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Medical costs of managed care in patients with type 2 diabetes mellitus.

The main objective of this study was to analyze the principal treatment cost drivers in patients with type 2 diabetes mellitus in a managed care setting. The study used retrospective integrated (linked) medical and pharmacy claims data for the calendar year 1995. The data were obtained from, and in cooperation with, the Hawaii Medical Service Association, Honolulu, Hawaii. The medical claims data included paid claims for services and procedures for diabetes and commonly associated comorbidities. Claims and associated costs for pharmacotherapy administered to the patient population were recorded in the pharmacy data. Patients aged > or =65 years were excluded because Medicare claims were unavailable for the type 2 diabetic population. The sample used in this study included 5171 patients. An ordinary least squares regression model was employed to identify principal cost drivers among the identified cohort to the managed care system. Independent variables in the analysis consisted of the presence or absence of a number of commonly observed comorbidities associated with diabetes mellitus (hypertension, hyperlipidemia, cardiovascular diseases, congestive heart failure, renal disorders, retinopathy, neurologic disorders, and any cardiac or noncardiac comorbidity combinations), pharmacologic therapy variables (insulin, oral medication, or both), a number of significant events (hospitalization, dialysis, hemoglobin A1c testing, and eye examination), patient enrollment category (fee-for-service vs a capitated system), and patient age and sex. The dependent variable was the natural logarithm of total medical costs of treatment for diabetes and commonly observed comorbidities. Results showed that among comorbidity variables, the 3 largest treatment cost drivers for patients with type 2 diabetes were the presence of neurologic disorders, renal disorders, and any comorbidity combination (cardiac or noncardiac or both), in decreasing order of significance. Similarly, higher costs of treatment were associated with episodes of hospitalization, use of antidiabetic medication, dialysis services, and hemoglobin A1c testing. Whether the patient was being treated under a capitated provider payment system or a fee-for-service system did not have any significant impact on the medical costs of diabetes-related treatment. Age was positively associated with these costs, indicating that older patients were more likely to incur higher costs to the system. The overall explanatory power of the model was 40%. In summary, unless diabetes is properly managed and glucose levels monitored, some component of an integrated health system (hospital vs pharmacy) necessarily bears financial risk. An understanding of the underlying cost distribution for a chronic disease could help in targeting interventions, integrating disease-management services, and managing the formal structure of the health plan being considered.

Adolescent↗

Prescription data as a tool in pharmacotherapy audit (II). The development of an instrument.

In many countries, prescription data are used as an instrument to provide feedback on prescribing. This article describes the development and implementation of a computer program as a tool for pharmacotherapy audit meetings and it illustrates the possibilities of such a program. The program was developed to support the optimisation of prescribing in the various stages of behavioural change. It enables pharmacists to make sophisticated overviews of prescribing by physicians in their audit group and furthermore, pharmacists can conduct drug utilisation studies or pharmaco-epidemiological studies in their own patient population. Forty percent of Dutch pharmacies have purchased the computer program since its introduction; it was distributed together with a technical handbook and a course book, which elaborated on the types of graphs available and their interpretation. An educational course was developed regarding the optimal selection and interpretation of graphs. Examples of prescription data as a tool to support various aims of audit meetings are given. The program is acknowledged as a welcome contribution to pharmacotherapy audit and to the pharmacists' advisory role in pharmacotherapy.

Attitude of Health Personnel↗

Towards safer drug prescribing, dispensing and administration in hospitals.

A multidisciplinary workshop was held in order to identify strategies likely to produce a reduction in adverse drug events, by targeting hospital systems involved in drug prescribing, dispensing and administration. Strategies identified at the workshop included: (i) improving the education and practice development of medical and nursing staff, concerning drug therapy and safe prescribing principles; (ii) introducing and using information technology and electronic prescribing processes; (iii) implementing the Australian Pharmaceutical Advisory Council (APAC) national guidelines to achieve the continuum of quality use of medicines between hospitals and the community; (iv) enhancing the importance of medication history taking as a routine part of the admission process; (v) instituting individual patient supply as the standard method of drug distribution in hospitals; and (vi) stimulating the hospital-based clinical pharmacy workforce.

