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At least 559 records · Page 31Linked to original sources
PubMed2004

Evolving a lingua franca and associated software infrastructure for computational systems biology: the Systems Biology Markup Language (SBML) project.

Biologists are increasingly recognising that computational modelling is crucial for making sense of the vast quantities of complex experimental data that are now being collected. The systems biology field needs agreed-upon information standards if models are to be shared, evaluated and developed cooperatively. Over the last four years, our team has been developing the Systems Biology Markup Language (SBML) in collaboration with an international community of modellers and software developers. SBML has become a de facto standard format for representing formal, quantitative and qualitative models at the level of biochemical reactions and regulatory networks. In this article, we summarise the current and upcoming versions of SBML and our efforts at developing software infrastructure for supporting and broadening its use. We also provide a brief overview of the many SBML-compatible software tools available today.

Biochemistry↗
PubMed1980

Managing the evolution of a laboratory computer system.

The Laboratory Information System (LABIS) of the National Naval Medical Center, Bethesda, Md., was installed in 1974. Since that time, the system has undergone transitions which suggest that its evolution proceeded in three distinct stages. The author details the different management techniques and supervisory qualifications that each stage of growth requires, and he explains how an understanding of these requirements will enable the pathologist to adjust better to the evolution of the system.

Communication↗
PubMed1999

[Computer systems in supporting the operation of medico-genetic establishments].

Nowadays there is a transition from the automation of some tasks to a complex computerization of medicogenetic service in Russia on the basis of the Federal genetic register. The system is multifunctional and ensures the keeping all medical records. It is realized through the corporate global network. The operations performed will also provide an intellectual support of medical geneticists' decisions.

Computer Systems↗
PubMed1986

A portable and inexpensive computer system to interpret arterial blood gases.

The hand-held computer (HHC) allows computer technology to be brought inexpensively to the patient's bedside. In this paper we describe HHC applications software that interprets oxygenation, ventilation, and acid-base status--and also provides a differential diagnosis and makes suggestions for therapy. Although this software was designed to be used in an emergency department, it has equally useful applications elsewhere such as in critical care units. Computerized arterial blood gas interpretation is especially helpful to students and others who infrequently interpret arterial blood gases. The software described here has been enthusiastically accepted by emergency department personnel in our institution.

Blood Gas Analysis↗
PubMed2002

Computer systems for the prediction of toxicity: an update.

In order to survive in the current economic climate, the pharmaceutical, agrochemical and personal product companies are required to produce large numbers of new, effective products whilst significantly reducing development time and costs. With the advent of combinatorial chemistry and high-throughput screening (HTS), the numbers of new candidate structures coming out of the discovery cycle has increased significantly. This has created a demand for faster screening of the toxicological properties of these candidates. Not surprisingly, computer methods for toxicity prediction offer an attractive solution to this problem because of their ability to screen large numbers of structures even before synthesis has occurred. In this paper the major, commercially available computer software systems for toxicity prediction are discussed together with their main strengths and limitations.

Animals↗
PubMed2002

[Computer system validation. The quality assurance procedure].

The use of computerized systems in preclinical studies has increased over the last ten years. This fact has caused dramatic changes in the way raw data are used in studies. Regulatory authorities, in fact, now require that computerized systems used during preclinical studies be validated. Quality assurance was given the task of organizing an approach to this challenge. Above all, this process applies to all company functions, from test facility management to technical staff. Moreover, various systems may be encountered during the process where the operating systems and the technologies used may be different. Another difficulty may be the lack of resources, changes requested by users or regulatory updates of legislation. Last but no least, archiving should not be underestimated.

Clinical Laboratory Techniques↗
PubMed1978

A simple way of obtaining a composite video output signal from the GAMMA-11 computing system.

Many departments of nuclear medicine are currently using the GAMMA-11 computer to process clinical images. Often practitioners would like to display the output pictures on conventional cathode-ray monitors that they already have. Some may want to record the images on a video tape recorder. Both of these devices require a composite video signal, which the computer does not provide. Such a signal can be obtained, however, by combining two signals that the system does produce. A number of relatively complicated systems for doing this have been suggested. The desired result can be obtained, however, by using two ten-cent resistors in the simple circuit described in this paper.

Computers↗