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At least 541 records · Page 30Linked to original sources
PubMed1982

Histamine1--histamine2 antagonism: effect of combined clemastine and cimetidine pretreatment on allergen and histamine-induced reactions of the guinea pig lung in vivo and in vitro.

In a preliminary study high doses of the H1-antagonist clemastine (clem) and the H2-antagonist cimetidine (cim) were used in order to detect the side effects of both drugs on allergic reactions. After pretreatment with clem or clem/cim different guinea pigs were challenged with either OA or histamine. Bronchial obstruction was measured by body plethysmography using a new parameter ('compressed air'). Pretreatment with clem/cim in high doses protected guinea pigs against OA-induced bronchial obstruction much more effectively than H1-receptor antagonism alone; lower cim doses produced insignificant effects. In histamine-challenged animals cim showed no protective effects. In vitro clem/cim caused a marked reduction of histamine release measured in perfused lungs from 16.9 +/- 4.2 ng/ml (eight control cases) to 2.8 +/- 1.7 ng/ml (n = 8). Our preliminary data suggest that high doses of clem/cim can protect sensitized guinea pigs against allergen-induced bronchial obstruction by inhibiting histamine release.

Allergens↗
PubMed1994

Iatrogenic and accidental colon injuries--what to do?

PURPOSE: This study was designed to formulate management guidelines for a variety of rare iatrogenic and accidental injuries to the colon and rectum. METHODS: This review collates the available evidence in the literature. RESULTS: Both investigative and therapeutic maneuvers involving the colon, particularly endoscopy and radiographic contrast studies, are the most common cause of significant injury although the incidence is low. Even less common are injuries produced, at open surgery and minimally invasive surgery, by foreign bodies, enemas, or compressed air. The mechanisms and management of these injuries are discussed in detail. CONCLUSIONS: Evidence exists to support that a nonoperative approach is safe for the majority of injuries, particularly when the colon is "clean" at the time of injury. Adequate resuscitation, observation, and repeated reassessment are mainstays of a conservative policy. Operation is essential for progression of abdominal signs. Patients with established peritonitis at the time of presentation or with an unprepared bowel are best served by prompt operation.

Barium Sulfate↗
PubMed1993

Effect of hyperbaric oxygen on prostaglandin and thromboxane synthesis in the cortex and the striatum of rat brain.

The effect of a previous exposure to hyperbaric oxygen (HBO) on the synthesis capacity of prostaglandin (PG) and thromboxane (TX) was investigated in the brain of male rats. Three groups of rats were used: 1. Neurotoxic HBO (n = 11): The rats were exposed to sixfold the atmospheric pressure (101.3 kPa), i.e., 6 absolute atmospheres (ATA), of pure O2 up to the first convulsion (6 ATA O2); 2. Mild hyperoxia (n = 10): The rats were exposed to compressed air at the same absolute pressure and for a similar time than that of the neurotoxic HBO group (here PO2 is 1.26 ATA); 3. Normoxia at atmospheric pressure (PO2 is 0.21 ATA) for control. There was no convulsion in groups 2 and 3. Decompression of the high pressure groups lasted 15 min. After decapitation, samples of the frontal cortex and the striatum were taken, weighed, washed, and then incubated in Krebs-Ringer bicarbonate for 1 h. The release of eicosanoids in the medium was determined by enzyme immunoassay. Mild hyperoxia only significantly reduced in the striatum the release of 6-keto-PGF1 alpha (1.3 +/- 2.4 vs 10.9 +/- 6.6 pg/mg wet tissue, p < 0.001; mean +/- SD) and PGE2 (3.2 +/- 2.7 vs 7.8 +/- 6.5 pg/mg wet tissue, p < 0.05), whereas TXB2 did not change.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed2002

The oxygen concentrator is a suitable alternative to oxygen cylinders in Nepal.

