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PubMedDate not supplied

[Object relation with drug--case report].

Psychoanalytic exploration of the action of psychotropic drugs has a long tradition which begins in the pioneer days of contemporary psychopharmacotherapy in 1950-ties. This exploration and publications based on them theorized about influence of neuroleptics on ego defences, id drives and intrapsychic conflicts and decrease in symptomatology as a result of action of the medication on all listed above. The paper presented is the case story about psychodynamic meaning of medication with a neuroleptic drug in a new context. The patient after a psychotic episode (paranoid type) was treated with quetiapine 600 mg per day and in the same time had an individual psychotherapy. During psychotherapy her inability to establish object stability was disclosed. In that particular intrapsychic situation the patient established a relation with an omnipotent and idealized representation of the drug. Medication was an absolutely idealized object for her one that was controllable and stabile and could not abandon her. The quality of relation with the drug was based on a primary defence mechanism like splitting, idealization and omnipotence and denial.

Adult↗

PubMed2001

Quantal and non-quantal current and potential fields around individual sympathetic varicosities on release of ATP.

The electrical phenomena that occur at sympathetic varicosities due to the release of ATP include spontaneous and evoked excitatory junction potentials (SEJPs and EJPs; recorded with an intracellular electrode) as well as fast and slow excitatory junctional currents (EJCs; recorded with a loose-patch electrode placed over varicosities). The electrical analysis of these transients is hampered by lack of a detailed theory describing how current and potential fields are generated upon the release of a quantum of ATP. Here, we supply such a theory and develop a computational model for the electrical properties of a smooth muscle syncytium placed within a volume conductor, using a distributed representation for the individual muscle cells. The amplitudes and temporal characteristics of both SEJPs and fast EJCs are predicted by the theory, but those of the slow EJCs are not. It is shown that these slow components cannot arise as a consequence of propagation of fast quantal components from their site of origin in the muscle syncytium to the point of recording. The possibility that slow components arise by a mechanism of transmitter secretion that is different from quantal release is examined. Experiments that involve inserting peptide fragments of soluble N-ethylmaleimide-sensitive fusion attachment protein (alpha-SNAP) into varicosities, a procedure that is known to block quantal release, left the slow component of release unaffected. This work provides an internally consistent description of quantal potential and current fields about the varicosities of sympathetic nerve terminals and provides evidence for a non-quantal form of transmitter release.

Adenosine Triphosphate↗

PubMed1976

Association of messenger ribonucleic acid with 70S monosomes from down-shifted Escherichia coli.

The complexed 70S ribosomes (monosomes) that accumulate in Escherichia coli after an energy source shift-down were examined in an electron microscope. In all cases, the ribosomes lie at or near one end of a ribonucleic acid (RNA) strand. This messenger RNA (mRNA) has a mean length of 168 nm and a length-average length of 200 nm, sufficient to code for polypeptides of a weight-average molecular weight of 20,000. The length distribution indicates that these strands are a reasonable representation of the population of monocistronic mRNA's of E. coli. The mRNA strands disappear entirely upon digestion with pancreatic ribonuclease, phosphodiesterase I, or polynucleotide phosphorylase. The susceptibility to digestion by 3'-exonucleases indicate that the ribosomes lie at the 5' end of the mRNA strands. These results are consistent with the hypothesis that down-shifted cells have a translational defect at a point subsequent to the binding of ribosomes to mRNA but prior to the formation of the first peptide bond, such that ribosomes remain bound at or near their points of initial attachment to mRNA.

Bacterial Proteins↗

PubMed2000

Asymmetry in 3-D perceptual organization: ground-like surface superior to ceiling-like surface.

