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PubMed1991

[Respiratory tract diseases due to Chlamydia pneumoniae].

A newly recognized chlamydial species, Chlamydia pneumoniae causes acute respiratory infections including pneumonia, bronchitis and pharyngitis. In this paper, eight cases of bronchitis and tonsillitis associated with C. pneumoniae are presented. Three cases came to the clinic because of persistent cough and productive sputum. C. pneumoniae was isolated from sputum of a patient and cultured in HeLa 229 cells. Other two patients were diagnosed serologically; Antibodies were measured by microimmunofluorescence using formalized elementary bodies of C. pneumoniae. A titer of 512 in the IgG class was detected. Four patients had sore throat. C. pneumoniae was isolated and cultured from tonsillar swabs in all of them. A patient with sore throat and cough diagnosed as pharyngolaryngitis was sero-positive. Antibodies to C. pneumoniae in IgG and IgM class were 128 and 32, respectively. All the patients were treated with macrolide antibiotics (erythromycin and rokitamycin), and clinical symptoms subsided. In five patients from whom the organism was isolated, the agents were eradicated by the treatment. However, clinical courses of those patients revealed that patient takes a long time to recover from the illness, if diagnosis and first choice of antimicrobial agent are not appropriate.

Adult↗
PubMed1996

[Immunoglobulin A in saliva of children: age dependence and effect of respiratory tract diseases].

Immunoglobulin A (IgA) plays an essential role in the local defence mechanism and is part of the immunologic system. It is transported to the endothelial surface either as a monomer or as a dimer of two molecules of IgA connected by a j-chain and attached to a secretory component. The aim of the present study was to assess the relation of salivary IgA to the age of children and to assess a possible influence by acute and chronic respiratory diseases. IgA was measured in the saliva of altogether 230 children by means of radial immunodiffusion (LC-IgA Partigen, Behring) following a standardised protocol. Relation to age was measured in 159 healthy children aged one month to 15 years. The median of IgA was 36 mg/l with a range of 3.5-291 mg/l. There was no statistically significant relationship between salivary IgA and the age of the children. Median IgA in the saliva of children without any respiratory disorders (n = 169) was 36 mg/l (3.5-291 mg/l), of children with acute respiratory diseases (n = 33) 51 mg/l (3.5-257 mg/l) and of children with chronic respiratory diseases (n = 28) 47 mg/l (3.5-165 mg/l). There was no statistically significant difference between these three groups. In conclusion, the results of this study show that IgA in the saliva of children may not be related to age or influenced by acute or chronic respiratory diseases.

Adolescent↗
PubMed1989

[Respiratory tract diseases caused by the environment].

Large variations in the development of chronic airway disturbances in the population have been uncovered, together with possible increased risk of such disturbances. There seems to be a connection to exposure to pollutants at work and in home environment. The interconnection and interaction between irritants, allergens, infectious agents and other biologically active substances may have a decisive impact on the risk an individual runs of developing chronic suffering in the upper and lower respiratory tract. Injuries in mucous membranes and airways, connected with the development of unspecific hyperreactivity may play a central role in the development of allergic and nonallergic airway disturbances and diseases. These findings may have a decisive influence on the choice of prophylaxis and therapy.

Environmental Pollution↗
PubMed1983

[Questionnaire survey on the effectiveness of health resort treatment of patients with occupational respiratory tract diseases].

The survey was carried out in 806 patients affected with different pneumoconioses or chronic respiratory system diseases treated at the Scientific Research Centre of Occupational Respiratory System Diseases at Szczawno-Zdrój. Tabular specification of individual questionnaires results showed the usefulness of such studies for evaluation of balneotherapy effect and length of period of improvement. Better results of treatment were found in less advanced forms of pneumoconioses and other chronic respiratory system diseases. Repeated treatment has lengthened the period of improvement. In elder patients, an evident subjective improvement is to be noticed which seems to be also an indication for spa treatment.

Adult↗
PubMed1978

[Morphological characteristics of acute respiratory tract diseases of mixed etiology in children].

The analysis of 30 etiologically deciphered (by the direct Coons method) autopsy observations of acute respiratory diseases in children under 8 is presented. Monoinfections were established only in 6 cases. Morphological examinations of respiratory organs in 24 cases of mixed acute respiratory diseases (associations of virus-bacteria and virus-Mycoplasma pneumoniae-diplostreptococcus) revealed marked circulatory disorders and desquamative, dystrophic, and inflammatory processes in segmental bronchi, bronchioles and alveoles. Morphometric studies demonstrated statistically significant differences in the cell composition of infiltrates of interalveolar septa in monoinfections and associated infections.

Acute Disease↗