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At least 559 records · Page 31Linked to original sources
PubMed2004

Colorectal cancer among Yemeni patients. Characteristics and trends.

OBJECTIVE: This study aimed to describe the characteristics and trends of colorectal cancer registered in Aden Cancer Registry. METHODS: A retrospective analysis of all registered cancers (1735) was performed at Aden Cancer Center, University of Aden, Aden, Yemen from the years 1997-2001, to describe colorectal cancers with regards to age, sex and residency distribution, subsites and histopathology, and incidence rates. RESULTS: The results indicate that digestive system cancers are the most common cancers (17.1%); and colorectal cancer (28%) is the most common of these. Developing countries characteristics of this cancer are clear. These include a relatively high proportion of early-onset tumor (19.3% of cases were <40 years), and left sided subsite distribution (49.4% of cases were in the rectum and rectosigmoid junction). CONCLUSION: Further analytical studies, to address the community-related risk factors, public education, and screening programs for colorectal cancer are mandatory.

Adult↗
PubMed1976

Nosocomial staphylococcal cervical lymphadenitis in infants: report of an outbreak.

Staphylococcus aureus infections developed in 16 of 721 infants born at a general hospital during a six-month period (October 1972 to March 1973). Twelve of the 16 affected infants had cervical adenitis, which usually became manifest two to four months after they were discharged from the hospital. Although most infants with adenitis underwent incision and drainage procedures, physicians noted few constitutional symptoms. Staphylococcal phage types from infants with adenitis were identical to phage types commonly recovered from colonized newborns and nursery personnel at the hospital. Despite the long period between hospital discharge and onset of clinical symptoms, cases of cervical adenitis were probably nosocomial in origin.

Cross Infection↗
PubMedDate not supplied

[Lymphogranuloma venereum].

Lymphogranuloma venereum (LGV) or Nicolas-Favre disease is a sexually transmitted disease (STD) which occurs throughout Africa and mostly affects men. The true prevalence of LGV in tropical countries is not known. The most prominent clinical signs of LGV are inguinal and rectal syndrome, with the inguinal syndrome being the most frequent sign in men. Inguinal adenitis is mostly unilateral. The glands are at first hard and tender but soon become matted together. Fistulae may develop within the glands in swollen areas, some of which break through the reddish-purple overlying skin in chronic cases. The groin fold often separates the glands into upper and lower groups. The rectal syndrome is not common in African patients. It is the second most common sign of LGV, but is not specific to this STD. Fluctuant, discharging, painful and often unilateral adenitis with or without a history of primary ulcerative lesion is most likely to be confused with cat-scratch fever, pyrogenic infections, tuberculosis, adenitis caused by syphilis, mycetoma and histoplasmosis. The diagnosis of LGV should be confirmed by culture, which can be used to isolate the L strain of Chlamydia trachomatis or by PCR (polymerase chain reaction). The histological features of adenitis and rectal lesions are not specific. Tetracycline antibiotics are the most effective treatment for LGV.

Adult↗
PubMed1984

Mycobacterial cervical lymphadenopathy. Relation of etiologic agents to age.

Age-related differences in etiology were examined in 214 instances of mycobacterial cervical lymphadenopathy. In adults, Mycobacterium tuberculosis was isolated from 147 lymph nodes and "atypical" mycobacteria was isolated from seven nodes. In contrast, M tuberculosis was isolated from only five nodes from children while other mycobacteria were isolated from 55 nodes. Mycobacterium tuberculosis clearly preponderates as the cause of mycobacterial cervical adenitis in adults while other mycobacteria are the cause of most cervical adenitis in children. The preponderance of Mycobacterium avium-intracellulare in cervical adenitis in children contrasts with reports of Mycobacterium scrofulaceum as the most frequent causative agent in other geographic areas and may reflect either a change in causative agents or geographic differences. However, the finding of M tuberculosis in 8% of nodes indicates that other mycobacteria cannot be assumed to be the only cause of this disease in children.

Adult↗
PubMed1992

Quantitative immunohistologic criteria are superior to the lymphocytic focus score criterion for the diagnosis of Sjögren's syndrome.

