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Results for “ECHINACEA”

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At least 559 records · Page 31Linked to original sources
PubMed2004

[Studies on anti-inflammatory and immunologic enhancement of kangning granules].

OBJECTIVE: To investigate the effect of Kangning granules on inflammatory and immunology. METHOD: Pedal swelling induced by 1% agar in mice, dermal capillary hyper-permeability induced by histamine in rats were used to evaluate the anti-inflammatory of Kangning granules, and the clearance rate of intravenous charcoal particles was used to study its effect on non-specific immunologic functions. Serum haemolysin level and the number of antibody secretory cells in spleen were determined to assess its effects of specific immunologic functions. MTT colored method was used to determine the effect of Kangning granules on T- or B-Lymphocytes proliferation. RESULT: 5, 10, 20 g x kg(-1) of Kangning Granules significantly inhibited pedal swelling induced by agar in mice (P < 0.05, P < 0.01). 2.4, 4.8, 9.6 g x kg(-1) of Kangning Granules evidently decreased dermal capillary hyper-permeability induced by histamine in rats (P < 0.05, P < 0.01). 10, 20 g x kg(-1) of Kangning Granules enhanced the phagocytic function and phagocytosing velocity in mice (P < 0.05). 5, 10, 20 g x kg(-1) of Kangning Granules obviously increased serum haemolysin level and the number of antibody secretory cells in spleen (P < 0.05, P < 0.01). 20 g x kg(-1) of Kangning Granules promoted B-Lymphocytes proliferation (P < 0.05). CONCLUSION: Kangning granules significantly inhibited inflammatory reaction and increase immune functions in animals.

Animals↗
PubMed2005

Optimization of "Askoeziuofito" tablets.

OBJECTIVE: To determine experimentally the optimal limits of excipients (silica colloidal anhydrous, magnesium stearate, potato starch, saccharose), which would determine the following technological properties of the tablets: sticking of the mass to the puansons, crushing strength, resistance to abrasion-off and the speed at which medicinal substances are released from the tablets. MATERIAL AND METHODS: The following technological parameters were assessed according to the requirements of European Pharmacopoeia 04/2002:0479: mean mass, crushing strength, resistance to abrasion, duration of decomposition, speed of release of ascorbic and chicoric acids. Ferments and ascorbic acid were identified by color and precipitation reactions. Flavonoids (quercetin, quercitrin, kempferol, hyperoside, vitexin, luteolin) were identified by method of high-pressure liquid chromatography; caffeic and ascorbic acids were identified by method of thin layer chromatography; and hydroxycinnamonic acids -- by method of spectrophotometry. In tablets, ascorbic acid was quantitatively determined using the method of oxidimetry, and chicoric acid -- using the method of spectrophotometry. It has been established that the use of techniques of mathematical planning (2(4-1) fraction replica plan, maximum gradient direction and orthogonal compositional plan) made it possible to select optimal amounts of excipients which determine optimal quality requirements for production of tablets: crushing strength, resistance to abrasion, pressing, disintegration time and release rate of medicinal substances. By applying chemical and physico-chemical methods of analysis in determining active substances in tablets, technology for analyzing such preparations has been developed and stability tests have been performed.

Ascorbic Acid↗
PubMed2005

Common cold.

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Ascorbic Acid↗
PubMedDate not supplied

Herbs and dietary supplement use in patients with stage 5 chronic kidney disease.

Herbal products and dietary supplements are complementary and alternative medicine (CAM) therapies that have grown faster than any other CAM treatments. Little information is available about the use of these products in the stage 5 chronic kidney disease (CKD) population. Information on the use, safety, efficacy, adverse effects, and recommended dosages in the nondialysis population are summarized in this article.

Chondroitin Sulfates↗
PubMed2006

Common cold.

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Anti-Bacterial Agents↗
PubMedDate not supplied

Effects of non-specific immunostimulants (echinacin, isoprinosine and thymus factors) on the infection and antigen expression in herpesvirus-6 exposed human lymphoid cells.

Non-specific immunostimulants such as plant extracts and natural and synthetic thymic preparations are widely used for enhancing the reactivity of the human defence system in chronic infections, immunodeficiency, autoimmunity and neoplastic diseases. Considering the high prevalence of latent infections by Lymphotropic herpesviruses and their frequent spontaneous reactivation, one wonders whether the stimulation of lymphoid cells by such immunostimulants may further support virus reactivation. We have performed tissue culture experiments using the well defined infectious system of human herpesvirus-6 (HHV-6) and the immature T cell HSB2 to test the effects of echinacin, isoprinosine and thymus factors on the frequency and extent of virus antigen expression in infected cells. The results show that various viral antigens related to virus replication and to the synthesis of structural components appear earlier in cells stimulated with such substances as echinacin, timunox and TP-1, but not following the stimulation with isoprinosine. Similarly, virus genome containing cells as determined by in situ hybridization techniques increased after stimulation with thymic preparations (thymostimulin and thymopentin), but not with echinacin and isoprinosine. The data suggest that the synthesis of proteins or DNA of lymphotropic viruses may be transiently enhanced when lymphoid cells are stimulated by certain non-specific immunostimulants. There was no evidence, however, of increased virus replication. Since the data presented here are rather preliminary results from tissue culture studies, the use of such substances in patients should include a critical monitoring of the activity of lymphotropic viruses to exclude untoward effects through persistent viral activity and/or autoimmune dysregulations (e.g. secondary to selective expression of viral antigens). More detailed studies are needed to this effect including long-term controls in patients treated by these substances.

Adjuvants, Immunologic↗