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Results for “Ciliary Body”

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At least 541 records · Page 30Linked to original sources
PubMed1990

Ultrastructural pleomorphism in medulloepithelioma of the ciliary body: a comparative study of tumour cells and fetal ciliary epithelium.

A locally aggressive nonteratoid intraocular medulloepithelioma occurring in a two-year-old boy was studied by electron microscopy. For comparison the primitive pars plana region was examined in human fetal eyes obtained at 16, 18 and 22 weeks of gestation. The tumour was polymorphic with neural, intermediate and epithelial components. The neural component of the tumour resembled the zonulae adherentes dominant cell junction seen in the apical part of the unpigmented epithelium at 16 weeks, while the well-developed junctional complexes and interdigitations seen in the unpigmented epithelium at 22 weeks resembled those in the epithelial component of the tumour. Intermediate cells which exhibited characteristics of both neural and epithelial components, particularly in the cell junctional features, were found. Pleomorphism in nonteratoid medulloepithelioma might be accounted for by the developmental stage at which the tumour is initiated.

Ciliary Body↗
PubMed1977

Aldosterone binding in bovine ciliary body.

The presence of aldosterone binding which was not identical with dexamethasone binding was verified in the ciliary body of the bovine eye in vitro. The site of aldosterone binding was presumably located in the non-pigmented layer of ciliary epithelium. Specific aldosterone binding was found also in lens epithelium but not in corneal epithelium. The finding of receptor-like aldosterone binding confirms the concept of possible mineralocorticoid-dependent active sodium transport through the ciliary and lens epithelium in the eye.

Aldosterone↗
PubMed1984

Cavitary melanocytoma of the ciliary body.

The clinical and pathologic findings of a patient with an unusual cavitary melanocytoma of the ciliary body are presented. Clinically and with ultrasonography the lesion appeared to have a cystic component. Differential diagnoses included a malignant melanoma or a cyst, and the lesion was excised by iridocyclectomy.

Ciliary Body↗
PubMed1983

Increase in SP-like immunoreactivity in nerve fibres of rabbit iris and ciliary body one to four months following sympathetic denervation.

Substance P (SP) levels in rabbit iris-ciliary body preparations were found to be significantly elevated 30 days after removal of the superior cervical ganglion when compared with the contralateral unoperated side. These elevated levels were still apparent after two and three months. Immunohistochemical studies, using a monoclonal antibody to SP, revealed an increase in the density of SP-immunoreactive nerve fibres in the region of the iris dilator muscle and in the ciliary processes one to four months after sympathectomy, although the density of these fibres in other regions of the iris was not altered.

Animals↗
PubMed1989

[Trans-scleral ciliary body coagulation with the neodymium:YAG-cw-laser in secondary glaucoma].

Transscleral coagulation of the ciliary body was performed by means of the continuous wave Neodymium: YAG laser in 39 eyes with various types of secondary glaucoma that was not controlled by medical therapy. Three days later, the mean intraocular pressure measured 54% of the pre-laser pressure; 3 months later it was 52%, 6 months later 47%, and 12 months later 58%. In 11 of 14 eyes (78.6%) treated in an attempt to preserve the remaining visual function, the pressure proved to be under control (less than or equal to 20 mmHg) 6 months after treatment. Major complications, such as hyphema or bleeding into the vitreous, were rare (7/39) and occurred only in the eyes with neovascular glaucoma.

Ciliary Body↗
PubMed1988

Pathogenesis of ciliary-body cysts associated with multiple myeloma.

A case history is presented which illustrates the occurrence of ciliary-body cysts in association with multiple myeloma. Gross pathologic, light-microscopic, ultrastructural, and immunofluorescent characteristics of the cysts are presented, and the observed morphology used to postulate their pathogenesis.

Ciliary Body↗
PubMed1989

Mesectodermal leiomyoma of the ciliary body: case report.

The clinical, light microscopical, and electron microscopical features of a mesectodermal leiomyoma of the ciliary body are presented. This exceptionally rare and apparently benign tumour is considered to be of neural crest origin. In the case described the tumour cells were seen to contain thin filaments with focal densities and conspicuous numbers of mitochondria, and smooth muscle protein was demonstrated by immunohistochemical means.

