[8 CASES OF PRIMARY TUBAL EPITHELIOMAS].
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Both heterotopic pregnancies and primary neoplasms of the fallopian tube are rare occurrences. A patient presented with early pregnancy, abdominal pain and ultrasound findings of an intrauterine gestation and a fallopian tube mass. Laparotomy revealed a primary leiomyoma of the fallopian tube.
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Five cases of intestinal endometriosis presented with infertility and pelvic pain. Rectal bleeding occurred in two patients and diarrhea in one. A diagnosis was achieved with a barium enema study and colonoscopy. All the patients had pelvic endometriosis as documented by laparoscopy. Endometriosis was present in the sigmoid colon in three patients and in the cecum in one; it was pericecal in the fifth. Bowel resection and pathologic study are necessary to relieve the symptoms and avoid neglecting a malignant tumor or other lesions.
The surprising disagreement in treatment results obtained by the various authors treating endometriosis is in large part due to differences in the severity of the disease. Only the adoption of a satisfactory staging system allows valid comparison between homogeneous groups of patients. This paper reviews and analyzes the various classifications proposed with the aim of showing the original aspects and the defects that led to the development of new systems including the most recent one published by the American Fertility Society. Devising a classification system presents unexpectedly great problems, but it is essential to be able to compare treatment results.
The risk of second primary cancer was evaluated in more than 25,000 women with cancer of the genital organs diagnosed between 1935 and 1982 in Connecticut. Significant excesses of subsequent cancers were observed following cancers of the cervix (35%, n = 656), uterine corpus (16%, n = 1,060), and ovary (58%, n = 366). When observed and expected second cancers of the female genital tract were excluded, these excesses became 40%, 30%, and 59% after cervix, uterine corpus, and ovary, respectively. Among women with either cancer of the cervix or uterine corpus, the risk of developing a second cancer rose with increasing duration of follow-up, reaching an excess of 61 and 34%, respectively, after 20 years. In contrast, among patients with ovarian cancer, the second cancer risk decreased over time to 41% after 10 years. Cancers related to smoking, i.e., oral cavity and pharynx, esophagus, and respiratory system, were notably increased among cervical cancer patients. The twofold to threefold risks observed for these second cancers are consistent with recent evidence linking cervical cancer to cigarette smoking and seem too large to be artifacts of confounding by low socioeconomic status. An increased incidence of second cancer of the abdominal organs (colon, rectum, kidney, bladder, ovaries) was generally observed for each gynecologic site. However, only rectal cancer was consistently linked with radiation treatment for the first primary cancer. Leukemia occurred in excess after cancers of the uterine corpus and ovary, but not after cervical cancer. The predominant cell type was acute nonlymphocytic leukemia, and the excess was associated with radiotherapy for uterine corpus cancer and with chemotherapy for ovarian cancer. Cancers of the breast and colon were increased following uterine corpus and ovarian cancer and vice versa, which supports the notion that these sites share a common etiology, perhaps related to dietary or hormonal factors. Cervical cancer patients experienced a deficit of subsequent breast cancer, possibly due to ovarian removal or ablation by radiation. Investigators need to explore further the association between the smoking-related cancer sites and cervical cancer, to clarify the role of radiotherapy and chemotherapy in relation to excess cancers, and to define more fully the etiologic factors that link cancers of the breast, colon, uterine corpus, and ovary.
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A histopathologic review of 959 cases of the endocervical, endometrial and tubal adenocarcinomas is presented. Most of the histopathologic types of the adenocarcinoma in each site were in consistent with that of it's native epithelium, which were 43.7%, 74.5% and 85.5%, respectively. However, other types besides native type may be found in any site adenocarcinoma. The pathologic features of the surroundings in some early lesions demonstrated a possible different morphogenesis. The synchronous multiple site primary adenocarcinomas in the mullerian system were common, comprising 7.8%, in which were composed of 91% in 2 sites, 7.5% in 3 sites, and 1.5% in 4 sites. Most of them were endometrial and ovarian adenocarcinomas, in 37.3%. These data suggested the complex histopathologic types of the mullerian adenocarcinomas including the endocervical, endometrial and tubal adenocarcinomas should be considered before diagnoses, especially in biopsy specimens. The synchronous multiple site primary adenocarcinomas were not rare for the same origin of histogenesis. Thus, a correct diagnosis will be conductive to stage and management.
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