Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “borderline”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 541 records · Page 30Linked to original sources
PubMed1982

Physical training of middle-aged men with borderline hypertension.

The aim of the study was to clarify the feasibility of physical training for middle-aged borderline-hypertensive males. Blood pressure of 59 subjects was followed for nine months, whereafter 25 persons were classified as borderline-hypertensive and 34 persons as normotensive. Both groups were randomly allocated into training and control groups. Training lasted for four months, of which the first two included supervised bicycle ergometer exercise. During the last two months training was unsupervised. After training estimated maximal oxygen consumption increased significantly both in borderline-hypertensive and normotensive men. After training resting diastolic blood pressure decreased significantly both in training and control groups. This finding supports the importance of sufficiently long follow-up of blood pressure before eventual drug therapy when blood pressure is mildly elevated. Diastolic blood pressure during 50-minute ergometer exercise was decreased after four months of training in borderline-hypertensives and did not any longer differ from that of normotensives. Individually prescribed physical training is worth regarding as one treatment modality for middle-aged borderline-hypertensive patients.

Blood Pressure↗
PubMed1980

[Borderline hypertension].

As to blood pressure values between 18.66 kPa and 21.14 kPa systolically and/or 11.99 kPa and 12.52 kPa diastolically according to the WHO-definition is spoken of borderline hypertension. In consequence of high rates of prevalence and incidence also in the borderline hypertension a particular preventive-medical interest is present. Own investigations yielded for 50 to 54-year-old males (n = 281) prevalence rates of 29% and for factory populations (n = 6,646 males and females) on an average 20.7%. Parallel to the results in hypertension in borderline hypertension in all age groups higher mean values of the triglycerides and of cholesterol were observed in normotonics. Under hormonal contraception in certain age groups (30--34, 35--39 and 40--49 years) altogether significantly higher systolic and diastolic values of blood pressure were found then in females without oral anticontraceptives. Within a clinical-ambulatory preventive programme performed for 8 years borderline hypertonics did not show any significant differences to the control group concerning the distribution of frequency of essential organ complications and the mortality. According to the present state of knowledge a permanent treatment of the borderline hypertension with substances reducing blood pressure still cannot be justified immediately.

Adult↗
PubMed1995

Detailed deletion mapping of chromosome 6q in borderline epithelial ovarian tumors.

We have used PCR amplification of tandem repeats and Southern blot analysis to study the pattern of allelic loss at chromosome 6q in borderline ovarian tumors and compared that with invasive ovarian carcinomas. DNA from 46 borderline ovarian tissues, 20 invasive ovarian tumor tissues, together with corresponding uninvolved (control) tissues was used. The invasive tumors demonstrated the highest percentage of loss of heterozygosity (13 of 45 informative cases, 29%) at the 6q25-27 locus site. In contrast, the borderline ovarian tumors showed only an 11% frequency of loss of heterozygosity (3 of 26). Our results display a sharp contrast in the pattern of loss of heterozygosity between invasive and borderline ovarian tumors and suggest that allelic loss at chromosome 6q may not be involved in the development of borderline ovarian tumors.

Alleles↗
PubMed1995

[A case-control study on risk factors for definite and borderline hypertension].

To study the risk factors for definite and borderline hypertension (HBP), a pair-matched case-control study was conducted with data from the outpatient service of department of internal medicine in Tianjin Binjiang Hospital in 1991-1992. The cases were selected from 312 patients with definite and borderline HBP diagnosed during period 1990-1992 and those newly identified during the survey. The controls were selected from other subjects with no histories of cardiovascular disease and matched by age and sex. The conditional logistic regression model was used by definition of definite and borderline HBP for analysis. The results showed that the risk factors for developing definite or borderline HBP were: family history of HBP, lower level of education, higher weight or body mass index (kg/m2). The association of all these variables with definite HBP were more significant than that with borderline HBP.

Body Weight↗
PubMed1993

Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy.

