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PubMed1980

[Cybernetics].

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Cybernetics↗
PubMed1981

[The cybernetic circuit of the regulation of antibody formation].

The current theory concerning the formation of antibodies is no more sustainable against the recent view on the formation of complex structures, that involves, together with a random variability, also an ordered variability derived from information interactions. This paper aims at showing that the formation of antibodies requires the existence of a complex sensor which can be excited by the presence of antigenic structures of any shape. The stimulation of this sensor originates both a mass type feedback and a form type feedback; the latter consisting in the activation of a conformational genetic variability that turns into a form variability of the immunoglobulinic active site. This site can thus take a form capable to react with the antigen. The reaction with the antigen acts back negatively upon the sensor and causes the permanent acquisition in repertory of the active form for the subsequent disappearance of the form variability in the immunoglobulinic active site.

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