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PubMed2004

Internal friction controls the speed of protein folding from a compact configuration.

Several studies have found millisecond protein folding reactions to be controlled by the viscosity of the solvent: Reducing the viscosity allows folding to accelerate. In the limit of very low solvent viscosity, however, one expects a different behavior. Internal interactions, occurring within the solvent-excluded interior of a compact molecule, should impose a solvent-independent upper limit to folding speed once the bulk diffusional motions become sufficiently rapid. Why has this not been observed? We have studied the effect of solvent viscosity on the folding of cytochrome c from a highly compact, late-stage intermediate configuration. Although the folding rate accelerates as the viscosity declines, it tends toward a finite limiting value approximately 10(5) s(-1) as the viscosity tends toward zero. This limiting rate is independent of the cosolutes used to adjust solvent friction. Therefore, interactions within the interior of a compact denatured polypeptide can limit the folding rate, but the limiting time scale is very fast. It is only observable when the solvent-controlled stages of folding are exceedingly rapid or else absent. Interestingly, we find a very strong temperature dependence in these "internal friction"-controlled dynamics, indicating a large energy scale for the interactions that govern reconfiguration within compact, near-native states of a protein.

Animals↗
PubMed2006

Nanoscale reduction in surface friction of polymer surfaces modified with Sc3 hydrophobin from Schizophyllum commune.

Hydrophobins are amphipathic self-assembling proteins secreted by filamentous fungi that exhibit remarkable ability to modify synthetic surfaces. Thin coatings of Sc3 hydrophobin isolated from the wood-rotting fungus Schizophyllum commune were prepared via spin coating and adsorption techniques onto polymeric surfaces. Surface morphology and nanotribological characteristics of the films were evaluated using lateral force microscopy (LFM) and nanoindentation techniques. This paper reports the first observation of reduction in nanoscale relative surface friction of Sc3 hydrophobin protein modified polymeric surfaces. Relative friction coefficients were dramatically reduced and hydrophilicity increased for polymer surfaces modified with Sc3 hydrophobin thin films. Morphology of the protein films as well as degree of surface modification was observed to be a function of film formation technique and composition of the substrate.

Adsorption↗
PubMed2005

Measurement of the kinetics of photo-oxidation of self-assembled monolayers using friction force microscopy.

The advancement of molecular nanotechnology requires new tools for the characterization of surface chemical reactivity with nanometer spatial resolution. While spectroscopy on sub-100 nm length scales remains challenging, friction force microscopy (FFM) is a promising tool for the characterization of molecular materials, although to date it has been little used in studies of surface reactivity. Here we report the use of FFM to measure the kinetics of photo-oxidation of self-assembled monolayers (SAMs) of alkanethiols adsorbed on gold surfaces. Two alternative approaches (analysis of friction-load plots and the use of line sections through images of patterned materials) are compared and found to yield data in very good agreement, with rate constants being found to be in good agreement despite being carried out on different microscopes. The use of line-section analysis provides a convenient method for the quantification of the extent of reaction in nanometer-scale patterns created in SAMs by the novel approach of scanning near-field photolithography.

Journal Article↗
PubMed2005

Elastic-hydrodynamic transition of gel friction.

We report the surface sliding friction of a high strength gel against a glass substrate under a normal pressure range of 0.01-2.5 MPa. The friction of the gel swollen with different viscous solvents is investigated over a wide velocity range. A velocity-viscosity conversion relationship is established. From the velocity-viscosity conversion relationship, a master curve that is characteristic to the elastic-hydrodynamic transition is observed. The results indicate that the adsorption model proposed by our previous work is valid even under a pressure up to MPa orders, which is the order of pressure that a cartilage sustains in the articular joints.

Adsorption↗
PubMed2002

Friction and wear of hydroxyapatite reinforced high density polyethylene against the stainless steel counterface.

