Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “CHROMOBLASTOMYCOSIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 559 records · Page 31Linked to original sources
PubMedDate not supplied

Distribution of an antifungal drug, itraconazole, in pathological and non-pathological tissues.

An antifungal drug, itraconazole (ITZ) is effective for chromomycosis patients, but the distribution of ITZ and its metabolite, hydroxy-intraconazole (OH-ITZ) is unclear in pathological tissues. This study investigated how much ITZ and OH-ITZ accumulated in the lesional tissues of chromomycosis and non-lesional skin after oral treatment with ITZ. We determined the concentrations of ITZ and OH-ITZ in the lesional tissues of chromomycosis by Foncecaea pedrosoi and non-lesional skin after oral treatment with a total dose of 2.3g of ITZ. ITZ concentration was significantly higher in pathological skin than non-pathological skin. The ITZ concentration in the lesional tissues was higher in the central site than in the marginal site. No difference was seen in the OH-ITZ concentrations among three skin parts, the center and the margin in lesional skin, and non-lesional skin adjacent to the lesion. This study showed higher concentrations of ITZ in pathological tissues than in non-pathological tissues.

Administration, Oral↗
PubMed2003

[Concurrent mycetoma and chromomycosis: case report from Senegal].

A 68-year-old cattle farmer from northern Senegal sought medical attention for tumefaction that had been progressing on the right foot and leg for 20 years. Physical examination of the right extremity revealed very firm tumefaction involving the foot and whole leg associated with numerous nodules. Bone radiographs and CT-scan of the foot and leg disclosed extensive osteolytic involvement. A specimen of squamous tissue from the top of nodules showed the presence of fumagoid cells characteristic of chromomycosis. Histologic examination after skin biopsy demonstrated fungal myocetoma. Due to the extent of involvement surgical and antifungal treatment was proposed but the patient refused to undergo surgery. Only one previous case of concurrent chromomycosis and mycetoma has been described. However the previous case involved actinomycetoma. The rarity of this combination of diseases despite their common contamination mode is due to different geographical distribution with mycetoma being found in the Sahelian region and chromomycosis in the humid equatorial region.

Aged↗
PubMed2004

Concurrent chromomycosis and aspergillosis of the maxillary sinus.

The authors describe a rare case of an infection of both the chromomycosis and aspergillosis of the maxillary sinus in an immunocompetent 72-year-old female who presented with progressive visual loss and dull aching pain of the left eye. Sinuscopy of the left maxillary sinus showed swelling of the mucosa with clay-like materials. Biopsy from the left maxillary sinus showed the typically characteristic morphology of chromomycosis and culture from sinus tissue which yielded Aspergillus. The patient responded to a combination therapy of surgical excision and antifungal agent.

Aged↗
PubMed2005

[The goat: approach to an animal model in human chromomycosis].

In Falcon State, Venezuela, human chromomycosis is mainly caused by a dimorphic fungus, Cladophialophora carrionii. Xerophytes plants are common in the State and goat breeding in an extensive system as the main way of living. There are not published reports of chromomycosis in goats, despite the fact of their permanent exposition to fungus by accidental inoculation with infected spines. To evaluate parasitic transformation to sclerotic cells, length of fungus-surviving period and histopathological lesions, goats of five months of age were inoculated with 1 x 10(6) cells of C. carrionii by subcutaneous route in the neck and biopsies at 10, 19, 30 and 60 days from inoculated places were performed. Tissues were analyzed by (a) direct test with KOH 10%; (b) inoculation in Saboraud dextrose culture and (c) histopathological techniques. Hyphae and sclerotic cells were observed on tissues treated with KOH 10%; growing of fungus was detected in specific medium up to four weeks post-inoculation. Tissue pathology showed necrotic foci, mixed polymorphonuclear infiltrate, predominance of mononuclear cells, lymphocytes, plasmocytes, cosinophils and giant cells, hyphae and sclerotic cells in each one of samples. C. carrionii caused cellular reactions in goats as those seen in humans at the first stages of infection; however, animals did not develop the typical macroscopic lesions of the human disease.

