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At least 559 records · Page 31Linked to original sources
PubMed2003

Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans.

Individual variability in human arsenic metabolism has been reported frequently in the literature. This variability could be an underlying determinant of individual susceptibility to arsenic-induced disease in humans. Recent analysis revealing familial aggregation of arsenic metabolic profiles suggests that genetic factors could underlie interindividual variation in arsenic metabolism. We screened two genes responsible for arsenic metabolism, human purine nucleoside phosphorylase (hNP), which functions as an arsenate reductase converting arsenate to arsenite, and human glutathione S-transferase omega 1-1 (hGSTO1-1), which functions as a monomethylarsonic acid (MMA) reductase, converting MMA(V) to MMA(III), to develop a comprehensive catalog of commonly occurring genetic polymorphisms in these genes. This catalog was generated by DNA sequencing of 22 individuals of European ancestry (EA) and 24 individuals of indigenous American (IA) ancestry. In (Italic)hNP(/Italic), 48 polymorphic sites were observed, including 6 that occurred in exons, of which 1 was nonsynonymous (G51S). One intronic polymorphism occurred in a known enhancer region. In hGSTO1-1, 33 polymorphisms were observed. Six polymorphisms occurred in exons, of which 4 were nonsynonymous. In contrast to hNP, in which the IA group was more polymorphic than the EA group, in hGSTO1-1 the EA group was more polymorphic than the IA group, which had only 1 polymorphism with a frequency > 10%. Populations representing genetic admixture between the EA and IA groups, such as Mexican Hispanics, could vary in the extent of polymorphism in these genes based upon the extent of admixture. These data provide a framework in which to conduct genetic association studies of these two genes in relevant populations, thereby allowing hNP and hGSTO1-1 to be evaluated as potential susceptibility genes in human arsenicism.

Arsenic↗
PubMed1991

Characteristics of the U.S. EPA's Office of Pesticide Programs' toxicity information databases.

The United States Environmental Protection Agency's Office of Pesticide Programs (OPP) requires that data from toxicity testing be submitted to the OPP to support the registration of pesticide chemicals. Once the toxicity data are submitted, they are entered into various toxicity databases. The studies are listed in an archival database to catalog and allow retrieval of the study for review. Reviews of toxicity studies are then placed into a separate database that can be retrieved to support a regulatory position. Toxicity information for health effects other than cancer and gene mutations from chronic exposure is reviewed through a reference dose (RfD) approach, and these decisions and supporting data are entered into an RfD database. Carcinogenicity data are reviewed by a peer review process, and these decisions are entered into a newly developed database to show the regulatory decision with supporting data. The mutagenicity data are reviewed and acceptable data are entered into the Genetic Activity Profile system to catalog and display the submitted information. These databases contain the information used for hazard evaluations as part of the OPP review of pesticide chemicals.

Animals↗
PubMed2006

Genome-scale identification of membrane-associated human mRNAs.

The subcellular localization of proteins is critical to their biological roles. Moreover, whether a protein is membrane-bound, secreted, or intracellular affects the usefulness of, and the strategies for, using a protein as a diagnostic marker or a target for therapy. We employed a rapid and efficient experimental approach to classify thousands of human gene products as either "membrane-associated/secreted" (MS) or "cytosolic/nuclear" (CN). Using subcellular fractionation methods, we separated mRNAs associated with membranes from those associated with the soluble cytosolic fraction and analyzed these two pools by comparative hybridization to DNA microarrays. Analysis of 11 different human cell lines, representing lymphoid, myeloid, breast, ovarian, hepatic, colon, and prostate tissues, identified more than 5,000 previously uncharacterized MS and more than 6,400 putative CN genes at high confidence levels. The experimentally determined localizations correlated well with in silico predictions of signal peptides and transmembrane domains, but also significantly increased the number of human genes that could be cataloged as encoding either MS or CN proteins. Using gene expression data from a variety of primary human malignancies and normal tissues, we rationally identified hundreds of MS gene products that are significantly overexpressed in tumors compared to normal tissues and thus represent candidates for serum diagnostic tests or monoclonal antibody-based therapies. Finally, we used the catalog of CN gene products to generate sets of candidate markers of organ-specific tissue injury. The large-scale annotation of subcellular localization reported here will serve as a reference database and will aid in the rational design of diagnostic tests and molecular therapies for diverse diseases.

Biomarkers, Tumor↗
PubMed2001

Protein array technology. Potential use in medical diagnostics.

