most other modalities. OBJECTIVE: We assessed the efficacy of topical diphencyprone (diphenylcyclopropenone) treatment for recalcitrant warts. METHODS: From September 1988 to June 1995, 134 patients with periungual and/or palmoplantar warts were entered into the study. Eight weekly applications were delivered. RESULTS: The scheduled treatment course and follow-up were completed by 111 patients. There were 49 complete and 18 partial remissions. The rate of positive responders (60%) compares with the results published by other authors. CONCLUSION: Diphencyprone is an effective treatment for resistant warts, especially in palmoplantar and periungual locations.

Adjuvants, Immunologic↗
PubMed1996

Taxol-induced acral erythema.

Chemotherapy-induced acral erythema is a peculiar localized cutaneous response to several chemotherapeutic agents, mostly antimetabolites. Taxol is a recently developed antineoplastic drug that acts on the mitotic spindle and does not interfere with nucleic acid synthesis. We describe the first case of taxol-induced acral erythema and report on additional data concerning the pathogenesis of this kind of toxic eruptions.

Adult↗
PubMed1995

Sweet's syndrome with myelofibrosis and leukemia: partial response to interferon.

Sweet's syndrome with malignancy or acute neutrophilic dermatosis (AND) is an unusual cutaneous disorder seen most commonly in association with acute myelogenous leukemia. A large majority of patients with AND and malignancy have neoplasms of hematopoietic, plasma cell or lymphoid nature. The patient reported here had myelofibrosis, chronic myelogenous leukemia and Sweet's syndrome. The individual lesions responded to intralesional interferon-alpha 2, which has not to our knowledge been reported previously. This result, however, was not as great as the response of AND to intralesional steroid injections.

Aged↗
PubMed1994

Acral psoriasiform hemispherical papulosis, a new entity?

A 46-year-old patient with 'locked-in syndrome' due to brainstem infarction developed symmetrically distributed, grouped erythematous cornified hemispherical papules on the fingertips and toes in 2 years. Histologically they showed psoriasiform changes. There was no evidence of internal malignancy nor a history of special drug intake. To our knowledge, such an eruption has not been previously reported.

Erythema↗
PubMed1994

Palmoplantar reactions.

The palmoplantar skin reacts monotonously to acute causes with vesicles or pustules and to chronic or chronically recurrent noxae with hyperkeratosis. Vesicular reactions are mostly triggered by eczematogens and fungi. Among the primary pustuloses, pustular psoriasis of the palms and soles is the dominating one, while the secondary pustuloses stem from infections of vesicular reactions with pyogens. Hyperkeratotic reactions may be caused directly by mechanical irritations or dehydration of the skin but also secondarily by chronic or chronically recurrent vesicular and pustular reactions.

Foot Dermatoses↗