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PubMedDate not supplied

Effects of probucol on the high density lipoprotein system in hypercholesterolaemic patients.

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Humans↗

PubMed2006

CETP levels rather than polymorphisms as markers of coronary risk: healthy athlete with high HDL-C and coronary disease--effectiveness of probucol.

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Adult↗

PubMed1988

The probucol experience: a review of the past and a look at the future.

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Animals↗

PubMed1988

Probucol, high-density lipoprotein metabolism and reverse cholesterol transport.

Accumulation of cholesterol within the arterial wall reflects an imbalance between delivery and efflux. Monocyte-derived macrophages play a major role in arterial wall cholesterol accumulation. Using tracer methodology in a rabbit model, several investigators have estimated the rate of cholesterol delivery and thus the steady-state rate of efflux to be between 0.4 and 2.4 micrograms/cm2/hour. The process responsible for arterial wall cholesterol efflux, "reverse cholesterol transport," can be conceptualized as a sequence of events including (1) loss of cell cholesterol, (2) intravascular cholesterol transport, (3) hepatic cholesterol uptake, and (4) biliary secretion. Work by many investigators has characterized these individual processes.

Animals↗

PubMed1984