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At least 541 records · Page 30Linked to original sources
PubMed2005

Genomic profiling of neutrophil transcripts in Asian Qigong practitioners: a pilot study in gene regulation by mind-body interaction.

BACKGROUND AND OBJECTIVES: The great similarity of the genomes of humans and other species stimulated us to search for genes regulated by elements associated with human uniqueness, such as the mind-body interaction. DNA microarray technology offers the advantage of analyzing thousands of genes simultaneously, with the potential to determine healthy phenotypic changes in gene expression. The aim of this study was to determine the genomic profile and function of neutrophils in Falun Gong (FLG, an ancient Chinese Qigong) practitioners, with healthy subjects as controls. SUBJECTS AND DESIGN: Six (6) Asian FLG practitioners and 6 Asian normal healthy controls were recruited for our study. The practitioners have practiced FLG for at least 1 year (range, 1-5 years). The practice includes daily reading of FLG books and daily practice of exercises lasting 1-2 hours. Selected normal healthy controls did not perform Qigong, yoga, t'ai chi, or any other type of mind-body practice, and had not followed any conventional physical exercise program for at least 1 year. Neutrophils were isolated from fresh blood and assayed for gene expression, using microarrays and RNase protection assay (RPA), as well as for function (phagocytosis) and survival (apoptosis). RESULTS: The changes in gene expression of FLG practitioners in contrast to normal healthy controls were characterized by enhanced immunity, downregulation of cellular metabolism, and alteration of apoptotic genes in favor of a rapid resolution of inflammation. The lifespan of normal neutrophils was prolonged, while the inflammatory neutrophils displayed accelerated cell death in FLG practitioners as determined by enzyme-linked immunosorbent assay. Correlating with enhanced immunity reflected by microarray data, neutrophil phagocytosis was significantly increased in Qigong practitioners. Some of the altered genes observed by microarray were confirmed by RPA. CONCLUSION: Qigong practice may regulate immunity, metabolic rate, and cell death, possibly at the transcriptional level. Our pilot study provides the first evidence that Qigong practice may exert transcriptional regulation at a genomic level. New approaches are needed to study how genes are regulated by elements associated with human uniqueness, such as consciousness, cognition, and spirituality.

Adult↗
PubMed2006

Mind over matter: exploring job stress among female blue-collar workers.

Although overall health has been defined holistically as the integration of a person's optimal mental, physical, social, intellectual, and spiritual well-being, a mental health focus remains on the fringe of many public health efforts. This report describes recent efforts by the Centers for Disease Control and Prevention (CDC) to explore job stress among female blue-collar workers. Using a more holistic approach to understand its impact on blue-collar women's overall health, health-related quality of life (HRQOL) was used to assess optimal human performance. Attempting to encapsulate how overall health affects one's ability to participate and fulfill daily personal/professional tasks, HRQOL yields a broader understanding of the interaction between psychological well-being (mind) and physical functioning (matter). Embedding CDC HRQOL-4 measures into a questionnaire used as part of a larger mixed methods project, blue-collar women responded to questions about their health, including both mental and physical. For these female workers, mental health appeared to be of greater consequence, which could be interpreted as mind being more significant than matter. This paper highlights the findings related to HRQOL issues experienced by these female blue-collar workers and summarizes recommendations for effective individual and organizational approaches to address job stress.

Adult↗
PubMed2001

Prefrontal regions involved in keeping information in and out of mind.