Attneave (1954) and Barlow (1961) proposed that the visual system might increase efficiency of representation by preferentially encoding spatiotemporally redundant patterns of the external world. The present experiments tested the application of this principle to three-dimensional (3-D) perceptual organization, capitalizing on the ecological constraint that human observers must frequently interact with objects arranged on the ground or on a surface parallel to it (Gibson, 1950). Observers performed a task that required them to perceptually segregate and search multiple items distributed in depth and embedded within a larger, 3-D array of distractors. Stimulus displays were organized to globally recede top-away in depth, as if attached to an underlying ground-like surface, or bottom-away, as if attached to an overhanging ceiling-like surface; ground-like and ceiling-like displays differed only in the direction of disparity gradient within the displays. Primary findings revealed superior performance with ground-like displays, suggesting that spatially and stereoscopically distributed items are more easily organized to represent an ecologically representative pattern, even when no inherent physical regularities favor that pattern.

Adult↗

PubMed1989

A cognitive perspective on object relations, drive development and ego structure in the second and third years of life.

This paper extends a recent line of research by correlating Piaget's theory of cognitive development with several psychoanalytic perspectives on development during the second and third years of life. The concrete, imagistic, unintegrated nature of mental representations associated by Mahler and Kernberg with this period, along with the mental operation of splitting, are related to preconceptual representation, a cognitive mode described by Piaget. Psychoanalytic perspectives on the body ego and object world associated with the anal period are also seen to involve concrete, unintegrated representations which show correspondence with preconceptual cognition. Parallels are explored between cognitive stages and the psychoanalytic understanding of ego and superego development. While psychoanalysis is not a cognitive psychology, aspects of its theory are concerned with cognitive structure and are enriched by a consideration of cognitive development.

Child Development↗

PubMed1993

Sagittal-plane mobility of the cat cervical spine.

The present study was conducted to evaluate the nature of sagittal-plane motion across cervical vertebral joints and to identify the centers of rotation for each joint in anaesthetized cats X-rayed in a range of head-neck postures. Relative positions of adjacent pairs of vertebrae were assessed by constructing transparent templates for each vertebra that could be overlaid onto different X-rays, and then by digitizing the locations of three markers attached at a distance from each template. The finite centers of rotation for each joint were estimated using a rigid-body method. The errors associated with the estimates were quantified further by using a method in which the positions of digitized markers were fitted to concentric circles using a least-squares approach. The center of rotation between the skull and C1 was located at the cranial articular facets between the two bones. The center of rotation between C1 and C2 was situated near the tip of the odontoid process close to the site of attachment of the transverse ligaments. Centers of rotation for the other cervical vertebral joints were located in the region of the intervertebral disc. A similar range of values was obtained for centers of rotation when extended or flexed postures were used for the calculations, suggesting that the centers of rotation may not move markedly throughout a range of sagittal-plane rotations of approximately 90 degrees at the skull-C1 joint and about 15-30 degrees at the other cervical joints. These results showed that all cervical joints rotated during sagittal-plane motion. A minimal representation of the musculoskeletal mechanics of the feline neck probably requires multiple segments, each corresponding to a single vertebral bone.

Animals↗

PubMed1990

The babel of the unconscious.

This paper illustrates our clinical and personal experiences concerning the vast and complex theme of 'Polylingualism in psychoanalysis'. The issue of polylingualism and polyglotism reintroduces some general psychoanalytic hypotheses. For instance, is the nature of the unconscious predominantly pre-verbal, or is it structured as a language? What occurs if some languages are known since very early childhood, and belong to a pre-symbolic structural patrimony closely bound to bodily sensations and concrete experiences? How does the learning of new languages, later on, affect or modify thought processes? How do new and old unconscious 'thing' and 'word' representations interact with each other? What are the related problems regarding repression and memory? Our paper illustrates and discusses problems of communication and comprehension within the clinical situation, in cases when the analytic language is not the mother-tongue of the analyst, or of the patient, or of either of them.

Adult↗

PubMed2000

Bacterial primary colonization and early succession on surfaces in marine waters as determined by amplified rRNA gene restriction analysis and sequence analysis of 16S rRNA genes.