Australia↗

Cost of a ventilator-associated pneumonia in a shock trauma intensive care unit.

BACKGROUND: Nosocomial pneumonia and especially ventilator-associated pneumonia (VAP) are costly complications for the hospitalized patient. Nosocomial pneumonia has been estimated to cost $5,000 per episode, but the specific cost for a VAP has not been well estimated. As part of a successful performance improvement program in decreasing VAP from 10 VAPs/100 ICU admissions to 2.5 VAPs/100 ICU admissions, we examined the costs associated with VAP. METHODS: From January 1, 2002, through September 30, 2003, Shock Trauma Intensive Care Unit patients and charts were reviewed concurrently by an infection control practitioner for development of VAP as defined by National Nosocomial Infection Surveillance (NNIS) guidelines. Costs were obtained from the hospital's cost accounting software Transition Systems version 3.1.01 (TSI). All patients requiring greater than one day of mechanical ventilation were evaluated. Seventy patients with VAP and 70 patients without VAP were matched according to age and Injury Severity Score. Differences were compared using Kruskal-Wallis and two sample T-tests. Significance was considered for p < 0.05. RESULTS: The ICU cost difference was significant (p < 0.05) between the case-controlled patients with VAP ($82,195) and those without VAP ($25,037). There was also a significant increase in ICU length of stay (21.6 versus 6.4 days) and the number of ventilator days (17.7 versus 5.8; both, p < 0.05). Mortality was not different in the case-controlled population. A substantial portion of the increased cost of a VAP was from the increase in ICU length of stay ($1,861/day). Pharmacy, respiratory and "other" also accounted for the increases when cost distribution was analyzed. This translates into a cost avoidance of approximately $428,685 per 100 admissions to the ICU. CONCLUSIONS: Ventilator-associated pneumonia not only leads to a significant increase in ventilator days and ICU length of stay, but adds substantially to hospital costs. In our ICU, an episode of VAP costs $57,000 per occurrence.

Adult↗

Who is using chronic acid suppression therapy and why?

OBJECTIVES: Acid suppression medications have become one of the most commonly prescribed classes of therapeutic agents. Because little data exists describing the chronic use of these agents among a general population, we sought to determine the patterns of use of proton pump inhibitors (PPIs) and histamine type 2 receptor antagonists (H2RAs) in clinical practice, as well as the distribution and severity of symptoms in patients prescribed these therapies. METHODS: Pharmacy billing data from two insurers were used to identify all patients on chronic (>90 days) PPIs and H2RAs within a large, eastern Massachusetts provider network. Patient demographics, diagnoses, frequency of office visits, and information about diagnostic testing were obtained from billing databases. A questionnaire addressing recent upper GI symptoms, over-the-counter medication use, and gastroenterologist consultations was mailed to a 1,139 patient subset (35%) of eligible patients. We compared the diagnoses of patients on chronic therapy with those of the general population of the network. We also compared the frequency of symptoms and diagnostic testing between those prescribed H2RAs and PPIs. RESULTS: From a total population of 168,727 adult patients, we identified 4,684 (2.8%) prescribed chronic acid suppression therapy, with 47% taking H2RAs and 57% taking PPIs (4% filled prescriptions for both simultaneously). A relevant GI diagnosis was found using billing data for only 61% of patients, mainly for gastroesophageal reflux disease (38%) and dyspepsia (42%), with many patients carrying both diagnoses. Our survey (response rate 59%) revealed that more than 30% of responders experienced heartburn or reflux more than twice a week, and more than half experienced symptoms of dyspepsia at least once a week. Diagnostic testing was uncommon, with only 19% having undergone esophagogastroduodenoscopy within the prior 2 yr. CONCLUSIONS: Acid suppression medications were used chronically by a large number of patients within this population. A significant proportion of patients on chronic PPI or H2RA lacked definitive upper GI diagnoses in their billing data. The high symptom burden and low use of diagnostic testing indicates opportunities for improvement in the care of patients on chronic acid suppression therapy.

