[Vaginal topical chemical contraception with C-film].
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Cultures were made from the cervix, rectum, and oropharynx of 2,019 women to determine the prevalence of gonorrhea. For patients of similar race and age, the rates of cervical gonorrhea among users of oral contraceptives (10.6/100) or IUD users (9.5/100) were significantly greater than observed with patients using barrier methods, condom-diaphragm-foam (1.7/100). On the other hand, there were no significant differences in rates of rectal or oral infection by method of contraception. Postpartum patients were found to have similar infection rates at all three sites as a comparable group of nonpuerperas. Recommendations for utilization of barrier methods are made for suitable patients, including those in the immediate puerperium.
BACKGROUND AND OBJECTIVES: Condom use is one of the most important preventive measures sex workers can take to reduce the risk of becoming infected with a sexually transmitted disease. However, a client may refuse to use a condom when requested. Some sexually transmitted disease prevention programs are recommending that sex workers use spermicide as an alternative prophylaxis when a condom is refused, yet little is known about the effect of this recommendation on prophylactic condom use. GOAL: To determine if using spermicide, either in conjunction with condoms or as a backup, influenced overall condom use among a group of sex workers at high risk of sexually transmitted diseases in Santa Fe de Bogota, Colombia. STUDY DESIGN: Participants were assigned randomly to one of three condom use groups: use of condoms only (Condoms Only), use of condoms and spermicides concurrently (Condom and Spermicide), or use of spermicide when condoms were refused (Spermicide as a Backup). A total of 199 sex workers entered the study and were asked to return for follow-up every 2 weeks for a period of 12 weeks. RESULTS: Women assigned to the Spermicide as a Backup group used a condom for an average of 78.1% of their reported acts of intercourse, compared with an average of 94.5% in the Condom Only and 92.3% in the Condom and Spermicide groups. However, women in the Spermicide as a Backup group used a condom or spermicide for an average of 96.9% of their acts of intercourse. Condoms were used for every intercourse act by less than 5% of the women in the Spermicide as a Backup groups, compared with 50.7% in the Condom Only group and 41.2% in the Condom and Spermicide group (P 0.001). When condoms were not used, client refusal was the primary reason reported. The incidence of sexually transmitted diseases and other urogenital inflammations in all groups was lower than expected. CONCLUSIONS: Among Colombian sex workers, condom use declined substantially when women were instructed to use spermicides if they were unable to persuade their partner to use a condom. However, these same women usually used the study spermicide as an alternate prophylaxis.
In an evaluation of the breakage rate of a thicker condom when used for anal intercourse, one hundred and eight gay men volunteered to use condoms which were 30% thicker than standard condoms. Of the 772 condoms used, 14 broke during anal sex, representing a breakage rate of 1.8%. When one subject was removed from the sample because of inappropriate use of the condom, the overall breakage rate was 1.6%. This compares favorably with the breakage rates reported for condom use during anal sex in other investigations, and is similar to the breakage rate for condom use during vaginal intercourse.
The contraceptive failure rate of condoms varies from 2 to 13%, depending on the study population, yet it is the contraceptive method with the greatest capacity to protect against sexually transmitted diseases (STDs) and AIDS. Breakage and slippage during intercourse are important causes of failure, and individual behavior leading to consistent and correct use is the most important factor in condom effectiveness. Female-controlled barrier methods may actually prevent more STDs than condoms, because of their more consistent use. Using the diaphragm continuously and without spermicide was well accepted and effective in preventing pregnancy in one study. The female condom appears to have a contraceptive effectiveness close to that of other vaginal methods. It is likely that it also protects against STDs and AIDS. Nonoxynol-9 appears to have a protective effect against some STDs and the data concerning the protective effect of spermicides containing nonoxynol-9 against HIV is conflicting, yet suggests some protection, especially if products are used with relatively low frequency that avoids dose-dependent vaginal irritation. New spermicides which could also protect against viral infection without affecting epithelial cells are currently being studied.
Despite intensive efforts to promote condoms as a means of preventing the spread of HIV, the rate at which the epidemic is expanding, highlights the need for additional prevention technologies, and in particular methods controlled by women. Virucides are anti-infective substances, formulated as gels, foams, creams, and suppositories and impregnated sponges, for vaginal application. Women will be able to insert them prior to sexual intercourse to protect themselves and their partners from infection with HIV. Unlike condoms, the woman will control them, and their use can be with or without her partner's consent or even knowledge. They will not create a physical barrier to reduce sexual pleasure, and it will be possible to apply them considerably in advance of sex so that there is no interruption to the natural course of events. Virucides will not necessarily be contraceptive; ideally, they will be available in a choice of contraceptive and non-contraceptive versions. Virucides are not intended to replace other prevention measures such as those based on male and female condoms-or vaccines when they become available-but will give people a wider choice of potentially life-saving methods of protection. About 60 candidate virucides are in the development pipeline, representing many different chemical categories and different mechanisms of action against infection. About half a dozen are scheduled to enter large-scale clinical trials in the near future. Virucides offer the prospect of a low-cost, woman-controlled option for self-administered, broad-spectrum protection against multiple HIV strains, other sexually transmitted pathogens and unwanted pregnancy.
