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Esophagectomy in patients with polysplenia: technical considerations.

We report a case and discuss the special considerations necessary for safe treatment of patients with polysplenia who require esophagectomy for cancer or other conditions. Polysplenia is a form of abnormal arrangement of body organs intermediate between situs solitus and situs inversus, sometimes associated with cardiac abnormalities. Abdominal manifestations include multiple spleens, a preduodenal portal vein, an interrupted inferior vena with azygous continuation, a short pancreas, and intestinal malrotation and malformations with anomalous blood supply. Esophagectomy is complicated in such patients by possible cardiac abnormalities, risk of hemorrhage from the enlarged azygous vein (adjacent to distal esophagus), limited exposure via right thoracotomy because of the dilated azygous venous system, and possibly restricted availability of stomach and colon for esophageal replacement (constraints of mobility stemming from anomalous blood supply and malposition/malrotation).

Adult↗

A case of early carcinoma of the oesophagus in association with annular pancreas.

A Chinese patient presented with a 3-week history of vomiting. Pre-operative barium swallow and upper endoscopy and biopsy revealed a squamous cell carcinoma of the lower oesophagus. Operative findings included a relatively early carcinoma of the oesophagus and an annular pancreas with dilated proximal duodenum. Oesophagectomy was performed and the whole stomach used for reconstruction. A pylorojejunostomy provided drainage for the stomach as well as decompression of the proximal duodenum. This patient's congenital anomaly, with its attendant symptoms, led to the early diagnosis and treatment of an oesophageal malignancy with an expected improved prognosis.

Aged↗

Improvement of weight loss and metabolic effects of vertical banded gastroplasty by an added duodenal switch procedure.

BACKGROUND: Some patients who underwent vertical banded gastroplasty (VBG) need revisional operations because of poor weight loss and remaining comorbidities. The duodenal switch (DS) procedure with partial gastrectomy is known as an effective method for treatment of severe obesity and related dyslipoproteinemias and diabetes mellitus type 2 (DM2). Other investigations have shown that DS without gastric resection similarly corrects hypercholesterolemia and DM2 in the "less than" morbidly obese patients. METHODS: Based on this knowledge, we performed a DS simultaneously with hernioplasty and panniculectomy in a 63-year-old woman with a fair EWL (36.4%), with remaining hypercholesterolemia and DM2 4 years after VBG. The pouch stoma diameter was 13 mm, and there was no pouch dilation nor staple-line disruption. The previously partitioned stomach was left in place. H2-blockers and polyvitamins were prescribed after operation. RESULTS: 1 year after DS there were no postoperative complications and undesirable effects except slight anemia. DS allowed improvement in weight loss, improved carbohydrate handling without need for insulin or other hypoglycemic agents, and corrected severe hypercholesterolemia. CONCLUSION: DS per se in the case presented had a decisive effect on DM2 and hypercholesterolemia. DS should be kept in mind as a second-step malabsorptive procedure after a failed purely restrictive operation.

Blood Glucose↗

[Diagnosis and treatment of paraduodenal hernia: a report of 16 cases].

OBJECTIVE: To summarize the experience of diagnosis and treatment for paraduodenal hernia (PDH). METHODS: The clinical data of 16 cases with PDH surgically treated from 1962 to 2003 were analyzed retrospectively. RESULTS: The average age of the patients was 36 years old. There were 13 cases with left PDH (Landzerts hernia) and 3 cases with right PDH (Waldeyer's hernia). Ten patients usually had no symptoms, while acute abdominal pain occurred after full food in 3 case and after vigorous movement in 13 cases respectively. X-ray revealed complete or incomplete intestinal obstruction in 12 cases, while ultrasonography and CT revealed dilated cystic jejunal loop between the pancreas and the stomach in 6 cases. Fourteen cases (87.5%) were misdiagnosed before operation. The hospital stay ranged from 10 to 13 days. All patients were followed up from 2 to 4 years without recurrence. CONCLUSION: With high misdiagnostic rate, it is the key to perform exploratory operation for suspicious PDH.