Hydroxyapatite (HA) reinforced high density polyethylene (HDPE) was invented as a biomaterial for skeletal applications. In this investigation, tribological properties (e.g. wear rate and coefficient of friction) of unfilled HDPE and HA/HDPE composites were evaluated against the duplex stainless steel in dry and lubricated conditions, with distilled water or aqueous solutions of proteins (egg albumen or glucose) being lubricants. Wear tests were conducted in a custom-built test rig for HDPE and HA/HDPE containing up to 40 vol % of HA. It was found that HA/HDPE composites had lower coefficients of friction than unfilled HDPE under certain conditions. HA/HDPE also exhibited less severe fatigue failure marks than HDPE. The degradation and fatigue failure of HDPE due to the presence of proteins were severe for low speed wear testing (100 rpm) as compared to high speed wear testing (200 rpm). This was due possibly to the high shear rate at the contact which could remove any degraded film instantaneously at high sliding speed, while with a low sliding speed the build-up of a degraded layer of protein could occur. The degraded protein layer would stay at the contact for a longer time and mechanical activation would induce adverse reactions, weakening the surface layer of HDPE. Both egg albumen and glucose were found to be corrosive to steel and adversely reactive for HDPE and HA/HDPE composites. The wear modes observed were similar to that of ultra-high molecular weight polyethylene. Specimens tested with egg albumen also displayed higher wear rates, which was again attributed to corrosion accelerated wear.

Journal Article↗
PubMed1999

Interpersonal friction and PTSD in female victims of sexual and nonsexual assault.

This study examines the relationship among features of social relationships, both negative and positive, and later posttrauma pathology. Using a prospective design, 142 female victims of sexual or nonsexual assault were assessed at both 2 weeks and 3 months following the assault. We examined self-reported perceptions of how often the participant has been the recipient of socially supportive actions by others and how often the participant has been engaged in interpersonal friction with others. Degree of interpersonal friction shortly after the assault predicted PTSD severity 3 months later. On the contrary, positive social support did not predict later PTSD severity. These results are consistent with previous studies that underscore the association between negative features of social relationships and PTSD.

Adult↗
PubMed1998

Some effects of representational friction, target size, and memory averaging on memory for vertically moving targets.

Observers viewed an animated ascending or descending target that varied in size and velocity across trials and appeared either (a) in isolation, (b) to slide along one side of a single larger stationary object, or (c) to slide between two larger stationary objects. Targets vanished without warning, and displacements (i.e., differences between actual and remembered final position) along the axis of motion and orthogonal axis were measured. Forward displacement (a) decreased with increases in implied friction, (b) increased with increases in target size for descending targets, and (c) decreased with increases in target size for ascending targets. When a larger stationary object was to one side of the target, orthogonal displacement was toward that object; when no object or objects on both sides were present, orthogonal displacement was near zero. Results are consistent with previous findings and speculation on the effects of representational friction, memory averaging, and target size on memory.

Analysis of Variance↗
PubMed2000

Thin films of fullerene-like MoS2 nanoparticles with ultra-low friction and wear

The tribological properties of solid lubricants such as graphite and the metal dichalcogenides MX2 (where M is molybdenum or tungsten and X is sulphur or selenium) are of technological interest for reducing wear in circumstances where liquid lubricants are impractical, such as in space technology, ultra-high vacuum or automotive transport. These materials are characterized by weak interatomic interactions (van der Waals forces) between their layered structures, allowing easy, low-strength shearing. Although these materials exhibit excellent friction and wear resistance and extended lifetime in vacuum, their tribological properties remain poor in the presence of humidity or oxygen, thereby limiting their technological applications in the Earth's atmosphere. But using MX2 in the form of isolated inorganic fullerene-like hollow nanoparticles similar to carbon fullerenes and nanotubes can improve its performance. Here we show that thin films of hollow MoS2 nanoparticles, deposited by a localized high-pressure arc discharge method, exhibit ultra-low friction (an order of magnitude lower than for sputtered MoS2 thin films) and wear in nitrogen and 45% humidity. We attribute this 'dry' behaviour in humid environments to the presence of curved S-Mo-S planes that prevent oxidation and preserve the layered structure.

Journal Article↗
PubMed1991

Comparison of the frictional coefficients for selected archwire-bracket slot combinations in the dry and wet states.

