Epilepsy and disorders of neuronal migration. II: Epilepsy as a symptom of neuronal migration defects.
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Sixty-one patients of a population of 343 with cerebral arteriovenous malformations (AVMs) were diagnosed with seizures. Their AVMs were larger (p less than 0.02) and more frequently superficial (p less than 0.05) as compared with the AVMs of patients who were diagnosed with haemorrhage. The factors influencing the development of denovo seizures in patients with diagnosed AVMs were surgical treatment, a presentation with haemorrhage, and age at diagnosis.
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Developmental processes; the types of neuron expressing particular gene products; the sites of these receptors/channels, transporters, etc., on neurons and in circuits; and compensatory processes such as activation of other genes, sprouting, pruning, and receptor plasticity will determine the nature of the epileptic phenotype induced by a particular genetic alteration, and the ultimate functional outcome.
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