The mutation of K-ras protooncogene was examined in 44 cases of borderline ovarian epithelial tumors and 18 cases of invasive ovarian carcinomas. In borderline tumors, K-ras mutations are a common feature, having been found in 21 of 44 cases (48%). Twenty of the 21 mutations were identified at codon 12, and one was identified at codon 13. A detailed analysis of the mutation pattern of K-ras revealed a close association with the histological cell types of the tumor. Mutation of K-ras was detected at a higher frequency in mucinous borderline tumor (identified in 12 of 19 cases) compared to serous borderline tumor (identified in 9 of 25 cases). K-ras mutation was also detected in invasive mucinous and serous ovarian carcinomas, hence supporting the notion that borderline ovarian tumors may represent a pathological continuum between benign and frankly invasive diseases.

Adenocarcinoma, Mucinous↗
PubMed1996

Prognosis and management of borderline tumours of the ovary.

The 5-year survival for women with stage I borderline tumours is favourable, about 95-97%, but the 10-year survival is only between 70 and 95%, caused by late recurrence. The 5-year survival for stage II-III patients is 65-87%. A more correct staging procedure, classification of true serous implants and agreement on the contribution to stage of the presence of gelatinous ascites in mucinous tumours may in the future change the distribution of stage and survival data by stage for women with borderline tumours. Independent prognostic factors in patients with epithelial ovarian borderline tumours without residual tumour after primary surgery are DNA ploidy, International Federation of Gynecology and Obstetrics stage, histologic type and patient age. Future questions to be addressed include the following: (1) Have patients with borderline tumours in general been overtreated and how should these patients be treated?; (2) How to define the high-risk patient?; (3) In which group of patients is fertility-sparing surgery advisable?; and (4) Do patients with borderline tumours benefit from adjuvant treatment?

Age Factors↗
PubMedDate not supplied

Numerical chromosomal aberrations in borderline, benign, and malignant epithelial tumors of the ovary: correlation with p53 protein overexpression and Ki-67.

OBJECTIVE: Ovarian tumors of low malignant potential (borderline tumors) have a 5-year survival rate of 69-98%, illustrating that while the prognosis is better than in the typical epithelial carcinoma, a significant number of women still succumb to this disease. The aim of our study was to elucidate the role of numerical chromosomal aberrations in borderline tumors of the ovary in comparison with benign and malignant epithelial tumors in an effort to develop parameters to differentiate prospectively borderline lesions from benign and invasive tumors. METHODS: Cytologic imprints of surgical specimens of 46 ovarian tumors of low-malignant potential, 17 invasive epithelial carcinomas of the ovary, and 18 benign epithelial tumors of the ovary were examined for numerical chromosomal aberrations (trisomy 7, trisomy 12, and trisomy 17) by fluorescence in situ hybridization (FISH). RESULTS: In benign tumors no evidence of trisomy 7 and 17 was present. Trisomy 12 was detected in six cases (33.3%). We did not find p53 protein overexpression in any case. Ki-67 stained positive in three cases (16.7%). In borderline tumors trisomy 12 was detected in 33 patients (71.7%). Numerical aberrations of chromosome 17 were absent in all cases. Fourteen patients (30.4%) showed trisomy 7. No immunohistochemical staining reaction for p53 protein was found. Staining of the proliferation marker Ki-67 was observed in two cases (4.3%). In malignant epithelial tumors of the ovary, trisomy 7, trisomy 12, and trisomy 17 were detected in 14 (82.3%), 11 (64.7%), and 5 (29.4%) cases, respectively. Four tumors (23.5%) showed immunohistochemically detected p53 protein overexpression. Thirteen tumors (76.5%) stained for Ki-67. CONCLUSION: Our results indicate that trisomy 7 argues against benign disease. Trisomy 17 was specific for invasive disease, while trisomy 12 is common in borderline tumors of the ovary.

Adult↗
PubMed1987

Are there differences between borderline and other personality disorders?

Using the method of blind retrospective evaluation of clinical records, 26 DSM-III borderline and 27 DSM-III nonborderline personality disorders were compared. Apart from the younger age of borderline patients, no really important differences emerged between the groups in the sociodemographic and clinical variables studied. It is possible that differences between borderline and nonborderline personality disorders are limited to the different phenomenology as defined by the respective diagnostic criteria. The borderline diagnosis proves to be a workable tool for further explorations, although its clinical justification remains to be demonstrated.

