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At least 541 records · Page 30Linked to original sources
PubMed1993

Mapping of sensory responses to epidural stimulation of the intraspinal neural structures in man.

A database is presented of sensory responses to electrical stimulation of the dorsal neural structures at various spine levels in 106 subjects subjected to epidural spinal cord stimulation. All patients were implanted for chronic pain management and were able to perceive stimulation in the area of pain. All patients entered in this study were able to reliably report their stimulation pattern. Several patients were implanted with more than one electrode array. The electrode arrays were placed in the dorsal epidural space at levels between C-1 and L-1. The structures that were likely involved include the dorsal roots, dorsal root entry zone, dorsal horn, and dorsal columns. At the present time, exact characterization of the structure being stimulated is possible only in limited instances. Various body areas are presented with the correspondent spine levels where implanted electrodes generate paresthesias. Areas that are relatively easy targets for stimulation are the median aspect of the hand, the abdominal wall, the anterior aspect of the thigh, and the foot. Some areas are particularly difficult to cover with stimulation-induced paresthesias; these include the C-2 distribution, the neck, the low back, and the perineum.

Abdominal Muscles↗
PubMedDate not supplied

Meralgia paresthetica: diagnosis and treatment.

Meralgia paresthetica is a symptom complex that includes numbness, paresthesias, and pain in the anterolateral thigh, which may result from either an entrapment neuropathy or a neuroma of the lateral femoral cutaneous nerve (LFCN). The condition can be differentiated from other neurologic disorders by the typical exacerbating factors and the characteristic distribution of symptoms. The disease process can be either spontaneous or iatrogenic. The spontaneous form is usually mechanical in origin. The LFCN is subject to compression throughout its entire course. Injuries most commonly occur as the nerve exits the pelvis. The regional anatomy of the LFCN is highly varied and may account for its susceptibility to local trauma. Relief of pain and paresthesias after injection of a local anesthetic agent is helpful in establishing the diagnosis. If no improvement is found, proximal LFCN irritation should be sought. Idiopathic meralgia paresthetica usually improves with nonoperative modalities, such as removal of compressive agents, nonsteroidal anti-inflammatory drugs, and, if necessary, local corticosteroid injections. If intractable pain persists despite such measures, surgery can be considered, although whether neurolysis or transection is the procedure of choice is still controversial. Iatrogenic meralgia paresthetica has been found to occur after a number of orthopaedic procedures, such as anterior iliac-crest bone-graft harvesting and anterior pelvic procedures. Prone positioning for spine surgery has also been implicated. Variations in the anatomy of the LFCN about the anterior superior iliac spine may place the nerve at higher risk for damage. Although nonoperative management usually results in satisfactory results, efforts should be made to avoid injury at the time of surgery.

Diagnosis, Differential↗
PubMed1993

Clinical and pathological studies on peripheral neuropathy of six Chinese patients with lung cancer: morphometric evaluation of the sural nerve on biopsy.

We attempted to elucidate the nature of the nerve fiber degeneration and clinical features of six Chinese patients with lung cancer preceded by sensory disturbances, with special emphasis put on the morphometric analysis of the nerve fibers of the sural nerve obtained on biopsy. The patients were all male and ranged from thirty-nine to sixty-seven years of age on admission. They all complained of paresthesia as the initial symptom in the distal portion of both extremities, two to seventy-two months prior to the diagnosis of the cancer. The paresthesia was slowly progressive and mild to moderate in severity without obvious subjective sensory loss. Four patients showed diminished Achilles reflex and decreased vibration sensation at the lateral malleolus. Morphometric evaluation of the sural nerve revealed that the loss of myelinated and unmyelinated fibers was not frequent and the increase in the density of the small myelinated fibers was prominent, suggesting the presence of axonal atrophy. Therefore, it was concluded that the histologic findings of our patients are different from those found in subacute carcinomatous sensory neuropathy associated with lung cancer that is well established clinically and histologically, and are compatible with those of axonal atrophy, partly related to unknown remote effects of cancer.

Adult↗
PubMed2000

Peripheral nerve injury from intravenous cannulation: a case report.