Adult↗

Managing oncology research protocols.

Oncology research protocol management is important for the effective execution of clinical trials with oncology patients. Clinical trials explore investigational drug safety, efficacy, and effectiveness. Investigational drugs have not received approval for widespread use and marketing by the Food and Drug Administration (FDA). The National Cancer Institute (NCI) has several branches concerned with investigational drug procurement, distribution, and recordkeeping of investigational cancer chemotherapy agents. Before an investigational drug is approved by the FDA for marketing in the United States, it must undergo several phases of pre-clinical and clinical trials. The Institutional Review Board (IRB) must review and approve clinical trials to ensure that studies meet legal, ethical, and scientific standards. The principal investigator (PI) takes responsibility for the clinical trial. Informed consent must be obtained from subjects before they may participate in clinical trials. The informed consent form is reviewed by the IRB. The investigational drug storage, accountability, ordering, distribution, and drug information dissemination process is improved with a pharmacy-coordinated investigational drug service.

Clinical Trials as Topic↗

The use of non-prescription sleep products in the elderly.

UNLABELLED: While sleep disorders are common in the elderly, the use of non-prescription products for sleep in this population has not been fully evaluated. The objectives of this project were to assess the use, perceived effectiveness and toxicity of non-prescription sleep products in an ambulatory elderly population. METHODS: A self-administered 20-question survey was distributed to seniors, aged 60 years or more, during hospital or pharmacy visits. RESULTS: Of the total respondents (N=176, mean age 74+/-7 years, 59% female), 84 (48%) indicated that they had used one or more therapies for sleep within the past year. These included non-prescription products (50% of therapies), prescription products (17%) and non-drug activities such as walking or drinking milk (34%). For those individuals who had used a non-prescription product in the past year (N=47, 27% of total respondents), the most frequently used products were: dimenhydrinate (21%), acetaminophen (19%), diphenhydramine (15%), alcohol (13%) and herbal products (11%). Most took them at least 1 day per week (79%) and 32% took them daily. These products subjectively improved sleep latency (mean 32 vs 61 minutes, p<0.001), number of nocturnal awakenings (mean 2 vs 3 awakenings, p<0.001) and total hours of sleep (mean 6.6 vs 5.4 hours, p<0.001). Mild side-effects were reported by 35 respondents (75%), the most common being dry mouth (N=22) and daytime drowsiness (N=13). Respondents were taking an average of four (SD+/-3, range 0-10) other medications currently. CONCLUSIONS: Non-prescription products are widely used by this population of ambulatory elderly for sleep disturbances. Most of the products were not marketed for sleep; however, they were perceived to be efficacious with low toxicity. The potential for drug interaction is high. Further research is warranted to evaluate the safety and effectiveness of non-prescription sleep products in the elderly.

Aged↗

Pharmacy information system for a health maintenance organization.

A computerized pharmacy system developed for a health maintenance organization (HMO) is described. The system has been operational for nearly three years. It is based on a coding scheme for (1) all drugs in the HMO formulary and (2) prescribing information. The information is processed by a computer which generates a variety of usage information. The system produces reports on frequency of drugs dispensed, number and percentage of patients obtaining each drug, and age-sex distribution of patients using a particular drug. The special characteristics of an HMO pharmacy as they relate to computerized systems are discussed. System requirements, maintenance procedures and cost estimates are also presented.

Computers↗

Factors motivating pharmacy students to pursue residency and fellowship training.