The human genome is sequenced, but only a minority of genes have been assigned a function. Whole-genome expression profiling is an important tool for functional genomic studies. Automated technology allows high-throughput gene activity monitoring by analysis of complex expression patterns, resulting in fingerprints of diseased versus normal or developmentally distinct tissues. Differential gene expression can be most efficiently monitored by DNA hybridization on arrays of oligonucleotides or cDNA clones. Starting from high-density filter membranes, cDNA microarrays have recently been devised in chip format. We have shown that the same cDNA libraries can be used for high-throughput protein expression and antibody screening on high-density filters and microarrays. These libraries connect recombinant proteins to clones identified by DNA hybridization or sequencing, hence creating a direct link between gene catalogs and functional catalogs. Microarrays can now be used to go from an individual clone to a specific gene and its protein product. Clone libraries become amenable to database integration including all steps from DNA sequencing to functional assays of gene products.

Diagnosis↗
PubMed2005

Making sense of high-throughput protein-protein interaction data.

Accurate systems biology modeling requires a complete catalog of protein complexes and their constituent proteins. We discuss a graph-theoretic/statistical algorithm for local dynamic modeling of protein complexes using data from affinity purification-mass spectrometry experiments. The algorithm readily accommodates multicomplex membership by individual proteins and dynamic complex composition, two biological realities not accounted for in existing topological descriptions of the overall protein network. A likelihood-based objective function guides the protein complex modeling algorithm. With an accurate complex membership catalog in place, systems biology can proceed with greater precision.

Journal Article↗
PubMed2006

High-throughput mutational analysis of the human cancer genome.

Cancer is essentially a genetic disease. Recent high-throughput mutational analyses of gene families in human colorectal, breast and lung cancer, myeloproliferative disorders, and other tumor types have identified a number of kinases and phosphatases that are mutated in the human cancer genome. This approach has been proven to be an efficient way to catalog tumor-specific mutations in human cancers. Although there are still some technical hurdles to overcome, it is not a far-reaching goal to perform genome-wide mutational analysis in all different tumor types. Systematic cataloging of tumor-specific mutations in the human cancer genome not only will lead to new insights into the mechanisms of tumorigenesis, but also provide unprecedented opportunities in the design of novel therapeutics for cancer patients. Personalized cancer therapy based on tumor-specific mutations will be a realistic goal in the near future.

Breast Neoplasms↗
PubMed1986

Aspects of the behavioral repertoire of an autistic/epileptic child.

The behavior of an autistic/epileptic child was investigated through indoor, outdoor, and laboratory contexts to acquire a catalog of behavior for the autistic condition, which to date was only partially available, and to provide the parameters of the units composing it. The catalog obtained is composed of 111 units of behavior whose descriptions and quantitative characteristics are also given. The study has also dealt with the subject's global behavioral output and lexical aspects of her repertoire. The results appear to admit the conclusion that the child's behavior was operating under a tendency to return to a stereotypic output state from other, short-lasting states of behavior. This observation needs a subsequent confirmatory analysis of behavioral output states involved. Moreover, the search for the orderly type/token relationship, proposed in 1977 by Fagen and Goldman to hold for behavior, has led to equivocal results.

Autistic Disorder↗
PubMed1996

Virtual design prototyping applied to medical facilities.

Over the past five years, MITRE has developed rapid 3D modeling and immersive environment capabilities that supports the application of virtual environment technology to many traditional and non-traditional domains [1]. This paper provides background information on these capabilities and describes the application of this technology to the experimental design prototyping of operating rooms of the future and to the design and retrofit of existing or proposed medical facilities. These capabilities employ contemporary commercial hardware and software and exploit stereoscopic projection displays and headsets. A unique user interface facilitates object manipulation within these immersive environments and addresses two key areas: 1) Visualization of the contents on the model server or library in a catalog form; and 2) Natural interaction and immersion of the user with the visualized catalog and selected visualized objects in a 3D synthetic environment. A brief discussion of two developing applications of this technology will be presented. In one application example, the modeling environment can be used to synthesize physical replicas (potentially full stereo scale) of actual surgical rooms used for training of medical personnel. Alternatively, it can be employed as the infrastructure for a new form of collaborative interactive visualization, namely, telesurgery. In another example, the rapid modeling capability provides designers, architects and medical personnel with a means of rapidly developing synthetic renderings of (potentially interactive and remotely operative) proposed medical facilities prior to construction. We also discuss key issues needing to be resolved for successful model interchange.

Computer Simulation↗
PubMed1999

Inventory of high-abundance mRNAs in skeletal muscle of normal men.

