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PubMed1987

[A 6-day subrenal capsule assay for predictive testing of primary esophageal cancers].

Subrenal Capsule Assay (SRCA) as a chemosensitivity test was performed on 14 esophageal squamous cell carcinomas in order to select a more effective form of chemotherapy. Of the 14 assays, 12 were evaluable. Mice were treated with anticancer agents (e.g. Cisplatin, Bleomycin, Methotrexate, Vindesine) on days 1 and 3 after transplantation, and on day 6, the sensitivities were determined. Fresh esophageal cancers yielded an evaluable assay rate of 74%. The implant grew progressively for six days in the remaining group of control mice. Histologically, host cell infiltration at the border of the implant was observed from day 3 after transplantation, and cells had degenerated or had been partially replaced by scar tissue by day 6. The results of chemosensitivity tests differed according to the anticancer agent used or from case to case. Clinically, correspondence between the assay results and clinical results was obtained in 5 out of 7 cases. SRCA is a new promising chemosensitivity test which is clinically useful, and the present results indicated the feasibility of its use in developing an effective chemotherapy for esophageal cancer.

Adult↗
PubMed1988

[Plasma, renal and tumor determination of total platinum during predictive tests of chemosensitivity of human tumor implants in the renal capsule in syngeneic mice].

During the study of chemotherapy responsiveness of twenty nine human tumors by 6 day subrenal capsule assay (SRCA), we measured, after cisplatinum regimen, the total platinum in human tumor implants and in mice plasma and renal tissue. The plasmatic (m = 0.36 +/- 0.13 microgram/ml) and renal (m = 16.1 +/- 6.4 ng/ml) total platinum concentrations are correlated. In human tumor implants the total platinum is measurable in only ten cases (above the minimum value of 7 ng/mg). There are no correlation between the tumor total platinum concentrations and the tumor cisplatinum chemosensitivity. The study is an example of anti-cancer drugs dosage in SRCA.

Animals↗
PubMedDate not supplied

[In unipolar depression does the response to the dexamethasone suppression test predict a symptomatic recurrence after clinical cure?].

We assessed the length and the quality of the remission of 13 unipolar endogenous depressed DST nonsuppressors before treatment in a 2-year prospective study. During this period, we recorded stressful life events. Persistent dexamethasone non-suppression after treatment and complete clinical recovery correlated highly with early clinical relapse. All six nonnormalizers but only one normalizer were rehospitalized within the following two years for a major depressive relapse. Persistent DST nonsuppression was unrelated to any impact of drug discontinuation, to the occurrence of stressful life events or to the length of illness-free intervals in the patient's prior course of illness. Persistent DST non-suppression appears to have a significant prognostic value.

Adult↗
PubMedDate not supplied

Feline mammary carcinomas as a model for human breast cancer. I. Sensitivity of mammary tumor cells in culture to cytostatic drugs. A preliminary investigation of a predictive test.

Feline mammary carcinomas were found to maintain well in short-term cultures. Principally the same types of nuclear DNA frequency distribution histograms were recognized in feline mammary carcinomas as in human mammary carcinomas. However, the more abnormal histograms are less frequent in feline than in human mammary carcinomas. Feline mammary carcinomas appeared, at least in vitro, most sensitive to Doxorubicin and 5-fluorouracil. Preliminary, thymidine incorporation studies indicate both cytotoxic and cytostatic effects of Doxorubicin and 5-FU. Methotrexate was found to stimulate thymidine incorporation.

Animals↗