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Permeation of captan through disposable nitrile glove.

The purpose of this study was to investigate the permeation of an aqueous emulsion of the pesticide, captan, as a wettable powder (48.9% captan) through a disposable nitrile glove material using an American Society for Testing and Materials (ASTM)-type I-PTC-600 permeation cell. The goal was to investigate the protective capability of the gloves against dermatitis. The analytical method was based on gas chromatography-mass spectrometry (GC-MS) and gas chromatography-electron capture detection (GC-ECD). The least quantifiable limit (LQL) was 6 ng for GC-ECD and 30 ng for GC-MS. Testing was conducted using the ASTM F739 closed-loop permeation method and a worst-case aqueous concentration 217 mg/ml of captan 50-WP. The average permeation rates were low, with 12+/-5 ng/(cm(2)min) after 2h, 50+/-25 ng/(cm(2)min) after 4h, and 77+/-58 ng/(cm(2)min) after 8h. The calculated diffusion coefficient was (1.28+/-0.10) x 10(-5)cm(2)/h. No significant swelling or shrinkage occurred at P</=0.05. Infrared (IR) reflectance analysis of pre- and post-exposure glove surfaces confirmed no outer or inner surface degradation. The disposable nitrile glove showed excellent resistance to a highly concentrated aqueous emulsion of captan. Because the ASTM normalized breakthrough detection time of 250 ng/cm(2) was <2h, these gloves should not be reused once worn, and decontamination is not advised. Protection is also advised for agricultural reentry field workers, because captan has been shown to persist on crops with a half-life greater than the current reentry intervals of 1-4 days.

Captan↗

A global inventory of hospitals using powder-free gloves: a search for principled medical leadership.

Scientific experimental and clinical studies have demonstrated that cornstarch on surgical and examination gloves promotes disease by acting as a reactive foreign body in tissue and serving as a vector for latex allergy. Consequently, hospitals have selected an innovative glove selection program utilizing only powder-free gloves. Healthcare workers in emergency medical systems are now wearing powder-free, latex-free gloves to care for the growing number of patients sensitized to latex. A global Internet search has now identified 70 hospitals in the United States and three hospitals in Europe that use only powder-free gloves.

Data Collection↗

Glove powder reduction and alternative approaches.

This article addresses the role of glove powder in facilitating allergic reactions to natural rubber latex (NRL) and to the chemical additives in synthetic and NRL gloves as well as its role in eliciting postsurgical complications. Various dusting powders have been used historically to prevent gloves from sticking to each other and to facilitate donning. All have manifested adverse consequences for health care professionals and patients. Manufacturing methods for powder reduction and elimination are presented. The recently developed ASTM methods for the quantitation of powder on powder-free and powdered gloves are reviewed along with the new ASTM maximum powder limits for all medical gloves. Caution must be exercised when methods of protein and powder reduction are implemented to minimize the possibility of creating other adverse consequences.

Gloves, Surgical↗

Glove perforation during surgical extraction of wisdom teeth.

OBJECTIVE: This study investigated the incidence of sterile surgical glove perforation during hospital-based surgical extractions of wisdom teeth performed with patients under general anesthesia. STUDY DESIGN: A total of 104 consecutive patients (420 gloves) were studied prospectively. A standardized water inflation technique was used. RESULTS: The operative perforation rate was 8.6%, or 4.3% per surgeon per operative side. The individual glove perforation rate was 2.1% per operation. Over 55% of perforations were not noticed at the time of surgery. There were no skin-penetrating injuries or visible contamination with body fluids. The perforation rate was the same with drill and chisel. CONCLUSIONS: The incidence of glove perforation is lower than previously reported. The surgical extraction of wisdom teeth carries a relatively low yet still significant risk with regard to exposure to bloodborne cross-infection. We recommend that high-quality surgical gloves be used and that universal precautions be adhered to.

Anesthesia, Dental↗

Latex sensitization in dental students using powder-free gloves low in latex protein:a cross-sectional study.