The following is a case report of a patient who had an intravenous (i.v.) catheter inserted into her cephalic vein and thereafter sustained an injury to the superficial branch of the radial nerve. When an i.v. catheter penetrates a nerve, it can cause temporary or permanent damage. After sustaining an injury, a nerve will regenerate in an attempt to reconnect with the fibers it once innervated. Recovery from nerve damage may take only weeks or a year or more. Some patients, however, may sustain lifelong damage depending on the severity of the needle stick to the nerve. To avoid injury to peripheral nerves when inserting i.v. catheters, a few recommendations should be followed. First, if inserting an i.v. catheter in the cephalic vein, be conscious of the proximity of the superficial peripheral nerves. Second, if a paresthesia is elicited when inserting an i.v. catheter, withdraw the catheter immediately. Third, if a patient complains of paresthesias or numbness near the i.v. site, remove the i.v. catheter immediately. Fourth, limit the amount of probing after inserting the catheter into the skin. Finally, if nerve damage is suspected from a peripheral i.v. cannulation, consult a hand specialist promptly.

Catheterization, Peripheral↗
PubMed2000

Fibrolipoma of the median nerve: a case report and review of the literature.

A 38 year-old patient presented with right median nerve distribution paresthesias. Electrodiagnostic studies confirmed severe carpal tunnel syndrome. A palmar mass prompted a magnetic resonance imaging scan, which suggested a fibrolipoma of the median nerve. Carpal tunnel release resulted in resolution of preoperative pain and paresthesias. We review the literature dealing with this primary nerve tumor.

Adult↗
PubMed2001

Puffer fish poisoning: clinical features and management experience in 25 cases.

Between 1989 and 1999, 25 cases of puffer fish poisoning (PFP) were admitted to the medical service of Chon Buri Hospital. The severity of the poisoning was classified into four stages based on clinical signs and symptoms of PFP. Of the 25 patients, 23 were males and 2 were females. Three patients were in stage 1, four were in stage 2 and eighteen were in stage 4. Paresthesia was the early presenting complaint of all patients. Paresthesia consisting of either numbness or tingling of lips, tongue, around the mouth, hands, and feet. Muscle weakness, dizziness, vertigo, nausea and vomiting were common complaints. Eighteen patients developed acute flaccid paralysis and respiratory failure requiring ventilatory support. All patients received symptomatic and supportive treatment and general supportive care, including gastric lavage and intravenous fluid. Intubation and mechanical ventilation was considered especially when paralysis was progressing rapidly. Most were taken off the respirator 12-48 hours later. All patients completely recovered without any sequelae. Clinical features of PFP, toxicity of puffer fish and management were discussed.

Animals↗
PubMedDate not supplied

Lateralization of the inferior alveolar nerve with simultaneous implant placement: a modified technique.

PURPOSE: Several nerve repositioning techniques have ben presented in the literature, each with limitations. This article presents a new technique involving the use of 2 osteotomies, with minimizes particularly the potential duration of sensory disruption and the risk of nerve paresthesia and inadvertent nerve transection or compression. MATERIALS AND METHODS: Ten patients ranging in age from 47 to 67 years were selected for nerve lateralization utilizing the modified technique. A total of 23 cylindrical implants were placed. An average follow-up period was 29.8 months. RESULTS: Of the 10 patients, 4 experienced total return of sensation within 3 to 4 weeks. One patient experienced complete recovery at 6 weeks. DISCUSSION: Creating 2 osteotomies as described minimizes the chances for postoperative neuropraxia and nerve paresthesia or anesthesia. CONCLUSION: When there is moderate-to-severe bone resorption of the mandible posterior to the mental foramen, repositioning the inferior alveolar nerve using both an anterior and posterior osteotomy allows for more bone to accommodate ideal placement and greater length of implant.

Aged↗
PubMedDate not supplied

[Possibility of nerve lesions related to peripheral nerve blocks. A study of the human sciatic nerve using different needles].