Goal-directed behaviour depends on keeping relevant information in mind (working memory) and irrelevant information out of mind (behavioural inhibition or interference resolution). Prefrontal cortex is essential for working memory and for interference resolution, but it is unknown whether these two mental abilities are mediated by common or distinct prefrontal regions. To address this question, functional MRI was used to identify brain regions activated by separate manipulations of working memory load and interference within a single task (the Sternberg item recognition paradigm). Both load and interference manipulations were associated with performance decrements. Subjects were unaware of the interference manipulation. There was a high degree of overlap between the regions activated by load and interference, which included bilateral ventrolateral and dorsolateral prefrontal cortex, anterior insula, anterior cingulate and parietal cortex. Critically, no region was activated exclusively by interference. Several regions within this common network exhibited a brain-behaviour correlation across subjects for the load or interference manipulation. Activation within the right middle frontal gyrus and left inferior frontal gyrus was correlated with the ability to resolve interference efficiently, but not the ability to manage an increased working memory load efficiently. Conversely, activation of the anterior cingulate was correlated with load susceptibility, but was not correlated with interference susceptibility. These findings suggest that, within the circuitry engaged by this task, some regions are more critically involved in the resolution of interference whereas others are more involved in the resolution of an increase in load. The anterior cingulate was engaged to a greater extent by the load than interference manipulation, suggesting that this region, which is thought to be involved in detecting the need for greater allocation of attentional resources, may be particularly implicated during awareness of the need for cognitive control. In the present study, interference resolution did not involve recruitment of additional inhibitory circuitry, but was instead mediated by a subset of the neural system supporting working memory.

Adolescent↗
PubMed2002

Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications.

A key aspect of social cognition is the ability to infer other people's mental states, thoughts and feelings; referred to as 'theory of mind' (ToM). We tested the hypothesis that the changes in personality and behaviour seen in frontal variant frontotemporal dementia (fvFTD) may reflect impairment in this cognitive domain. Tests of ToM, executive and general neuropsychological ability were given to 19 fvFTD patients, a comparison group of Alzheimer's disease patients (n = 12) and matched healthy controls (n = 16). Neuropsychiatric assessment was undertaken using the Neuropsychiatric Inventory (NPI). Patients with fvFTD were impaired on all tests of ToM (first-order false belief; second-order false belief; faux pas detection; and Reading the Mind in the Eyes), but had no difficulty with control questions designed to test general comprehension and memory. By contrast, the Alzheimer's disease group failed only one ToM task (second-order false belief), which places heavy demands on working memory. Performance on the faux pas test revealed a double dissociation, with the fvFTD group showing deficits on ToM-based questions and the Alzheimer's disease group failing memory-based questions only. Rank order of the fvFTD patients according to the magnitude of impairment on tests of ToM and their degree of frontal atrophy showed a striking concordance between ToM performances and ventromedial frontal damage. There was a significant correlation between the NPI score and more sophisticated tests of ToM in the fvFTD group. This study supports the hypothesis that patients with fvFTD, but not those with Alzheimer's disease, are impaired on tests of ToM, and may explain some of the abnormalities in interpersonal behaviour that characterize fvFTD.

Adult↗
PubMed2000

The impact of sign language on the cognitive development of deaf children: the case of theories of mind.

The ability to attribute false beliefs (i.e., demonstrate theory of mind) by 155 deaf children between 5 and 8 years of age was compared to that of 39 hearing children ages 4 to 6. The hypotheses under investigation were (1) that linguistic features of sign language could promote the development of theories of mind and (2) that early exposure to language would allow an easier access to these theories. Deaf children were grouped according to their communication mode and the hearing status of their parents. The results obtained in three false belief tasks supported the hypotheses: effective representational abilities were demonstrated by deaf children of deaf parents, whereas those born to hearing parents appeared delayed in that regard, with differences according to their communication mode.

Journal Article↗
PubMed2001

Theory of mind development in deaf children: a nonverbal test of false-belief understanding.

Our aim in this study was to investigate whether previous findings pointing to a delay in deaf children's theory of mind development are replicated when linguistic demands placed on the deaf child are minimized in a nonverbal version of standard false-belief tasks. Twenty-four prelingually deaf, orally trained children born of hearing parents were tested with both a verbal and a nonverbal version of a false-belief task. Neither the younger (range: 4 years 7 months-6 years 5 months) nor the older (range: 6 years 9 months-11 years 11 months) children of the final sample of 21 children performed above chance in the verbal task. The nonverbal task significantly facilitated performance in children of all ages. Despite this facilitation, we observed a developmental delay: only the older group performed significantly above chance in the nonverbal false-belief task, even though the younger children were at the average age when hearing children normally pass standard false-belief tests. We discuss these findings in light of the hypothesis that language development and conversational competence are crucial to the acquisition of a theory of mind.

