Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Capillary Permeability”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 559 records · Page 31Linked to original sources
PubMed1993

Middle cerebral artery occlusion increases cerebral capillary permeability.

One hour after middle cerebral artery occlusion, the regional blood to brain transfer coefficient of alpha-aminoisobutyric acid was determined in eight barbiturate anaesthetized rats. The transfer coefficient (microliter/min-1/g-1) was significantly higher in the ischaemic cortex (10.6 +/- 2.3) than in the contralateral cortex (6.5 +/- 1.0). Cerebral regional capillary surface area was determined in another group of twelve rats using an alkaline phosphatase stain for the total capillary bed and fluorescein isothiocyanate-dextran to visualize the perfused capillaries. Perfused capillary surface area (cm2/cm3) was lower in the ischaemic cortex (141 +/- 31) than in the contralateral cortex (426 +/- 32). Using these values for the transfer coefficient, surface area and our previously published data of regional cerebral blood flow after middle cerebral artery occlusion, we calculated the extraction fraction of alpha-aminoisobutyric acid, the permeability-surface area product and the permeability of cerebral regional capillary beds. Although, there are numerous reports of permeability-surface area product of brain capillaries, to our knowledge, the permeability has never been determined before. The calculated extraction fraction ratio for alpha-aminoisobutyric acid for ischaemic cortex/contralateral cortex was 3.1. Similar ratios for permeability-surface area product and capillary permeability were 1.6 and 4.4, respectively. Thus, there was a more than four fold increase in capillary permeability to small molecules in the ischaemic cortex one hour after middle cerebral artery occlusion.

Aminoisobutyric Acids↗
PubMed2000

Simultaneous MRI measurement of blood flow, blood volume, and capillary permeability in mammary tumors using two different contrast agents.

A technique for the simultaneous measurement of three vascular parameters: blood flow (Frho), blood volume (v(b)), and the capillary permeability-surface area product (PSrho) in breast tumors using dynamic contrast-enhanced magnetic resonance imaging (MRI) is presented. Features of the technique include measurement of precontrast tumor T(1), rapid temporal sampling, measurement of the arterial input function, and use of a distributed parameter tracer kinetic model. Parameter measurements are compared that were determined using two contrast agents of different molecular weights, gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA; 0.6 kDa) and Gadomer-17 (17 kDa), in 18 spontaneous canine mammary tumors. Measurements of Frho and v(b) corresponded well with literature values, and the mean PSrho measured using Gd-DTPA was a factor of 15 higher than that measured using Gadomer-17. J. Magn. Reson. Imaging 2000;12:991-1003.

Animals↗