G42875rial analysis of gene expression (SAGE) method was used to generate a catalog of 53,875 short (14 base) expressed sequence tags from polyadenylated RNA obtained from vastus lateralis muscle of healthy young men. Over 12,000 unique tags were detected. The frequency of occurrence of each tag reflects the relative abundance of the corresponding mRNA. The mRNA species that were detected 10 or more times, each comprising >/=0.02% of the mRNA population, accounted for 64% of the mRNA mass but <10% of the total number of mRNA species detected. Almost all of the abundant tags matched mRNA or EST sequences cataloged in GenBank. Mitochondrial transcripts accounted for approximately 20% of the polyadenylated RNA. Transcripts encoding proteins of the myofibrils were the most abundant nuclear-encoded mRNAs. Transcripts encoding ribosomal proteins, and those encoding proteins involved in energy metabolism, also were very abundant. The database can be used as a reference for investigations of alterations in gene expression associated with conditions that influence muscle function, such as muscular dystrophies, aging, and exercise.

Expressed Sequence Tags↗
PubMed1998

Towards semantic integration within an existing medical information system.

Talking about the problems of integration in medical information systems, the necessity to provide end users with a consistent and coherent view of patient's data, has been largely reported. In order to attempt this goal, systems need to perform semantic integration. We propose a pragmatic way to describe the semantics of the elements of a database, based on a bottom-up three steps process: 1. a back documentation of the elements of the system from their description contained in the data catalog of the database 2. a first semantic extension to transform a data catalog into a data dictionary 3. a second semantic extension to create a dictionary of the medical concepts from a data dictionary. This dictionary of concepts can be considered as the final result of "semantic integration". It contains a set of entities directly understandable by the end users. These entities are deduced or built from the elements collected and characterized in the data dictionary. This work reports the conceptual analysis and the implementation of such a data dictionary.

Database Management Systems↗
PubMed2002

Resource selection for an interdisciplinary field: a methodology.

The Health Sciences and Human Services Library of the University of Maryland developed and implemented a methodology to evaluate print and digital resources for social work. Although this methodology was devised for the interdisciplinary field of social work, the authors believe it may lend itself to resource selection in other interdisciplinary fields. The methodology was developed in response to the results of two separate surveys conducted in late 1999, which indicated improvement was needed in the library's graduate-level social work collections. Library liaisons evaluated the print collection by identifying forty-five locally relevant Library of Congress subject headings and then using these subjects or synonymous terms to compare the library's titles to collections of peer institutions, publisher catalogs, and Amazon.com. The collection also was compared to social work association bibliographies, ISI Journal Citation Reports, and major social work citation databases. An approval plan for social work books was set up to assist in identifying newly published titles. The library acquired new print and digital social work resources as a result of the evaluation, thus improving both print and digital collections for its social work constituents. Visibility of digital resources was increased by cataloging individual titles in aggregated electronic journal packages and listing each title on the library Web page.

Books↗
PubMed2003

Mind your pricing cues.

For most of the items they buy, consumers don't have an accurate sense of what the price should be. Ask them to guess how much a four-pack of 35-mm film costs, and you'll get a variety of wrong answers: Most people will underestimate; many will only shrug. Research shows that consumers' knowledge of the market is so far from perfect that it hardly deserves to be called knowledge at all. Yet people happily buy film and other products every day. Is this because they don't care what kind of deal they're getting? No. Remarkably, it's because they rely on retailers to tell them whether they're getting a good price. In subtle and not-so-subtle ways, retailers send signals to customers, telling them whether a given price is relatively high or low. In this article, the authors review several common pricing cues retailers use--"sale" signs, prices that end in 9, signpost items, and price-matching guarantees. They also offer some surprising facts about how--and how well--those cues work. For instance, the authors' tests with several mail-order catalogs reveal that including the word "sale" beside a price can increase demand by more than 50%. The practice of using a 9 at the end of a price to denote a bargain is so common, you'd think customers would be numb to it. Yet in a study the authors did involving a women's clothing catalog, they increased demand by a third just by changing the price of a dress from $34 to $39. Pricing cues are powerful tools for guiding customers' purchasing decisions, but they must be applied judiciously. Used inappropriately, the cues may breach customers' trust, reduce brand equity, and give rise to lawsuits.

Attitude↗
PubMed2004

[Specification and application of cephalometric analysis and image database].

PURPOSE: To summarize the basic requirement of cephalometric analysis and database product concluded from practice, and apply related products to improve the levels of medical treatment, teaching and scientific research. METHODS: By the use of digital X ray machine, digital camera, oral endoscope,scanner to import the image into system database, to edit, measure, make diagram, analyze and store the images, to catalog diagnosis according to the different need of patient to make convenient for retrieving by group, to design multi-page electronic case report including oral general diagram, the result of diagnosis cataloging, the result diagram of analysis, picture and text report, all of the above mentioned constitute a complete patient database system. RESULTS: About 400 medical case were accumulated, and these improved evidently the effect to present the production of medical treatment to potential patients, were convenient to the professional communication between doctors and conformation of treatment plan, provided a solid foundation to multimedia teaching, and promoted the development of the task of graduate student and the task of scientific research. CONCLUSION: Using related product with perfect functions to develop standardized cephalometric analysis and build standardized patient's database including image information, when such information is accumulated to certain extent, will become the invaluable treasure of relevant medical institution, will bring the obvious effect to improve the level of medical treatment, teaching and scientific research.