Adolescent↗

The effect of cider vinegar on some nutritional and physiological parameters in mice.

The present work was designed to investigate health effects of cider vinegar using mice as experimental model. Groups of female ICR (CD-1) mice were treated with daily oral doses of 0.17, 0.51 and 1.02 ml of the vinegar/kg body weight for 4 weeks. Cider vinegar induced a significant reduction in weight gain in animals treated with 0.51 ml/kg while others showed no significant differences in weight gain. The mean dry matter intake increased in animals treated with the smallest dose and significantly decreased in others. Hemoglobin (Hb), total erythrocyte counts (TEC) and total leukocyte counts (TLC) were raised in all treated groups. The activity of liver aspartate amino transferase (AST) decreased in the group treated with the smallest dose while no significant variations were recorded in the other groups. No significant differences were recorded neither in the activity of hepatic alanin amino transferase (ALT) nor in hepatic acid phosphatase (ACP). Liver alkaline phosphatase (ALP) noticeably elevated only in animals treated with 0.51 ml of vinegar/kg body weight per day. Treated groups also showed statistically significant increases in both mean liver and spleen weight. Kidney weight did not show significant differences. High doses of cider vinegar induced histopathological alterations in liver, stomach and duodenum. Vacuolated hepatocytes, erosion of gastric mucosa, dilatation in gastric glands and duodenum villus blunting are the common observed lesions noticed in organs of high dose-treated animals.

Acetic Acid↗

The tracheo-esophageal septum--fact or fantasy? Origin and development of the respiratory primordium and esophagus.

The so-called tracheo-esophageal septum is in fact the curved primitive floor that results from the ventrocaudal out-growth of the respiratory primordium from the caudal end of the laryngeal sulcus of the foregut. This floor, which separates the openings of the respiratory diverticulum and esophagus, is apparent in transverse sections as a bridge of tissue separating the lumina. The respiratory and hepatic primordia are contiguous initially, but they are separated very early by the rapid growth of the heart and liver, and the resultant stretching of the slower-growing foregut. The portion of foregut between the primordia is drawn out into a narrowing tube that develops into the esophagus and stomach. The respiratory primordium is drawn cranialward; it proliferates, dilates, bifurcates, and grows caudally, dragging out a stalk from the ventral aspect of the foregut. Most of the stalk above the bifurcation will develop into the trachea.

Embryo, Mammalian↗

[Distension of the digestive tract. A pathology caused by altitude?].

A rare manifestation of digestive tract distension involving all the cavities was observed in a patient who had journeyed at high altitude. There was no organic obstruction suggesting that the increase in organ volume was related to decreased atmospheric pressure according to Maiotte's law. Distension may have been favoured by the diminished abdominal muscle tone, resulting in a lack of adaptation. Dilatation was predominant in the large organs, particularly the stomach and the colon.

Aged↗

Eosinophilic gastroenteritis of the pancreas: an unusual cause of obstructive jaundice.

Eosinophilic gastroenteritis (EG) is a rare gastrointestinal disorder of undetermined etiology and is manifest by eosinophilic infiltration of any area of gastrointestinal tract, most frequently stomach and small intestine. Peripheral eosinophilia is present in about 80% of patients. Definitive diagnosis requires histologic evidence of eosinophilic infiltration; which is usually patchy in distribution. Steroids are the mainstay of treatment. We present a case of 47-year-old man with abdominal pain, jaundice, and marked eosinophilia. Endoscopic retrograde cholangio-pancreatogram revealed a dilated common bile duct. There was biopsy proven eosinophilic infiltration in stomach, duodenum, gall bladder, and pancreas. Obstructive jaundice is an extremely rare manifestation of EG. This unusual case illustrates the wide variety of gastrointestinal manifestations caused by EG and emphasizes the importance of clinical suspicion and endoscopic mucosal biopsies in diagnosis of EG. This entity should be considered in the patients with chronic and relapsing gastrointestinal symptoms.