The nearly universal colonization of surfaces in marine waters by bacteria and the formation of biofilms and biofouling communities have important implications for ecological function and industrial processes. However, the dynamics of surface attachment and colonization in situ, particularly during the early stages of biofilm establishment, are not well understood. Experimental surfaces that differed in their degrees of hydrophilicity or hydrophobicity were incubated in a salt marsh estuary tidal creek for 24 or 72 h. The organisms colonizing these surfaces were examined by using a cultivation-independent approach, amplified ribosomal DNA restriction analysis. The goals of this study were to assess the diversity of bacterial colonists involved in early succession on a variety of surfaces and to determine the phylogenetic affiliations of the most common early colonists. Substantial differences in the representation of different cloned ribosomal DNA sequences were found when the 24- and 72-h incubations were compared, indicating that some new organisms were recruited and some other organisms were lost. Phylogenetic analyses of the most common sequences recovered showed that the colonists were related to organisms known to inhabit surfaces or particles in marine systems. A total of 22 of the 26 clones sequenced were affiliated with the Roseobacter subgroup of the alpha subdivision of the division Proteobacteria (alpha-Proteobacteria), and most of these clones were recovered at a high frequency from all surfaces after 24 or 72 h of incubation. Two clones were affiliated with the Alteromonas group of the gamma-Proteobacteria and appeared to be involved only in the very early stages of colonization (within the first 24 h). A comparison of the colonization patterns on the test surfaces indicated that the early bacterial community succession rate and/or direction may be influenced by surface physicochemical properties. However, organisms belonging to the Roseobacter subgroup are ubiquitous and rapid colonizers of surfaces in coastal environments.

Alphaproteobacteria↗

PubMed2004

A transitory homosexual passion in the course of an analytic treatment.

Do homosexualities express a sexual conflict originating in bisexuality or must we look for their deep determinism in the narcissistic conflict and its vicissitudes? Two clinical sequences from the treatment of a borderline patient, which occurred during years seven and eight of treatment, a period characterised by intense drive turbulence and the unexpected occurrence of a transitory homosexual passion, will enable the reader to follow the psychical movements and evolution of the work of representation. The first sequence throws light on the links between her sudden involvement in this homosexual passion and the traumatic dangers of a breakdown of her ego's capacity for representation, linked to a reactivation in the transference of early and later traumatic traces whose reverberation in the transfero/countertransference dynamic was the source of a painful transference that was responsible for this lateral transference movement. The second sequence shows the links between the strengthening of her capacity for representation, thanks to the working through of the oedipal conflict in its two aspects, and her renunciation of this passion. The roots of this transitory homosexual passion in the deep flaws of her psychical functioning raise metapsychological questions concerning, in particular the dynamic of the 'double' ('twin') and narcissism.

Adult↗

PubMed1982

Extraosseous vascular supply to the mature dog's coxofemoral joint.

Blood vessels supplying the coxofemoral joint were identified and described in 8 healthy, mature dogs. An accurate representation of the blood vessels was obtained by intra-arterial methyl methacrylate injection and sodium hydroxide corrosion of soft tissues until only the pelvis, femurs, and casts of the blood vessels remained. The sources of vascular supply to the dog's coxofemoral joint, from most to least contributory, were the lateral circumflex femoral artery, the medial circumflex femoral artery, the caudal gluteal artery, the cranial gluteal artery, and the iliolumbar artery. In addition, important vascular relationships were demonstrated. Many blood vessels were associated with the periosteal surfaces of the coxofemoral joint in areas of muscular and articular capsular attachment; fewer vessels were present in areas of loose periosteal attachment. Also, extra-articular anastomoses were identified. The most significant anastomosis was an extracapsular vascular ring located at the femoral attachment of the articular capsule. The extracapsular vascular ring was formed by branches of the lateral and medial circumflex femoral and caudal gluteal arteries.

Animals↗

PubMed2003

Representational models associated with fear of failure in adolescents and young adults.