OBJECTIVE: The aim of the present study was to evaluate the diagnostic value of quantitative immunohistologic criteria for Sjögren's syndrome (SS) in labial salivary gland biopsies. METHODS: Quantitative immunohistologic examination was performed on labial salivary gland biopsy samples from 80 healthy controls, 32 patients with primary SS, 14 patients with secondary SS, 5 with "probable" SS, 36 with keratoconjunctivitis sicca (KCS) with a lymphocytic focus score less than 1 on the lip biopsy, and 18 with rheumatoid arthritis (RA) without clinical evidence of SS. RESULTS: This is the first study to show that immunohistologic criteria for SS, based on the percentages of IgA-containing and IgG-containing plasma cells, are able to 1) confirm the diagnosis of SS in labial salivary glands of KCS patients in the absence of grade IV lymphocytic adenitis; and 2) distinguish between a grade IV focal lymphocytic adenitis in the labial salivary glands of SS patients and of RA patients without SS. CONCLUSION: Quantitative immunohistologic criteria were shown to be much more sensitive and disease specific than the widely accepted grade IV lymphocytic adenitis criterion, which corresponds to a lymphocytic focus score greater than 1, and these criteria should be included in the international diagnostic criteria for Sjögren's syndrome.

Adolescent↗
PubMed1999

Lymphadenitis due to nontuberculous mycobacteria in children: presentation and response to therapy.

The most common manifestation of infection due to nontuberculous mycobacteria (NTM) in children is cervical lymphadenitis in an otherwise healthy patient. We identified and reviewed 19 cases of proven or presumptive lymphadenitis due to NTM seen at our hospital over the course of 13 months. Nine patients underwent initial surgical excision of involved lymph nodes. Ten children did not have involved lymph nodes excised initially and were treated with macrolide-containing antibiotic regimens. Of these patients, five required subsequent surgical excision and five were cured with combination chemotherapy. Six patients underwent radiographic imaging of the head and neck that revealed asymmetrical adenopathy with ring-enhancing masses but minimal inflammatory stranding of the subcutaneous fat, a finding that may distinguish adenitis caused by NTM from staphylococcal and streptococcal adenitis. Our data suggest that if surgical excision is not considered feasible, antimicrobial therapy for adenitis due to NTM may be beneficial for some patients.

Anti-Bacterial Agents↗
PubMed1995

Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1.

Bartonella (Rochalimaea) henselae causes a variety of diseases, including bacillary angiomatosis, peliosis hepatis, lymphadenitis, aseptic meningitis with bacteremia, and cat-scratch disease (CSD). Cases of B. henselae-related disease were collected from September 1991 through November 1993. Patients with suspected CSD, unexplained fever and lymphadenitis, or suspected B. henselae infection who were seen in the Infectious Diseases Clinic at Wilford Hall Medical Center (Lackland Air Force Base, TX) underwent physical and laboratory examinations. In addition to three previously described cases, 23 patients with R. henselae-related infection were identified. The patients included 19 immunocompetent individuals presenting with lymphadenitis (11), stellate neuroretinitis (5), Parinaud's oculoglandular syndrome with retinitis (1), chronic fatigue syndrome-like disease (1), and microbiologically proven adenitis without the presence of immunofluorescent antibodies to B. henselae (1) and four patients infected with human immunodeficiency virus type 1 presenting with isolated lymphadenitis (1), diffuse upper-extremity adenitis (1), neuroretinitis (1), and aseptic meningitis (1). A couple with neuroretinitis and their pet cat, a persistently fatigued patient, and a patient with Parinaud's oculoglandular syndrome were shown to have bacteremia. Tissue cultures were positive for B. henselae in three recent cases of adenitis. Twenty-two patients were exposed to cats. This series further demonstrates the similarities between B. henselae-related diseases and CSD and identifies several new syndromes due to B. henselae.

Adolescent↗
PubMed2004

Nontuberculous mycobacteria-induced parotid lymphadenitis successfully limited with clarithromycin and rifabutin.