In Germany, employers must provide low-protein, powder-free gloves. This study was carried out to determine the current prevalence of latex sensitization in dental students using these gloves and to compare our results with a study of the same design dating from 1990/1991 at our university. A cross-sectional study was performed by questionnaire, prick testing and determination of specific IgE antibodies. 226 of 403 dental students underwent prick testing with a panel of 8 aero-allergens, 1 commercially available latex extract and 5 high-ammonia accelerator-free latex fluids. 39 of 226 dental students (17.3%) had a positive prick test response to at least 1 of the 6 latex substances tested. The prick test positivity was similar in preclinical education (semester 1-6) and in clinical education (semester 7-10), at 17.1% and 17.4%, respectively. In 9 of 32 persons with positive prick tests, specific IgE antibodies to latex could be detected. Within the past 10 years, prick test positivity increased from 8.7% to 17.3%. 14 students (6.2%) reported a history of glove intolerance, 3 of them (1.3%) showing a positive prick test to latex. By the use of low-protein, powder-free gloves less students with glove intolerance were observed. The observed reactions to between 1 and 3 of 6 latex substances tested may indicate a decrease in intensity and spectrum of sensitization. Additionally non-occupational sensitization may be of importance.

Adult↗

Protective effect of glove on median nerve compression in the carpal tunnel.

OBJECTIVES: To determine the protective effect of gel padded glove on median nerve compression in the carpal tunnel. METHODS: Median nerve conduction parameters, skin temperature, laser Doppler flowmetry and pain modifications were measured during and after a 30-min carpal tunnel external compression protocol performed with and without glove in a random order on six healthy volunteers. RESULTS: Compression induced a rapidly reversible increase in sensory and motor distal latencies, a decrease in sensory amplitude, finger laser Doppler flowmetry and hand skin temperature supporting the hypothesis of a reversible conduction block of ischemic origin. There was no statistical difference between the tests (with or without glove) except for pain that was significantly reduced by glove protection. CONCLUSION: Gel padded glove does not seem to have a protective effect on the carpal tunnel syndrome induced by compression but provides significant comfort.

Action Potentials↗

Electronic evaluation of the value of double gloving.

BACKGROUND: Breakdown of the surgeon-patient barrier represents a risk for transmission of infectious disease. Such breakdowns are frequently not recognized by the surgical team. The protection afforded by double gloving under normal operating conditions was evaluated. METHODS: An electronic device detected breakdown of the surgeon-patient barrier in a series of 80 surgical procedures, randomly assigned to either double or single gloving. Fluid contact due to glove perforation, porosity or gown wetting was recorded during 151 individual surgeon episodes covering 238 operator-hours. Surgical procedures were called superficial for incisions of less than 10 cm. RESULTS: Double gloving reduced the number of perforation and porosity alarms twofold in both superficial and deep surgical procedures. Deep procedures carried a sevenfold increased risk of barrier breakdown compared with superficial procedures, the risk being greatest for the principal operator. CONCLUSION: Without electronic detection, a large majority of barrier breakdowns would remain undetected by the surgical team and lead to prolonged contact with potentially contaminating body fluids. The use of double gloving provides real protection against such contamination risks.

Electronics↗

An evaluation of complications following dental extractions using either sterile or clean gloves.

This randomized prospective study aims to evaluate any differences in the postoperative infection rate from dental extraction using either sterile or clean surgical gloves and to determine any predisposing factors that may complicate socket healing. A total of 609 patients were randomly assigned to two groups, with the operators wearing either sterile or clean gloves in performing forcep extractions. 551 patients, who had 811 extractions performed, returned for the postoperative assessment visit. There was no difference in the incidence of an acutely inflamed socket, acutely infected socket and dry socket and also no significant predisposing factors found between the sterile and clean glove groups. The pre-operative diagnosis of caries, periodontal disease or retained root had a higher tendency of producing an acute-inflamed socket, whereas an acutely infected socket only developed in the cases of retained root. On the pain intensity level, an acutely inflamed socket caused mild to moderate pain, on acutely infected socket caused moderate to severe pain; and a dry socket caused severe pain in the majority of cases. The study concluded that the use of sterile surgical gloves does not offer an advantage over clean gloves in minimizing socket inflammation, infection, as well as a dry socket following dental extraction.