Animals↗
PubMed1991

[Tropical mycoses].

The most common tropical subcutaneous and deep mycoses include chromomycosis, sporotrichosis and mycetoma. All are commonly found in Natal and in other sub-tropical countries. Although blastomycosis is endemic in North America, only four cases have been identified in Natal during the last 25 years and all presented with atypical clinical features. African histoplasmosis caused by H. capsulatum var. duboisii and limited mainly to central and western Africa has been found in only one patient in Natal. Paracoccidioidomycosis, although the most common deep mycosis in Latin America, is limited to that area and we have no experience of this disease in South Africa. Over the past eight years itraconazole has been used in clinical trials for all these mycoses. The results in sporotrichosis, non-meningeal blastomycosis and paracoccidioidomycosis suggest that for these diseases itraconazole may be the drug of choice. The results in histoplasmosis are encouraging as are the results in chromomycosis particularly those cases associated with C. carrionii. However, where F. pedrosoi is the causal agent and in mycetomas, successful management still remains a therapeutic problem. In our own experience and that of other using itraconazole, even over prolonged periods, this drug has an impressive safety profile. In our present series of 42 patients, no side effects were observed, no adverse reactions occurred and serum chemistry values remained within normal limits. It appears, therefore, that itraconazole, although not the final answer to management of the deep mycoses, is certainly a major improvement on previous drugs.

Antifungal Agents↗
PubMed1991

Inflammatory linear verrucous epidermal naevus (ILVEN) versus linear psoriasis. A clinical, histological and immunohistochemical study.

Inflammatory Linear Verrucous Epidermal Nevus (ILVEN) has been suggested to be a separate disease entity. However, the distinction from linear psoriasis has been discussed in the literature over recent decades. The aim of the present study was to investigate, in addition to the clinical and histological criteria, the immunohistochemical aspects of inflammation, epidermal proliferation and keratinization. From a clinical and histological point of view, ILVEN and psoriasis, according to the established criteria, have been proved to overlap. The immunohistochemical study suggests that the following procedures have an additional diagnostic impact: assessment of elastase-positive cells, assessment of keratin 16 and of keratin 10.

Adult↗
PubMed1990

[A case of chromomycosis in a nonendemic region].

A 43-year-old miner of the Donetsk coal fields is described, who developed in a month after a microinjury of the skin of the thoracic left side an intumescence and skin reddening. Later an agglomeration of nodules formed there with small ulcers regularly appearing, that did not heal for a long time. Histologic and bacteriologic analysis confirmed chromomycosis. The disease focus was resected. No recurrences were recorded in the following 8 months. This observation points to a wider prevalence of chromomycosis in a nonendemic area, the European part of the USSR, than it is reported in literature.

Accidents, Occupational↗
PubMed1989

Chromomycosis: a twenty-year analysis of histologically confirmed cases in Jamaica.

Thirty-one cases of histologically confirmed chromomycosis seen at the University Hospital of the West Indies (UHWI) between 1967 and 1986 were reviewed. A mean age of 56 years and a 5 to 1 male to female ratio were recorded. The lower limb was infected most frequently and both the macroscopic and microscopic disease showed typical features. Fonsecaea species were isolated in all 16 cases in whom mycological information was available (14 cases of F. pedrosoi). Surgical excision and split skin grafting produced long term cure in 7 to 10 cases with limited disease. Chromomycosis is more common in Jamaica than previous records would suggest.

Adult↗
PubMedDate not supplied

[Chromomycosis with unusual location. Presentation of 2 cases].

Two cases of chromomycosis of unusual location, one in the face and other in the auricular area, are reported. Though these two areas are highly vulnerable as far as trauma is concerned, the literature reviewed includes few cases in these areas.

Aged↗