Adult↗
PubMed1981

Trabeculoiridocyclectomy of tumors of the iris and ciliary body.

A microsurgical technique of trabeculoiridocyclectomy for malignant tumors of the iris extending to the angle and ciliary body has been reported. With this technique, the lamellar dissection of the sclera anteriorly into the corneal stroma across the limbus permits excision of the trabecula which is involved with the tumor. In addition, the en bloc excision of the lesion avoids the necessity for a corneo-scleral graft because the outer lamellae are preserved. The ultimate value of this procedure must await long-term follow-up in operated cases.

Adult↗
PubMed2002

Chemokine gene expression in iris-ciliary body during experimental autoimmune uveoretinitis.

PURPOSE: To evaluate, through differential gene expression of chemokines in iris-ciliary body (I/CB), the extent to which leukocyte recruitment to the ocular anterior segment participates in the pathogenesis of experimental autoimmune uveoretinitis (EAU) in mice. METHODS: B10.A mice were immunized with 50 microg of interphotoreceptor retinoid binding protein (IRBP) mixed with complete Freund's adjuvant. Aqueous humor (AqH) was collected at 0, 11, 17, and 28 days and assayed for leukocyte content and protein levels. Enucleated eyes were subjected to histologic analysis. Chemokine gene expression in I/CB was determined at these same time points by a multiprobe ribonuclease protection assay (RPA) system. RESULTS: Inflammation was detected in the anterior chamber (AC) at 11 days and leukocyte recruitment continued thereafter. Polymorphonuclear neutrophils (PMN) were the predominant cell type in the AC, whereas macrophages/monocytes and lymphocytes were predominant in the retina/subretinal space at 17 days. Peak gene expression of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and MIP-2 and interferon-gamma-inducible protein of 10 kd (IP-10) was detected in I/CB on day 11, whereas peak expression of RANTES and eotaxin was observed at 17 days. CONCLUSIONS: Early I/CB peak expression of mRNA for MIP-2 followed by PMN recruitment into the AC, suggests that PMN may play an important role in EAU pathogenesis.

Aging↗
PubMed2006

In vivo reactivation of a quiescent cell population located in the ocular ciliary body of adult mammals.

Rare quiescent cells with stem cell characteristics have been isolated from the ocular ciliary body (CB) of adult mammals. In vitro, adult retinal stem cells were reported to generate sphere colonies containing multipotent retinal progenitor cells. Whether proliferation of this stem cell population can be stimulated in vivo in order to generate new retinal cells is an important issue. Herein we report on the in vivo reactivation of a quiescent cell population present in the CB upon growth factors (GF) stimulation. GF stimulation resulted in the re-acquisition of embryonic characteristics (Nestin) and expression of the cell cycle entry markers CyclinD1 and Ki67 by a subset of CB epithelial cells. This inductive effect was not observed in the neural retina. GF-activated CB epithelial cells co-express the retinal progenitor homeodomain transcription factors Pax6 and Chx10. Serial GF injections led to do novo proliferation of clusters of cells in the CB, in a dose-dependent manner, as revealed by bromodeoxyuridine (BrdU) incorporation. Analysis of cells' BrdU content within individual clusters suggests a mode of cell division that is predominantly asymmetric. Cell proliferation was not induced by CB or retinal damage, as indicated by the absence of TUNEL-labeled cells. Newly produced cells did not migrate into the retina nor did they differentiate into retinal neurons. This study demonstrates that proliferation of a quiescent cell population with retinal stem/progenitor cell characteristics can be reactivated in vivo upon GF injections and suggests that, in adult mammals, the CB is a non-permissive environment for cell migration and neurogenesis.

Animals↗
PubMed1977

Angle-closure secondary to ciliary body swelling.

A 44-year-old man had unilateral closure of the anterior chamber angle associated with ciliary body swelling. He was treated with topical cycloplegics and corticosteroids. The shallow chamber deepended to equal the fellow eye in 6 days, and no recurrence has been noted.

Adult↗