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At least 541 records · Page 30Linked to original sources
PubMed1990

Invention of anti-Leishmania drugs on the basis of the nucleoside structures.

3'-Deoxy-3'-fluoroinosine is a potent inhibitor for the growth of the promastigote form of Leishmania tropica and Leishmania donovani. In culture, the EC50 values of 3'-deoxy-3'-fluoroinosine are 2.3 x 10(-7) and 1.0 x 10(-6) M for the promastigotes of L. tropica and L. donovani, respectively. It is less toxic towards mouse mammary tumor FM3A cells: the EC50 value is 2.0 x 10(-4) M. 3'-Deoxy-3'-fluoroinosine is metabolized by Leishmania promastigotes to give 3'-deoxy-3'-fluoroadenosine-5'-triphosphate. This metabolic conversion provides a mechanism for the parasite-selective toxicity of 3'-deoxy-3'-fluoroinosine.

Animals↗
PubMed1989

[Water absorption and resistance to wear of 2 newly invented composite resins].

Two recently built composites, one for posterior teeth, and the other for general employ, were evaluated in relation to their water absorption and resistance to wear by means of the "scratch test". Critical loads and attrition of the two materials were also evaluated, with statistical analysis. The results supported the good qualities of the two composites, which are to be considered very advanced in the field of esthetic reconstruction materials.

Absorption↗
PubMed1989

Finding and inventing alternative therapies: how I do it.

The author discusses methods of developing alternative therapies when standard treatments have proved ineffective or do not exist. Specific treatments for a wide range of stubborn or difficult dermatologic conditions are presented.

Complementary Therapies↗