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PubMed1983

Pulse-radiolysis studies on the interaction of one-electron-reduced species with ascorbate oxidase in aqueous solution.

The interaction of e-aq., CO2-. and one-electron reduced nitroaromatics (RNO2-.) with ascorbate oxidase (AAO) was studied in aqueous solution at pH 6.0 and 7.5 by using the technique of pulse radiolysis. From observations at 330, 410 and 610 nm, interaction of e-aq. and CO2-. with AAO results in non-specific reduction of the protein followed by reduction of Type 1 Cu in a rate-determining intramolecular step. Only a few per cent of the reducing equivalents ultimately results in reduction of Type 1 Cu. With large excesses of reducing equivalents (e-aq. and CO2-.) with respect to the copper concentration, the amount of Type 1 copper reduced never exceeds 50% of the total amount of Type 1 copper after a single radiation pulse. With less-powerful reducing agents, e.g. RNO2-. reduction of Type 1 Cu occurs via a bimolecular step, and there is no evidence for formation of radicals on protein residues. From observations at 330 nm it is evident that Type 2 and/or Type 3 Cu may also be reduced along with Type 1 Cu. Almost stoichiometric reduction of AAO by RNO2-. was observed, e.g. the protein accepts 6-7 reducing equivalents. It is inferred that the various types of redox couples Cu2+/Cu+ are in equilibrium and that intramolecular electron transfer between the different types of Cu is not rate-determining when using RNO2-. as reducing agent.

Ascorbate Oxidase↗
PubMedDate not supplied

Therapeutic activity of sulphadimethoxine and bifuran against E. tenella and effect of medication on the development of immunity.

Therapeutic activity of sulphadimethoxine and Bifuran in drinking water against different levels of infection (5,000 10,000, 25,000 and 50,000 oocysts per chick) with Eimeria tenella and effect of medication on development of immunity was assessed. Medication was started after 96 hours of the infection. Sulphadimethoxine gave better control (performance indices: 234, 193, 155 and 112, respectively) than Bifuran (performance indices: 194, 129, 74 and 40, respectively) against all levels of the infection tested. Effectiveness of both the drugs decreased with increasing levels of the infection. Both the drugs interfered in the development of immunity which was inversely proportionate to the level of infection. Interference in development of immunity was more with sulphadimethoxine but these chicks were still solidly immune to the challenge infection.

Animals↗
PubMed1981

Theoretical approach for radiosensitizers. Correlation between calculated electroaffinity and sensitization factors of nitro-compounds.

The electron affinity of eight well-known nitroaromatic and nitroheterocyclic radiosensitizers is computed resorting to a quantum mechanical approach. Four of the compounds studied were nitroimidazoles; but p-nitroacetophenone and some 5-nitrofuran derivatives were also investigated for comparison. A good correlation between the theoretical electroaffinity values and the radiosensitization efficiencies is found in the case of the nitroimidazoles, in which the pi-electron system appears to be limited to the aromatic ring, except for small side groups. In the case of molecules where the pi-electron system spreads out on the side-chain the theoretical procedure seems to fail.

Acetophenones↗