As a descriptive trait, fear of failure (FF) has been associated with serious problems in achievement and health. Psychodynamic theories emphasizing interpersonal processes and early object relations are often used to explain the etiology of FF despite little comprehensive research on such theories in the FF domain. The present study employed the Structural Analysis of Social Behavior to study associations between FF and representational models of self and others among 211 high school and college-aged students and athletes. FF was strongly associated with hostile representational models of self while failing (large effect size). This hostility paralleled the manner in which high FF participants reported being treated by their parents and most significant instructors (all moderate effect sizes). Overall, results supported the complementary nature of these theoretical perspectives and provided further evidence for interpersonal theories of FF.

Achievement↗

PubMedDate not supplied

Six-month-old infants' categorization of containment spatial relations.

Six-month-old infants' ability to form an abstract category of containment was examined using a standard infant categorization task. Infants were habituated to 4 pairs of objects in a containment relation. Following habituation, infants were tested with a novel example of the familiar containment relation and an example of an unfamiliar relation. Results indicate that infants look reliably longer at the unfamiliar versus familiar relation, indicating that they can form a categorical representation of containment. A second experiment demonstrated that infants do not rely on object occlusion to discriminate containment from a support or a behind spatial relation. Together, the results indicate that by 6 months, infants can recognize a containment relation from different angles and across different pairs of objects.

Cognition↗

PubMed1992

Some functions of the self personified by the father.

I have presented clinical material in order to illustrate a series of fantasies of parental intercourse which represent the self in successive stages of individuation from early projective identification to later introjective identification. From this is abstracted the idea of 'father' both as a component of the self representation and as the personification of the urge towards continuing development. Evidence is also gathered from the clinical material, supported by mythological parallels, to suggest that the whole process, including those components explicitly identified with the mother, is subsumed under an identification of the deintegrating self, its identity and integrity, with 'the father'.

Adult↗

PubMed2001

Object loss and object relations in depressive personality analogues.

The author investigated the extent to which self-reported early object loss and Thematic Apperception Test (TAT) measures of object relations differentiated individuals with a depressive personality from dysthymic persons and highly dependent individuals. In an undergraduate analogue sample of 54 students, those with a depressive personality reported a nonsignificantly higher proportion of object loss than did dysthymic and highly dependent participants. Those in the depressive personality and dependent groups had less complex representations of others than did those with dysthymia, and those with a depressive personalitiy and dysthymia tended to view others in a more negative, pessimistic fashion than did the highly dependent individuals. The author concludes that persons with a depressive personality can be identified, in part, by their experience of object loss and their distinctive object relations.

Adult↗

PubMed1975

Differential variations in the DNA of Drosophila melanogaster during development.

Evidence is presented that during development there is active regulation of the information content of the genome of Drosophila melanogaster. This regulation involves a large fraction of the DNA sequences active in transcription. RNA/DNA hybrids formed under the conditions described were primarily with middle repetitive DNA sequences. RNA molecules transcribed from the highly repetitive centromeric DNA sequences or from the attached less repetitive "spacer' DNA (Kram et al., 1972) are not present in larval RNA. The hybrids formed were divided into (a) rRNA hybrids (formed by the two major rRNA species), and (b) non-ribosomal hybrids (formed by hnRNA and mRNA). There was a six-fold reduction in the production of non-ribosomal RNA/DNA hybrid formed with DNA of larvae collected 40 hours after hatching compared with that formed with DNA of eggs and adults. 90 hour larval DNA contained twice the proportion of these sequences present in 40 hour larval DNA. This was not due to the under-representation of the Y-chromosome in polytene tissues, nor could artifacts of extraction account for the differences. These findings are discussed in relation to the "one gene, one chromosome' concept, various anomolies in the behaviour of polytene chromosomes, intercalary heterochromatin and regulation of the content of the genome during development.

Animals↗

PubMed1998

[Feeding disorders in infancy: feeding interaction concept in diagnosis and treatment].