Cephalometry↗
PubMed2003

[Description of the seismological network of the Venezuelan Andes].

Western Venezuela shows a broad zone characterized by a moderate seismicity level, which has been the scenery of various historic earthquakes of destructive character. The beginning of the seismic instrumentation in the area dates from 1969, nevertheless it was 10 years later when the seismological network of the Venezuelan Andes (REDSAV) was permanently installed in order to characterize the regional earthquake activity. The REDSAV is an array of 10 remote seismic stations that sends the seismic signals by analog telemetry to the central station, located in the city of Mérida, where the digitalization, automatic event detection in real time and the analysis and off-line processing of the seismic information is carried out. During the last 10 years important advances have been taken place in terms of its operativity, which includes a dynamic web site (http://lgula.ciens.ula.ve) with a catalog of western Venezuela earthquakes, where the user can visualize the seismograms, the P and S wave arrival time, the polarities and epicentral maps; moreover, it is possible to select events applying temporal, spatial and magnitute criteria. In this paper the technical characteristic of the equipment are described and the advances registered in the last years referring to the automatic acquisition system, processing of the information and seismologic catalog of the REDSAV, whose systematic use during a decade has permitted to gather the biggest information base of related with the seismicity of the south-western Venezuela.

English Abstract↗
PubMed1972

Mechanization of Library Procedures in the Medium-Sized Medical Library: XIV. Correlations between National Library of Medicine Classification Numbers and MeSH Headings.

The purpose of this study was to determine the amount of correlation between National Library of Medicine classification numbers and MeSH headings in a body of cataloging which had already been done and then to find out which of two alternative methods of utilizing the correlation would be best.There was a correlation of 44.5% between classification numbers and subject headings in the data base studied, cataloging data covering 8,137 books. The results indicate that a subject heading index showing classification numbers would be the preferred method of utilization, because it would be more accurate than the alternative considered, an arrangement by classification numbers which would be consulted to obtain subject headings.

Journal Article↗
PubMed2006

[A comparison of two existing catalogues of the alleles of gliadin-coding loci in winter common wheat].

Two catalogs of alleles of gliadin-coding loci, controlling synthesis of a storage protein of wheat caryopsis, gliadin, were compared. One catalogue comprises the alleles detected according to the electrophoretic patterns in starch gels; the other, in polyacrylamide gels. Determination of the allelic state of gliadin-coding loci in 31 previously not studied cultivars of winter common wheat allowed us to construct a matching system for the alleles compiled in the two catalogs, which gives the possibility to compare the results of wheat cultivar analyses performed at different scientific institutions.

Alleles↗
PubMed2006

Evaluating the strengths and weaknesses of tuberculosis educational activities for prisoners in Honduras.

SETTING: Prisons throughout Honduras. OBJECTIVE: To assess the strengths, weaknesses, and opportunities to improve non-standardized tuberculosis (TB) educational campaign materials utilized in prisons. DESIGN: A qualitative assessment was conducted. Prison staff completed a survey describing development and implementation of educational activities at each prison (n=25). Completed surveys with photographs or copies of educational materials were collected and cataloged. The content, literacy demand, illustrations, learning stimulation, and cultural appropriateness of cataloged items were assessed using an adapted version of the Suitability Assessment of Materials Instrument. Results from this assessment were examined in conjunction with information collected through focus groups conducted with prisoners and interviews with prison staff. RESULTS: Campaign strengths included the development and dissemination of print materials appropriate for individuals with low literacy levels. By actively engaging prisoners in the campaigns, materials often incorporated the language, values, and experiences encountered within prison culture. Content of print materials and presentations focused on correcting misperceptions and facilitating acceptance of TB control activities. Campaign weaknesses included the creation of illustrations that could perpetuate the stigma associated with TB and use of some materials in which the purpose was not apparent. CONCLUSIONS: The campaigns were generally suitable, and the evaluation allowed for their improvement.

Adult↗
PubMed1990

[Comparative studies of measuring methods for the six-dimensional recording of spatial mandibular movements].

A catalog of criteria has been developed for testing and judging methods to record extensive movements of the mandible. The aim is to find a method that functions in all six dimensions (translation and rotation) and precludes system errors. Two methods that seem to be in principle able to fulfil the criteria have been tested with calibration sets. The catalog, the results of the survey and developments to improve these methods are presented.

Dental Equipment↗