Adolescent↗

Rates of hand disinfection associated with glove use, patient isolation, and changes between exposure to various body sites.

BACKGROUND: Handwashing is the most effective and economic intervention shown to reduce nosocomial infection rates. However, studies have consistently documented low hand disinfection compliance. Literature regarding the roles that concomitant glove use and isolation precautions play in health care worker compliance with hand disinfection is limited. It is unclear whether workers change gloves and disinfect hands adequately between exposures to different body sites/secretions while caring for a patient. METHODS: This was an observational study in which hand disinfection compliance and glove use among workers was evaluated in 2 intensive care units at a tertiary care hospital. RESULTS: Five hundred eighty-nine opportunities for hand disinfection were recorded in 40 hours of observation. Overall compliance was 22.1%. We found a statistically significant, positive association between glove use and subsequent hand disinfection (relative risk [RR], 3.9 [95% CI, 2.5-6.0]; P <.0001). Isolation precautions did not significantly increase disinfection compliance. Only 4.8% (3/63) of workers appropriately complied with disinfection when hands were exposed to multiple body sites/secretions while caring for a patient. CONCLUSIONS: Glove use increases compliance with hand disinfection. Isolation precautions do not increase compliance. Workers do not appropriately comply with disinfection guidelines when attending to multiple body sites/secretions on the same patient. Compliance with hand disinfection remains low.

Attitude of Health Personnel↗

Di(2-ethylhexyl) phthalate contamination of retail packed lunches caused by PVC gloves used in the preparation of foods.

Plasticizer contamination of foods sold in retail packed lunches and set lunches in restaurants was determined by GC/MS. The phthalate esters were as follows: diethyl, dipropyl, dibutyl, dipentyl, dihexyl, butylbenzyl, dicyclohexyl, di(2-ethylhexyl), dioctyl, diisooctyl (mixture of isomers) and diisononyl (mixture). Di(2-ethylhexyl) adipate was also determined. Sixteen packed lunches and ten set lunches were analysed, and in all samples the concentration of di(2-ethylhexyl) phthalate (DEHP) was the highest, at 0.80-11.8 mg/kg in packed lunches and 0.012-0.30 mg/kg in set lunches. The DEHP content of five packed lunches exceeded 1.85 mg, which is the EU tolerable daily intake (TDI) for a person of 50 kg body weight. Foodstuffs that were components of the packed lunches were taken from the factory at each step of preparation and phthalates were determined. For example, chicken contained 0.08 mg/kg DEHP when uncooked, 13.1 mg/kg after frying and 16.9 mg/kg after packing. Disposable PVC gloves used in the preparation of foods were apparently the source of high DEHP concentrations. The gloves used during cooking or packaging were sprayed with 68% (w/w) ethanol to sterilize them. PVC gloves from the factory contained 22 or 41% by weight of DEHP. To confirm the link with the contamination problem, samples of boiled rice, croquette and boiled dry radish were handled in the laboratory with PVC gloves containing 30% (w/w) DEHP. DEHP migration levels of 0.05 mg/kg in rice or 0.33 mg/kg in croquette, and 11.1 mg/kg in radish were found. The alcohol sprayed onto the gloves increased the migration of DEHP to 2.03 mg/kg in rice, 2.45 mg, kg in croquette, and 18.4 mg/kg in radish.

Diethylhexyl Phthalate↗

Modeling organic solvents permeation through protective gloves.

Several researchers have studied the diffusion of organic solvents through chemical protective gloves and have estimated the diffusion coefficients by using various models. In this study, permeation experiments of benzene, toluene, and styrene through nitrile and Neoprene gloves were conducted using the ASTM F-739 standard test method. The diffusion coefficients were estimated using several models from the literature. Using a one-dimensional diffusion equation based on Fick's second law and the estimated diffusion coefficients, the permeation concentrations were simulated and compared with the experimental results. The modeling results indicated that the solubility of the solvent in the glove materials obtained by immersion tests was not an appropriate boundary condition for organic solvent permeation through the polymer gloves. The modeling work of this study will assist industrial hygienists to assess exposure of chemicals to workers through the chemical protective gloves.

