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PubMed1990

New perspectives on Sanguinaria clinicals: individual toothpaste and oral rinse testing.

Clinical studies conducted since 1983 on oral care products containing sanguinaria extract have yielded a variety of results. A careful review of these trials suggests that the designs used to conduct many of these trials may have had affected the study outcomes. Review of these trials suggests that studies testing the efficacy of anti-plaque products exercise the following guidelines: 1) use parallel instead of crossover designs, 2) select appropriate study populations, 3) use sufficient numbers of subjects to ensure statistical power, 4) select appropriate controls, 5) ensure intra- or inter-rater reliability prior to the start of the study, and 6) use proper statistical methodology. This review was undertaken to provide perspective into the results of these early studies, and furnish the rationale for the planning of subsequent clinical testing of sanguinaria-containing products.

Alkaloids↗
PubMed1990

[The use of aluminum-containing toothpaste and its potential risk].

Epidemiological studies from Norway and England suggest that there is a relation between the frequency of Alzheimer's disease and the concentration of aluminum in the drinking water. A recent Dutch study suggests further that the role of aluminum from tooth pastes may be even more important than that from drinking water. For this reason we determined in samples from the Belgian market which tooth pastes contained aluminium oxyhydroxide as abrasive. This happened to be the case in 5 out of 27 brands. It is not know to us which part of the market these tooth pastes represent.

Aluminum Hydroxide↗