Bile Ducts, Intrahepatic↗

Veins with saccular dilatations in gastric mucosa of the rat.

It is well known that blood from the gastric mucosa of the rat is drained by collecting veins (venules). The aim of this study was to describe hitherto unrecognized saccular dilatations connected with these vessels. Rats received atropine or papaverine l h before ligation of the portal vein, Stomachs fixed in formaldehyde were prepared in toto after clearing in methyl salicylate or processed by standard histological technique. A single stomach contained about 1000 connecting veins localized exclusively in the oxyntic mucosa. After administration of relaxing agents and portal vein ligation the collecting veins were enlarged and in 80 percent of them one to three sacculi filled with blood could be seen. Histological observations shown that collecting veins empty into veins running between lamina muscularis and lamina propria mucosae. Sacculi were partially separated from the lumen of the collecting vein by a tissue band. In view of the relaxing effect evoked by atropine the veins and their sacculi appear to be under vagal control. Conceivably, their alternate expansion and collapse could facilitate movement of glandular content to the surface of the stomach and/or movement of interstitial fluid between cells.

Animals↗

[Clinical anatomy of the pyloric region].

The pylorus is not an isolated sphincter but is rather a concentration of muscle bundles derived from the antral muscles and interwoven with the aboral sphincter complex of the stomach. The pyloric canal can be regarded as a narrow gastric segment of merely minor dilatability. In terms of muscular architecture, the prepyloric antrum, pyloric region, and duodenal bulb are the components of the aboral sphincter mechanism of the stomach (motor unit).

Duodenum↗

[Clinical significance of echography in the diagnosis of portal circulatory disorders].

Forty-one patients with the endoscopically diagnosed varicose veins of the esophagus and stomach were examined. The echograms of 32 patients with liver cirrhosis showed the impoverishment of the vascular pattern of the liver parenchyma, dilatation of the portal, superior mesenterial and splenic veins, enlargement of the coronary vein of the stomach, uncovered gastroesophageal and splenorenal collaterals, the umbilical vein, and increase in the size and echogenicity of the spleen. In 5 patients with neoplastic and in 4 patients with inflammatory occlusion of the main veins of the portal system, the normal or high-contrast vascular pattern of the liver parenchyma, no signs of the recanalization of the umbilical vein attested to the absence of any correlation between portal hypertension and liver diseases.

Adult↗

Gastric juvenile polyposis associated with germline SMAD4 mutation.

We treated a 39-year-old woman with hypoproteinemia and anemia who had profuse gastric polyposis. Radiographic and endoscopic examination showed numerous polyps restricted to the stomach. The patient had pulmonary arteriovenous malformations in the left lung. Histological examination of the resected stomach revealed the gastric polyposis to be composed of cystic dilatation of the glands with small areas of adenocarcinoma. These findings were compatible with gastric juvenile polyposis (GJP) accompanied by gastric cancer. Analysis of genomic DNA revealed that the patient had truncating mutation of SMAD4, a responsible gene for juvenile polyposis (JP). Our case suggests that SMAD4 is possibly a responsible gene for GJP.

Adult↗

Postoperative ischemic jejunal stenosis treated with balloon catheter dilation and Wallstent implantation.

Ischemic stenosis of the jejunum is rare. For technical, anatomical, and pathological reasons, ischemic stenosis of the jejunal segment used for the replacement of the esophagus or the stomach, or both, represents a special entity. The present study reports a case of balloon catheter dilation of ischemic strictures of the jejunal segment, used for substitution after gastrectomy. In this patient, an occlusion of the blood vessels supplying the affected segment was observed at its aortic origin, and a Wallstent was implanted. A rare late complication, aortoesophageal fistula, appeared one year after placement of the Wallstent. The case presented in this study suggests that using balloon catheters and implanting a Wallstent may be a useful approach to the management of postoperative ischemic strictures of the jejunum in selected cases. The minimally invasive technique with special indications used here has not previously been described. The rare complication mentioned, however, requires special attention.

Aged↗