Diffusion↗

Contamination of gowns, gloves, and stethoscopes with vancomycin-resistant enterococci.

OBJECTIVE: [corrected] To measure directly the rate of contamination, during routine patient examination, of gowns, gloves, and stethoscopes with vancomycin-resistant enterococci (VRE). SETTING: A large, academic, tertiary-care hospital. PATIENTS: Between January 1997 and December 1998, 49 patients colonized or infected with VRE were entered in the study. DESIGN: After routine examination, the examiner's glove fingertips, gown (the umbilical region and the cuffs), and stethoscope diaphragm were pressed onto Columbia colistin-nalidixic acid (CNA) agar plates with 5% sheep blood plus vancomycin 6 pg/mL. The stethoscope diaphragm was sampled again after cleaning with a 70% isopropanol wipe. RESULTS: VRE were isolated from at least 1 examiner site (gloves, gowns, or stethoscope) in 33 (67%) of 49 cases. Gloves were contaminated in 63%, gowns in 37%, and stethoscopes in 31%. All three items were positive for VRE in 24%. One case each had stethoscope and gown contamination without glove contamination. Only 1 (2%) of 49 stethoscopes was positive after wiping with an alcohol swab. Contamination at any site was more likely when the patient had a colostomy or ileostomy. Patients identified by rectal-swab culture alone were as likely to contaminate their examiners as were those identified by clinical specimens. CONCLUSIONS: Our study revealed a high rate of examiner contamination with VRE. The similar risk of contamination identified by surveillance and clinical cases reinforces concerns that patients not known to be colonized with VRE could serve as sources for dissemination. Wiping with alcohol is effective in decontaminating stethoscopes.

Academic Medical Centers↗

Effectiveness of liquid soap vs. chlorhexidine gluconate for the removal of Clostridium difficile from bare hands and gloved hands.

OBJECTIVE: To compare liquid soap versus 4% chlorhexidine gluconate in 4% alcohol for the decontamination of bare or gloved hands inoculated with an epidemic strain of Clostridium difficile. DESIGN: C difficile (6.7 log10 colony-forming units [CFU], 47% spores), was seeded onto bare or latex gloved hands of ten volunteers and allowed to dry. Half the volunteers initially washed with soap and half with chlorhexidine, followed by the other agent 1 week later. Cultures were done with Rodac plates at three sites on the hand: finger/thumbtips, the palmar surfaces of the fingers, and the palm. Statistical comparison was by paired Student's t test. RESULTS: On bare hands, soap and chlorhexidine did not differ in residual bacterial counts on the finger/thumbtips (log10 CFU, 2.0 and 2.1, P = NS) and fingers (log10 CFU, 2.4 and 2.5, P = NS). Counts were too high on bare palms to quantitate. On gloved hands, soap was more effective than chlorhexidine on fingers (log10 CFU 1.3 and 1.7, P < .01) and palms (log10 CFU 1.5 and 2.0, P < .01), but not finger/thumbtips (log10 CFU 1.6 with each, P = NS). Residual C difficile counts were lower on gloved hands than bare hands (P < 0.01 to < 0.0001). CONCLUSIONS: The two agents did not differ significantly in residual counts of C difficile on bare hands, but on gloved hands residual counts were lower following soap wash than following chlorhexidine wash. These observations support the use of either soap or chlorhexidine as a handwash for removal of C difficile, but efficacy in the prevention of C difficile transmission must be determined by prospective clinical trials.

Aerosols↗

Gown-glove interface: a possible solution to the danger zone.

The gown-glove interface is the weakest point in the present barrier system of gown and glove protection for the surgeon and other healthcare professionals who come into direct contact with body liquids. Try it yourself: put on a fluid-resistant gown and surgical gloves. See that the glove cuff is well proximal to the stockinette. Hold your wrist and forearm for a moment under running water. Wait a minute to see if your forearm is wet. A wet forearm during surgery would be a blooded one. We propose a gown redesign that creates a dart at the terminal forearm, sealed by a liquid-proof method, and then similarly sealing the proximal end of the glove to the sleeve.

