Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “CHOLELITHIASIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 559 records · Page 31Linked to original sources
PubMed2005

[Effects of Shengqing Capsules on cholelithiasis-related genes in guinea pigs].

OBJECTIVE: To explore the molecular mechanisms of Shengqing Capsules in treating cholelithiasis. METHODS: Sixty female guinea pigs were randomized into 3 groups: group I (fed with normal diet), group II (fed with low-protein diet) and group III (fed with low-protein diet and Shengqing Capsules). After six-week feeding, the gallstone formation and the expressions of bilirubin UDP-glucuronosyltransferase (B-UGT) mRNA and cholesterol 7alpha-hydroxylase (CYP7A1) mRNA were observed. RESULTS: The proportions of stone-formed in groups I, II and III were 2/14, 9/12 and 4/14, respectively. There were significant differences among the three groups (P<0.05). The expressions of B-UGT and CYP7A1 mRNAs were higher in both group I and group III as compared with those in the group II (P<0.05). CONCLUSION: Shengqing Capsules can reduce the rate of stone-formation, which may be due to its interference of metabolism of bilirubin and cholesterol and up-regulation of the expressions of B-UGT and CYP7A1 mRNAs.

Animals↗
PubMed2006

Cholelithiasis associated with haemolytic-uraemic syndrome.

Cholelithiasis occurs infrequently in the paediatric age group. Hereditary spherocytosis, sickle cell anaemia and thalassemia are the haemolytic disorders most commonly associated with development of gall stones in paediatric age group. The question is whether an isolated episode of haemolysis can cause gallstones.

Adolescent↗
PubMedDate not supplied

The surgical treatment of cholelithiasis in cats: a study of nine cases.

Nine cats that had surgical treatment for obstructive cholelithiasis were reviewed to evaluate clinical signs, diagnostic test results, and outcome after surgery. Common clinical signs included progressive vomiting (9/9), dehydration (9/9), anorexia (6/9), icterus (5/9), and lethargy (4/9). Five cats had a cholecystectomy performed, one cat had a cholecystotomy, and three cats had a biliary diversion procedure. Four of the cats that had a cholecystectomy had no recurrence of vomiting or anorexia. The majority of cats (7/9) had multiple choleliths, which were radiopaque and most commonly composed of calcium carbonate. Seven cats were diagnosed with cholangiohepatitis, and four of these cats did not need long-term medical therapy. Most cats (7/9) survived long term postsurgery (mean, 21 months; median, 24 months) without additional medical therapy, while the two cats with concurrent hepatic lipidosis died. Cholecystectomy appeared to have low morbidity with good clinical success.

Animals↗
PubMed1979

Cholelithiasis: length-of-stay analysis in two series of surgical patients.

Two series of patients undergoing surgical treatment for cholelithiasis at Hornsby Hospital are described. Data are drawn from the routine morbidity reporting system of the hospital and processed by manual techniques. The morbidity data presented in this analysis demonstrate the capacity of currently operating reporting systems to provide diagnosis-specific information, and to describe the behaviour of relevant subgroups within a "diagnostic population". The need for specificity when attempting to make comparisons of length-of-stay "performance" either between or within hospitals is highlighted.

Adult↗
PubMed1984

The natural history of cholelithiasis: the National Cooperative Gallstone Study.

The National Cooperative Gallstone Study, a double-masked, placebo-controlled, therapeutic trial of chenodiol (chenodeoxycholic acid), provided an opportunity to study the natural history of cholelithiasis in patients who choose nonsurgical management. The major component of the study comprised 916 patients, 305 of whom were randomly assigned to receive a placebo for 24 months. Among these 305 patients, the probability of having biliary tract pain during the 24 months of prospective evaluation was significantly increased if the patient had had a history of biliary tract pain in the 12 months before entry into the study (69% versus 31%). Thirty-eight percent of patients had stone growth (greater than 0.5 cm3), and 18% had a spontaneous decrease in stone volume. Despite the high incidence of biliary tract pain, nonelective cholecystectomy was required in only 4% of patients during the 24 months.

Actuarial Analysis↗
PubMed1975

Prevalence of cholelithiasis in idiopathic late-onset immunoglobulin deficiency.

Twelve of 50 consecutive patients with idiopathic late-onset immunoglobulin deficiency had cholelithiasis. This represents a prevalence rate of 24%, which is significantly above the rate in a control group of 500 patients from this medical center matched 10:1 for age and sex (P less than 0.005). This finding adds a new gastrointestinal abnormality to those known to occur in idiopathic late-onset immunoglobulin deficiency.