PURPOSE: To review the efficacy and reliability of oxygen concentrators used over the last six years in Nepal. The apparatus used was a DeVilbiss(R) oxygen concentrator that provided O(2) for anesthesia supplemented with compressed air to drive a Penlon Manley Multivent Ventilator(R). It remains difficult to supply oxygen in cylinders to peripheral hospitals in Nepal due to lack of proper roads. METHODS: We conducted a retrospective analysis of a sample of 378 cases anesthetized at the Bir Hospital and at a private hospital in Kathmandu from April through October 1999. The Bain circuit or its modification was used in adults, and Bain or Ayre's T piece in children. High flows from the oxygen concentrator used with the Bain and Ayre's T-circuits were reduced to 2 L/min, delivered through the halothane vaporizer, supplemented by room air in the modified Bain circuit. Positive pressure ventilation was provided with an Ambubag, Oxford Inflating Bellows or Penlon Manley Multivent Ventilator. Blood pressure, electrocardiogram, FiO(2) and SpO(2) were monitored in all cases. RESULTS: Surgery included urologic, general surgery, obstetrics and gynecological procedures, neurosurgery and closed mitral valvotomy. Age ranged from six months to 78 yr. The anesthetic time lasted from 45 min to 12 hr. The FiO(2) ranged from 0.5 to 0.6 in the Bain and Ayre's T circuits, and from 0.34 to 0.40 in the modified Bain circuit with a flow of oxygen of 2 L/min from the concentrator. CONCLUSION: With regular maintenance and servicing done locally, the oxygen concentrator can be used safely in adults and children. Use of the oxygen concentrator is a suitable alternative to oxygen cylinders in the developing world.

Adolescent↗
PubMed1991

The influence of one hyperbaric oxygen-induced seizure on brain eicosanoid content.

The levels of prostaglandin F1 (6-keto-PGF1 alpha), thromboxane B2 (11-dehydro-TxB2), and peptidoleukotriene C4 (LTC4) were measured (acetylcholinesterase immunoassay) in the frontal cortex (FC) and the striatum (SA) of the rat brain to study the possible role of eicosanoids in seizures induced by hyperbaric oxygen (HBO). The rats were exposed to (1) hyperbaric oxygen (HBO, 6 ATA O2) up to the first seizure (2) compressed air (6 ATA air, i.e., approximately equal to 1.25 ATA O2) or (3) atmospheric pressure (1 ATA air, i.e., 0.21 ATA O2); there was no seizure in groups 2 and 3. Transition from 6 ATA to atmospheric pressure was obtained in 15 min; the rats were then decapitated and their heads frozen in liquid nitrogen before extraction and analysis of prostanoids. Whatever the conditions, cortical levels of 6-keto-PGF1 alpha and 11-dehydro-Tx B2 are higher than striatal levels; considering the same area, 11-dehydro-Tx B2 and LTC4 concentrations were not significantly different whatever the condition, but there is a trend for lower 6-keto-PGF1 alpha levels in FC after HBO seizure. Biochemical mechanisms are discussed. Eicosanoids do not seem to play a major role in HBO seizures, although some modifications of their metabolism may take place.

Animals↗
PubMed2000

[Severe diving accidents: physiopathology, symptoms, therapy].

Decompression injuries are potentially life-threatening incidents, generated by a rapid decline in ambient pressure. Although typically seen in divers, they may be observed in compressed air workers and others exposed to hyperbaric environments. Decompression illness (DCI) results from liberation of gas bubbles in the blood and tissues. DCI may be classified as decompression sickness (DCS) or arterial gas embolism (AGE), depending on where the gas bubbles lodge. DCS occurs after longer exposures to a hyperbaric environment with correspondingly larger up-take of inert gas. DCS may be classified into type 1 with cutaneous symptoms and musculoskeletal pain only or type 2 with neurologic and/or pulmonary symptoms as well. AGE usually results from a pulmonary barotrauma, and with cerebral arterial involvement, the symptoms are similar to a stroke. The most important therapy, in the field, is oxygen resuscitation with the highest possible concentration and volume delivered. The definitive treatment is rapid recompression with hyperbaric oxygen therapy. Additional therapeutic measures are discussed.

Animals↗
PubMed1997

Modifications of breathing pattern induced by inhaled sulphur mustard in mice.

A head-only exposure assembly was used for exposing mice to vapours of sulphur mustard (SM). The respiration was monitored using an on-line computer program, capable of recognizing the breathing pattern as sensory irritation, airflow limitation and pulmonary irritation. SM was dissolved in acetone and vapourized using a compressed air nebulizer. Mice were exposed to the vapours (8.5, 16.9, 21.3, 26.8, 42.3 and 84.7 mg/m3) for 1 h in a body plethysmograph fitted with a 20-gauge needle and a microphone for sensing the respiratory flow signals. The signals were amplified, digitized and integrated to give tidal volume, and stored in a computer for further analysis. The respiration of the mice was followed for modifications in the breathing pattern until 7 days post-exposure. SM induced sensory irritation during exposure, and there was a concentration dependent decrease in the respiratory frequency and an increase in tidal volume. Lower concentrations showed recovery after stopping the exposure. RD50, the concentration that depresses 50% of the respiration was estimated to be 27.4 mg/m3. Following exposure to higher concentrations the animals started dying after 6 days. The LC50 was estimated to be 42.5 mg/m3 (14 days observation period). The respiratory frequency decreased on subsequent days of exposure depending upon the exposure concentration, and the breathing pattern was characteristic of airflow limitation. The ratio of flow/tidal volume was decreased following exposure to concentrations of 26.8 and 42.3 mg/m3. The ratio of flow/tidal volume may be a better measurement than the measurements based on flow alone for the assessment of airflow limitation. Pulmonary irritation was not observed showing that the lungs were not affected. The body weight of the animals decreased progressively. The present methodology will be useful for identifying the effects of SM on the respiratory system, one of the endpoints considered when establishing occupational exposure limits.