Gloves, Surgical↗

A survey of starch particle counts in the hospital environment in relation to the use of powdered latex gloves.

As latex proteins, which cause latex hypersensitivity, can be found on starch particles and inhalation may be a route for sensitization, the presence of starch particles in hospital air was examined. The starch particles were demonstrated by immobilization onto cellulose acetate filters and staining with iodine. Rooms in which powdered latex gloves were used gave counts of up to > 3,667 particles per cubic meter of air. Starch particles were not found in the air in rooms where latex gloves were not used, and were highest in rooms with a high glove usage but no ventilation. A change to powder-free gloves significantly reduced the count of starch particles in the unventilated Accident/Emergency Department air. Use of powder-free gloves should be considered especially in unventilated areas in healthcare premises.

Air Pollutants, Occupational↗

Evaluation of tungsten and lead surgical gloves for radiation protection.

We present experimental results on the radiation protection offered by some types of gloves commercialized for use in operating rooms where x rays are used and in interventional radiology rooms. Some gloves with lead as the attenuating element and others containing tungsten were evaluated. The composition of some gloves was determined by x-ray fluorescence analysis. Attenuations for direct beam and for scattered radiation were obtained with different quality x-ray beams. The results obtained are compared with data supplied by the manufacturers. We have also simulated numerically the attenuation of x-ray spectra of different kVp and filtrations to establish the possible advantages of tungsten as an attenuating element. It is concluded that the use of tungsten as an attenuating element is clearly more advantageous than lead in the whole range of energies used in diagnostic radiology since gloves with tungsten offer the same protection while also allowing much better tactile perception than gloves with lead.

Biophysical Phenomena↗

Examination of several instruments for the electrical detection of holes in latex gloves during use.

The initial purpose of this research was to investigate the use of electrical conductivity for detecting holes in latex gloves, while they are being worn, using both recently developed devices and laboratory equipment. The individual devices were not evaluated or critically compared. The use of this technique as a quality assurance procedure, and to determine the degradation of latex gloves due to storage and exposure to disinfectants, was also investigated. The following conclusions were reached: (1) These devices alarm if the latex is breached by an object of at least 300 um-diameter and both the inside and outside of the glove are wet with a conductive fluid. False alarms from latex hydration is the primary disadvantage. (2) This technique is a sensitive QA procedure if any hole to be detected is wet with a conductive liquid. (3) Sealed, sterile latex gloves may degrade over many months. (4) There was no obvious degradation of latex gloves after two hours' exposure to three commonly used disinfectants.

Dermatitis, Allergic Contact↗

The frequency of glove contamination during cesarean delivery.

OBJECTIVE: To determine the frequency of glove contamination associated with fetal extraction during cesarean delivery. METHODS: The study was performed in 25 women having scheduled or unscheduled cesarean delivery. Surgeons double-gloved for all procedures. Immediately before and after delivery of the fetus, the dorsal aspect of the fingers and hand of the surgeon's outer glove was swabbed with cotton-tip applicators and cultured for aerobic and anaerobic organisms. Only the glove from the hand that was used to deliver the infant was cultured. RESULTS: Nine of 25 cultures (36%, 95% confidence interval [CI] 17-55) performed immediately before fetal extraction were positive for staphylococci. No other organisms were isolated. Cultures performed following fetal extraction showed non-staphylococcal bacteria in 11 of 14 (79%, 95% CI 58-100) laboring women and one of 11 (9%, 95% CI 0-26) nonlaboring women, a statistically significant difference (P < .01). In the laboring patients, non-staphylococcal bacteria were isolated with similar frequency from the dorsal aspect of the hand (seven of 14, 50%, 95% CI 24-76) and the fingers (ten of 14, 71%, 95% CI 47-95). These cultures yielded mostly bacterial species from the Enterobacteriaceae family. CONCLUSION: In laboring patients with ruptured membranes, delivery of the fetal head frequently results in contamination of the surgeon's glove with pathogenic bacteria. This finding may partially explain the increased frequency of post-cesarean endometritis associated with manual extraction of the placenta.

Bacteria↗