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At least 559 records · Page 31Linked to original sources
PubMed1995

[Internal medicine and geriatrics in the United States. Face to face].

Chiefs of American University medical departments met with their geriatrician counterparts, in order to define the role of Geriatrics within the discipline of Internal Medicine. Options for pregraduate training, practical courses during the period of study and specific teaching during specialization or during further education were carefully chosen. Fundamental and clinical research is considered indispensable, for this alone will permit the dawning of "Centres of excellence" in Geriatrics, which will be the guarantee of a training that has been rendered necessary by demographic and public health considerations.

Geriatrics↗
PubMed1997

Not just another pretty face: regulation of platelet function at the cytoplasmic face of integrin alpha IIb beta 3.

Integrin alpha IIb beta 3 is necessary for platelet thrombus formation by virtue of its ability to bind fibrinogen and von Willebrand factor in a regulated fashion and to mediate platelet aggregation. Moreover, alpha IIb beta 3 transduces inward signals in response to ligand binding which promote cytoskeletal reorganization and other post-ligand binding events. Anchorage and signaling through alpha IIb beta 3 appear to be controlled by interactions of intracellular proteins with the cytoplasmic tails of alpha IIb and/or beta 3. The cytoplasmic tails and associated cytoskeletal components may function as a scaffold or nucleation site for the assembly of enzymes, substrates and adaptor molecules into a signaling complex. Identification of the components of this signaling complex and characterization of their dynamic interactions should lead to insights into the molecular basis of platelet activation defects and may provide a rationale for the development of new anti-thrombotic drugs.

Blood Platelets↗
PubMedDate not supplied

Face to face.

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Adult↗