Administration, Inhalation↗
PubMedDate not supplied

Vibroliposuction: a study of rate of aspiration.

Challenges in suction-assisted lipoplasty (SAL) along with ultrasound-assisted lipoplasty (UAL) include physical effort by the surgeon, surface irregularities and undulations, risk of perforations (SAL), risk of burns (UAL), and lengthy operative time. In this study of 74 patients, vibro-assisted liposuction (VAL) was evaluated by rate of aspiration. In this group, variables included diameter of the cannula, number of openings, and pressure of compressed air. Our findings suggest that operative time is decreased with a greater number of openings into the cannula and a higher air pressure.

Adolescent↗
PubMed1999

Anticancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice.

PURPOSE: To test the anticancer properties of the water-insoluble derivative of camptothecin, 9-nitrocamptothecin (9-NC) against human breast, colon and lung cancer xenografts in nude mice when administered in liposome aerosol. METHODS: The drug was formulated with dilauroylphosphatidylcholine and nebulized in a particle size of 1.6 microm +/- 2.0 mass median diameter to deliver doses of usually less than 200 microg/kg daily, 5 days per week. 9-NC liposome aerosols were generated with a Aerotech II nebulizer (CIS-USA) flowing at 101/min from a compressed air source and delivered to mice in sealed plastic cages or in a nose-only exposure chamber. RESULTS: Tumor growth was greatly reduced or tumors were undetectable after several weeks of treatment. Colon tumor was least responsive. 9-NC was better than the parent compound, camptothecin, also water-insoluble, tested by aerosol in a similar liposomal preparation. Equivalent doses of 9-NC liposome preparations administered by mouth were substantially without effect while there was some effect, but limited, of the liposome preparation given intramuscularly. CONCLUSIONS: 9-NC liposome aerosol was strikingly effective in the treatment of three human cancer xenografts growing subcutaneously over the thorax in nude mice at doses much smaller than those traditionally used in mice administered by other routes.

Animals↗
PubMed2003

Gastric barotrauma in a scuba diver: report of a case.

Stomach rupture can occur as a consequence of the expansion of compressed air during rapid ascent after diving. We present the case of a middle-aged woman who suffered a gastric tear from surfacing too quickly after diving, and discuss the diagnosis and management of such patients by reviewing previously reported similar events. Gastric barotrauma should be suspected in divers who complain of abdominal pain, even in the absence of frank signs of peritoneal irritation. Although pneumoperitoneum is always present in these patients, it can also occur as a consequence of pulmonary barotrauma, making gastroscopy or radiological contrast studies, or both, essential for a definitive diagnosis. Surgical repair represents the treatment of choice for an active full-thickness tear and, if associated with arterial gas embolism or decompression sickness, should ideally be performed in a center where a category I (intensive care-capable) hyperbaric unit is available.

Barotrauma↗
PubMed1982

Effects of carbon dioxide-oxygen inhalations on subjective anxiety and some neurovegetative parameters.

The immediate effects of double inhalations of a 35% CO2-65% O2 mixture were studied on 12 subjects, all of them undergraduate students. For placebo control double inhalations of compressed air were administered to the same experimental subjects. In comparison, CO2/O2 inhalations were found to provoke significantly stronger autonomic reactions, viz, drops in heart rate and diastolic blood pressure. Reduction in subjective feeling of anxiety was observed with both CO2/O2 and air intake. On this parameter of subjective feeling the order in which the treatments were received interacted with the gas variable, i.e. CO2/O2 and air. The occurrence of a carry-over effect was indicated: Subjects having taken the placebo before CO2/O2 showed lower SUD scores than did those treated reversely.

Anxiety↗
PubMed1980

Effectiveness of hardening films on die stone.

1. Cyanoacrylate resins and resinous die hardeners effectively improved the hardness and abrasion resistance of stone dies. 2. Application of liquid resins followed by blotting and/or blowing with compressed air produced an improved surface without clinically significant dimensional change. The extent of film buildup was qualitatively related to the viscosity of the resin. 3. Application of multiple coats of resin or simply soaking the dies in resin without further blotting or other mode of removal of the excess produced a thick film which can obliterate surface detail.