Factors that influence pharmacy students to pursue residency and fellowship training were studied. Directors of 514 residency or fellowship programs were asked to distribute to their residents or fellows a survey concerning factors that influenced their decision to enter a residency or fellowship. Deans of the 75 U.S. pharmacy schools were sent a related survey and asked to forward it to the faculty or staff member who was most involved in promoting residencies and fellowships to students. This survey asked about methods for promoting the programs and the faculty member's opinion on why students chose to become residents and fellows. Residents and fellows cited "to gain knowledge and experience," "recognition of new and challenging roles," and "desire for specialized training" as their leading reasons for entering their programs. The pharmacy school representatives also cited "to gain knowledge and experience" and "desire for specialized training" as leading reasons. The residents and fellows thought instruction on residencies and fellowships should occur earlier in the pharmacy degree programs than it was being provided. The pharmacy school respondents considered the largest barriers to entering such programs "financial" and "a job was available upon graduation from pharmacy school." The pharmacy school survey results were broken into two groups: the 9 schools that produced the most students who went on to residencies and fellowships, and the rest of the schools. The former group was more likely to offer the Pharm.D. degree and to involve preceptors, residents, and fellows in didactic and clerkship teaching. Two factors--"to gain knowledge and experience" and "desire for specialized training"--were cited most frequently by survey respondents as important factors in students' decisions to pursue residencies and fellowships, and schools that produce more residents and fellows tended to involve preceptors, residents, and fellows in didactic and clerkship training.

Adult↗

Report on the survey of international activities of U.S. health professions schools.

The Educational Commission for Foreign Medical Graduates recently undertook a survey of all accredited U.S. schools of medicine, dentistry, pharmacy, and public health to determine each school's domestic and foreign participation in international education, research, administration, and health care. The response rate was good, especially for schools of medicine, with 125 (98%) of 127 schools providing information. The resulting directory, published in July 1988, lists 494 programs involving 84 countries: 319 in medicine, 44 in dentistry, 30 in pharmacy, and 101 in public health. Directors, titles and objectives of programs are listed, along with descriptions of areas of emphasis, types of affiliation, personnel involved, and sources of funding. International involvement of the schools was unevenly distributed: about 16% of the medical and public health schools and 6% of the dental and pharmacy schools accounted for half of the international programs in each of these four disciplines. Schools of public health had the largest mean number of international programs per school, followed by schools of medicine. The majority of programs emphasized education and research; lesser numbers were in administration and health care. The majority of programs were in developing countries, the People's Republic of China, and Mexico, together accounting for 19% of the programs listed. In addition to providing needed aggregate and individual information on programs in international health, the directory may serve as a basis for planning by students, scholars, and institutions.

Data Collection↗

Pharmaceutical services in the treatment of hemophiliac patients.

Pharmaceutical services in the treatment of hemophiliac patients in Sweden are described. To prevent arthropathy and improve quality of life, patients with severe hemophilia receive prophylactic treatment. Hemophiliac patients are referred for diagnosis, treatment, and follow-up to one of three hemophilia treatment centers. Patients are seen once or twice yearly for routine checkups. A new system for the distribution of antihemophilic factor and factor IX has been implemented to improve availability and reduce risks and costs. Patients registered at a center receive antihemophilic factor or factor IX from the corresponding hospital pharmacy. The number of different manufactured batches to which a patient can be exposed is restricted, and complete distribution data are recorded for each patient, enabling follow-up studies and facilitating withdrawals of faulty batches. Distribution of emergency kits to patients who do not receive supervised home therapy ensures the availability of treatment for bleeding episodes. Two studies performed to explore ways to reduce drug waste led to improvements in patient information, product guidelines, and equipment and a better understanding of the problems associated with product changes. Specialized pharmaceutical services in Sweden contributed to successful hemophilia treatment and reduced its cost.

Factor IX↗

PharmaTrend as a management tool: introduction.