OBJECTIVES/HYPOTHESIS: Nontuberculous mycobacterial adenitis of the parotid gland is often difficult to diagnose. The rarity of these infections in the parotid region and the lack of specific guidelines pose a treatment challenge to the clinician. Three cases of nontuberculous mycobacterial adenitis are presented, with clinical response to antibiotics before surgery. STUDY DESIGN: Retrospective chart review was made of children up to 18 years of age presenting with a parotid mass diagnosed as nontuberculous mycobacterial infection. METHODS: Three patients (age range, 15 to 30 mo) with nontuberculous mycobacteria-induced parotid lymphadenitis were treated with a combination antibiotic regimen of clarithromycin and rifabutin or with clarithromycin alone. RESULTS: All three patients responded clinically to the antibiotic treatment as evidenced by a smaller mass size and resolution of the overlying discoloration. Subsequent parotidectomy or biopsy appeared to be easier to perform because of decreased inflammation and edema and a more readily dissectible facial nerve. CONCLUSION: Children with nontuberculous mycobacteria-induced parotid lymphadenitis should be started on a trial of antibiotic treatment before surgery. Although surgery remains the definitive treatment modality, a larger study of preoperative antibiotic use against nontuberculous mycobacterial adenitis of the parotid in children is necessary.

Anti-Bacterial Agents↗
PubMed1994

S100-positive histiocytes in T-cell-dependent area in human lymph nodes express P-glycoprotein.

In the present study, we examined P-glycoprotein (P-gp)-expressing cells in human lymph nodes (LN) from patients with reactive lymph adenitis and various malignant lymphomas (ML). MDR1 mRNA was detected in all reactive LN and in 8 of 10 ML samples examined by reverse transcription polymerase chain reaction (RT-PCR). The signal intensity of the bands was stronger in samples from T-cell ML LN than in those from LN of reactive lymph adenitis and B-cell ML. Immunohistochemistry also showed positive reactivity with cellular components in the LN. The P-gp-positive cells, detected by UIC2, in reactive lymph adenitis and ML samples were large in size in the T-cell-dependent paracortical area in LN. Further, morphological characteristics were similar in UIC2-positive cells between reactive and ML LN. Double staining with UIC2 and a hematopoietic cell lineage-specific monoclonal antibody showed that UIC2-positive cell co-expressed S-100, but not other lymphocyte- and ML cell-specific antigens, indicating that these cells correspond to histiocytes in the T-cell-dependent paracortical area. Our results show that P-gp was expressed in histiocytes but not ML cells in LN, and suggest that this molecule may play an important role in the biological function of histiocytes and/or for maintenance of homeostatic levels in T-cell ML LN.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMed1990

Histologic assessment of the submandibular glands in autoimmune-disease-prone mice.

Submandibular glands were examined from three autoimmune-disease-prone strains of mice (NZB/W, MRL/l and MRL/n) and controls (C57BL/6J). Focal lymphocytic adenitis was more prevalent and more severe in autoimmune-disease-prone strains than controls and in females than males. Lymphocytic foci were more frequent in older age groups, but female MRL/1 mice exhibited high levels of focal lymphocytic adenitis irrespective of age. Salivary parenchyma was generally well preserved. In the strain-age groups with the highest focal lymphocytic scores proportional acinar volumes were significantly less than in controls. However, the proportion of acinar tissue showed no consistent relation to the severity of focal lymphocytic adenitis across all strains and age groups of either sex. Sexual dimorphism in granular duct prominence was weakened in NZB/W and MRL/l strains compared to controls.

Aging↗
PubMed1988

Pathological findings in the bulbourethral glands of bulls.

The bulbourethral glands of 323 Bos indicus or B. indicus crossbred bulls more than 1 1/2 years old were examined in an abattoir study. Bulbourethral adenitis was diagnosed grossly and confirmed by histological examination in 4 (1.2%). Unilateral chronic interstitial inflammation was seen in 2 cases; one of these was associated with a degenerative-type seminal vesiculitis. In the others adenitis was bilateral; in one case it was associated with a concretion and foreign (plant) material in the principal duct of the left bulbourethral gland; in the other bilateral case, numerous calculi were present and microscopically, a chronic active and diffuse inflammation was observed. Chemical analysis of the calculi showed calcium oxalate and tricalcium phosphate to be the most important components. Corynebacterium spp was isolated from the lesion with multiple calculi but attempts to isolate Chlamydia spp, Mycoplasma spp and Brucella abortus from the 4 adenitis cases were unsuccessful. Congenital abnormalities such as glandular fusion (2.2%) or unilateral aplasia (0.6%) were also observed. Cysts were the most common finding (19.2%), and duct dilation was frequent (7.1%). The significance of these findings in relation to fertility is considered.