UNLABELLED: When a needle tip comes too close to a nerve axon, the mechanical effect over the nerve membrane produces paresthesia. We examined the hypothetical mechanical damage of short bevel and long bevel needles over sciatic nerve bundles under scanning electron microscopy. METHODS: We obtained samples of sciatic nerve from three patients of 68, 74 and 76 years old. These samples were fixed, dehydrated and coated with gold microfilm for their observation under scanning electron microscopy. Ten short bevel needles and ten long bevel needles were studied under the same microscopic technique. We interpolated microscopic images from sciatic nerve samples and different needle bevels at various angles to study the mechanical damage of these needles to nerve axons. RESULTS: Sciatic nerve bundles were found 0.1 to 0.2 mm deep in the samples; information was given about the bevel length and angle of needles. The damage is perceptible under scanning electron microscopy, when the needle bevel is introduced 0.3-0.4 mm deep into the nerve bundle; here, the needle tip cuts through the perineurum, piercing the nerve bundle. At a depth of 1 mm, the lesion caused by short bevel needles is greater than that caused by long bevel needles. The type of epineural lesions caused by short bevel needles is also different from the ones caused by long bevel needles. CONCLUSIONS: Lesions that affect superficially the epineurum can cause paresthesia by compression of nerve fascicles without damaging the axons. If the perineurm is damaged, the lession will also affect the blood-nerve barrier, leading probably to posterior sequels.

Aged↗
PubMed1992

[Long-term treatment of Lambert-Eaton syndrome by 3, 4 diaminopyridine].

A patient with a 5 year history of slow-progressive Lambert-Eaton Myasthenic Syndrome (LEMS) was treated for a period of 12 months with 3,4-diaminopyridine (3,4-DAP). The therapy led to an objective increase in muscle power. During the treatment period, there was no increase in muscle weakness, but attempts at withdrawal of the drug confirmed a progression. The mouth dryness disappeared and autonomic regulation disturbances were improved. All of the laboratory parameters remained unchanged. A neoplasia was excluded by extensive endoscopic and radiological investigations. Side-effects included initial perioral paresthesia and, later, paresthesia down the skin and along the ulnar edge of the forearm. 3,4-DAP seems to be an effective and acceptable long-term symptomatic therapy in LEMS.

4-Aminopyridine↗
PubMedDate not supplied

Morbidity of third molar extraction in patients between 12 and 18 years of age.

OBJECTIVE: An analysis is made of the incidence of complications following third molar surgical extraction in patients between 12 and 18 years of age. PATIENTS AND METHOD: A retrospective study was conducted of 390 surgical extractions of upper and lower third molars in 173 patients operated upon under locoregional anesthesia during the year 2000 in the Master in Oral Surgery and Implantology of Barcelona University Dental School (Spain). The patients were divided into three age groups (A: 12-14 years, B: 15-16 years, C: 17-18 years). The reason for extraction, the degree of dental development, and third molar position, angle and impaction were recorded. Finally, the association of these variables to the appearance of postoperative complications was analyzed. RESULTS: Most patients were females (66.9%), and the age group in which most extractions were carried out (62.8%) corresponded to Group C (17-18 years). The main reason for extraction was orthodontist indication (40.5%), closely followed by prophylaxis (39.5%). The existence of clinical manifestations was an indication for extraction in 20% of cases. The postoperative complications rate after the extraction of the global 390 molars was 15.6%. In Groups A, B and C the complication risks were 17.4%, 19% and 13.7%, respectively. All complications were reversible and of short duration. One case each of inferior alveolar nerve paresthesia and lingual nerve paresthesia was recorded, which subsided after one and two months, respectively. CONCLUSIONS: There were no significant differences in complications between the three age groups. An increased tendency towards complications was observed in females, and the percentage of postoperative problems increased.

Adolescent↗
PubMed2005

Microelectrode recording-determined subthalamic nucleus length not predictive of stimulation-induced side effects.