Cholelithiasis↗
PubMed1978

Cholelithiasis in the cottonrat, Sigmodon hispidus, from the high plains of Texas.

A high prevalence (71%) of gallstones was noted in free-ranging cottonrats, Sigmodon hispidus, collected from one site in Lubbock County, Texas. The gallbladder of affected animals was distended and filled with white, soft, friable, cholesterol gallstones of variable sizes. Focal hyperplasia of the epithelium and connective tissue layer of the gallbladder was evident in affected cottonrats. As the forage available to affected animals was different from that available to gallstone-free animals collected from other areas, this may be the cause of the higher prevalence of cholelithiasis in this population. The significance of this disease and possible use of the cottonrat as an experimental model are discussed.

Animals↗
PubMed1976

[The present state of cholelithiasis research in Japan (author's transl)].

Research on cholelithiasis in Japan deals with such different aspects as development and composition of gallstones, geographical distribution of the disease, intrahepatic formation of gallstones, diagnostic and surgical procedures. This paper presents results on these current research topics.

Bilirubin↗
PubMed1999

[The pathogenesis of liver functional disorders after cholecystectomy in cholelithiasis].

AIM: To study hepatic function after cholecystectomy and the role of absorptive-excretory function of the liver and hormonal factors in development of postcholecystectomy syndrome. MATERIALS AND METHODS: 106 patients long after cholecystectomy for cholelithiasis were examined for absorptive-excretory function of the liver and blood hormones (hydrocortisone, insulin, gastrin, thyroxine, triiodothyronine, thyrotropine). I-131-bengal-rose hepatography, dynamic hepatobiliscintigraphy with brommeside-Tc-99m, radioimmunoassay were employed. RESULTS: Impairment, often subclinical, of hepatic absorption and excretion after cholecystectomy was found in 94% of the patients. External function of the liver after cholecystectomy was disturbed depending on the condition of its absorptive-excretory function. Hepatic dysfunctions and changes in blood hormones correlated. CONCLUSION: Absorptive-excretory function and hormonal factors are essential in pathogenesis of postcholecystectomy syndrome.

Cholelithiasis↗
PubMedDate not supplied

[Cholelithiasis in pediatric age: three cases].

The cholelithiasis is a unusual pathology of paediatric age; it is exceptional pathology in the earliest childhood. The disease is often unsymptomatic and it can be correlated with several pathologies. The echography is the golden standard. We describe three cases with different peculiarities.

Child↗
PubMed1999

Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes.

There is no consensus whether hepatic lipid regulatory enzymes play primary or secondary roles in cholesterol cholelithiasis. We have used inbred mice with Lith genes that determine cholesterol gallstone susceptibility to evaluate the question. We studied activities of regulatory enzymes in cholesterol biosynthesis (HMG-CoA reductase), cholesterol esterification (acyl-CoA:cholesterol acyltransferase) and the "neutral" (cholesterol 7alpha-hydroxylase) and "acidic" (sterol 27-hydroxylase) pathways of bile salt synthesis in strains C57L/J and SWR/J as well as recombinant inbred (AKXL-29) mice, all of which have susceptible Lith alleles, and compared them to AKR/J mice with resistant Lith alleles. We determined hepatic enzyme activities of male mice before and at frequent intervals during feeding a lithogenic diet (15% dairy fat, 1% cholesterol, 0.5% cholic acid) for 12 weeks. Basal activities on chow show significant genetic variations for HMG-CoA reductase, sterol 27-hydroxylase, and acyl-CoA: cholesterol acyltranferase, but not for cholesterol 7alpha-hydroxylase. In response to the lithogenic diet, activities of the regulatory enzymes in the two bile salt synthetic pathways are coordinately down-regulated and correlate inversely with prevalence rates of cholesterol crystals and gallstones. Compared with gallstone-resistant mice, significantly higher HMG-CoA reductase activities together with lower activities of both bile salt synthetic enzymes are hallmarks of the enzymatic phenotype in mice with susceptible Lith alleles. The most parsimonious explanation for the multiple enzymatic alterations is that the primary Lith phenotype induces secondary events to increase availability of cholesterol to supply the sterol to the hepatocyte canalicular membrane for hypersecretion into bile.

