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Results for “Ovulation Detection”

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PubMed1983

Evaluation of a rapid method for determination of total urinary estrogens in morning samples from normally menstruating women.

Total urinary estrogens (TUE) in morning urine samples delivered during seven days around midcycle from 14 normally menstruating women were analyzed and the results were compared with those obtained by radioimmunoassay of serum estradiol-17 beta (E2) and LH. The Spinnbarkeit of the cervical mucus was also determined daily and ovulation was confirmed by RIA of serum progesterone. Significant correlations (p less than 0.01) between day of peak levels of serum E2 and the day with the highest TUE value were obtained. Peak values for Spinnbarkeit, estradiol, TUE and LH were on the average obtained on cycle day 13.1 (10-17), 13.3 (10-16), 13.9 (11-18) and 14.1 (11-17), respectively, and the mean cycle length was 27.9 (24-32) days. The difference in mean peak day for estradiol and TUE, estradiol and Spinnbarkeit, estradiol and LH was significant in each comparison (p less than 0.01). Assays of TUE in morning samples as compared to analysis of TUE in 24 h urine portions were compared during 48 h in 10 women. The day with the highest TUE excretion was found to be the same in 7 women irrespective of the type of urinary sample analyzed. Analysis of urinary creatinine did not improve the TUE results. Levels of TUE in normally cycling females (n = 14); in women taking contraceptive steroids (n = 10), in menopausal women (n = 10) and in normal men (n = 10) agreed with those previously reported. It is concluded that the TUE determination by RIA may be helpful as a rapid method for everyday clinical use.

Adult↗
PubMed1996

An updated basal body temperature method.

Basal body temperature (BBT) readings are handicapped as fertility predictors by exogenous influences on women's temperatures, many of which could be adjusted for by the presence of a non-cycling control. We, a married, cohabiting couple, tracked our BBTs for two months. We found substantial temperature covariability. When there were difficult-to-explain changes in the female partner's temperature, similar changes in the male partner's temperature suggested that these fluctuations were not attributable to ovulation. Additionally, a clear mid-cycle widening of our temperature gap suggested that ovulation had occurred. This is a limited trial of a new method. However, the potential for substantially improving the accuracy and usefulness of a globally utilized method, coupled with its inexpensiveness, ease, and painlessness, call for a larger study.

Adult↗
PubMed1996

Development of new formulas to identify the fertile time of the menstrual cycle.

The calendar method is perceived to be less effective than other methods of family planning. A large existing data set was used to determine how well the fertile time is identified using the traditional calendar method formula and to determine if better formulas could be developed to identify the fertile time more accurately and require less abstinence. We compared the traditional formula with three alternatives, two of which were developed for this analysis. All three alternative formulas performed better than the traditional formula in identifying the presumed fertile time. The result of our analysis is a summary table which can be used to select the best rules for testing the effectiveness of the calendar method.

Family Planning Services↗
PubMed1999

Incidence of irregular cycles among Mayan women who reported having regular cycles: implications for fertility awareness methods.

Despite the low contraceptive prevalence among the Mayan population of Guatemala, past research has found interest in natural methods. A calendar rhythm method with a simple blanket rule would appear to be preferable to more complicated methods. Under a blanket rule, the number of days of abstinence is predetermined and all couples are instructed to abstain during the same interval of the menstrual cycle. However, regular menstrual cycles may be key to successful practice of a calendar method. A database of 880 cycles of 301 women of the Guatemalan highlands was analyzed to determine the length and regularity of menstrual cycles in this population.

Adolescent↗
PubMed1976

Predetermination of ovulation timing by luteinizing hormone assay.

A modified rapid,solid-phase radioimmunoassay for serum luteinizing hormone requiring only 1 1/2 hours of incubation is presented. The method has been used to predetermine the time of ovulation in six infertile patients. Its advantages are presented in these cases. The simplicity and accuracy of the method make it practical, and it can serve well in the management of infertility.

Adult↗
PubMed1977

A study of the relationship between coitus and the luteinizing hormone surge.

Twenty-seven wives participating in a study of sexual activity patterns had identifiable shifts in basal body temperature and midcycle surges of serum luteinizing hormone (LH). When sexual activity data were examined using the LH surge as a centering point, it was observed that the day before the LH surge had only an average probability of coitus and organism. These findings suggest that neither coitus nor orgasm often triggers ovulation in humans. This cannot be taken as evidence that coitus-induced ovulation never occurs.