Animals↗
PubMed2006

Complications associated with the bacille Calmette-Guérin vaccination in Ireland.

INTRODUCTION: BCG vaccination is currently recommended for all newborns in Ireland except where specifically contraindicated. This paper describes a marked increase in the number of referrals of patients with localised complications after vaccination to two Dublin paediatric hospitals. This increase coincided with the introduction of a new strain of BCG vaccine METHODS: A population surveillance study was undertaken to determine the frequency and spectrum of complications associated with the new strain of BCG vaccine introduced in Ireland. Patients were identified though review of the infectious disease service case records and microbiology laboratory culture reports for the two year period from August 2002 to July 2004. Prospectively gathered data were supplemented by retrospective chart review. All infants who had inoculation site abscesses, suppurative adenopathy, or non-suppurative adenopathy with nodes > or =2 cm were included. RESULTS: Fifty eight patients presented a median of 13 weeks post-inoculation: 32 with suppurative adenitis, 17 with inoculation site abscess, three with both inoculation site abscess and suppurative adenitis, and six with non-suppurative adenopathy. The overall complication rate was estimated at 1/931 vaccinees with 1/1543 developing suppurative adenitis. Twenty six infants required surgery. DISCUSSION: This series illustrates the role of hospitals in sentinel surveillance and highlights the importance of having a well functioning and responsive system of adverse event reporting. These events raise a serious question as to the suitability of this vaccine strain for use in a national immunisation programme in a country where the prevalence of tuberculous disease is 10.4/100,000.

Abscess↗
PubMed1970

Lymphocytic sialadenitis in the major and minor glands: a correlation in postmortem subjects.

In the present investigation, the prevalence of focal lymphocytic adenitis in the submandibular salivary gland was observed in a series of 116 postmortem subjects after suitable exclusions had been made. Focal lymphocytic adenitis could not be demonstrated in the labial salivary glands. The degree of lymphocytic infiltration in the labial salivary glands is positively correlated with the level of focal lymphocytic adenitis in the submandibular glands in the same subject. Lymphocytic foci and lymphocytic infiltrations found under these circumstances are probably related. This finding provides conceptual support for the examination, by biopsy, of the labial glands in patients suspected of Sjögren's syndrome.

Adult↗
PubMed2001

Lymphatic filariasis in children: adenopathy and its evolution in two young girls.

Lymphatic filariasis is a widespread infectious disease of children in endemic areas, but little is known about the early lymphatic damage in children and its evolution, either with or without treatment. Two girls (ages 6 and 12 years) from a Wuchereria bancrofti endemic region of Brazil presented with chronic inguinal adenopathy. Neither had microfilaremia. By ultrasound both were shown to have living adult worms in their enlarged inguinal nodes and had occult local lymphatic damage (lymphangiectasis). One girl spontaneously developed acute adenitis in the affected node prior to any intervention; this adenitis resolved within 10 days and was associated with the progressive disappearance over 45-90 days of all local abnormalities detectable by ultrasound. In the other child, after treatment with a single dose of diethylcarbamazine (DEC), the same clinical picture of transient adenitis and resolving abnormalities (detectable by ultrasound) occurred. These findings demonstrated filariasis as the cause of adenopathy in children, and also both spontaneous and treatment-induced worm-death, with subsequent reversal of lymphatic abnormalities.

Animals↗
PubMed1999

[Cat-scratch disease: series of 14 cases. The diagnostic usefulness of serology].

BACKGROUND: Disease by cat scratch (CSD) is a syndrome characterized by regional adenopathies following cat scratch or bite. Despite knowing the etiologic agent of the same, there is still controversy in the diagnosis of the syndrome in daily clinical practice. MATERIALS AND METHODS: The cases of CSD diagnosed from 1990 to 1997 with positive serology for Bartonella henselae performed by indirect immunofluorescence were reviewed. RESULTS: In 13 out of the 14 patients studied direct contact with cats was reported. Lymph node involvement corresponded to the following regions: axillary (57%), inguinal (28%), epitroclear (21%), cervical (14%), and periauricular (7%). In 35% of the cases, several territories were involved. In 3 patients the adenopathies were fluctuating. Eleven anatomopathologic studies were performed with 6 diagnoses of granulomatous adenitis, 3 reactive adenitis and 2 purulent adenitis. The serology for Bartonella henselae was positive in all the patients with a range of 1/64-1/256. The evolution was favorable in all the patients. DISCUSSION: Interpretation of the results of serology should be cautions and always related to the clinical and epidemiological picture of the patient. This technique should be considered as another criteria in the diagnosis of cat scratch disease to the detriment of the cutaneous test.