Use of the PharmaTrend computerized management information system to document workload and productivity in hospital pharmacy departments is described. PharmaTrend provides indicators in the areas of revenue, cost, drug distribution, clinical services, research, education, and management support; examples are total direct cost per admission, total drug cost per drug distribution work unit, and comparisons between cost and revenue, supportive staff and pharmacist work hours, and total staff work and paid hours. The key information provided by PharmaTrend is not specific indicators or values, however, but the display of trends. PharmTrend files can be downloaded to other spreadsheet and database management programs; the sophisticated user can recalculate values for indicators or develop new indicators. Information about revenue and the cost of drug distribution is easily obtained from reports; this information, combined with data on hours worked to provide drug distribution services, can provide access to all the key PharmaTrend indicators. Institution-specific data are made available to managers elsewhere by submitting them for use in the PharmaTrend national report, which is organized so that users can compare values for their indicators with those reported by hospitals of various size in various geographic regions. PharmaTrend can be a valuable tool in hospital pharmacy management and provides a basis for developing accurate and meaningful workload standards for pharmacy practice.

Database Management Systems↗

Impact of automation on pharmacist interventions and medication errors in a correctional health care system.

The implementation and impact of an automated check-and-sortation system in a correctional health care system are described. In February 1998 the Managed Health Care Division of the University of Houston College of Pharmacy submitted a proposal to the Texas State Board of Pharmacy for installing an automated check-and-sortation device in its distributive system serving Texas Department of Criminal Justice offenders. The new system would eliminate final visual verification of medication orders by pharmacists and thereby give them more time for in-depth reviews of patient profiles and for recommending clinical interventions. A vendor interested in developing a prototypic automated system was identified, and a disease management training course was developed to enable staff pharmacists to provide evidence-based pharmacotherapy recommendations. Twelve months of data before automation (February 1997 to January 1998) were compared with 16 months of postautomation data (June 1998 to September 1999). The number of clinical interventions increased from 396 per 100,000 medication orders filled before automation to 1075 per 100,000 orders after automation. Dispensing errors decreased from 6.3 to 4.1 per 100,000 medication orders filled. Identified filling errors increased from 224 to 256 per 100,000 orders. The reliability of the automated system was evidenced by a dispensing error rate of 0.6 per 100,000 orders. Implementation of an automated check-and-sortation device in a correctional health care system appeared to reduce dispensing errors and give pharmacists more time to review patient profiles and recommend clinical interventions.

Delivery of Health Care↗

Gas Man--an example of goal oriented computer-assisted teaching which results in learning.

Gas Man is an educational computer simulation program. The goal of the program is for the user to learn the theory and application of inhalation anesthesia uptake and distribution. The program and accompanying text are designed to be used by medical students, pharmacy students, anesthesia residents, nurses, practicing anesthesiologists, and medical equipment technicians and engineers. After using the program, the learner should understand the time course of patient response to inhalation anesthesia. He should know the factors which influence patient response and be able to predict their impact in specific situations. The key to Gas Man's success are: A well-defined and valid educational goal, teaching anesthesia uptake and distribution. An identifiable and testable set of educational objectives. A specific set of learner tasks to achieve those objectives, the actual simulation exercises. The appropriate educational medium, computer simulation and graphics. Effective software implementation, the Gas Man Program.

Anesthesia, Inhalation↗

Pharmacy's societal purpose.

The changing societal purpose of pharmacy is discussed. Historically, the societal purpose of pharmacy has been to make drugs and medicines available. While this core function of pharmacy remains unchanged, the profession's purpose has evolved with new medical and pharmaceutical knowledge and technological advancements. The traditional role of dispensing medications has been expanded to include developing and managing drug distribution systems that provide access points to consumers and assure drug safety and compliance with legal and professional standards. These new responsibilities have required pharmacists to acquire expertise in the storage of data, distribution, and inventory control functions, and the management of data for drug histories, patient records, quality assurance programs, and drug information services. Pharmacists and support personnel who are qualified to perform the physical and scientific aspects of drug distribution and control must also be able to handle the interpersonal relationships required at the interface of the pharmacy system and the ultimate consumer. Today's pharmacists must provide services that transmit the knowledge and skills they have at their command to physicians, other pharmacists, and patients. The service component of pharmacy should supplement and complement its core function.

Delivery of Health Care↗

Cost of comprehensive pharmaceutical services in a 45-bed rural hospital.