Alleles↗
PubMedDate not supplied

Situs inversus with cholelithiasis.

Situs inversus totalis is a form of heterotaxia which is usually detected accidentally while investigating for any associated condition. If undetected, this condition can create a diagnostic puzzle. We report one such case in which situs inversus was associated with cholelithiasis.

Adult↗
PubMed2000

[Laparoscopic cholecystectomy in the treatment, rehabilitation and clinical health certification of the flying personnel with cholelithiasis].

Applicability of laparoscopic cholecystectomy (LSCE), a modern approach to the treatment of cholelithiasis, to rehabilitation, and military medical and military aviation certification was evaluated. Since 1994, 303 LSCE operations, including to 97 patients-aviators, have been performed by way of penetrating the abdominal wall with a standard laporoscopic stand (K-Chtorz, Germany). After introduction of LSCE, only 9 operations (2.9%) were fulfilled with the conventional technique. Immediate results of treatment of aviators were satisfactory and characterized by a good cosmetic effect, more rapid recovery of the motor activity, minimal complications (2.2%), absence of severe post-operational pancreatic/biliary dysfunctions, and expedited course of treatment.

Adult↗
PubMedDate not supplied

[Video laparoscopic cholecystectomy in a female patient with cholelithiasis in Steinert's myotonic dystrophy].

Steinert's disease (SD) is a rare (3-5/100000) myotonic myopathy responsible for chronic restrictive respiratory insufficiency and dilatative myocardiopathy. The authors report the case of a 52-years-old female patient with SD who underwent laparoscopic cholecystectomy for cholelithiasis. Postoperative course was uneventful and the patient was discharged after 4 days. Laparoscopic surgery was effective and safe in the treatment of this pathology.

Anesthesia, General↗
PubMed2000

[Minimally invasive surgery in cholelithiasis].

The results of minimally invasive surgical interventions (percutaneous transhepatic cholecystostomy, retrograde cholangiopancreatography with endoscopic papillosphincterotomy, percutaneous transhepatic cholangiostomy with endobiliary intervention, extracorporeal shock wave lithotripsy, laparoscopic cholecystectomy) in 1590 patients were analyzed, 2 methods and more were used in 74 of them. In 155 patients minimally invasive interventions were combined with open surgery. Rational combination of minimally invasive methods in cholelithiasis permits to cure majority of the patients, to avoid open operation and associated complications.

Adult↗
PubMed2001

[Cholecystectomy by mini-approach in the treatment of cholelithiasis].

Along with wide-spread laparoscopic cholecystectomy, cholelithiasis can be treated with another sparing technique--miniaccess cholecystectomy (MACE). Case histories and long-term treatment outcomes were analysed for 168 patients aged 23-77 years subjected to MACE with elements of open laparoscopy for chronic calculous cholecystitis. Surgery was made using a special surgical kit "Mini-assistant" by the team of two surgeons and an instrument nurse. After MACE the patients resume their jobs after a shorter period of inability, suffer from side effects of surgery in rare cases, have higher quality of life than patients after laparoscopic cholecystectomy.

Cholecystectomy↗
PubMed2001

[Surgical treatment of patients with purulent cholangitis in cholelithiasis].

Results of treatment of 89 patients with cholelithiasis complicated by obstructive jaundice and purulent cholangitis using the minimally invasive technologies are analyzed. The advantages of two-stages surgical treatment of these patients are demonstrated. The decompression of biliary tract are performed as the first stage, radical operations by laparoscopy or minilaparotomy--as the second stage. This method permits to refuse the large and traumatic operations and to improve significantly the nearest and long-term results of treatment.

Adult↗
PubMed1979

[Bacteriological findings in patients with cholelithiasis and duodenal diverticuli].

In a prospective study of 70 patients with duodenal diverticula and calculous biliary tract disease, bacteriocholia with typical intestinal bacteria was found in 69%, whereas in cholelithiasis without duodenal diverticula this complication was present in 30% of the cases. With growing distance between duodenal diverticula and the papilla of Vater the rate of bacteriocholia decreases. Rising age of patients results in augmentation of bacteriocholia. Bacteriocholia on the basis of duodenal diverticula seems to present an additional pathogenetic factor for inflammatory biliary tract disease in 69% and for pancreatitis in 20% of the cases. Consequently the pathologic value of diverticulas close to the papilla of Vater is more prominent than reported so far.

Bile↗