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At least 541 records · Page 30Linked to original sources
PubMed2005

A case of Kaposi varicelliform eruption in Darier-White disease.

Darier-White disease (DWD), otherwise known as keratosis follicularis, is a rare disorder of keratinization of the epidermis, mucous membranes, and nails. It is autosomal dominant in transmission. Patients with DWD are prone to frequent superinfection including the rare complication of Kaposi varicelliform eruption. It is postulated that a defect in cell-mediated immunity may contribute to this predisposition.

Acyclovir↗
PubMedDate not supplied

[Valaciclovir-related neuro- and nephro-toxicity in two geriatric patients].

BACKGROUND: Valaciclovir (VAL) is the L-valyl ester of acyclovir and it is quickly hydrolysed to acyclovir. Acyclovir-related nephrotoxicity is associated with high drug infusion doses and VAL-related neurotoxicity to pre-existing renal failure. We observed two geriatric patients with normal serum creatinine who developed acute renal failure (ARF) and neurotoxicity after ingesting the drug at the conventional therapeutic dose. CASE REPORTS: The first patient was a 77-year-old female admitted to the intensive care unit because of anuria associated with coma and respiratory insufficiency. Baseline serum creatinine (Scr) was 0.9 mg/dL. Four days previously she had started VAL 1 g/bd for cutaneous HZ. Scr was 7 mg/dL and urinary output was <100 cc/24 h. The patient was ventilated and hemodialysis (HD) was started. After 6 days her urinary output increased and dialysis was discontinued. Two weeks after admission, Scr was 1.5 mg/dL, ventilation was discontinued and her consciousness level was normal. The second patient was a 73-year-old male. Baseline Scr was 0.7 mg/dL. He started VAL 1 g/TD because of hepatic cheratitis. After 4 days, he developed oliguria and stupor. At admission, Scr was 5.5 mg/dL, potassium was 6 mEq/L and the patient was unconscious. After drug withdrawal the diuresis increased and his consciousness level returned to normal. After 7 days Scr was 0.9 mg/dL. COMMENT: The clinical evolution suggested that the syndrome was related to the antiviral therapy. ARF preceded neurotoxicity. We suggest that high bioavailability, reduced glomerular filtration rate (GFR) related to age, and possibly the simultaneous ingestion of other drugs could have caused these side effects. We recommend the emphasis on potential side effects of antiviral therapy when treating geriatric patients even if Scr is in the normal range.

Acyclovir↗
PubMed2005

[Antiherpetic therapy].

The development of the antiherpetic therapeutical system was remarkable in the last decade. Nucleoside analogs (5-iodine-2-deoxiuridine, citodine-arabinotide, adenine-arabinotide), as well as specific inhibitors of viruses (Zovirax or Acyclovir) are active medicines for both local and wide-spread forms of the herpes virus infection.

2-Aminopurine↗
PubMed2004

Is viral shedding a surrogate marker for transmission of genital herpes? A discussion document.

While the concept linking herpes simplex virus (HSV) shedding to transmission is plausible, few data support shedding as a surrogate marker. If shedding is to be used as a surrogate marker in future clinical studies, it must be clear how far shedding must be reduced, and what the shape of the transmission:viral load curve (or transmission:detection frequency curve) is before transmission is reduced. It remains unclear whether peak virus load, frequency of detection of virus, or the area under curve of the time:virus load plot is the critical parameter in the transmission of HSV. This paper reports on an international meeting of experts and a debate at the International Herpes Management Forum (IHMF) Annual Meeting (2004), convened to examine whether a surrogate marker for HSV transmission is necessary, and whether there is any evidence, either in studies involving HSV or other viral infections, to suggest that viral shedding could be used as such a surrogate.

2-Aminopurine↗
PubMed2005

Genital herpes.

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2-Aminopurine↗
PubMed2005

Cytomegalovirus DNAemia and disease: incidence, natural history and management in settings other than allogeneic stem cell transplantation.

BACKGROUND AND OBJECTIVES: Despite increasing intensity and profound immunosuppression associated with newer therapies for hematologic malignancies, little information exists regarding cytomegalovirus (CMV) reactivation in settings other than allogeneic stem cell transplantation (SCT). DESIGN AND METHODS: We reviewed the epidemiology of CMV disease in patients who were CMV polymerase chain reaction (PCR) positive during treatment for hematologic malignancies without allogeneic SCT from June 1999 to June 2004. RESULTS: Thirty-six patients with CMV reactivation were identified. Of these, 92% were undergoing investigation for fever. Fifteen patients with CMV DNAemia were treated with ganciclovir without CMV disease developing. Notably, 20 patients with untreated CMV DNAemia did not develop CMV disease during a median follow-up of 3.5 (1-19) months. The highest rates of reactivation were observed with HyperCVAD (7.8%) and alemtuzumab (50%). INTERPRETATION AND CONCLUSIONS: We recommend that screening for CMV DNAemia be instituted and pre-emptive therapy contemplated for asymptomatic CMV reactivation only in patients receiving alemtuzumab therapy, but not routinely for other patients outside the allogeneic SCT setting. Indeed for such patients, detection of isolated CMV DNAemia does not imply the need for immediate therapy and future studies are needed to validate PCR detection of CMV DNA and CMV DNA titers as predictors for CMV disease.

Acyclovir↗
PubMed2005

Genital herpes.

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2-Aminopurine↗
PubMed2005

Herpes labialis.

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Acyclovir↗