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At least 559 records · Page 31Linked to original sources
PubMed1995

Local antibiotic therapy for severe open fractures. A review of 1085 consecutive cases.

We reviewed 1085 consecutive compound limb fractures treated in 914 patients at the University of Louisville over a nine-year period. Of these fractures, 240 (group 1) received only systemic antibiotic prophylaxis and 845 (group 2) were managed by the supplementary local use of aminoglycoside-polymethylmethacrylate (PMMA) beads. There were no significant differences in age, gender, fracture type, fracture location or follow-up between the two groups. All had copious wound irrigation, meticulous debridement and skeletal stabilisation, but wound management and the use of local antibiotic depended on the surgeon's individual preference and there was no randomisation. In group 1 there was an overall infection rate of 12% as against 3.7% in group 2 (p < 0.001). Both acute infection and local osteomyelitis showed a decreased incidence in group 2, but this was statistically significant only in Gustilo type-IIIB and type-IIIC fractures for acute infection, and only in type-II and type-IIIB fractures for chronic osteomyelitis. Our review suggests that the adjuvant use of local antibiotic-laden PMMA beads may reduce the incidence of infection in severe compound fractures.

Adolescent↗
PubMed1993

[Arteriovenous aneurysm--an uncommon complication in open fractures of the leg].

The authors describe a less common complication of external osteosynthesis--a false arteriovenous aneurysm. On the case-history of a patient they demonstrate the risk associated with insertion of nails, the necessity of careful follow-up of patients after operation, and in case of suspicion, the necessity of accurate diagnosis and urgent surgical operation.

Adult↗
PubMed1997

[Use of muscular flaps for the treatment of open fractures of limbs. Apropos of 42 cases].

PURPOSE OF THE STUDY: Since 1988, skin defect associated with upper (6 cases) or lower (34 cases) limb fractures were treated in our Orthopaedic Department with regional or free muscular flaps. The aim of this study was to demonstrate that muscular flaps represent a treatment of choice for infection prevention and consolidation. MATERIAL AND METHODS: 42 patients have been treated: 29 Cauchoix III or IV, 12 secondary exposed fractures, 1 amputation. A total of 42 flaps, including 28 regional flaps and 14 microvascular free-tissue transfers were performed. A first stage included thorough debridement, fixation with external fixator in 85 per cent, and revascularization (4 cases). A second look was necessary in all but 3 cases: flap coverage was performed at this stage. A bone graft was proposed in 17 cases after a mean time of 3 months and 20 days. RESULTS: Bony healing was found in 37 cases (86.5 per cent) with a mean delay of 7 months 20 days. 5 patients required another method of treatment because of flap necrosis or non-union, with an average time to bony healing of 13 months. 42 tissue transfers were performed with an overall success rate of 95.3 per cent (2 necrosis of latissimus dorsi flaps). 3 partial necrosis involved 2 regional and 1 free flap. One of them needed another treatment. No infection was encountered in 40 cases (95 per cent) even if most of the patients were treated after initial treatment elsewhere. DISCUSSION: Experience with regional muscle transfer has advocated the gastrocnemius and proximal pedicle medial soleus as reliable and excellent choice for reconstruction of the proximal and middle third of the leg. Latissimus dorsi transfer, which can be used totally, partially, or as a "vascular graft flap" represent the treatment choice for extensive upper or lower limb exposed fracture especially for distal lower limb fracture (exposure of the tibia). Muscle flap coverage in the acute period (within 48 or 72 hours) remains for us the best treatment.

Adolescent↗
PubMed1976

[Alkaline phosphatase of granulocytes in open fractures of the long tubular bones].

Investigations carried out in 60 patients with open fractures of long tubular bones in osteosynthesis with the Ilizarov apparatus indicated that alkaline phosphatase (AP) of granulocytes fully reflects the postoperative course. 10--24 hours following the trauma the level of AP in patients with grave injuries exceeds that in patients with slight ones. The differences are found to be reliable from the 1st to the 5th day after the injury.

Adolescent↗