Calcium Sulfate↗
PubMed1983

Protective effect of polystyrene liners for composite resin restorations.

The main purpose of lining cavities before insertion of composite resin restorations is to prevent bacterial contamination at the cavity walls. A thin film of polystyrene liner dissolved in ethyl acetate applied to all surfaces by compressed air provided good protection against bacteria on cavity walls under composite resin restorations. An antibacterial primer in an alcohol solution applied prior to the liner may improve this protection. This procedure had no detectable injurious effect on the pulp.

Animals↗
PubMed1983

Effects of cyanoacrylates on die stone.

An evaluation was made of the effects of the application of an increasing number of coats of cyanoacrylate on die stone. The application of one coat of cyanoacrylate adhesive on the surface of trimmed and marked dies increases the surface hardness, increases the scratch resistance, will not change the dimensions of the die appreciably, and renders the margin marking more permanent. Excess resin should be removed immediately by compressed air. The use of hardener instead of water is recommended for mixing Type IV dental stone. Use of the cyanoacrylate method will aid the dentist and the technician in achieving an accurate crown fit.

Calcium Sulfate↗
PubMed1996

A new method for aversive Pavlovian conditioning of heart rate in rhesus monkeys.

Aversive Pavlovian conditioning is an important tool used to investigate neurobiological mechanisms underlying the acquisition and expression of fear. Most studies have used nonprimate species employing electrical shock as the unconditioned stimulus (US). Although important advances have been made in understanding the neural substrates of conditioned fear, the extent to which these findings apply to primates is unclear. Research in primates has not progressed because of the lack of a conditioning paradigm that does not use shock. Therefore, we developed a method that uses a US consisting of a loud noise coupled with a stream of compressed air aimed at the face to aversively condition heart rate response in rhesus monkeys. With this US, rhesus monkeys rapidly acquire a conditioned bradycardia. The availability of an easy, reliable, and efficient method of aversive conditioning that does not require electrical shock, will facilitate studies investigating neurobiological mechanisms underlying the acquisition and expression of fear in primates.

Animals↗
PubMed1989

Improved efficacy of some phosphate-based dentin-bonding agents.

The gap-reducing efficacy of four phosphate-based dentin-bonding agents was tested after various treatments of the dentin and/or the bonding agents. The investigation was carried out on extracted human teeth. One of the root surfaces was ground flat, and a cylindrical butt-joint cavity was prepared in the ground dentin surface. It was found that the efficacy of two of the adhesives, presumably being chloro-substituted phosphates, could be markedly improved if the primed dentin was rinsed with copious amounts of water, dried by compressed air, and a second layer of bonding agent applied. The mechanism behind this improvement is assumed to be the formation of hydrogen chloride, which dissolves part of the smear layer.

Dental Bonding↗
PubMed1991

The effects of primers on the sensitivity of dentin.

The effects of dentin primers on the sensitivity of dentin were examined by measurement of the repetitive firing observed when a class V cavity prepared in the dentin of the lower jaw of a rabbit was irritated by a blast of compressed air. It was possible to conclude that the combined application of an aqueous solution of 35% hydroxyethyl methacrylate and a commercially available dentin bonding agent was effective for reducing the repetitive firing and for maintaining such a "sedative " effect. Although the dentin tubules were sealed mechanically by the resin material, it was impossible to explain the mechanism by which the dentin primer application reduced firing.

Aminosalicylic Acids↗
PubMed1993

Enhanced evaporation of mercury from amalgams in non-oxidizing environments.

The release of mercury from two freshly triturated amalgams exposed to a reducing atmosphere, hydrogen, was quantitated at three different temperatures. A low-copper and a high-copper amalgam were placed into a flowing hydrogen gas atmosphere for 60 min after trituration, and then the hydrogen was replaced by compressed air. The results were compared to those obtained in a previous study in which air and argon atmospheres were used under identical conditions. At 37 degrees C, the rate of evaporation of mercury from the amalgams was similar when they were exposed to hydrogen before being exposed to air. During exposure to hydrogen, the evaporation rate appeared to exceed the limit of the gold film mercury analyzer (284 pg/mm2/s), but was rapidly reduced upon exposure to air. The results were identical to those from argon exposure. When the same experiment was performed at 80 degrees C, the evaporation rate after hydrogen exposure was greater than that after exposure to argon, and far greater than that during exposure to air alone. Similar results were achieved at 110 degrees C, but there was less difference between hydrogen and argon exposure. The results support previous studies which show that the evaporation of mercury from amalgam is mainly limited by the formation of an oxide film.

Air↗