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Results for “PRECIPITINS”

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At least 541 records · Page 30Linked to original sources
PubMed1979

Detection by counterimmunoelectrophoresis of anti-Candida precipitins in sera from cancer patients.

Five antigen preparations from yeast-phase cells and hyphalphase cells of Candida albicans were used to detect antibodies in sera from cancer patients by use of counterimmunoelectrophoresis (CIE). Sera from uninfected patients, patients with superficial infections, and patients who had invasive or systemic candidiasis were analyzed for antibodies. A high incidence (27%) of false-negative data was obtained for patients who had systemic candidiasis. Serum titers of all patient groups were below 1:10. Of the antigens tested, cytoplasmic antigen from yeast-phase cells provided the greatest sensitivity and diagnostic value.

Antigens, Fungal↗
PubMed1982

Immunological studies on Alternaria sensitivity. Use of crossed radioimmunoelectrophoresis, precipitins and enzyme-linked immunosorbent assay.

Characterization of the immunological response to Alternaria in sensitive subjects is not complete. We used crossed radioimmunoelectrophoresis (CRIE) to identify antigens in Alternaria extracts reacting with IgE antibody in five patients with Alternaria-sensitive asthma, four with Alternaria-induced rhinitis, three non-allergic asthmatics, and three normal controls. All five Alternaria-asthma patients and three of four Alternaria-rhinitis patients showed IgE binding to a third antigen. These results suggest an analogy of Alternaria antigens with that found in ragweed pollen extracts, i.e. that IgE antibody is directed against more than one antigen. Using the enzyme-linked immunosorbent assay (ELISA), we found a significant difference (P less than 0.05, unpaired Student's t-test) in IgG binding between Alternaria-sensitive asthmatics and normal controls. There was no apparent difference in IgG binding between untreated Alternaria-sensitive asthmatics and those receiving high-dose immunotherapy.

Alternaria↗
PubMed1977

Association of precipitins and coeliac disease.

Four fractions, fraction A,B, C, and D, were isolated from the aqueous extract of wheat flour on a Sephadex G-75 column. It was found that the repeated gel-filtrated fraction A reacts as an antigen with the sera of coeliac patients. On the basis of its molecular weight and amino acid compositions, it is gliadin. Each of the 28 coeliac patients had heat-stable precipitating antibody and higher than normal IgE levels were found in the sera of only three individuals. Specific antigliadin IgE in low quantity was found in only one case. The sera reacting with antigens in high titres were absorbed by anti-IgG and anti-IgA whereupon the antibody level considerably decreased. The main circulating antibody of the patients was IgG.

Amino Acids↗