Adolescent↗
PubMed1999

[Diagnosis of lymphadenopathy in children: role of fine needle aspiration biopsy].

BACKGROUND: Lymphadenopathy in children can be a challenging clinical situation that requires a careful approach. AIM: To report the experience with fine needle aspiration biopsy for the diagnosis of lymphadenopathy. PATIENTS AND METHODS: Analysis of 95 pediatric patients, aged 3 months to 19 years old, referred by primary care physicians for the study of lymphadenopathy. All were subjected to a complete medical examination, laboratory tests and fine needle aspiration biopsy. RESULTS: Seventy seven per cent of enlarged lymph nodes were located in the neck. Fine needle aspiration showed a hyperplastic adenitis in 44 patients (46%). In 13 patients, an infectious adenitis, sometimes suppurated was observed. In 9 patients a BCG or tuberculous adenitis with caseum was found. In 13 patients, cytology disclosed a non lymphatic mass, in four patients a Hodgkin disease and in one, malignant cells of unknown origin. Four patients had a normal lymph node and in 2 the sample was insufficient for cytological analysis. CONCLUSIONS: Fine needle aspiration biopsy is a simple and safe diagnostic method for lymphadenopathy in children.

Adolescent↗
PubMed1991

[Invasion of human lung adenocarcinoma cell line LTEP-a2 into various organs of different species].

The invasiveness of human lung adenocarcinoma cell line LTEP-a2 was investigated in co-culture system of tumor cells and fragments of the heart and liver from the newborn, rabbit and rat. It was found that the tumor cells had different invasive behaviors, for example cell diastrophism, proliferation or invasion speed and adenic formation when invading various species or various organs in the same species. When invading the fragments of newborn heart and liver, strong cell diastrophism potential, cell twist or formation of multiprocess pseudopodia and mitosis could be observed. The result was contrary to the above when the fragments of rat heart and liver were used as the target. When the fragments of rabbit liver were invaded, marked adenization was formed by cancer cells with the invading speed increased. However, the adenic structure was absent as the heart fragments of rabbit were invaded. The results indicate that target organs could change biological behavior of the invading tumor cells to different degrees even their differentiation. It may be related to structure and biochemical property of the target organs.

Adenocarcinoma↗
PubMed1980

[Chronic granulomatous disease: clinical and functional studies in six cases (author's transl)].

Six cases of chronic granulomatous disese (CGD), three of which correspond to the X-linked genetic form and the three other to the autosomic recessive type are reported. The fact of half of the patients being females is relevant as only 24 are cited by Klebanoff and Clark in their revision in 1978. X-linked CGD: The three patients, two of them brothers, presented their first manifestations in the first year of life; in one of the BCG given at one week of life resulted in adenitis of protracted course with calcificaton. The clinical course has been very severe in two of them. At the present time the patients are 15, 11 and 9 years old. Functional studies have shown very low values in NBT tests, O2 consumption, iodination and bactericidal activity in all three. Intermediate values in the mothers and normal values in the fathers were found. Autosomal CGD: Of our three patients, two were sisters. The first manifestations appeared during the first thrimester of life. The eldest had hepatic and pulmonary granulomata at three years old. At five years, she presented an intestinal obstruction syndrome with gastric antral, duodenal and ileal stenosis caused by intramural granulomata and inflammation; she died of pneumonia shortly after. Her sister had dermatitis, hepatic abscess, pneumonia, adenitis and osteomyuelitis of the ribs; she died at six years old after a bronchopneumonia. Last patient had a sister who died at two years old affected probably gy CGD. At present our patient is 17 months old and so far had recurrent otitis, adenitis, a pneumonia and, recently, hepatic granulomata have been found. Fonctional studies in the two sisters showed similar alterations as those of the three boys. In this patient an alteration of chemotaxis of cellular origen was found as well.

Adolescent↗