In infancy clinical manifestations of psychological distress are mainly somatic. Feeding disorders are one of the most common and nonspecific manifestations of different kinds of disturbed parent-child relationships. These disturbances may have their origins in the baby's constitution and physical status, in the parent's personality structure, or both, as has been conceptualized in the transactional model of normal and abnormal development. Among the daily interactions a baby has with parents, feeding has special inherent impact on the early parent-child relationship because of its psychological meanings. Therefore, feeding disorders, with or without failure to thrive, often reflect various disorders of infancy, still not well recognized in the medical community, such as regulatory disorders, attachment disorders, depression of infancy, disorders of separation-individuation, and post-traumatic eating disorder. 3 clinical cases are brought to increase awareness of psychological distress in the infant, and of feeding disorders as 1 of its manifestations. Each illustrates a different kind of feeding disorder in terms of etiology and pathogenesis. Through these cases we emphasize the need for a multi-disciplinary, integrative approach in diagnosis and treatment. Our conceptual background is based both on the transactional model of development (infant and parental factors impact on each other) in a very dynamic paradigm, and on psychodynamic premises. Intrapsychic conflicts and past representations impact heavily on the parenting characteristics. We emphasize the psychological significance of disturbed feeding interactions, with or without failure to thrive.

Feeding and Eating Disorders↗

PubMed1992

Maternal separation anxiety: its developmental course and relation to maternal mental health.

Maternal separation anxiety is a construct that describes a mother's experience of worry, sadness, or guilt during short-term separations from her child. This investigation examined potential differences in psychological correlates between mothers with high and low levels of anxiety when their children were 8 months, 3 1/2 years, and 6 years of age. High levels of maternal separation anxiety had different psychological correlates contingent upon the age of the child. Depressive symptomatology and separation anxiety were unrelated at times 1 and 2, but when the children were 6 years old, mothers who had the highest levels of anxiety tended to have more depressive symptomatology, fewer coping skills, a more negative representation of self, and embraced more traditional sex-role values. Study findings are discussed with respect to their relevance to the mother's role as developmental partner to the child and linked to major theoretical perspectives that address the mother-child relationship.

Adaptation, Psychological↗

PubMed1990

Functional construction of the superficial and deep fascia system of the lower limb in man.

The muscular system, the connective tissue and the bones are the components of a biomechanical pelvis-lower extremity model. The occasional electrical events in the muscles were not taken into account, as they can only be measured by physiological methods. In this publication, the connective tissue of the lower extremities is examined. The connective tissue system of the thigh and leg was prepared; after removal of the muscles the so-called 'hollow' lower extremity could be studied. A topographical documentation followed, and the structure and directions of the fibers were observed with polarized light. The connective tissue systems of the lower extremities and bones form a biomechanical, effective and functional system, the bone-fascia-tendon system. The components of the connective tissue in such a system are the fascia lata, the crural fascia, the iliotibial tract, the femoral and crural intermuscular septa, and the membrana interossea. The iliotibial tract is not the sole part of this system having a tension band effect, other components--above all the lateral femoral intermuscular septum--also reduce the forces acting on the bones. Therefore, the tensile strength of the iliotibial tract has to be considered lower as supposed. The iliotibial tract is not a part of the fascia lata; it is an independent, vertically tightened tendon of the 'pelvic deltoid muscle' (gluteus maximus, tensor fasciae latae). The iliotibial tract passes over the greater trochanter like on a roller bearing. It is not attached directly to the greater trochanter and to the lateral femoral condyle, so that previous models have to be modified. The iliotibial tract glides in a fascia bag which is composed of oblique and horizontal fibers of the broad fascia. The iliotibial tract, as tendon of the pelvic deltoid muscle, continues in a lateral location into the leg where it is fixed to the lateral malleolus. The present report provides a new description of the structure of the connective tissue system of the lower extremities. The model reported complies with the laws of similarity mechanics by describing exactly the geometric, physical and functional conditions. This representation could facilitate the construction of a computer-aided, efficient, biomechanical model of the pelvis-lower extremity region considering also the complex functional circumstances, in contrast to previous models. In order to construct such a model, the data obtained by the examination of the connective tissue of the lower extremities have to be given into a data bank, which, however, has to be built up.

Biomechanical Phenomena↗