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At least 541 records · Page 30Linked to original sources
PubMed2004

Swan-neck deformity and paresthesia following giant orf.

Orf is a zoonotic infection caused by a parapoxvirus that primarily infects sheep and goats. Human orf infection can take place when abraded skin comes into contact with infected animals. It occurs most commonly on the index finger. The characteristic lesion resembles a tumor and resolves spontaneously, usually without any complications. However, rare complications such as lymphangitis, adenitis, erythema multiforme, erysipelas, papulovesicular eruption, Pseudomonas aeruginosa infection, and bullous pemphigoid have been reported. Herein, we report a case of giant orf causing swan-neck deformity and paresthesia. These complications have not been previously reported in the literature.

Animals↗
PubMed1977

Orf: a family with unusual complications.

Three members of a farming family and their local postman contracted orf. One of those affected had had no direct contact with infected sheep. Two of the family developed a widespread papulo-vesicular eruption of the skin and mucosae with pyrexia, malaise and lymphadenopathy lasting 4-5 weeks. The eruption did not resemble erythema multiforme or the toxic erythemas usually associated with this infection.

Adolescent↗
PubMed1986

Giant orf in a patient with chronic lymphocytic leukaemia.

A case of orf is presented in a patient with chronic lymphocytic leukaemia treated with chlorambucil and prednisone. Diagnosis was confirmed by electron microscopy and histopathology. Human orf is normally a self-limiting and benign condition but in this case the lesion grew to a size of 60 X 60 X 28 mm. When it was excised, local recurrence was treated with topical idoxuridine.

Ecthyma, Contagious↗
PubMed1994

Immune responses of patients to orf virus infection.

Orf is a disease of sheep and goats which is caused by a parapox virus. It can be transmitted to humans, and is considered an occupational hazard by those handling sheep. In this paper we present the first report of both cell-mediated and humoral immune responses to naturally acquired orf virus infection in humans. Lymphoproliferative responses of peripheral blood mononuclear cells of patients to an orf virus antigen were vigorous soon after infection, but rapidly declined. Orf virus antibody levels, detected by ELISA, were shown to rise during infection. Western blot analysis confirmed this, and demonstrated that the antibody produced in response to the infection was directed against the 40-kDa viral surface tubule protein. Where direct comparisons were possible, the immune response of humans to orf virus infection was similar to that previously reported for sheep. Evidence was obtained suggesting that prior exposure to vaccinia virus (smallpox vaccination) provided no protection from subsequent orf virus infection. In addition, orf virus infection did not enhance immune responses to vaccinia virus antigens.

Adolescent↗
PubMedDate not supplied

Orf and pregnancy.

A 31-year-old woman presented with orf on the forefingers at 34 weeks of gestation. The disease, contracted after handling sheep a week before, was uncomplicated, and the patient gave birth at term to a normal baby. Although some cases with features suggestive of viremic spread had been described, the authors find an overall benign picture of orf in man and recommend symptomatic therapeutic measures.

Adult↗
PubMed1993

A close comparative study on the response of sheep and goats to experimental orf infection.

A comparative experimental study of the clinico-pathological and serological response of sheep and goats to orf infection was made. All infected animals depicted typical orf lesions and seroconverted. The clinical, serological, gross and histopathological responses were similar in both species. However, the disease span was longer in sheep than in goats. It was concluded that sheep could play an important role in maintenance of the virus in the environment.

Animals↗