Adult↗
PubMed1984

Psychobiology of the borderline disorders--a heuristic approach.

A psychophysiologic approach to understanding borderline behavior is presented in which psychological and biological explanations complement, rather than exclude, one another. Descriptive-objective diagnoses or a target symptom approach are not sufficient to explain borderline behaviors. Phenomena are described that suggest underlying pathophysiologic processes, although they are usually accorded ego psychological explanations. Their underlying common denominator may be inadequate limbic system "filtering" of irrelevant stimuli. Each patient must be seen as an individual, rather than be fitted to a chosen model. Though the borderline constitutes a unique descriptive category, borderline behaviors result from processes generalizable across a broad range of psychopathology.

Arousal↗
PubMed2004

Update on pharmacotherapy of borderline personality disorder.

Pharmacotherapy is a very common form of treatment for borderline personality disorder or its concomitant disorders. This paper reviews all the open-label and placebo-controlled trials of second generation medications studied in samples of well-defined borderline patients. Most of the medications studied in double-blind, placebo-controlled trials were efficacious. Most of these medications were also useful in treating symptoms of affective dysregulation and impulsive aggression, which have been suggested to be the core dimensions of psychopathology of underlying borderline personality disorder. Taken together, the results of these studies suggest that the choice of medication can be guided as much by tolerability and safety as by symptom presentation. It also suggests that the common practice of polypharmacy, which has no empiric support, may be unnecessary for most patients with borderline personality disorder.

Affect↗
PubMed1989

Auditory P300 does not differentiate borderline personality disorder from schizotypal personality disorder.

The P300 response to an auditory two-tone discrimination task has previously been reported to have prolonged latency and reduced amplitude in schizophrenia and borderline personality disorder. In this study, P300 was recorded from 23 subjects with borderline personality disorder, 12 subjects fulfilling criteria for both borderline and schizotypal personality, and 11 subjects with schizotypal personality. The mean P300 latency was similar in each of these groups and was significantly longer than in 32 patients with neuroses and other personality disorders and 74 nonpatient controls. These findings suggest that borderline and schizotypal patients share a similar abnormality in auditory stimulus evaluation and question whether or not these disorders are separate.

Adolescent↗
PubMedDate not supplied

Childhood experiences of borderline patients.

The childhood histories of 50 outpatients meeting both Diagnostic Interview for Borderlines (DIB) and DSM-III criteria for Borderline Personality Disorder, 29 outpatients meeting DSM-III criteria for Antisocial Personality Disorder, and 26 outpatients meeting DSM-III for Dysthymic Disorder as well as DSM-III criteria for some other type of Axis II disorder were assessed, blind to proband diagnosis, using a semistructured interview. Borderlines were significantly more likely than those in either control group to report a history of abuse, particularly verbal and sexual abuse. They were also significantly more likely than antisocial controls to report a history of neglect, particularly emotional withdrawal, and significantly more likely than dysthymic other personality disorder controls to report a history of early separation experiences. The authors conclude that the development of Borderline Personality Disorder is more strongly associated with (1) exposure to chronically disturbed caretakers than prolonged separations from these same adults and (2) a history of abuse than a history of neglect.

Adolescent↗
PubMedDate not supplied

Predicting outcome for borderline personality disorder.

The purpose of this study is to identify variables predictive of the psychosocial outcomes of borderline patients 2 years following an acute psychiatric hospitalization. Of the initial 88 inpatients scoring positive for the Diagnostic Interview for Borderlines (DIB), 65 (73.8%) were reinterviewed, 14 (15.9%) refused, five (5.7%) were unable to be located, and four (4.6%) suicided. The dropouts (n = 19) were significantly more likely to be single, separated, or divorced, to be male, and to be diagnosed as having co-existing antisocial personality disorder than the followed-up probands (n = 69). In terms of global functioning, over the 2-year follow-up period, 61 (87.7%) of the 69 probands were judged to be functioning normally less than 50% of the follow-up interval. Using logistic regression, two variables, initial impulse action scores and poor premorbid functioning, predicted poor versus good outcome. This study supports the literature, which indicates that the early course of borderline personality disorder (BPD) is stormy. Impulsivity and poor premorbid functioning may be predictive of poor short-term outcome in borderline patients.