Adult↗
PubMed1977

Accuracy of endometrial biopsy dating in relation to the midcycle luteinizing hormone peak.

The accuracy of endometrial biopsy dating was evaluated in a selected group of apparently normal women in whom the basal body temperature (BBT), the onset of subsequent menstruation, the midcycle luteinizing hormone (LH) peak, and the 17beta-estradiol peak were determined. Forty-two women with regular cycles, normal ovaries at laparoscopy, and luteal phases of 12 to 15 days were studied. In group I (n=20), the infertility could be explained satisfactorily by either tubal occlusion or infertility of the husband, while in group II (n=22) no explanation was found for the infertility. In group I the duration of the luteal phase, defined as the interval between the LH peak and the onset of subsequent menstruation, was 13.4+/-0.7 days. The plasma 17beta-estradiol concentration declined (P less than 0.01) on the day of the LH peak in both groups of women, while the first significant rise (P less than 0.05) in BBT occurred in groups I and II, respectively, 1 and 2 days following the LH peak. Dating of the endometrial biopsy correlated with the LH peak with standard deviations of 1.2 and 1.3 days, respectively, in groups I and II. It is suggested that, in women with a progressive rise in BBT over several days, the localization of the LH peak can be helpful for correct interpretation of the endometrial biopsy.

Biopsy↗
PubMed1977

Comparison of serum progesterone and endometrial biopsy for confirmation of ovulation and evaluation of luteal function.

An endometrial biopsy and a blood sample for progesterone determination obtained simultaneously in the midluteal phase of the cycles of 55 infertile women were compared for reliability for confirmation of presumptive ovulation and evaluation of luteal function. Progesterone levels of 3 ng/ml or greater were found in 90.5% of the cycles. Secretory endometrium was identified in 81% of the cycles. Thirty-three cycles yielded sufficient information to compare the two methods for evaluation of luteal function. Histology and progesterone levels were consistent with each other and the presumed time of ovulation in only 11 cycles. Histology was inconsistent with the presumed time of ovulation in 20 cycles, while progesterone was inconsistent in only two cycles. Additional samples for progesterone determinations were obtained during the biopsy cycles of 15 patients who presented adequate data for evaluation of luteal function. A single, well-timed progesterone determination appeared adequately to reflect the data obtained from serial samples in the same cycle. These results support the thesis that a single, well-timed serum progesterone determination is superior to a single endometrial biopsy as a screening method for confirmation of presumptive ovulation and for evaluation of luteal function.

Adult↗
PubMed1977

Relation between indices of semen analysis and pregnancy rate in infertile couples.

Both partners of 198 consecutive infertile couples were evaluated. Studies in the female included clinical evaluation of ovulation for a minimum of two menstrual cycles, investigation of tubal patency, and evaluation of sperm survival in cervical mucus. Six semen specimens were analyzed from each male. Laparoscopy, scrotal exploration, and testicular biopsies were performed as required. Where indicated, the female was treated intensively. The only therapy offered to the males was ligation of varicoceles, if present. The couples were grouped on the basis of sperm counts, total sperm counts, motile sperm counts, and total motile sperm counts, and the incidence of pregnancy was computed. Pregnancy rates of approximately 50% occurred in couples where sperm counts or total sperm counts were in the range of 5 to 60 million/ml or 25 to 200 million/ejaculate, respectively. When sperm counts were over 60 million/ml or total sperm counts over 200 million/ejaculate, pregnancy rates increased to above 70%. These observations emphasize the importance of considering infertility as a problem of a couple rather than as a specific disorder of one of the partners. These data also demonstrate a lack of direct correlation between sperm density in the ranges of 5 to 60 million/ml and pregnancy rates in couples where the wife is treated intensively.

Cell Count↗
PubMed1978

The use of a one-day luteinizing hormone assay for timing of artificial insemination in infertility patients.