Journal Article↗
PubMed1993

The aging mind: potential and limits.

Research on the aging mind has moved from a simple growth vs decline view to a conception of a joint consideration of potential and limits. This development is illustrated by research on two categories of cognitive functioning: the cognitive mechanics and the cognitive pragmatics. The cognitive mechanics (comparable to fluid intelligence) are primarily determined by the evolution-based neurophysiological architecture of the mind, whereas the cognitive pragmatics (comparable to crystallized intelligence) primarily reflect the impact of culture. Testing-the-limits research on basic memory serves as a prototypical instantiation of the aging of cognitive mechanics; research on wisdom and the cognitive management of the self are prototypical examples of the aging of cognitive pragmatics. In the cognitive mechanics, as one would expect from a phenomenon which is largely genetically and biologically controlled, there is definite aging loss. Conversely, in the cognitive pragmatics, which is primarily culture-based, there is evidence for stability and positive change in persons who reach old age without specific brain pathology, and who live in favorable life circumstances. A model of successful aging, selective optimization with compensation, is presented to illustrate how individuals and societies might effectively manage the age-related shift toward a less positive balance between gains and losses and the associated dynamics between culture-based growth and biology-based decline in level of functioning.

Aged↗
PubMed1990

Mind-body and the future of psychiatry.

Philosophical perspectives are deeply relevant to psychiatric theorization, investigation, and practice. There is no better instance of this than the perennially vexing mind-body problem. This essay eschews reductionist, dualist, and identity-theory attempts to resolve this problem, and offers an ontology--"monistic dual-aspect interactionism"--for the biopsychosocial model. The profound clinical, scientific, and moral consequences of positions on the mind-body relation are examined. I prescribe a radically biological cure for psychiatry's--and all medicine's--chronic dogmatism and fragmentation.

Consciousness↗
PubMed1996

An east Asian perspective of mind-body.

This paper addresses a need to re-examine the mind-body dualism established since Descartes. Descartes' dualism has been regarded by modern philosophers as an extremely insufficient solution to the problem of mind and body, from which is derived a long opposition in modern epistomology between idealism and empiricism. This dualism, bifurcating the region of spirit and matter, and the dichotomous models of thinking based on this dualism, have long dominated the world of modern philosophy and science. The paper examines states of conscious experience from an East Asian perspective allowing analysis on achieved supernormal consciousness rather than a focus on "normal" or "subnormal." The nature of the "transformation" of human consciousness will be studied both philosophically, as a transformation from "provisional" dualism to non-dualism, and neurophysiologically. The theoretical structure of the transformation will, in part, be examined through the model provided by a Japanese medieval Zen master, Takuan Sôhô. Then, to verify Takuan's theoretical explanation, toposcopic analysis of electroencephalographs will be presented of the performance of individuals practicing the martial arts technique of tôate.

Buddhism↗
PubMed1991

Psychophysiologic control mechanisms in ischemic heart disease: the mind-heart connection.

The cardiovascular system is a unified, dynamic, constantly responding system. Adjustments are made in response to local metabolic factors, systemic physiologic factors, or peripheral and central nervous system factors. This article focuses on the interactions of the cardiovascular system with the peripheral and central nervous system. Since activation of the sympathetic branch of the autonomic nervous system appears to play an important role in cardiovascular physiology and pathophysiology, a more detailed description of this system appears. Using Engel's Biopsychosocial Model of Health and Disease, the impact of the mind and emotions on cardiovascular behavior and health is emphasized. Several key nursing interventions that have been shown to impact favorably on mind-heart interactions are highlighted.

Coronary Disease↗
PubMedDate not supplied

Effects of mind mapping on student achievement in a nursing research course.

Nurse educators face the problem of getting students to understand massive amounts of content and see relationships between concepts. The author addresses this problem by comparing the effectiveness of one technique, mind mapping, to more traditional approaches. In addition, creative teaching strategies such as mind mapping can make a class not only more interesting, but fun.

Education, Nursing, Baccalaureate↗
PubMedDate not supplied

A scale for measuring the occurrence of positive states of mind: a preliminary report.