Two major limitations have been identified in semen extender technology in the dog; the longevity of canine sperm cells is greatly decreased by cooling or freezing, and the anatomy of the canine cervix acts as a barrier to intrauterine deposition of semen via a vaginal insemination. Currently, the ability to predict ovulation time indirectly by measuring serum progesterone levels has increased the success rate using both chilled and frozen canine semen. The American Kennel Club now routinely registers litters produced with both of these methods, and will allow foreign semen from recognized kennel clubs to be imported for domestic use.
OBJECTIVES: This paper describes the sexual risk behaviors of Puerto Rican men who have sex with men and their perceived obstacles to condom use. METHODS: Interviews were conducted with 182 Puerto Rican men living in New York, NY. RESULTS: Condoms were used inconsistently or not at all by half of the men who had anal sex with other men, by two thirds of the men who had vaginal sex, and by three fifths of those who had anal sex with women. Most of the men had had unprotected oral sex and more than one sexual partner in the previous year. Three of 10 were positive for the human immunodeficiency virus (HIV). Dislike of condoms was the most frequently cited obstacle, followed by perception of low risk, trust in and emotional connection with partner, unavailability and inconvenience of condom use, lack of control, and indifference. CONCLUSIONS: Barrier methods other than condoms, such as a microbicidal, gel, need to be developed.
The use of a simple, improvised mould for vaginoplasty is described. It is made of rubber foam rolled over a winged infusion cannula and covered over by condoms. It offers a number of advantages over conventional moulds, the main ones being its simplicity of construction and its ease of application and removal from the neo-vagina.
The characteristics of women reporting cervical cytology screening has been evaluated using data from control subjects collected in the framework of a case-control study on invasive cervical cancer conducted since 1981 in the greater Milan area. A total of 515 women admitted for nonneoplastic, nongynecologic, nonendocrine-related acute conditions to a network of general and university hospitals were interviewed. The frequency of cervical screening utilization decreased with age: regular screening (greater than or equal to 3 lifetime Pap smears) was reported by 46% of women aged 44 years or less, but only 11% of those aged 65 or more. Married women reported about 50% more frequently occasional (1 or 2) and about three times regular (greater than or equal to 3) cervical screening than unmarried ones. Parous women were more frequently screened, but no trend emerged with number of births. Similarly number of medical consultations in the year before the interview was associated with an increased number of Pap smears. There was no consistent association between number or recency of Pap smears and smoking, sexual habits or education, but women in low social classes tended to be less frequently screened. Ever contraceptive users (oral contraceptives or barrier methods) reported an increased probability to be screened regularly and within two years before the interview.
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The results of 3 years of developing the collagen sponge as an intravaginal contraceptive are presented. Postcoital tests were used to evaluate the efficacy of the sponge as a mechanical barrier. Results with the collagen sponge alone were compared to those of the sponge with spermicidal cream or spermicidal solution (acid buffer and zinc) and of spermicidal cream alone. The presence of any motile spermatozoa in the cervical mucus was considered a failure of the barrier method. The collagen sponge alone or with acid and zinc and spermicidal cream alone had failure rates of 22, 20, and 14%, respectively, whereas the collagen sponge with spermicidal cream had a 6% failure rate. The authors conclude that the combination of a mechanical and a chemical barrier is a more effective contraceptive method than a mechanical barrier or chemical agent alone.
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Male and female rats emit ultrasonic vocalizations in reproductive encounters. While estrous bedding has been used to elicit vocalizations of males, the number of responses is variable. We report a reliable method to assess vocalizations using exposure to a stimulus animal. The stimulus rat is placed behind a wire barrier for 5 min, then removed. Vocalizations are then recorded for 5 min. Experiment 1 validated this method and it was used for subsequent experiments. In Experiment 2, male rats were castrated and tested for the restoration of vocalizations. In one group, males were allowed to copulate freely; in the other, females had vaginal masks to prevent ejaculation, but not mounting. Vocalizations were restored only in males allowed to ejaculate. In Experiment 3, we measured vocalizations in sexually nai;ve and sexually experienced males following exposure to either castrated (CAS) males, testosterone (T)-treated males, ovariectomized (OVX) females, or OVX females receiving estrogen plus progesterone (E+P). Males vocalized most after exposure to E+P females, whether they were sexually experienced or naive. However, the rate of vocalizations was significantly higher after exposure to E+P females when the males were sexually experienced. In Experiment 4, we measured vocalizations in females following exposure to CAS males, T-treated males, OVX females, or E+P females. Females vocalized most after exposure to T-treated males. Our results show that (1) sexual experience facilitates vocalizations in male rats, (2) vocalizations are highest after exposure to hormonally receptive conspecifics, and (3) ultrasonic signaling is a sensitive index for assessing the hormonal disposition of conspecifics.
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At a recent major international workshop held in Guatemala, the state of the art of barrier contraception was examined. While there are promising leads to new methods, none is likely to be available in the near future.
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