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Results for “Cyclohexanecarboxylic Acids”

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At least 541 records · Page 30Linked to original sources
PubMed1984

Effect of cicloxilic acid on bile flow and biliary lipid secretion in humans.

Previous investigations have shown that cicloxilic acid, a hydrocholeretic drug, lowers bile cholesterol saturation without interfering with the intestinal absorption of cholesterol as well as with the hepatic synthesis of both cholesterol and bile acids. The mechanism whereby cicloxilic acid antagonizes lithogenic bile secretion is still unknown. However, most evidence favors the view of a relationship between choleretic and antilithogenic effects of the drug. To test this hypothesis the effects of a single oral dose (240 mg) of cicloxilic acid on bile flow and biliary lipid excretion rates have been examined in four nonobese cholecystectomized patients with balloon-occludable, reinfusion T-tubes. The results indicate that cicloxilic acid exerts a marked choleretic effect combined with a reduced output of bile cholesterol and an increase in bile acid excretion. Bile cholesterol saturation significantly decreases 90 min after cicloxilic acid in respect to control value. These data provide evidence of a link between choleretic and antilithogenic effects of cicloxilic acid and suggest its usefulness in the treatment of bile cholesterol supersaturation.

Adult↗
PubMed2004

Indirect photometric assay determination of gabapentin in bulk drug and capsules by capillary electrophoresis.

A capillary electrophoresis (CE) method was developed for the assay determination of gabapentin (GBP) in bulk drug and capsules. Separation was carried out on 74cm (62.5cm effective length) x 75microm i.d. fused silica capillary by applying a potential of -20kV at ambient temperature. Background electrolyte (BGE) consisting of 5mM 5-sulphosalicylic acid and 0.5mM cetyltrimethylammonium bromide (CTAB), pH 11.0 was employed for the separation. Indirect method of UV detection was performed at a wavelength of 215nm using sulphosalicylate ion as a chromophore. A linear calibration curve was obtained over a concentration range 20-200microg/ml of GBP in deionized water with a correlation coefficient (r) of 0.9998. Recoveries were shown to be >/=98% both in bulk drug and capsules with standard deviation (S.D.) </=2.3%. No placebo (matrix) peaks were observed at the migration times of GBP and L-glutamic acid (internal standard, I.S.).

Amines↗
PubMed1978

Effects of cicloxilic acid on secretory function of the liver. I. Effect on bile flow and on biliary secretion of bilirubin and glucuronic acid in anesthetised bileduct-cannulated rat.

Both in normal and experimentally jaundiced rats cis-2-hydroxy-2-phenyl-cyclohexanecarboxilic acid (cicloxilic acid) induces a greater and longer lasting increase in bile flow and a greater increase in bilirubin and glucuronic acid secretion than do the choleretics sodium 2-(2-hydroxy-3n hexoxy-propoxy)-benzoate and dehydrocholic acid. The intense increase in bilirubin secretion is interpreted as the outcome of stimulation of the biliary secretion mechanisms whilst the effect on bile flow and on the biliary secretion of glucuronic acid are attributed to the kinetics of biliary secretion of cicloxilic acid.

Anesthesia↗