It may be as important to measure a failure to achieve desirable states of mind as it is to measure negative moods. The proposed measure of positive states of mind was found to be internally consistent, sensitive to degrees of life stress, well accepted, quick to administer, and amenable to use as a repeated measure in longitudinal studies. Data from 187 men and women in a college student sample are reported.

Affect↗
PubMedDate not supplied

Additional validation of a scale to assess positive states of mind.

OBJECTIVE: Numerous studies have linked stress and negative states to adverse health outcomes. However, in addition to engendering negative states, stress may impair capacities to experience positive states. Such failure to experience positive states may represent a risk factor for poor health in and of itself. The research reported here examines a brief, easily repeated measure of positive states of mind (PSOM) including: focused attention, productivity, responsible caretaking, restful repose, sharing, sensuous nonsexual pleasure, and sensuous sexual pleasure. METHOD: The PSOM Scale and measures of psychological distress, stress, and physical symptoms were administered in four independent samples: two samples of college students and two samples of pregnant women, one undergoing a potentially stressful medical procedure (amniocentesis). The relationship between PSOM scores and several conceptually related, but distinct, psychological variables was examined, controlling for the effect of social desirability where necessary. RESULTS: The range of scores on the items of the PSOM indicated that impairments of ability to have the relevant experiences did occur in the subjects who were experiencing stress. The overall PSOM Scale score consistently showed an inverse relationship with anxiety and with indicators of stress. In addition, lower scores on the PSOM Scale were associated with more somatic symptomatology. CONCLUSION: The results provide evidence that positive states of mind are linked to negative psychological states and are responsive to stressful events. The PSOM scale provides a useful, brief measure for research in stress and health.

Adaptation, Psychological↗
PubMedDate not supplied

A randomized, wait-list controlled clinical trial: the effect of a mindfulness meditation-based stress reduction program on mood and symptoms of stress in cancer outpatients.

OBJECTIVE: The objective of this study was to assess the effects of participation in a mindfulness meditation-based stress reduction program on mood disturbance and symptoms of stress in cancer outpatients. METHODS: A randomized, wait-list controlled design was used. A convenience sample of eligible cancer patients enrolled after giving informed consent and were randomly assigned to either an immediate treatment condition or a wait-list control condition. Patients completed the Profile of Mood States and the Symptoms of Stress Inventory both before and after the intervention. The intervention consisted of a weekly meditation group lasting 1.5 hours for 7 weeks plus home meditation practice. RESULTS: Ninety patients (mean age, 51 years) completed the study. The group was heterogeneous in type and stage of cancer. Patients' mean preintervention scores on dependent measures were equivalent between groups. After the intervention, patients in the treatment group had significantly lower scores on Total Mood Disturbance and subscales of Depression, Anxiety, Anger, and Confusion and more Vigor than control subjects. The treatment group also had fewer overall Symptoms of Stress; fewer Cardiopulmonary and Gastrointestinal symptoms; less Emotional Irritability, Depression, and Cognitive Disorganization; and fewer Habitual Patterns of stress. Overall reduction in Total Mood Disturbance was 65%, with a 31% reduction in Symptoms of Stress. CONCLUSIONS: This program was effective in decreasing mood disturbance and stress symptoms in both male and female patients with a wide variety of cancer diagnoses, stages of illness, and ages. cancer, stress, mood, intervention, mindfulness.

Ambulatory Care↗
PubMed2005

Impaired "affective theory of mind" is associated with right ventromedial prefrontal damage.

OBJECTIVE: To examine the hypothesis that patients with ventromedial (VM) frontal lesions are impaired in the affective rather than cognitive facets of theory of mind (ToM). BACKGROUND: Prefrontal brain damage may result in impaired social behavior, especially when the damage involves the orbitofrontal/VM prefrontal cortex (PFC). It has been previously suggested that deficits in ToM may account for such aberrant behavior. However, inconsistent results have been reported, and different regions within the frontal cortex have been associated with ToM impairment. METHOD: The performance of 26 patients with localized lesions in the PFC was compared with responses of 13 patients with posterior lesions and 13 normal control subjects. Three ToM tasks differing in the level of emotional processing involved were used: second-order false belief task, understanding ironic utterances, and identifying social faux pas. RESULTS AND CONCLUSIONS: The results indicated that patients with VM (but not dorsolateral) prefrontal lesions were significantly impaired in irony and faux pas but not in second-order false belief as compared with patients with posterior lesions and normal control subjects. Lesions in the right VM area were associated with the most severe ToM deficit. These results are discussed in terms of the cognitive and affective facets of "mind-reading" processes mediated by the VM cortex.