OBJECT: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become a popular treatment for patients with medically refractory Parkinson disease. Many surgeons believe that microelectrode recording (MER) during DBS electrode implantation is needed to optimize placement, whereas stimulation-induced side effects such as paresthesias, dystonic contractions, dyskinesias, and ocular motor signs that become apparent postoperatively may be an indicator of the proximity of the electrode to various boundaries of the STN. This study was performed to evaluate the relationship between mapping of the STN by using MER and postoperative stimulation-induced side effects. METHODS: Eighty-two electrodes implanted in 75 patients between March 1999 and March 2003 were retrospectively examined to evaluate the length of the STN defined by MER, and the number of and threshold for postoperative stimulation-induced side effects. Electrodes were typically tested with increasing stimulation amplitudes (maximum 6 V) by using a monopolar array. The 82 electrodes were associated with 97 stimulation-induced side effects. The mean time between surgery and testing stimulation-induced side effects was 3.9 months. Statistical analysis (two-tailed t-test) revealed no significant difference in the number of stimulation-induced side effects (or the mean threshold for paresthesias, the most common side effect) for electrodes associated with an STN length less than 4.5 mm (13 electrodes) compared with those associated with an STN greater than or equal to 4.5 mm (69 electrodes, p = 0.616). For every electrode, the target adjustment based on MER results was within 2 mm of the image-planned target (usually 1 mm anterior). In the x axis (medial-lateral orientation), there was no systematic difference in adjustments made for the electrodes associated with the shorter compared with the longer STN lengths. In the y axis (anterior-posterior orientation), there was a very small statistically significant difference in the mean adjustment (0.4 mm) between the two groups. CONCLUSIONS: Analysis of these results suggests that a shorter MER-determined STN length alone does not reliably predict the incidence of stimulation-induced side effects.

Chi-Square Distribution↗
PubMedDate not supplied

Neuroelectric procedure does not discriminate between painful and paresthetic diabetic neuropathy.

To investigate whether pain and paresthesias could identify two different subclasses of small-fibre diabetic neuropathy, and to evaluate their relation to the metabolic control, we tested nerve conduction velocity (NCV) of median nerve (sensitive-SM, and motor-MM) and deep peroneal nerve (DP) in 48 diabetics (24 IDDM, 24 NIDDM) reporting pain (group A) or paresthesias (group B) that might be due to diabetic polyneuropathy. Glycated haemoglobin (HbA1c) was also assessed. No difference between group A and group B was found either in NCV, in all nerves tested, or in HbA1c. No relation was observed between NCV of nerves tested and HbA1c, duration of diabetes, age and type of diabetes in both groups.

Adult↗
PubMed1987

Late-life migraine accompaniments: a case presentation and literature review.

Migraine headaches that occur in the 15- to 30-year-old age group are well documented. In patients in the stroke age bracket, however, who present with a history of neurologic deficit, transient ischemic attacks can be confused with migraine accompaniments. The typical patient is 50 years old, is without a past history of migraines, and complains of scintillating visual disturbances (20 percent), marching paresthesis (22 percent), or a myriad of neurologic deficits. In one series of 70 neurology patients aged over 55 years, 16 percent reported that they experience the new onset of scintillations. Once fully evaluated, the cause of unexplained marching paresthesias, dysphagia, or hemiplegia, once reserved for thrombotic or embolic phenomena, may be attributed to migraine accompaniments. In the face of a normal evaluation, neurologic deficit in the stroke age bracket may be attributed to migraine accompaniments. A case of a 47-year-old woman with sudden onset of left-sided paresthesia, dysarthria, and confusion is presented. The discussion includes a description of migraine pathophysiology and a review of concepts regarding accompaniments.

Confusion↗
PubMed1987

Protecting the brachial plexus during median sternotomy.

