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At least 541 records · Page 30Linked to original sources
PubMed1996

Management of drug overdoses in accident and emergency departments in the United Kingdom.

A questionnaire consisting of 10 overdose scenarios was sent to 190 career accident and emergency staff in the United Kingdom, asking in each case how the respondents would treat a patient to prevent drug absorption. The responses showed lack of consensus in treatment methods. There was extensive use of both ipecacuanha induced emesis and gastric lavage despite a lack of experimental evidence to support these techniques.

Adolescent↗
PubMed1985

Ipecacuahana induced emesis in the treatment of self-poisoned adults.

One hundred consecutive adult patients presenting to an Accident and Emergency Department following intentional self-poisoning were given 50 to 80 ml Paediatric Ipecacuahana Emetic Mixture BP as an emetic, together with two or three glasses of strong orange juice. A satisfactory emetic result was obtained in 99 patients. No toxic effects were noted in these patients, or in the one patient in whom emesis did not occur, and who subsequently refused gastric lavage. The potential toxicity of Ipecacuahana Syrup itself is discussed, and attention drawn to the lower Emetine content of Paediatric Ipecacuahana Emetic Mixture (BP), rather than that of the formulations used in previously published reports. The use of Paediatric Ipecacuahana Emetic Mixture B.P. in adults is effective and safe in this dosage.

Adolescent↗
PubMed1986

Recovery of ingested heroin packets.

Two patients deliberately ingested single paper packages containing heroin. These were recovered intact by induction of emesis with syrup of ipecacuanha.

Adult↗
PubMed1986

Ipecacuanha.

Explore the source record for details and available documents.

Child, Preschool↗
PubMed1990

A comparison of the efficacy of gastric lavage, ipecacuanha and activated charcoal in the emergency management of paracetamol overdose.

The aim of this prospective trial was to compare the efficacy of gastric lavage, activated charcoal and ipecacuanha at limiting the absorption of paracetamol in overdose and to assess the significance of the continued absorption of paracetamol following treatment. Patients aged 16 and over who had ingested 5 gms or more of paracetamol within 4h of admission were entered into the trial. The percentage fall in plasma paracetamol level was used as the measure of the success of a treatment at limiting absorption. The mean percentage fall was 39.3 for gastric lavage, 52.2 for activated charcoal and 40.7 for ipecacuanha, with a significant difference between the treatment methods (p = 0.03). Activated charcoal was more effective at limiting the absorption of paracetamol following overdose than either gastric lavage or ipecacuanha induced emesis. In treated patients continuing paracetamol absorption is not significant if more than 2h have elapsed since ingestion.

Absorption↗
PubMed2000

The treatment of overdose--time for a change?

To determine emergency management of overdose relating to gastrointestinal decontamination procedures in Scottish Accident & Emergency (A & E) Departments. A postal questionnaire was sent to the 28 main A & E Departments in Scotland. There was a 75% response rate. Nineteen departments(90%) continue to perform gastric lavage, with the majority carrying out this procedure more than one hour post-ingestion of commonly presenting overdoses. Sixteen departments (76%) regularly administer activated charcoal and four (19%) use syrup of ipecacuanha. Twenty departments (95%) had access to Toxbase. The majority of respondents (86%) feel there is a need for standardisation of treatment in acute overdose. Despite the availability of guidelines provided by the UK National Poisons Information Service and the Position Statements, there is no consensus in the actual management of acute overdose among Scottish A&E departments.

Charcoal↗
PubMed1991

Residual gastric content after gastric lavage and ipecacuanha-induced emesis in self-poisoned patients: an endoscopic study.

Flexible endoscopy was used to assess the intragastric residue after either ipecacuanha-induced emesis or gastric lavage in 30 self-poisoned patients. Of the 13 patients treated by induced-emesis, five (38.5%) had residual solid in the stomach; 17 patients were treated by gastric washout, and 15 (88.2%) of these had residual intragastric solid. The study provides direct evidence that the gastric decontaminating procedures employed, and especially gastric lavage, do not remove stomach contents completely.

Adolescent↗
PubMed1991

Gastric emptying procedures in the self-poisoned patient: are we forcing gastric content beyond the pylorus?

A prospective, randomized, single-blind study was carried out to determine whether gastric content is forced into the small bowel when gastric-emptying procedures are employed in self-poisoned patients. They were asked to swallow barium-impregnated polythene pellets, immediately prior to either gastric lavage or ipecacuanha-induced emesis. A second group of patients, who did not require treatment, were used as controls. Sixty patients were recruited to the study. The data show a significant difference in the number of residual pellets in the small bowel of the treated group (n = 40), when compared with the control group (P less than 0.0001). There was no statistical difference in the number of pellets in the small bowel when the treated groups were compared with each other. In addition, the inefficiency of gastric-emptying procedures is highlighted; 58.5% of the total number of pellets ingested were retained in the gastrointestinal tract of the ipecacuanha-treated group, while 51.8% of total pellets ingested were retained in the gastric lavage-treated group.

Adolescent↗
PubMed1995

Prevention of drug absorption in simulated theophylline overdose.

1. The effects of emesis, gastric lavage and oral activated charcoal on theophylline absorption were compared in healthy volunteers. 2. One of four regimes (ipecacuanha-induced emesis, gastric lavage, oral activated charcoal and no treatment) was randomly chosen one hour after a simulated overdose with sustained-release theophylline on four separate occasions in twelve healthy volunteers. 3. Syrup of ipecacuanha produced emesis in all twelve volunteers but only seven vomited any tablets. Gastric lavage yielded tablets in only one volunteer. 4. The mean systemic availabilities (areas under the concentration-time curves relative to control) of theophylline for ipecacuanha-induced emesis, gastric lavage and charcoal, were 107.1%, 101.1% and 16.9%, respectively. 5. Oral activated charcoal was thus highly effective, while gastric lavage and emesis were ineffective in preventing theophylline absorption. Activated charcoal is potentially the most effective first-line treatment for acute overdosage with sustained-release theophylline tablets.

Administration, Oral↗