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Well differentiated hepatocellular carcinoma metastasizing to jaw and oral cavity within six months of primary diagnosis.
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A perspective of oral cancer.
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The case for elective prophylactic neck dissection.
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[Evaluation of the functional state of the hemostatic system before and after surgery in patients with malignant tumors of the maxillo-facial region].
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Carcinogen: DNA adducts in tobacco smoke-associated cancer of the upper respiratory tract.
Mortality connected with tobacco smoke-associated laryngeal cancer in Poland markedly exceeds the relevant epidemiological data from other European countries. The main groups of genotoxic agents considered as potential carcinogens present in tobacco smoke are polycyclic aromatic hydrocarbons, aromatic amines, N-nitrosoamines and reactive oxygen species. Aromatic DNA adducts, N7-alkylated guanosines and oxidative DNA damage derived from tobacco smoke exposure were detected in laryngeal and oral (tumour and non-tumour) biopsies, and white blood cells of cancer subjects. Further, DNA lesions were analysed to estimate the significance of such confounders as intensity of smoking, subject's sex, age, topography of larynx, cancer staging and genetic factor. The number of cigarettes smoked per day was found to be the main determinant of an individual's DNA adduct level. The occurrence of DNA lesions was established as a reliable marker of former exposure to tobacco smoke genotoxicants. On the other hand, a comparison of DNA lesion levels in various regions of larynx indicates limited usefulness of DNA adduct analysis as an estimate of cancer risk. For a better risk estimation one has to take into account DNA lesions in proto-oncogenes and tumour suppressor genes and the efficacy of DNA repair. Altogether, DNA adducts formation and removal has to be considered as a single stage in the multistep carcinogenesis.
[Basal metabolism in patients with malignant tumors of the maxillofacial region].
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[Gallium-67 scintigraphy in the diagnosis of tumors in oromaxillofacial surgery].
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[Advances and emphasis in tumor treatment involving the oral, mandibular and facial regions].
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[Serum immunoglobulins in patients with malignant tumors of the maxillofacial region].
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[Multiple cancers of the oral cavity. An unusual association of an epidermoid carcinoma of the mucosa with a bone carcinoma of salivary origin].
Multiple cancers cannot be considered as accidentally discovered curiosities. They have their own characteristics and differ from multifocal cancers or those secondary to a primary cancer. The authors describe the rare case of a patient suffering from two different types of cancer of the oral cavity; the first one was an epidermoid carcinoma of the upper alveolar mucosa, the second a salivary carcinoma of both epidermoid and glandular type situated within the bone of the mandible. A comparative study was carried out on the muco-epidermoid tumour and the adenosquamous carcinoma which proved the separate indentity of the second cancer. The galloping development of the adenosquamous carcinoma raises the problem of the effect of the primary cancer on the development of the second.
[Eight cases of myxofibroma appearing in the oral region (author's transl)].
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[Röntgenological diagnosis].
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[The prevention of malignant tumors in the maxillofacial region].
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[Autoimmune reactions in patients with various tumor localizations].
Autoantibody levels in patients with malignancies of the oral cavity and lung and autoimmune disorders have been assayed. It was found that tumors initiated polymorphous autoimmune reactions to various tissue antigens. Autoantibody production rates in tumor patients were comparable with those in autoimmune disorders. The role of autoimmune reactions in cancer pathogenesis is discussed.
[Treatment of oral epidermoid carcinoma].
The in 1994 published work in an issue of the Revue Belge de Médecine Dentaire devoted to oral cancer, aimed to describe and analyse the treatment modalities of oral cancer. Surgical treatment, radiotherapy and chemotherapy were systematically detailed. The esthetic and functional problems inherent to radical oncological surgery in the face and mouth were analysed. In most cases, surgical and/or prosthetic rehabilitative or reconstructive methods could limit these functional and esthetic inconvenient to acceptable sequelae. Dental prosthetic rehabilitation could with some limits benefit from dental osseointegrated implants: the problematic of dental implants in irradiated jaws has been claimed. The genuine indications of external radiotherapy and of brachytherapy were described and the risks so as the primordial prevention of jaw osteoradionecrosis were pointed out. Chemotherapy, either as palliative, adjuvant or as inductive treatment, had clearly shown important therapeutic limits. This presented work compares the actual treatment modalities of the oral cancer, pointing the main therapeutic acquisitions in the last 5 years and gives some optional indications for the future.
Tobacco-associated lesions of the oral cavity: Part II. Malignant lesions.
Nonmalignant tobacco-associated lesions of the oral cavity were discussed in the first part of this two-part article. Here, we describe malignant lesions associated with tobacco use, basic biopsy principles for such lesions and intervention strategies that dental professionals may use to reduce the chances of their patients developing precancerous lesions or primary malignancies.
Indications for selective neck dissection: when, how, and why.
Selective neck dissection is a procedure that is primarily indicated in patients with clinically negative nodal disease in which there is a high risk of occult metastases. Others have advocated its use for patients with positive nodes, although under very specific circumstances and in combination with postoperative radiation therapy. The type of selective neck dissection performed varies according to the site of the primary, because the pattern of metastases is unique in each case. This review presents the author's philosophy on when, how, and why to employ the procedure, based on the location of primary cancers at oral, pharyngeal, laryngeal, cutaneous, thyroid, and salivary gland sites.