Fragmentation of immunoglobulin G in immune serum globulin. Prepared by the Committee on Plasma and Plasma Substitutes of the Division of Medical Sciences, National Research Council.
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In a randomized controlled single blind trial in 50 volunteers the problem was investigated whether a combination of dimethpyrindene (0.1 mg/kg b.w.) and cimetidine (10 mg/kg b.w.) could prevent anaphylactoid or allergoid reactions following Haemaccel infusion. In the control group 6 anaphylactoid and 9 allergoid reactions were observed, in the H1 + H2-group, however, none of those reactions occured. No single wheal could be detected. It is considered appropriate to recommend the general use premedication of an H1 + H2-blocker before all anaesthetics and operations. This mainly depends on further clinical trials with the antihistaminic drugs concerning their side-effects under various conditions.
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The investigation of parameters of the circulating blood volume, rheological properties of blood and hemostasis was performed in 183 patients operated upon for diseases of organs of the abdominal cavity and major vessels. The authors recommend to use rheopolyglucin and the 5% solution of albumin (2:1) for the operative normovolemic hemodilution.
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