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At least 559 records · Page 31Linked to original sources
PubMed2005

[Immunoregulatory disorders in chronic sinusitis in patients with atopy].

UNLABELLED: Disorders of immunoregulatory activity of T lymphocytes and excessive immunogenic activity of antigen presenting cells are recognised as an important pathogenic elements in allergic diseases. Successful prevention of development of these pathomechanisms determines the effectiveness of administered therapy. The aim of presented investigations was to assess the kind and the degree of immune disorders in the group of 40 patients with chronic allergic sinusitis (CAS). The range of evaluated parameters comprised the indices of immune competence of T cells in microcultures of mononuclear cells isolated from the blood (response to mitogens PHA and Con A, saturation of IL-2 receptors, T-cell suppressive activity--SAT index), indices of immunogenic activity of monocytes (LM index correlated with the ratio of concentrations of IL-1 beta/IL-1ra, concentrations of IL-1beta, IL-1ra, IL-4 and IL-6 in the culture supernatants). The results were compared with the similar estimations performed in the group of 20 healthy blood donors. RESULTS: The obtained results demonstrated significant deficiency of T cell immune competence in the group of patients suffering from CAS (hyperreactivity of non-matured T cells to Con A, decreased saturation of IL-2 receptors, deficient T-cell suppressive activity and quantitative deficiency of TCD8 cells). In contrast to that, the immunogenic activity of monocytes was significantly elevated in the group of CAS patients as compared to the control group (significantly higher values of LM index, considerable increased concentrations of IL-1b, IL-4 and IL-6). CONCLUSIONS: The observed immunoregulatory deficiency of T-cell population and increased immunogenic activity of antigen presenting cells (monocytes) in CAS patients seem to suggest that the routine antiinflammatory treatment in these patients should be supplemented with the immunocorrective therapy aimed to restore the deficient thymus-dependent immune competence.

Adult↗
PubMed1993

Coronal CT scan abnormalities in children with chronic sinusitis.

Coronal computed tomography (CT) scans are currently the optimal study to display the normal and abnormal anatomy in children with chronic and recurrent acute sinusitis after failure of medical therapy. To assess the extent and distribution of disease as well as associated anatomic abnormalities in this pediatric population, 74 coronal CT scans of children with continued symptoms of sinusitis after failure of extensive medical therapy were reviewed retrospectively. Twelve children with cystic fibrosis showed the characteristic features of medial displacement of the lateral nasal wall in the middle meatus and uncinate process demineralization, creating the appearance of a maxillary sinus mucocele. Nine of these 12 children had increased attenuation in the maxillary sinus on soft-tissue windows. In the remaining 62 children, a significantly greater frequency of disease, when compared with that reported for adults, was seen in the maxillary, anterior ethmoid, posterior ethmoid, and frontal sinuses. Children with asthma (n = 33) had more extensive disease. Bony anatomic abnormalities were similar to those reported for adults, except for a lower incidence of septal deformity.

Acute Disease↗
PubMed2005

[The syndrome of dyskinetic cilia as the cause of chronic sinusitis].

UNLABELLED: The syndrome of dyskinetic cilia is the cause of chronic inflammatory processes of upper and lower airways. The research studies concerning cilia's structure were held during 50s. About 20 types of cilia's defects were characterized by now, classified as inborn defects. OBJECTIVES: The presentation of the case is because of both the rarity of incidence and diagnostical's problem and treatment. In this case, we observed who re-occurrence of chronic inflammation accompanied by having infections of lower respiratory tract it is necessary to expand diagnosis to find out the reasons of such disease. MATERIALS AND METHODS: A 7 years old girl was admitted to our Clinic. Since couple years she has been under assistance of Specialist Clinic. She was also hospitalized because of aggravation inflammatory state of lower airways. After computers tomography of sinuses she was qualified to surgical treatment. During operation a material to study of cilia immobility was taken. The electron microscope study confirm the diagnosis of the group of dyskinetic cilia. RESULTS: The follow-up examination was held 14 months after operation. During this time the girl did not take any antibiotic (before antibiotherapy was held couple times during the year). Clinical status proved. Better results were also on computer tomography. CONCLUSIONS: In this case, re-occurrence, inflammatory process both upper and lower respiratory tract are necessary to expand the diagnostics to find out the cause of illnesses. The methods of treatments the group of in-movement's cilia based on the symptomatic treatment, but the role of physiotherapy of respiratory system is stressed as the operation of removal of secretion's retention. There is an important role of regular laryngology care and surgical treatment allow partly to control the disease.

Child↗
PubMedDate not supplied

Chronic sinusitis: a surgical perspective.

Rhinosinusitis is one of the most common chronic diseases with significant symptoms and impact on the quality of life. Surgery is indicated when appropriate medical treatment fails. A review of the clinical presentations of rhinosinusitis is presented, as well as an overview of current medical and surgical treatment options. Although external approaches are still mandated in some selected instances, endoscopic sinus surgery has become the standard for surgical treatment of sinonasal pathologies, by aiming at restoring the physiological functions of the nasal and paranasal cavities. This technique presents numerous advantages with a minimally invasive approach, better visualization of structures, camera magnification of the surgical field, and allows thorough exploration of difficult-to-reach areas. The risks and complications of endoscopic sinus surgery are well identified and may be reduced significantly by the adjunct use of computer-assisted image guidance and intraoperative fluoroscopy. Surgical simulation also is a promising tool to help reduce surgical errors and improve surgeon training in the future.

Chronic Disease↗