Injury to the brachial plexus was prospectively assessed in 335 patients undergoing median sternotomy for cardiac operation. All patients were placed in the hand-up position (elbows elevated, arms abducted 90 degrees, and elbows flexed) after right internal jugular vein cannulation (23 cannulation attempts were bilateral). Twenty-eight patients had new upper extremity complaints after the operation, of whom 16 (4.8%) had symptoms considered related to injury of the brachial plexus: one with generalized weakness of the left arm, six with localized weakness, pain, or paresthesia plus objective hypesthesia or weakness, and nine with paresthesias but no objective signs. Four injuries were right sided, four left sided, and eight bilateral. At the time of discharge, 15 of 16 were symptom free and the patient with generalized weakness was rapidly improving. Postoperative plexopathy was not related to degree of sternal retraction, dissection of the internal mammary artery, or cannulation of the internal jugular vein. We believe the low incidence and benign course of brachial plexus problems in these patients resulted from careful sternal retraction and use of the hands-up position. Finally, our data do not support internal jugular cannulation as a major cause of plexus injuries after median sternotomy.

Brachial Plexus↗
PubMed1979

Upper trunk brachial plexopathy in football players.

Ten football players seen from 1973 through 1977 at the University of Wisconsin Hospitals were found to have clinical and electrodiagnostic evidence of injury to the upper trunk of the brachial plexus. Each had upper limb paresis following one or more blows to the head or shoulders. The development of persistent weakness often was preceded by burning paresthesias in the upper limb. Our experience suggests that the syndrome of burning paresthesias and subsequent arm weakness frequently is secondary to stretching of the brachial plexus.

Arm↗
PubMed1981

[Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)].

A 20-year-old patient with biologically-confirmed lupus developed a perirenal abscess following puncture biopsy of the kidney. Postoperative treatment included metronidazole at a mean dose of 2.5 g daily for 68 days (total dose : 165 g). Generalised convulsive seizures occurred on four occasions, associated with paresthesia of the four limbs, but without loss of motor or reflex activity, though some distal hypoesthesia was detected. An acute lupus attack was eliminated, the convulsive seizures not recurring after discontinuation of treatment, and the paresthesias diminishing progressively over a period of three months. Electrical investigations showed lack of motor anomalies but a marked reduction in sensory conduction. This is the 13th reported case of polyneuritis due to metronidazole, the 4th case of convulsive seizures, and the first case in which both manifestations occurred. The plasma concentration curve after oral administration of 1 g of the product to this patient demonstrated that the product was not being metabolised in a pathological manner.

Abscess↗
PubMed1995

The T4 syndrome.

OBJECTIVE: To discuss two cases of the T4 syndrome in order to raise awareness and aid its clinical recognition. CLINICAL FEATURES: Paresthesias, numbness, or upper extremity pains associated with or without headaches and upper back stiffness characterize the T4 syndrome. In addition, no hard neurological signs are present. Upper thoracic joint dysfunction, especially in the region of the T4 segment, appeared to be the major cause of the upper extremity symptoms and headaches. A nontraumatic onset is common and the peculiar glove-like distribution of hand or forearm pain can often lead to a mistaken diagnosis, including psychogenesis. INTERVENTION AND OUTCOME: Joint manipulation, stretching, and strengthening exercises directed at the upper thoracic dysfunctional segments were used with good results. CONCLUSION: Upper extremity symptoms of nocturnal or early morning paresthesias, especially in a glove-like distribution, coupled with headaches and a stiff upper thoracic spine without neurological signs of disease may indicate a T4 syndrome. Manipulation of the dysfunctional upper thoracic segments may relieve these symptoms.

Adult↗
PubMed1993

[Clinical analysis of paralytic shellfish poisoning following ingestion of oysters].

We describe five patients of paralytic shellfish poisoning (PSP) following ingestion of oysters in January 1991, in Nagato, Yamaguchi. The five patients (four men and one woman, age range:37-80 years) developed symptoms three-nine hours after consuming oysters. Symptoms included paresthesia of the mouth and tongue (three), paresthesia of the extremities (five), and quadriparesis (five). The median duration of neurological symptoms was 16 hours. All five patients completely recovered. Although PSP is rare as compared with globe fish poisoning in Japan, the fatality rate of PSP is 8%-9%, with deaths occurring in one-12 hours secondary to respiratory failure. PSP is an important disorder for differential diagnosis of acute paralytic illnesses, such as globe fish poisoning, botulism, acute polyradiculoneuropathy, fisher syndrome, myasthenia gravis, and periodic paralysis.

Adult↗