Letter: Limitations in the use of hydrolytic rate constants for the simultaneous determination of drug and metabolite in serum.
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Evaluation Studies as Topic↗
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Results for “GLUTETHIMIDE”
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The effect of ethchlorvynol on the drug-metabolizing enzymes of rats and dogs.
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Aminopyrine↗
Studies of the relationship between chemical structure and porphyria-inducing activity. IV. Investigations in a cell culture system.
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Amides↗
Biochemical changes in rat liver in response to treatment with drugs and other agents. 3. Effects of centrally acting drugs.
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Aminopyrine↗
Drug-induced porphyrin biosynthesis. II. Simple procedure for screening drugs for porphyria-inducing activity.
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Animals↗
Comparison of the efficacy of pretreatment protection against adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene and by 7-methyl-12-methylbenz(a)anthracene in rats.
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Adrenal Glands↗
Interference of barbiturates with pyrimidine incorporation. II. Structural specificity of the inhibition of orotate uptake in Bacillus cereus.
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Amobarbital↗
Drug-induced porphyrin biosynthesis. 3. Inhibition of drug-induced porphyria by protohemin.
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Acetamides↗
Changes in D-glucaric acid excretion in relationship to alterations in the rate of antipyrine metabolism in man.
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Adipates↗
Inhibition of aldehyde reductase isoenzymes in human and rat brain.
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Aldehyde Oxidoreductases↗
A thirty-minute determination of sedatives in plasma by gas-liquid chromatography.
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Amobarbital↗
New mixed bed column for rapid gas-liquid chromatographic determination of sedatives and Dilantin in serum.
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Amobarbital↗
Application of a digital computer to emergency toxicology.
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Barbiturates↗
Effectiveness of sleep medications: all night studies of hypnotic drugs.
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Chloral Hydrate↗
Dexetimide, a useful tool in acetylcholine-receptor localization.
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Acetamides↗
The diazepam stimulus complex: specificity in a rat model.
Rats were trained to discriminate between one dose of diazepam (2.0 mg/kg) and saline in a two-lever operant chamber. When the group (n = 7) reached the training criterion, other drugs were introduced to test. Test drugs with supposed agonistic effects included drugs sharing one or more effects with diazepam, while drugs with supposed antagonistic effects were selected in relation to both reported effects and a supposed neurochemical substrate for the diazepam discriminative stimulus complex (DSC). It is concluded that a discriminative stimulus complex induced by a low dose of diazepam is highly specific and dependent on specific elements in the training procedure as well as in the testing procedure.
Animals↗
Modifiers of steroid-hormone metabolism: a review of their chemistry, biochemistry and clinical applications.
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Adrenal Cortex↗
Effects of various depressant drugs on deprivation-induced water consumption.
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Animals↗