Adult↗
PubMedDate not supplied

Is there a neural basis for borderline splitting?

It is proposed here that borderline splitting and borderline pathology may have a neural basis. For the infant who splits its emotional and cognitive constitution of its mother during separation-individuation, the "good mother"--"bad mother" engram may be lateralized in the brain in a different way than for an infant who does not use this defense. The infant may be developmentally vulnerable to the effects of splitting during separation-individuation (18 to 36 months) because interhemispheric communication necessary for mental unity is not possible at this time, since neurons connecting left and right hemispheres are not totally myelinated and because the infant has not yet fully acquired language, a prerequisite for an integrated psychological reality. Two separate, unintegrated--and alternating--mental systems may come into being. Later, as myelination is completed, the infant's split emotional and cognitive constitutions of mother and of self may create a neural "template" for splitting all further experience and behavior through the two separate, alternating mental systems. The possibility that emotional trauma occurring later than separation-individuation, and involving other issues, may be the occasion for splitting is considered, as well as the possibility that a congenital abnormality in brain structure or function may be a primary factor in borderline pathology. Ways to test the hypothesis that borderline splitting has a neural basis are suggested.

Borderline Personality Disorder↗
PubMedDate not supplied

Cognitive and perceptual distortions in borderline personality disorder and schizotypal personality disorder in a vignette sample.

Clinical vignettes of patients with borderline personality disorder (BPD) and schizotypal personality disorder (STPD) were evaluated and rated for evidence of cognitive and perceptual distortions. The differences in the distortions of each group were then compared. The findings show that while STPD patients have significantly more cognitive and perceptual distortions than borderlines, there is an abundance of such distortions in the borderline group. The borderline group may differ, moreover, in that their cognitive and perceptual distortions were found to be significantly more object-related than those of the schizotypal group.

Borderline Personality Disorder↗
PubMedDate not supplied

Differential perception of parental bonding in schizotypal and borderline personality disorder patients.

Fifty-four patients with schizotypal and/or borderline personality disorders were compared with 165 patients with other personality disorders and 52 patients with no personality disorders as to their perception of parental behavior in childhood. Both schizotypals and borderlines reported low care; however, schizotypals remembered underprotection and borderline overprotection. The study suggests parental neglect in the childhood memory of schizotypals and negative over-involvement for borderlines.

Adolescent↗
PubMed1984

Psychopathology of the physically abusing parent: a comparison with the borderline syndrome.

This article compares the psychopathology of the physically abusing parent and that of the borderline patient in four specific areas: common personality characteristics; personal history; psychopathology; and psychodynamics of the abusive act. The first major personality characteristic is the umbrella characteristic of arrested emotional development, the other four characteristics are: poor self image, emotionally isolated, depressive loneliness and poorly suppressed aggression. These correlate with the four major characteristics of the core borderline personality. The personal history for both abusing parents and borderline patients indicate maternal deprivation in preverbal development. The abusing parent's psychopathology is very similar to that of the borderline patient. They both have poor ego strength, a punitive superego and use primitive ego-defenses of denial, splitting and projection. The act of abuse is related to these ego defects but in particular projective identification plays a major role. Further research is indicated and tentative implications are made as regards psychodynamically oriented treatment.

Adult↗
PubMed1991

Relationship of depression and cognitive impairment to self-injury in borderline personality disorder, major depression, and schizophrenia.

Self-injury was studied in 64 adults with borderline personality disorder, major depression, or chronic paranoid schizophrenia. Subjects were rated according to acute depression, chronic depression, self-injurious behaviors, and neurocognitive deficits, as measured by cognitive function examination. Borderline patients showed more self-injurious behaviors and more chronic depressive symptoms than the major depression or schizophrenia groups. Self-injury was not significantly correlated with acute or chronic depression in any group, but self-injury was correlated with neurocognitive deficits in borderline and schizophrenic groups. The results are explained in the context of a neurocognitive model of psychotic thought process in borderline disorder and schizophrenia.

Adaptation, Psychological↗