A 1-day rapid assay for luteinizing hormone (RLH) was developed by combined alteration of incubation temperatures and immune-complex precipitation of a commercially available LH kit. The RLH assay, compared with the standard 3-day assay, had the following characteristics: standard curve slope values of --2.47 and --2.314; assay sensitivity of 5.5 and 3.8 mIU/ml of serum; average coefficients of variation for the standard curves of 13.6% and 14.1% and for serum controls of 10.6% and 13.1%, respectively. Two consecutive RLH assays of split samples were highly correlated (r = 0.9908; P less than 0.001), as were split aliquots measured by RLH or the 3-day assay (r = 0.993; P less than 0.001). When 52 samples from portions of 5 normal menstrual cycles were assayed in both systems, agreement was again high (r = 0.9871; P less than 0.001). Representative curves of both RLH and standard LH assays, together with other data, are presented to show the feasibility of applying this method for timing of artificial insemination.

Adult↗
PubMed1980

Protein A as an immunoadsorbent in radioimmunoassay: usefulness in a rapid assay for urinary luteinizing hormone.

A staphylococcal cell wall protein, designated protein A, is known specifically and rapidly to bind to immunoglobulin G. We have utilized this protein as an immunoadsorbent to separate antigen-antibody complexes from free antigen in a rapid 6-hour radioimmunoassay for urinary human luteinizing hormone (hLH). We have further documented the efficacy of this system and the optimal conditions for this assay. The ability of this assay to provide rapid and reliable measurements of hLH in timed urinary specimens provides a useful tool for determination of the preovulatory LH surge and prediction of the time of ovulation in women.

Antigen-Antibody Complex↗
PubMed1980

Echographic study of follicular maturation and ovulation during the normal menstrual cycle.

Follicular development was followed by echography during 18 menstrual cycles in 10 women volunteers. Results were correlated with changes in serum hormone levels, basal body temperature curves, and cervical mucus changes. The average follicular growth as measured from the time of echographic visualization was 0.3 cm/day. The diameter of the follicle measured the day before disappearance was 2.7 +/- 0.3 cm. In all cases echography was shown to indicate accurately the time of ovulation. Given its inoffensive nature, the usefulness of echography in determining the physical event of ovulation is demonstrated. Possible applications in the surveillance of ovulation induction methods and in artificial insemination are discussed.

Adult↗
PubMed1980

Return of ovulation after abortion and after discontinuation of oral contraceptives.

The return of ovulation after abortion and discontinuation of oral contraceptives was determined by plasma progesterone measurements. Plasma samples were obtained from 67 women at 3 to 6 weeks after abortion and in two groups of postabortion women at 3 to 6 weeks after cessation of oral contraceptives. In the first of these latter two groups, 50 women started taking the pills (containing 30 microgram of ethinylestradiol and 150 microgram of levonorgestrel) immediately after abortion, and the second group of 29 women started taking the pills from the first postabortion menses. Ovulation had recurred in 34% of the women 3 weeks after abortion and in 78% of the women at 6 weeks. The return of ovulation had occured in approximately 55% at 3 weeks after cessation of oral contraceptives in both groups. At 6 weeks after cessation, approximately 85% of women had ovulated in both groups. Luteal function in these two groups was found to be equal and was significantly better in both groups than during the first postabortion cycle (P < 0.005). It is concluded that the early return of ovulation after abortion makes it necessary to commence effective contraception immediately after abortion. The immediate administration of oral contraceptives after abortion does not affect the return of ovulation after discontinuation of oral contraceptives.

Abortion, Legal↗
PubMed1981

Interpretation of plasma luteinizing hormone assay for the collection of mature oocytes from women: definition of a luteinizing hormone surge-initiating rise.

Analysis of plasma luteinizing hormone (LH) assays (4 assays per day) permits the discernment of the onset of the physiologic effects of ovulatory release. This threshold value of LH plasma concentration (LH surge-initiating rise, LH SIR) is determined for each cycle in terms of the average baseline level of the previous day. The chronology of follicle and oocyte maturation after LH SIR is similar to that which follows chorionic gonadotropin (hCG) administration: none of the 20 patients, compared with 2 out of 10, had ovulated when laparoscopy was performed 30 to 35 hours and 36 to 38 hours after LH SIR time, respectively; 1 out of 3, 9 out of 14, and 5 out of 5 patients had an in vitro fertilized egg when oocytes were collected 30 to 32, 33 to 35, and 36 to 38 hours after LH SIR time, respectively. Thus the oocyte can be collected 34 to 35 hours after the LH SIR; at this point ovulation has not occurred and the oocyte is capable of being fertilized.

Adult↗