The treatment of varicosities and accompanying complications; (the ambulatory treatment of phlebitis with compression bandage).
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OBJECTIVE: To study in vitro the micro-organism absorption properties of a hydrogel wound dressing, TenderWet. METHOD: Microbial films on agar plates and suspensions with common wound bacteria (Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa) and a fungal strain (Candida albicans) were studied. RESULTS: The hydrogel dressing reduced the number of micro-organisms significantly, both on the agar plate and in suspension. The in vitro data show that the hydrogel dressing absorbed the micro-organisms from the environment. Electron microscopic imaging clearly demonstrated that the germs were attached to the surface of the dressing's superabsorbent polymer core. CONCLUSION: In vitro data show that the hydrogel dressing TenderWet attracts and retains micro-organisms and reduces the number of viable germs. Clinical experience underlines this fast cleansing and debriding effect of the hydrogel wound dressing.
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The authors worked out a simple method, which enables an orientative evaluation of different skin substitutes as to their effectiveness in preventing gross evaporative water loss from decorticated dermis. The method is based on the loss of weight of decorticated dermis samples (covered by different materials) incubated in a thermostat for 1, 2, 3 and 4 hours at 37 degrees C. Following skin substitutes were tested: Lyofoam; Epigard; collagen foil; freeze dried amniotic membrane; freeze dried porcine xenografts; deep frozen porcine xenografts; and fresh porcine xenografts. Controls lost during 4 hours incubation at 37 degrees C 61.34% of the original weight (similarly as samples covered by synthetic skin substitutes or amniotic membrane). Samples covered by freeze dried xenografts lost only 33.07%, samples covered by deep frozen xenografts 13.20% and by fresh xenografts, 6.06%.
A review of skin substitutes currently in use is presented. These include allografts, xenografts, embryonic membranes, tissue derivatives and synthetic skin substitutes. Clinical results from Langerhans cell depressed cadaver allografts on burned patients and crural ulcers are presented.
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This paper introduces a new apparatus and method that suits to measuring the water vapor transmission rate (WVTR) of wound covering materials. WVTR of synthetic materials, amniotic membrane, porcine and cadaveric skin was measured under different conditions of four temperatures, three mediums, and "water cup" or "inverted water cup". The temperature was in close relationship with the WVTR except Omiderm, amniotic membrane, and cadaveric skin between 30 degrees C and 37 degrees C groups. The medium did not affect the WVTR (P > 0.05). There was significant difference between the "water cup" and "inverted water cup" groups(P < 0.01). This study suggests that the apparatus is easy-to-operate, reliable and suitable for the measurement of WVTR of burn wound coverings and other membranous materials.
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