Adult↗
PubMed1998

Polar localization of the MinD protein of Bacillus subtilis and its role in selection of the mid-cell division site.

Cell division in rod-shaped bacteria is initiated by formation of a ring of the tubulin-like protein FtsZ at mid-cell. Division site selection is controlled by a conserved division inhibitor MinCD, which prevents aberrant division at the cell poles. The Bacillus subtilis DivIVA protein controls the topological specificity of MinCD action. Here we show that DivIVA is targeted to division sites late in their assembly, after some MinCD-sensitive step requiring FtsZ and other division proteins has been passed. DivIVA then recruits MinD to the division sites preventing another division from taking place near the newly formed cell poles. Sequestration of MinD to the poles also releases the next mid-cell sites for division. Remarkably, this mechanism of DivIVA action is completely different from that of the equivalent protein MinE of Escherichia coli, even though both systems operate via the same division inhibitor MinCD.

Adenosine Triphosphatases↗
PubMed2004

Quantum models of the mind: are they compatible with environment decoherence?

Quantum models of the mind associate consciousness with coherent superposition of states in the brain. Some authors consider consciousness to be the result of a kind of internal quantum measurement process in the brain. In this paper we discuss the ideas of Hameroff-Penrose and Tegmark and their calculation for an estimate of decoherence time. We criticize the Hameroff-Penrose model in the context of a quantum brain model by gravitational collapse orchestrated objective reduction (OOR), assumed by Penrose, and we propose instead that the decoherence process is caused by interaction with the environment. We consider it useful to exploit this possibility because of the growing importance of the decoherence theory in quantum measurement, and also because quantum mechanics can be applied to brain study independently of the Hameroff-Penrose model for mind and consciousness. Our conclusion is that the Hameroff-Penrose model is not compatible with decoherence, but nevertheless the quantum brain can still be considered if we replace gravitational collapse OOR with decoherence. However, our result does not agree with Tegmark's conclusion of refuting not only the Hameroff-Penrose gravitational collapse but also the quantum brain, based on decoherence time calculations in specific cases in the brain. In spite of this fact we also disagree with some points of the response to Tegmark's article given by Hagan, Hameroff, and Tuszynski.

Adaptation, Physiological↗
PubMedDate not supplied

Meta-analysis of theory-of-mind development: the truth about false belief.

Research on theory of mind increasingly encompasses apparently contradictory findings. In particular, in initial studies, older preschoolers consistently passed false-belief tasks-a so-called "definitive" test of mental-state understanding-whereas younger children systematically erred. More recent studies, however, have found evidence of false-belief understanding in 3-year-olds or have demonstrated conditions that improve children's performance. A meta-analysis was conducted (N = 178 separate studies) to address the empirical inconsistencies and theoretical controversies. When organized into a systematic set of factors that vary across studies, false-belief results cluster systematically with the exception of only a few outliers. A combined model that included age, country of origin, and four task factors (e.g., whether the task objects were transformed in order to deceive the protagonist or not) yielded a multiple R of .74 and an R2 of .55; thus, the model accounts for 55% of the variance in false-belief performance. Moreover, false-belief performance showed a consistent developmental pattern, even across various countries and various task manipulations: preschoolers went from below-chance performance to above-chance performance. The findings are inconsistent with early competence proposals that claim that developmental changes are due to tasks artifacts, and thus disappear in simpler, revised false-belief tasks; and are, instead, consistent with theoretical accounts that propose that understanding of belief, and, relatedly, understanding of mind, exhibit genuine conceptual change in the preschool years.

Child↗