Coefficients of friction were evaluated in the dry and wet (saliva) states for stainless steel, cobalt-chromium, nickel titanium, and beta-titanium wires against either stainless steel or polycrystalline alumina brackets. For both operators' experiments, an 0.010" stainless steel ligature wire pressed each archwire into the 0.018" or 0.022" bracket slot at 34 degrees C. In the dry state and regardless of slot size, the mean kinetic coefficients of friction were smallest for the all-stainless steel combinations (0.14) and largest for the beta-titanium wire combinations (0.46). The coefficients of the polycrystalline alumina combinations were generally greater than the corresponding combinations that included stainless steel brackets. In the wet state, the kinetic coefficients of the all-stainless steel combinations increased up to 0.05 over the dry state. In contrast, all beta-titanium wire combinations in the wet state decreased to 50% of the values in the dry state. The mixed reports that saliva may promote adhesive and lubricious behaviors may have some substance.

Aluminum Oxide↗
PubMed2002

Lamellar subcomponents of the cuticular cell membrane complex of mammalian keratin fibres show friction and hardness contrast by AFM.

There is a substantial body of information indicating that 18-methyleicosanoic acid (18-MEA) is covalently linked to the outer surface of all mammalian keratin fibres and also forms the outer beta-layer of the cuticular cell membrane complex (CCMC) which separates the cuticle cells from each other. Low cohesive forces are expected between the lipid-containing outer beta-layer and the delta-layer of the CCMC, thus providing a weak point for cuticular delamination and presenting a fresh layer of 18-MEA to the newly exposed surface. We have used lateral force microscopy and force modulation atomic force microscopy (AFM) to examine human hair fibres in which the non-covalently linked fatty acids have been removed. Examination of the lateral force images of new cuticle surfaces revealed by the attrition of overlying cuticle layers showed three separate zones of clearly defined frictional contrast. These are thought to correspond with the delta-layer, the proteinaceous epicuticle and outer beta-layers of the CCMC. The delta-layer was found to have a thickness of 16 nm (SD = 1 nm, n = 25), comparable to the 18.0 nm thickness measured from transverse cross-sections of fibres with transmission electron microscopy. Force modulation AFM showed that the outer beta-layer was softer than the epicuticle and the delta-layer. The frictional contrast was removed following treatment with methanolic KOH (0.1 mol dm-3) at 25 degrees C for 30 min, suggesting the hydrolysis of the thioester linkage and removal of 18-MEA from the surface.

Animals↗
PubMed2003

Bullous malignant melanoma: an unusual differential diagnosis of a hemorrhagic friction blister.

BACKGROUND: A 66-year-old woman presented to our outpatient clinic with a 3 x 2.5-cm tense, hemorrhagic-appearing bulla on her forefoot. Histopathology and immunohistochemistry confirmed a transtumoral-transepidermal blister formation within an advanced acrolentiginous malignant melanoma (MM). OBJECTIVE: To study bullous malignant melanoma. METHODS: Blistering in MMs represents a rare but clinically important pitfall in clinical differential diagnosis. The blisters are typically due to the disruption of the cohesion between neoplastic cells and keratinocytes, but physical friction may also contribute. RESULTS: Hemorrhagic blistering is, in many cases, a relatively insignificant finding in which frictional forces are imposed. CONCLUSION: The case reported here underscores that in rare cases MMs, particularly if acrally located, can be complicated by hemorrhagic blistering. Because of the life-threatening consequences, one should be aware of this rare differential diagnosis.

Aged↗
PubMed2000

Low-friction arthroplasty in patients younger than 40 years old: 20- to 25-year results.

A total of 67 low-friction arthroplasties were performed from 1971 through 1978 in patients <40 years old and followed an average of 21.7 years. There have been 33 cup loosenings and 17 stem loosenings. The average rate of wear of the cup was 0.12 mm/y for the entire series and 0.16 mm/y for the revised cups. Although the preoperative diagnosis leading to low-friction arthroplasty commonly reflected some deficiency in bone structure, particularly in the acetabulum, there were no primary osteoarthrosis cases. The femoral stem proved to be durable, but acetabular cups gave poorer results in younger patients than in older patients. The 2 major factors limiting the longevity of the cemented cup were acetabular bone quality and wear.

Adolescent↗
PubMed2004

Self-affine roughness influence on the friction coefficient for rubbers onto solid surfaces.