The financial impact of a comprehensive pharmacy program on patient charges and hospital operating costs in a 45-bed community hospital was studied. Data were collected retrospectively for the fiscal year prior to initiating pharmacy services (FY73), the fiscal year during program development (FY74) and the fiscal year following full operations (FY75). The total cost of pharmacy services increased 75% from FY73 to FY75, with the largest dollar increase being in pharmacy salaries. Large increases among other cost items also were noted. The average total cost for pharmacy services increased from $3.28 per patient day in FY73 to $6.04 in FY75 (84%). Total hospital cost per patient day increased by approximately $35 from FY73 to FY75 (5%). The pharmaceutical services fee per dose of medication administered did not change from FY73 to FY75. Patient charges per day for medications and pharmaceutical services increased $0.55 (9.8%) from FY73 to FY75. There was a 55% reduction in the number of items carried in pharmacy inventory from FY73 to FY74 following the initiation of a formulary and a unit dose drug distribution system.

Costs and Cost Analysis↗

Interpersonal perception: a theory and method for studying pharmacists' and patients' views of pharmaceutical care.

OBJECTIVES: To identify the congruency between pharmacists' and their patients' perceptions of the benefits of services a pharmacist would provide if practicing according to the pharmaceutical care model, and to characterize the relationship between the congruency of their perceptions and the extent to which each reports that such services are provided. DESIGN: This study employed the interpersonal perception method, a communication theory and tool through which two people's perceptions are compared to assess their agreement with and understanding of one another regarding a particular issue. SETTING AND PARTICIPANTS: Six independent community pharmacies participated in a written survey of perceptions of pharmaceutical care. Questionnaires were distributed to 100 adult patients from each store. Pharmacists completed a self-report of the pharmaceutical care services provided to their patients; patients were asked whether they received such services. MAIN OUTCOME MEASURES: Pharmacists' and patients' perceptions of pharmaceutical care; pharmacists' and patients' reports of pharmaceutical care activities. RESULTS: Pharmacists and patients were found to disagree on the potential benefits of pharmaceutical care services. Pharmacists tended not to understand their patients' perceptions. The differences were not found to be related to the level of pharmaceutical care reportedly provided. CONCLUSION: The extent to which pharmacists' and patients' perceptions serve as barriers to the provision of pharmaceutical care is yet unknown. This study shows that differences in these perceptions exist and may perpetuate both patients' traditional perceptions of dispensing activities in the community pharmacy and pharmacists' perceptions of lack of patient interest in pharmaceutical care.

Adolescent↗

A large private university hospital system. The Johns Hopkins Oncology Center.

Clinical trials are a major commitment for a university-based comprehensive cancer center. In 1992, The Johns Hopkins Hospital registered 3508 new patients with cancer and, from this large population, 2880 patients were entered in clinical trials (many patients participated in more than one protocol). The Oncology Center, one of many departments at Johns Hopkins that conducts clinical research, participates in phase I and II new drug trials, phase III comparative studies, and, increasingly, in epidemiologic and prevention research. This calls for much broader participation by community hospitals and for many more patients who normally would not come to Johns Hopkins for their care. There are more than 100 protocols available from the Eastern Cooperative Oncology Group, but Johns Hopkins may participate in no more than 20 at any given time. Thus, every research facility must be selective about the trials in which it participates, given the finite number of hours, dollars, and resources available to carry out these programs. The institution provides safeguards to protect the interest of the patient. These include review and annual overseeing of the concept, design, and specifics of the proposed study. The pharmacy and nursing staff play an important role in control of chemotherapy distribution and use. Patients and physicians, however, must understand the questions the study is asking and agree that they are worth answering. There are problems in motivation; information; costs to the patient, hospital, insurers, and the physician; the concept of the placebo; and informed consent. Clinical research is the most ethical way to test drugs, radiation therapy, surgical procedures, or other new treatments. The clinical trial must meet rigorous criteria of design, conduct, and analysis. The patient must understand the issues and be a volunteer. We must make every effort to help patients and physicians get information about clinical trials and to participate if they choose.

Baltimore↗