In this paper we investigate the influence of self-affine roughness on the friction coefficient mu(f) of a rubber body under incomplete contact onto a solid surface. The roughness is characterized by the rms amplitude w, the correlation length xi, and the roughness exponent H. It is shown that with increasing surface roughening at short and/or long length scales (decreasing H and/or increasing ratio w/xi, respectively), the maximum of the friction coefficient mu(f) shifts to lower sliding velocities. The latter occurs only for conditions of incomplete contact for small contact length scales lambda ( >xi).

Journal Article↗
PubMed2004

Presliding friction identification based upon the Maxwell Slip model structure.

The problem of presliding friction identification based upon the Maxwell Slip model structure, which is capable of accounting for the presliding hysteresis with nonlocal memory, is considered. The model structure's basic properties are examined, based upon which a priori identifiability is established, the role of initial conditions on identification is investigated, and the necessary and sufficient conditions for a posteriori identifiability are derived. Using them, guidelines for excitation signal design are also formulated. Building upon these results, two new methods, referred to as Dynamic Linear Regression (DLR) and NonLinear Regression (NLR), are postulated for presliding friction identification. Both may be thought of as different extensions of the conventional Linear Regression (LR) method that uses threshold preassignment: The DLR by introducing extra dynamics in the form of a vector finite impulse response filter, and the NLR by relaxing threshold preassignment through a special nonlinear regression procedure. The effectiveness of both methods is assessed via Monte Carlo experiments and identification based upon laboratory signals. The results indicate that both methods achieve significant improvements over the LR. The DLR offers the highest accuracy, with the NLR striking a very good balance between accuracy and parametric complexity.

Journal Article↗
PubMed2004

Memory effect in friction on a particle caused by a system of fixed or moving scatterers with power law potential.

The memory function for friction on a particle caused by a system of fixed or moving scatterers is evaluated for power law interaction. For a dilute system the study extends the steady-state calculation based on the Boltzmann equation to the case of frequency dependence due to the dynamics of the scattering process. For a dense gas an Enskog approximation can be used. The power law potential leads to scaling behavior of the dynamical friction coefficient as a function of reduced mass, coupling coefficient, and energy.

Journal Article↗
PubMed2004

Translational friction coefficients for cylinders of arbitrary axial ratios estimated by Monte Carlo simulation.

Translational friction coefficients for cylinders of arbitrary axial ratios (including disks) are calculated using Monte Carlo simulation and an approximate description of the hydrodynamic interaction. The calculations indicate that the approximate description is exact for ellipsoids and this result is generalized to include cylinders, which possess the same symmetry as ellipsoids. From the result an approximate formula for the translational friction coefficient of cylinders is calculated which is compared to results from other sources.

Journal Article↗
PubMed2004

Friction and diffusion of a Brownian particle in a mesoscopic solvent.

The friction and diffusion coefficients of a massive Brownian particle in a mesoscopic solvent are computed from the force and the velocity autocorrelation functions. The mesoscopic solvent is described in terms of free streaming of the solvent molecules, interrupted at discrete time intervals by multiparticle collisions that conserve mass, momentum, and energy. The Brownian particle interacts with the solvent molecules through repulsive Lennard-Jones forces. The decays of the force and velocity autocorrelation functions are analyzed in the microcanonical ensemble as a function of the number N of solvent molecules and Brownian particle mass and diameter. The simulations are carried out for large system sizes and long times to assess the N dependence of the friction coefficient. The decay rates of these correlations are confirmed to vary as N(-1) in accord with earlier predictions. Hydrodynamic effects on the velocity autocorrelation function and diffusion coefficient are studied as a function of Brownian particle mass and diameter.

Journal Article↗
PubMed2005

Two-particle friction in a mesoscopic solvent.

The effects of hydrodynamic interactions on the friction tensors for two particles in solution are studied. The particles have linear dimensions on nanometer scales and are either simple spherical particles interacting with the solvent through repulsive Lennard-Jones forces or are composite cluster particles whose atomic components interact with the solvent through repulsive Lennard-Jones forces. The solvent dynamics is modeled at a mesoscopic level through multiparticle collisions that conserve mass, momentum, and energy. The dependence of the two-particle relative friction tensors on the interparticle separation indicates the importance of hydrodynamic interactions for these nanoparticles.

Journal Article↗